Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.


:Proprioception, the sense of limb and body position, is essential for generating proper movement. Unconscious proprioceptive information travels through cerebellar-projecting neurons in the spinal cord and medulla. The progenitor domain defined by the basic-helix-loop-helix (bHLH) transcription factor, ATOH1, has been implicated in forming these cerebellar-projecting neurons; however, their precise contribution to proprioceptive tracts and motor behavior is unknown. Significantly, we demonstrate that Atoh1-lineage neurons in the spinal cord reside outside Clarke's column (CC), a main contributor of neurons relaying hindlimb proprioception, despite giving rise to the anatomical and functional correlate of CC in the medulla, the external cuneate nucleus (ECu), which mediates forelimb proprioception. Elimination of caudal Atoh1-lineages results in mice with relatively normal locomotion but unable to perform coordinated motor tasks. Altogether, we reveal that proprioceptive nuclei in the spinal cord and medulla develop from more than one progenitor source, suggesting an avenue to uncover distinct proprioceptive functions.


Cell Rep


Cell reports


Yuengert R,Hori K,Kibodeaux EE,McClellan JX,Morales JE,Huang TP,Neul JL,Lai HC




Has Abstract


2015-11-10 00:00:00












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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Chea S,Schmutz S,Berthault C,Perchet T,Petit M,Burlen-Defranoux O,Goldrath AW,Rodewald HR,Cumano A,Golub R

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    journal_title:Cell reports

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    authors: Hackett EE,Charles-Messance H,O'Leary SM,Gleeson LE,Muñoz-Wolf N,Case S,Wedderburn A,Johnston DGW,Williams MA,Smyth A,Ouimet M,Moore KJ,Lavelle EC,Corr SC,Gordon SV,Keane J,Sheedy FJ

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    authors: Fucci C,Resnati M,Riva E,Perini T,Ruggieri E,Orfanelli U,Paradiso F,Cremasco F,Raimondi A,Pasqualetto E,Nuvolone M,Rampoldi L,Cenci S,Milan E

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    pub_type: 杂志文章


    authors: Flor-Parra I,Iglesias-Romero AB,Salas-Pino S,Lucena R,Jimenez J,Daga RR

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    pub_type: 杂志文章


    authors: Wang X,Tucciarone J,Jiang S,Yin F,Wang BS,Wang D,Jia Y,Jia X,Li Y,Yang T,Xu Z,Akram MA,Wang Y,Zeng S,Ascoli GA,Mitra P,Gong H,Luo Q,Huang ZJ

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    pub_type: 杂志文章


    authors: Berger C,Harzer H,Burkard TR,Steinmann J,van der Horst S,Laurenson AS,Novatchkova M,Reichert H,Knoblich JA

    更新日期:2012-08-30 00:00:00

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    pub_type: 杂志文章


    authors: Mandoli A,Singh AA,Prange KHM,Tijchon E,Oerlemans M,Dirks R,Ter Huurne M,Wierenga ATJ,Janssen-Megens EM,Berentsen K,Sharifi N,Kim B,Matarese F,Nguyen LN,Hubner NC,Rao NA,van den Akker E,Altucci L,Vellenga E,Stunnenb

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    journal_title:Cell reports

    pub_type: 评论,杂志文章


    authors: Navin NE

    更新日期:2014-02-13 00:00:00