Abstract：
:The transcription factor NKX2-1 is best known for its role in the specification of subsets of cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and intersectional focal septal deletion that NKX2-1 is selectively required in the embryonic septal neuroepithelium for the development of cholinergic septohippocampal projection neurons and large subsets of basal forebrain cholinergic neurons. In the absence of NKX2-1, these neurons fail to develop, causing alterations in hippocampal theta rhythms and severe deficiencies in learning and memory. Our results demonstrate that learning and memory are dependent on NKX2-1 function in the embryonic septum and suggest that cognitive deficiencies that are sometimes associated with pathogenic mutations in NKX2-1 in humans may be a direct consequence of loss of NKX2-1 function.
journal_name
Cell Repjournal_title
Cell reportsauthors
Magno L,Barry C,Schmidt-Hieber C,Theodotou P,Häusser M,Kessaris Ndoi
10.1016/j.celrep.2017.07.053subject
Has Abstractpub_date
2017-08-15 00:00:00pages
1572-1584issue
7issn
2211-1247pii
S2211-1247(17)31032-Xjournal_volume
20pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Diet-induced obesity (DIO) predisposes individuals to insulin resistance, and adipose tissue has a major role in the disease. Insulin resistance can be induced in cultured adipocytes by a variety of treatments, but what aspects of the in vivo responses are captured by these models remains unknown. We use global RNA se...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.08.039
更新日期：2013-10-17 00:00:00
abstract：:Graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic cell transplantation (allo-HCT). Lysosomal acid lipase (LAL) mediates the intrinsic lipolysis of cells to generate free fatty acids (FFAs), which play an essential role in the development, proliferation, and function of T cells. Here, we f...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108316
更新日期：2020-10-27 00:00:00
abstract：:Appropriate regulation of genes that coordinate pancreas progenitor proliferation and differentiation is required for pancreas development. Here, we explore the role of H3K4 methylation and the Trithorax group (TrxG) complexes in mediating gene expression during pancreas development. Disruption of TrxG complex assembl...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.035
更新日期：2019-08-13 00:00:00
abstract：:Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely understood. We profiled microglia of a discrete developing CNS region, the murine ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.04.062
更新日期：2019-05-14 00:00:00
abstract：:Transport of RNAs to dendrites occurs in neuronal RNA granules, which allows local synthesis of specific proteins at active synapses on demand, thereby contributing to learning and memory. To gain insight into the machinery controlling dendritic mRNA localization and translation, we established a stringent protocol to...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.11.023
更新日期：2013-12-26 00:00:00
abstract：:The diversity and complexity of the cancer transcriptome may contain transcripts unique to the tumor environment. Here, we report a LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. Expression of LIN28B-TST is associated with significantly poor p...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.02.002
更新日期：2018-02-20 00:00:00
abstract：:Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells. Here, we demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumor progression. NRCP was highly upregulated in ovarian tumors, a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.11.047
更新日期：2015-12-22 00:00:00
abstract：:Inflammasome activation is associated with numerous diseases. However, in vivo detection of the activated inflammasome complex has been limited by a dearth of tools. We have developed transgenic mice that ectopically express the fluorescent adaptor protein, apoptosis-associated speck-like protein containing a caspase ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.011
更新日期：2016-07-12 00:00:00
abstract：:Bacterial genes that change in expression upon environmental disturbance have commonly been seen as those that must also phenotypically matter. However, several studies suggest that differentially expressed genes are rarely phenotypically important. We demonstrate, for Gram-positive and Gram-negative bacteria, that th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.07.062
更新日期：2017-08-15 00:00:00
abstract：:Investigating mechanisms that regulate endothelial cell (EC) growth and survival is important for understanding EC homeostasis and how ECs maintain stem cell niches. We report here that targeted loss of Id genes in adult ECs results in dilated, leaky sinusoids and a pro-inflammatory state that increases in severity ov...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107572
更新日期：2020-04-28 00:00:00
abstract：:Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal development and cancer. We describe a program of multisite phosphorylation that regulates the conversion of Gli proteins into transcriptional activators. In the absence of Hh ligands, Gli activity is restrained by the direct phospho...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.12.003
更新日期：2014-01-16 00:00:00
abstract：:Neural modulation in primate motor cortex exhibits complex patterns. We found that modulation during reaching could be separated into discrete temporal epochs. To determine if these epochs are driven by behavioral events, monkeys performed variations of a center-out reaching task. Monkeys viewed a computer cursor matc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.11.069
更新日期：2019-12-17 00:00:00
abstract：:Trimethylation of histone H3 at lysine-4 (H3K4me3) is associated with eukaryotic gene promoters and poises their transcriptional activation during development. To examine the in vivo function of H3K4me3 in the absence of DNA replication, we deleted CXXC finger protein 1 (CFP1), the DNA-binding subunit of the SETD1 his...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.07.011
更新日期：2017-08-01 00:00:00
abstract：:The ultimate goal of protein design is to introduce new biological activity. We propose a computational approach for designing functional antibodies by focusing on functional epitopes, integrating large-scale statistical analysis with multiple structural models. Machine learning is used to analyze these models and pre...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.10.081
更新日期：2018-11-20 00:00:00
abstract：:Successful anti-viral response requires the sustained activation and expansion of CD8+ T cells for periods that far exceed the time limit of physical T cell interaction with antigen-presenting cells (APCs). The expanding CD8+ T cell pool generates the effector and memory cell populations that provide viral clearance a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.06.075
更新日期：2018-07-31 00:00:00
abstract：:Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of new unmodified histones during each cell cycle, and the principl...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.12.060
更新日期：2020-01-28 00:00:00
abstract：:Recent reports suggest that botulinum neurotoxin (BoNT) A, which is widely used clinically to inhibit neurotransmission, can spread within networks of neurons to have distal effects, but this remains controversial. Moreover, it is not known whether other members of this toxin family are transferred between neurons. He...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.104
更新日期：2016-08-16 00:00:00
abstract：:The spindle assembly checkpoint (SAC) prevents premature segregation of chromosomes during mitosis. This process requires structural remodeling of MAD2 from O-MAD2 to C-MAD2 conformation. After the checkpoint is satisfied, C-MAD2 is reverted to O-MAD2 to allow anaphase-promoting complex/cyclosome (APC/C) to trigger an...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.01.027
更新日期：2018-02-06 00:00:00
abstract：:Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand in conditions of low glucose supply. Many tissues oxidize fat as an alternate energy substrate. Here, we show th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.05.035
更新日期：2018-06-12 00:00:00
abstract：:X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations in XIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using gene-targeted mice, we show that loss of XIAP or deletion of its...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.05.008
更新日期：2014-06-26 00:00:00
abstract：:The first cell fate choice of the preimplantation embryo generates the extraembryonic trophoblast and embryonic epiblast lineages. Embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) can be utilized to investigate molecular mechanisms of this first cell fate decision. It has been established that ESCs can be...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.04.040
更新日期：2017-05-09 00:00:00
abstract：:The asymmetric distribution of auxin leads to the bending growth of hypocotyls during gravitropic and phototropic responses, but the signaling events downstream of auxin remain unclear. Here, we identify many SAUR genes showing asymmetric expression in soybean hypocotyls during gravistimulation and then study their ho...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107529
更新日期：2020-04-21 00:00:00
abstract：:Mutations of WD40-repeat protein 62 (WDR62) have been identified recently to cause human MCPH (autosomal-recessive primary microcephaly), a neurodevelopmental disorder characterized by decreased brain size. However, the underlying mechanism is unclear. Here, we investigate the function of WDR62 in brain development an...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.12.016
更新日期：2014-01-16 00:00:00
abstract：:The MYC proto-oncogene is a transcription factor implicated in a broad range of cancers. MYC is regulated by several post-translational modifications including SUMOylation, but the functional impact of this post-translational modification is still unclear. Here, we report that the SUMO E3 ligase PIAS1 SUMOylates MYC. ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.05.015
更新日期：2016-06-07 00:00:00
abstract：:The JAK/STAT1 pathway is generally activated by cytokines, providing essential antiviral defense. Here, we identify that STAT1 activation is independent of cytokines and JAKs at the early infection stage of some viruses, including influenza A virus (IAV). Instead, STAT1 is activated mainly through spleen tyrosine kina...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108627
更新日期：2021-01-19 00:00:00
abstract：:Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and progression of fibr...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.03.062
更新日期：2014-05-22 00:00:00
abstract：:Evolutionary expansion of the human neocortex is partially attributed to a relative abundance of neural stem cells in the fetal brain called outer radial glia (oRG). oRG cells display a characteristic division mode, mitotic somal translocation (MST), in which the soma rapidly translocates toward the cortical plate imm...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.06.058
更新日期：2014-08-07 00:00:00
abstract：:Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs). Both cold exposure and iAdFASNKO upregulate the sympathetic nerve fiber (SNF) modulator Neuregulin 4 (Nrg4), activate ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107998
更新日期：2020-08-04 00:00:00
abstract：:PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.03.030
更新日期：2015-04-21 00:00:00
abstract：:Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory disease. Once activated, the cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase (cGAS)-STING pathway induces both type I interferon ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.03.056
更新日期：2020-04-07 00:00:00
