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Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis.

Abstract：

:The distinct lineage potential is a key feature of hematopoietic stem cell (HSC) heterogeneity, but a subset of HSCs specialized for a single lymphoid compartment has not been identified. Here we report that HSCs expressing junctional adhesion molecule 2 (Jam2) at a higher level (Jam2high HSCs) have a greater T cell reconstitution capacity. Jam2high HSCs are metabolically dormant but preferentially differentiate toward lymphocytes, especially T cell lineages. Jam2high HSCs uniquely express T cell-related genes, and the interaction with Jam1 facilitates the Notch/Delta signaling pathway. Frequency of Jam2high HSCs changes upon T cell depletion in vivo, potentially suggesting that Jam2 expression may reflect scarcity of T cells and requirement of T cell replenishment. Our findings highlight Jam2 as a potential marker for a subfraction of HSCs with an extensive lymphopoietic capacity, mainly in T lymphopoiesis.

journal_name

Cell Rep

journal_title

Cell reports

authors

Radulovic V,van der Garde M,Koide S,Sigurdsson V,Lang S,Kaneko S,Miharada K

doi

10.1016/j.celrep.2019.05.028

subject

Has Abstract

pub_date

2019-06-04 00:00:00

pages

2826-2836.e5

issue

10

issn

2211-1247

pii

S2211-1247(19)30639-4

journal_volume

27

pub_type

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