Abstract:
:Oligodendrocyte progenitors (OPs) arise from distinct ventral and dorsal domains within the ventricular germinal zones of the embryonic CNS. The functional significance, if any, of these different populations is not known. Using dual-color reporter mice to distinguish ventrally and dorsally derived OPs, we show that, in response to focal demyelination of the young adult spinal cord or corpus callosum, dorsally derived OPs undergo enhanced proliferation, recruitment, and differentiation as compared with their ventral counterparts, making a proportionally larger contribution to remyelination. However, with increasing age (up to 13 months), the dorsally derived OPs become less able to differentiate into mature oligodendrocytes. Comparison of dorsally and ventrally derived OPs in culture revealed inherent differences in their migration and differentiation capacities. Therefore, the responsiveness of OPs to demyelination, their contribution to remyelination, and their susceptibility to age-associated functional decline are markedly dependent on their developmental site of origin in the developing neural tube.
journal_name
Cell Repjournal_title
Cell reportsauthors
Crawford AH,Tripathi RB,Richardson WD,Franklin RJMdoi
10.1016/j.celrep.2016.03.069subject
Has Abstractpub_date
2016-04-26 00:00:00pages
761-773issue
4issn
2211-1247pii
S2211-1247(16)30358-8journal_volume
15pub_type
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