Abstract:
:The CARMA1/CARD11-BCL10-MALT1 (CBM) complex bridges T and B cell antigen receptor (TCR/BCR) ligation to MALT1 protease activation and canonical nuclear factor κB (NF-κB) signaling. Using unbiased mass spectrometry, we discover multiple serine phosphorylation sites in the MALT1 C terminus after T cell activation. Phospho-specific antibodies reveal that CBM-associated MALT1 is transiently hyper-phosphorylated upon TCR/CD28 co-stimulation. We identify a dual role for CK1α as a kinase that is essential for CBM signalosome assembly as well as MALT1 phosphorylation. Although MALT1 phosphorylation is largely dispensable for protease activity, it fosters canonical NF-κB signaling in Jurkat and murine CD4 T cells. Moreover, constitutive MALT1 phosphorylation promotes survival of activated B cell-type diffuse large B cell lymphoma (ABC-DLBCL) cells addicted to chronic BCR signaling. Thus, MALT1 phosphorylation triggers optimal NF-κB activation in lymphocytes and survival of lymphoma cells.
journal_name
Cell Repjournal_title
Cell reportsauthors
Gehring T,Erdmann T,Rahm M,Graß C,Flatley A,O'Neill TJ,Woods S,Meininger I,Karayel O,Kutzner K,Grau M,Shinohara H,Lammens K,Feederle R,Hauck SM,Lenz G,Krappmann Ddoi
10.1016/j.celrep.2019.09.040subject
Has Abstractpub_date
2019-10-22 00:00:00pages
873-888.e10issue
4issn
2211-1247pii
S2211-1247(19)31228-8journal_volume
29pub_type
杂志文章相关文献
Cell Reports文献大全abstract::Parsing diverse nerve cells into biological types is necessary for understanding neural circuit organization. Morphology is an intuitive criterion for neuronal classification and a proxy of connectivity, but morphological diversity and variability often preclude resolving the granularity of neuron types. Combining gen...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.02.040
更新日期:2019-03-12 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disease biochemically characterized by aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein aggregates in the cell are cleared by autophagy, a mechanism impaired in AD. To investigate the role of autophagy in Aβ pathology in vivo, we cr...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.08.042
更新日期:2013-10-17 00:00:00
abstract::Embryonic cells transcriptionally repress the expression of endogenous and exogenous retroelements. Trim28, a key player in this silencing, is known to act in a large DNA-bound complex, but the other components of the complex are not fully characterized. Here, we show that the zinc finger protein Yin Yang 1 (YY1) is o...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.06.003
更新日期:2013-07-11 00:00:00
abstract::Insulin stimulates glucose uptake through the membrane translocation of GLUT4 and GLUT1. Peroxisome proliferator-activated receptor γ (PPARγ) enhances insulin sensitivity. Here, we demonstrate that insulin stimulates GLUT4 and GLUT1 translocation, and glucose uptake, by activating the signaling pathway involving nicot...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2012.10.018
更新日期:2012-12-27 00:00:00
abstract::DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How DNA methylation is regulated in developmental and cellular processes and ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.11.082
更新日期:2017-12-19 00:00:00
abstract::One puzzling observation in patients affected with Hutchinson-Gilford progeria syndrome (HGPS), who overall exhibit systemic and dramatic premature aging, is the absence of any conspicuous cognitive impairment. Recent studies based on induced pluripotent stem cells derived from HGPS patient cells have revealed a lack ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2012.05.015
更新日期:2012-07-26 00:00:00
abstract::The locomotion of C. elegans is balanced by excitatory and inhibitory neurotransmitter release at neuromuscular junctions. However, the molecular mechanisms that maintain the balance of synaptic transmission remain enigmatic. Here, we investigated the function of voltage-gated Ca2+ channels in triggering spontaneous r...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.02.023
更新日期:2018-02-27 00:00:00
abstract::Horizontal transmission of the microbiota between different individuals is widely used to normalize the microbiota in laboratory mice. However, little is known about the dynamics of microbial communities and the level of microbiota transmission after cohousing. We extensively analyzed the fecal microbiota in Jackson a...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.05.042
更新日期:2019-06-11 00:00:00
abstract::Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner. In all settings, developmental lymphangiogenesis is considered driven by vascular endothe...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.07.055
更新日期:2019-08-20 00:00:00
abstract::Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of these drugs in breast cancer and other tumor types, clinical response remains variable. Tumor-associated macrophages (TAMs) suppress the duration of Taxol-indu...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.03.038
更新日期:2017-04-04 00:00:00
abstract::In response to DNA double-strand breaks (DSBs), H2AX is rapidly phosphorylated at Ser139 to promote DSB repair. Here we show that H2AX is rapidly stabilized in response to DSBs to efficiently generate γH2AX foci. This mechanism operated even in quiescent cells that barely expressed H2AX. H2AX stabilization resulted fr...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.11.054
更新日期:2015-12-29 00:00:00
abstract::To study contributions of N-methyl-D-aspartate receptors (NMDARs) in presynaptic and postsynaptic neurons of the developing visual system, we microinject antisense Morpholino oligonucleotide (MO) against GluN1 into one cell of two-cell-stage Xenopus laevis embryos. The resulting bilateral segregation of MO induces pos...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.107955
更新日期:2020-07-28 00:00:00
abstract::Nucleoplasmin (Npm) is an abundant histone chaperone in vertebrate oocytes and embryos. During embryogenesis, regulation of Npm histone binding is critical for its function in storing and releasing maternal histones to establish and maintain the zygotic epigenome. Here, we demonstrate that Xenopus laevis Npm post-tran...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.02.038
更新日期:2015-03-17 00:00:00
abstract::PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.03.030
更新日期:2015-04-21 00:00:00
abstract::The chemokine receptor CCR7 plays a crucial role in the homing of central memory and naive T cells to peripheral lymphoid organs. Here, we show that the HIV-1 accessory protein Vpu downregulates CCR7 on the surface of CD4(+) T cells. Vpu and CCR7 were found to specifically interact and colocalize within the trans-Golg...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.05.015
更新日期:2014-06-26 00:00:00
abstract::The joint contribution of pre-existing and de novo genetic variation to clonal adaptation is poorly understood but essential to designing successful antimicrobial or cancer therapies. To address this, we evolve genetically diverse populations of budding yeast, S. cerevisiae, consisting of diploid cells with unique hap...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.09.046
更新日期:2017-10-17 00:00:00
abstract::Developing strategies that promote the resolution of vascular inflammation and atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes produced by naive bone marrow-derived macrophages (BMDM-exo) contain anti-inflammatory microRNA-99a/146b/378a that are further increased in exosomes produced...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.107881
更新日期:2020-07-14 00:00:00
abstract::Dentate gyrus (DG) development requires specification of granule cell (GC) progenitors in the hippocampal neuroepithelium, as well as their proliferation and migration into the primordial DG. We identify the Plexin family members Plxna2 and Plxna4 as important regulators of DG development. Distribution of immature GCs...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.12.044
更新日期:2018-01-09 00:00:00
abstract::The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development. Here, we describe the generation of a RhoA-fluorescence resonance e...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.09.022
更新日期:2017-10-03 00:00:00
abstract::Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome (PWS), a genetic obesity syndrome characterized by severe hyperphagia. We fou...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.03.018
更新日期:2018-03-27 00:00:00
abstract::Autophagy is an essential cellular survival mechanism that is required for adaptive lymphocyte development; however, its role in innate lymphoid cell (ILC) development remains unknown. Furthermore, the conditions that promote lymphocyte autophagy during homeostasis are poorly understood. Here, we demonstrate that Atg5...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.04.082
更新日期:2016-05-31 00:00:00
abstract::Katanin was the first microtubule (MT)-severing enzyme discovered, but how katanin executes MT severing remains poorly understood. Here, we report X-ray crystal structures of the apo and ATPγS-bound states of the catalytic AAA domain of human katanin p60 at 3.0 and 2.9 Å resolution, respectively. Comparison of the two...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.01.020
更新日期:2019-01-29 00:00:00
abstract::Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells (NFAT) signaling pathway is central to endothelial cell angiogenic responses, and it is activated by ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.04.008
更新日期:2018-05-08 00:00:00
abstract::Lipoprotein cholesterol is delivered to the limiting membrane of late endosomes/lysosomes (LELs) by Niemann-Pick C1 (NPC1). However, the mechanism of cholesterol transport from LELs to the endoplasmic reticulum (ER) is poorly characterized. We report that oxysterol-binding protein-related protein 1L (ORP1L) is necessa...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.05.028
更新日期:2017-05-30 00:00:00
abstract::Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and that, basally, IRFs contribute to the expression of type I IFN ligands and ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.108345
更新日期:2020-11-03 00:00:00
abstract::Ribosomes and a subset of cellular mRNAs are trafficked into axons of developing neurons. The axonal localization of translational machinery allows new proteins to be rapidly and locally synthesized during axonal growth and pathfinding. However, in mature neurons, axonal ribosomes are significantly reduced or even abs...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.06.080
更新日期:2019-07-23 00:00:00
abstract::Cognitive dysfunction and decreased mobility from aging and neurodegenerative conditions, such as Parkinson and Alzheimer diseases, are major biomedical challenges in need of more effective therapies. Increasing brain resilience may represent a new treatment strategy. Klotho, a longevity factor, enhances cognition whe...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.07.024
更新日期:2017-08-08 00:00:00
abstract::The achievement of the final form of an individual requires not only the control of cell size and differentiation but also integrative directional cues to instruct cell movements, positions, and orientations. In Drosophila, the adult epidermis of the abdomen is created de novo by histoblasts. As these expand and fuse,...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.11.036
更新日期:2018-12-04 00:00:00
abstract::Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is highly expressed in the skin and downregulated in psoriasis patients. We report an investigation in cellular targets of IL-38 during the progression of ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.03.082
更新日期:2019-04-16 00:00:00
abstract::The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase-1 activation and interleukin (IL)-1β maturation in response to microbial infection and cellular damage. However, aberrant activation of the NLRP3 inflammasome contributes to the pathogenesis of several inflammatory disorders, inc...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.108405
更新日期:2020-11-17 00:00:00