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Lack of Transcription Triggers H3K27me3 Accumulation in the Gene Body.

Abstract：

:Trimethylated H3K27 (H3K27me3) is associated with transcriptional repression, and its abundance in chromatin is frequently altered in cancer. However, it has remained unclear how genomic regions modified by H3K27me3 are specified and formed. We previously showed that downregulation of transcription by oncogenic Ras signaling precedes upregulation of H3K27me3 level. Here, we show that lack of transcription as a result of deletion of the transcription start site of a gene is sufficient to increase H3K27me3 content in the gene body. We further found that histone deacetylation mediates Ras-induced gene silencing and subsequent H3K27me3 accumulation. The H3K27me3 level increased gradually after Ras activation, requiring at least 35 days to achieve saturation. Such maximal accumulation of H3K27me3 was reversed by forced induction of transcription with the dCas9-activator system. Thus, our results indicate that changes in H3K27me3 level, especially in the body of a subset of genes, are triggered by changes in transcriptional activity itself.

journal_name

Cell Rep

journal_title

Cell reports

authors

Hosogane M,Funayama R,Shirota M,Nakayama K

doi

10.1016/j.celrep.2016.06.034

subject

Has Abstract

pub_date

2016-07-19 00:00:00

pages

696-706

issue

3

issn

2211-1247

pii

S2211-1247(16)30774-4

journal_volume

16

pub_type

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