Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.


:Proprioception, the sense of limb and body position, is essential for generating proper movement. Unconscious proprioceptive information travels through cerebellar-projecting neurons in the spinal cord and medulla. The progenitor domain defined by the basic-helix-loop-helix (bHLH) transcription factor, ATOH1, has been implicated in forming these cerebellar-projecting neurons; however, their precise contribution to proprioceptive tracts and motor behavior is unknown. Significantly, we demonstrate that Atoh1-lineage neurons in the spinal cord reside outside Clarke's column (CC), a main contributor of neurons relaying hindlimb proprioception, despite giving rise to the anatomical and functional correlate of CC in the medulla, the external cuneate nucleus (ECu), which mediates forelimb proprioception. Elimination of caudal Atoh1-lineages results in mice with relatively normal locomotion but unable to perform coordinated motor tasks. Altogether, we reveal that proprioceptive nuclei in the spinal cord and medulla develop from more than one progenitor source, suggesting an avenue to uncover distinct proprioceptive functions.


Cell Rep


Cell reports


Yuengert R,Hori K,Kibodeaux EE,McClellan JX,Morales JE,Huang TP,Neul JL,Lai HC




Has Abstract


2015-11-10 00:00:00












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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Vila IK,Badin PM,Marques MA,Monbrun L,Lefort C,Mir L,Louche K,Bourlier V,Roussel B,Gui P,Grober J,Štich V,Rossmeislová L,Zakaroff-Girard A,Bouloumié A,Viguerie N,Moro C,Tavernier G,Langin D

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  • Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva.

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    journal_title:Cell reports

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Vigilante A,Laddach A,Moens N,Meleckyte R,Leha A,Ghahramani A,Culley OJ,Kathuria A,Hurling C,Vickers A,Wiseman E,Tewary M,Zandstra PW,HipSci Consortium.,Durbin R,Fraternali F,Stegle O,Birney E,Luscombe NM,Danovi D,

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  • Suppression of host p53 is critical for Plasmodium liver-stage infection.

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    journal_title:Cell reports

    pub_type: 杂志文章


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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Li X,Qin L,Li Y,Yu H,Zhang Z,Tao C,Liu Y,Xue Y,Zhang X,Xu Z,Wang Y,Lou H,Tan Z,Saftig P,Chen Z,Xu T,Bi G,Duan S,Gao Z

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    journal_title:Cell reports

    pub_type: 评论,杂志文章


    authors: Mellert H,Espinosa JM

    更新日期:2013-05-30 00:00:00

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    pub_type: 杂志文章


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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Ryu H,Gygi SP,Azuma Y,Arnaoutov A,Dasso M

    更新日期:2014-06-26 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Huang X,Li J,Dorta-Estremera S,Di Domizio J,Anthony SM,Watowich SS,Popkin D,Liu Z,Brohawn P,Yao Y,Schluns KS,Lanier LL,Cao W

    更新日期:2015-08-18 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Urbain N,Fourcaud-Trocmé N,Laheux S,Salin PA,Gentet LJ

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Scheefhals N,Catsburg LAE,Westerveld ML,Blanpied TA,Hoogenraad CC,MacGillavry HD

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Kouloulia S,Hallin EI,Simbriger K,Amorim IS,Lach G,Amvrosiadis T,Chalkiadaki K,Kampaite A,Truong VT,Hooshmandi M,Jafarnejad SM,Skehel P,Kursula P,Khoutorsky A,Gkogkas CG

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    pub_type: 杂志文章


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    journal_title:Cell reports

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Clottu AS,Mathias A,Sailer AW,Schluep M,Seebach JD,Du Pasquier R,Pot C

    更新日期:2017-01-03 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


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    更新日期:2013-01-31 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Devergne O,Sun GH,Schüpbach T

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Sengar AS,Li H,Zhang W,Leung C,Ramani AK,Saw NM,Wang Y,Tu Y,Ross PJ,Scherer SW,Ellis J,Brudno M,Jia Z,Salter MW

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    pub_type: 杂志文章


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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Vissers JHA,Froldi F,Schröder J,Papenfuss AT,Cheng LY,Harvey KF

    更新日期:2018-11-06 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Hernandez S,Qing J,Thibodeau RH,Du X,Park S,Lee HM,Xu M,Oh S,Navarro A,Roose-Girma M,Newman RJ,Warming S,Nannini M,Sampath D,Kim JM,Grogan JL,Mellman I

    更新日期:2018-10-02 00:00:00

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    abstract::The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand crosslinks (ICLs), where it coordinates DNA repair through mechanisms t...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Unno J,Itaya A,Taoka M,Sato K,Tomida J,Sakai W,Sugasawa K,Ishiai M,Ikura T,Isobe T,Kurumizaka H,Takata M

    更新日期:2014-05-22 00:00:00

  • Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis.

    abstract::During bacterial sepsis, proinflammatory cytokines contribute to multiorgan failure and death in a process regulated in part by cytolytic cell granzymes. When challenged with a sublethal dose of the identified mouse pathogen Brucella microti, wild-type (WT) and granzyme A (gzmA)(-/-) mice eliminate the organism from l...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Arias MA,Jiménez de Bagües MP,Aguiló N,Menao S,Hervás-Stubbs S,de Martino A,Alcaraz A,Simon MM,Froelich CJ,Pardo J

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    abstract::The twin-ATPase ABCE1 has a vital function in mRNA translation by recycling terminated or stalled ribosomes. As for other functionally distinct ATP-binding cassette (ABC) proteins, the mechanochemical coupling of ATP hydrolysis to conformational changes remains elusive. Here, we use an integrated biophysical approach ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Gouridis G,Hetzert B,Kiosze-Becker K,de Boer M,Heinemann H,Nürenberg-Goloub E,Cordes T,Tampé R

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    abstract::PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Matsumoto N,Sato K,Nishimasu H,Namba Y,Miyakubi K,Dohmae N,Ishitani R,Siomi H,Siomi MC,Nureki O

    更新日期:2015-04-21 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Nishiguchi MA,Spencer CA,Leung DH,Leung TH

    更新日期:2018-09-25 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Wienerroither S,Shukla P,Farlik M,Majoros A,Stych B,Vogl C,Cheon H,Stark GR,Strobl B,Müller M,Decker T

    更新日期:2015-07-14 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Yadav V,Matsakas A,Lorca S,Narkar VA

    更新日期:2014-08-07 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Sadakane O,Masamizu Y,Watakabe A,Terada S,Ohtsuka M,Takaji M,Mizukami H,Ozawa K,Kawasaki H,Matsuzaki M,Yamamori T

    更新日期:2015-12-01 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Yu H,Lim HH,Tjokro NO,Sathiyanathan P,Natarajan S,Chew TW,Klonisch T,Goodman SD,Surana U,Dröge P

    更新日期:2014-02-27 00:00:00