Motile axonal mitochondria contribute to the variability of presynaptic strength.

abstract：:Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1). In addition to numerous other targets, core histone tails are primary acceptors of Ser-ADPr in the DNA damage response. Here, we s...

journal_title：Cell reports

authors： Bartlett E,Bonfiglio JJ,Prokhorova E,Colby T,Zobel F,Ahel I,Matic I

更新日期：2018-09-25 00:00:00

abstract：:The efficient generation of hematopoietic stem cells from human pluripotent stem cells is dependent on the appropriate specification of the definitive hematopoietic program during differentiation. In this study, we used T lymphocyte potential to track the onset of definitive hematopoiesis from human embryonic and indu...

journal_title：Cell reports

authors： Kennedy M,Awong G,Sturgeon CM,Ditadi A,LaMotte-Mohs R,Zúñiga-Pflücker JC,Keller G

更新日期：2012-12-27 00:00:00

abstract：:Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and Cdt1. We find that the three origins in the single chromosome of the...

journal_title：Cell reports

authors： Samson RY,Xu Y,Gadelha C,Stone TA,Faqiri JN,Li D,Qin N,Pu F,Liang YX,She Q,Bell SD

更新日期：2013-02-21 00:00:00

abstract：:The endoplasmic reticulum (ER) unfolded protein response (UPR(er)) pathway plays an important role in helping pancreatic β cells to adapt their cellular responses to environmental cues and metabolic stress. Although altered UPR(er) gene expression appears in rodent and human type 2 diabetic (T2D) islets, the underlyin...

journal_title：Cell reports

authors： Rabhi N,Denechaud PD,Gromada X,Hannou SA,Zhang H,Rashid T,Salas E,Durand E,Sand O,Bonnefond A,Yengo L,Chavey C,Bonner C,Kerr-Conte J,Abderrahmani A,Auwerx J,Fajas L,Froguel P,Annicotte JS

更新日期：2016-05-03 00:00:00

abstract：:The local synthesis of transmembrane proteins underlies functional specialization of dendritic microdomains in neuronal plasticity. It is unclear whether these proteins have access to the complete machinery of the secretory pathway following local synthesis. In this study, we describe a probe called pGolt that allows ...

journal_title：Cell reports

authors： Mikhaylova M,Bera S,Kobler O,Frischknecht R,Kreutz MR

更新日期：2016-01-12 00:00:00

abstract：:Lipoprotein cholesterol is delivered to the limiting membrane of late endosomes/lysosomes (LELs) by Niemann-Pick C1 (NPC1). However, the mechanism of cholesterol transport from LELs to the endoplasmic reticulum (ER) is poorly characterized. We report that oxysterol-binding protein-related protein 1L (ORP1L) is necessa...

journal_title：Cell reports

authors： Zhao K,Ridgway ND

更新日期：2017-05-30 00:00:00

abstract：:Synapse elimination is crucial for precise neural circuit formation during postnatal development. We examined how relative differences in synaptic strengths among competing inputs and/or absolute synaptic strengths contribute to climbing fiber (CF) to Purkinje cell (PC) synapse elimination in the cerebellum. We genera...

journal_title：Cell reports

authors： Kawata S,Miyazaki T,Yamazaki M,Mikuni T,Yamasaki M,Hashimoto K,Watanabe M,Sakimura K,Kano M

更新日期：2014-08-21 00:00:00

abstract：:The development of an embryo requires precise spatiotemporal regulation of cellular processes. During Drosophila gastrulation, a precise temporal pattern of cell division is encoded through transcriptional regulation of cdc25(string) in 25 distinct mitotic domains. Using a genetic screen, we demonstrate that the same ...

journal_title：Cell reports

authors： Momen-Roknabadi A,Di Talia S,Wieschaus E

更新日期：2016-09-13 00:00:00

abstract：:CISD2 is located within the chromosome 4q region frequently deleted in hepatocellular carcinoma (HCC). Mice with Cisd2 heterozygous deficiency develop a phenotype similar to the clinical manifestation of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Cisd2 haploinsufficiency causes a...

journal_title：Cell reports

authors： Shen ZQ,Chen YF,Chen JR,Jou YS,Wu PC,Kao CH,Wang CH,Huang YL,Chen CF,Huang TS,Shyu YC,Tsai SF,Kao LS,Tsai TF

更新日期：2017-11-21 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is a transcription factor central to axon regrowth with an enigmatic ability to act in different subcellular regions independently of its transcriptional roles. However, its roles in mature CNS neurons remain unclear. Here, we show that along with nuclear tran...

journal_title：Cell reports

authors： Luo X,Ribeiro M,Bray ER,Lee DH,Yungher BJ,Mehta ST,Thakor KA,Diaz F,Lee JK,Moraes CT,Bixby JL,Lemmon VP,Park KK

更新日期：2016-04-12 00:00:00

abstract：:Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. Combining a genetic strategy with longitudinal live imaging, we find that indiv...

journal_title：Cell reports

authors： Gao X,Zhang Z,Mashimo T,Shen B,Nyagilo J,Wang H,Wang Y,Liu Z,Mulgaonkar A,Hu XL,Piccirillo SGM,Eskiocak U,Davé DP,Qin S,Yang Y,Sun X,Fu YX,Zong H,Sun W,Bachoo RM,Ge WP

更新日期：2020-02-25 00:00:00

abstract：:Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, we show that a previously unidentified subpopulation, EpCam(+)UEA1(-)Ly-51(+)PLET1(+)MHC class II(hi), which comprises <0.5% of adult TECs, contains bipotent ...

journal_title：Cell reports

authors： Ulyanchenko S,O'Neill KE,Medley T,Farley AM,Vaidya HJ,Cook AM,Blair NF,Blackburn CC

更新日期：2016-03-29 00:00:00

abstract：:Recent reports suggest that botulinum neurotoxin (BoNT) A, which is widely used clinically to inhibit neurotransmission, can spread within networks of neurons to have distal effects, but this remains controversial. Moreover, it is not known whether other members of this toxin family are transferred between neurons. He...

journal_title：Cell reports

authors： Bomba-Warczak E,Vevea JD,Brittain JM,Figueroa-Bernier A,Tepp WH,Johnson EA,Yeh FL,Chapman ER

更新日期：2016-08-16 00:00:00

abstract：:Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress, and progressively develop traits similar to those observed following an acute and strong oxidative stress inflected...

journal_title：Cell reports

authors： Rekaik H,Blaudin de Thé FX,Fuchs J,Massiani-Beaudoin O,Prochiantz A,Joshi RL

更新日期：2015-10-13 00:00:00

abstract：:The flat bones of the skull are densely innervated during development, but little is known regarding their role during repair. We describe a neurotrophic mechanism that directs sensory nerve transit in the mouse calvaria. Patent cranial suture mesenchyme represents an NGF (nerve growth factor)-rich domain, in which se...

journal_title：Cell reports

authors： Meyers CA,Lee S,Sono T,Xu J,Negri S,Tian Y,Wang Y,Li Z,Miller S,Chang L,Gao Y,Minichiello L,Clemens TL,James AW

更新日期：2020-05-26 00:00:00

abstract：:Selecting a suitable site to deposit their eggs is an important reproductive need of Drosophila females. Although their choosiness toward egg-laying sites is well documented, the specific neural mechanism that activates females' search for attractive egg-laying sites is not known. Here, we show that distention and con...

journal_title：Cell reports

authors： Gou B,Liu Y,Guntur AR,Stern U,Yang CH

更新日期：2014-10-23 00:00:00

abstract：:Mcm2-7 helicase is loaded onto double-stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling that trigger helicase activation in S phase remain unknown. Here, we develop an approach to detect and purify the endogenous DHs directly. Through cellular fractionation, we pro...

journal_title：Cell reports

authors： Quan Y,Xia Y,Liu L,Cui J,Li Z,Cao Q,Chen XS,Campbell JL,Lou H

更新日期：2015-12-22 00:00:00

abstract：:Maintaining organelle function in the face of stress is known to involve organelle-specific retrograde signaling. Using Caenorhabditis elegans, we present evidence of the existence of such retrograde signaling for peroxisomes, which we define as the peroxisomal retrograde signaling (PRS). Specifically, we show that pe...

journal_title：Cell reports

authors： Rackles E,Witting M,Forné I,Zhang X,Zacherl J,Schrott S,Fischer C,Ewbank JJ,Osman C,Imhof A,Rolland SG

更新日期：2021-01-19 00:00:00

abstract：:The CARMA1/CARD11-BCL10-MALT1 (CBM) complex bridges T and B cell antigen receptor (TCR/BCR) ligation to MALT1 protease activation and canonical nuclear factor κB (NF-κB) signaling. Using unbiased mass spectrometry, we discover multiple serine phosphorylation sites in the MALT1 C terminus after T cell activation. Phosp...

journal_title：Cell reports

authors： Gehring T,Erdmann T,Rahm M,Graß C,Flatley A,O'Neill TJ,Woods S,Meininger I,Karayel O,Kutzner K,Grau M,Shinohara H,Lammens K,Feederle R,Hauck SM,Lenz G,Krappmann D

更新日期：2019-10-22 00:00:00

abstract：:Understanding how antibiotics impact bacterial metabolism may provide insight into their mechanisms of action and could lead to enhanced therapeutic methodologies. Here, we profiled the metabolome of Escherichia coli after treatment with three different classes of bactericidal antibiotics (?-lactams, aminoglycosides, ...

journal_title：Cell reports

authors： Belenky P,Ye JD,Porter CB,Cohen NR,Lobritz MA,Ferrante T,Jain S,Korry BJ,Schwarz EG,Walker GC,Collins JJ

更新日期：2015-11-03 00:00:00

abstract：:Epithelial tissues, such as the skin, rely on cellular plasticity of stem cells (SCs) from different niches to restore tissue function after injury. How these molecularly and functionally diverse SC populations respond to injury remains elusive. Here, we genetically labeled Lgr5- or Lgr6-expressing cells from the hair...

journal_title：Cell reports

authors： Joost S,Jacob T,Sun X,Annusver K,La Manno G,Sur I,Kasper M

更新日期：2018-10-16 00:00:00

abstract：:GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of the release sensor contributes to these signaling properties remains unclear. Here, we examined the Ca2+ sensor of exocytosis at GABAergic basket cell (BC) to Pu...

journal_title：Cell reports

authors： Chen C,Arai I,Satterfield R,Young SM Jr,Jonas P

更新日期：2017-01-17 00:00:00

abstract：:How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic factors to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF, and WDR5, an essential member of the MLL chromatin modifying complex, that reg...

journal_title：Cell reports

authors： Li Q,Mao F,Zhou B,Huang Y,Zou Z,denDekker AD,Xu J,Hou S,Liu J,Dou Y,Rao RC

更新日期：2020-01-14 00:00:00

abstract：:Presenilin 1 (PS1) is the catalytic core of γ-secretase, which cleaves type 1 transmembrane proteins, including the amyloid precursor protein (APP). PS1 also has γ-secretase-independent functions, and dominant PS1 missense mutations are the most common cause of familial Alzheimer's disease (FAD). Whether PS1 FAD mutat...

journal_title：Cell reports

authors： Woodruff G,Young JE,Martinez FJ,Buen F,Gore A,Kinaga J,Li Z,Yuan SH,Zhang K,Goldstein LS

更新日期：2013-11-27 00:00:00

abstract：:The stress-activated protein kinases c-Jun N-terminal kinase (JNK) and p38 are important players in cell-fate decisions in response to environmental stress signals. Crosstalk signaling between JNK and p38 is emerging as an important regulatory mechanism in inflammatory and stress responses. However, it is unknown how ...

journal_title：Cell reports

authors： Miura H,Kondo Y,Matsuda M,Aoki K

更新日期：2018-09-04 00:00:00

abstract：:One critical event in reprogramming to pluripotency is erasure of the somatic transcriptional program of starting cells. Here, we present the proof of principle of a strategy for reprogramming to pluripotency facilitated by small molecules that interfere with the somatic transcriptional memory. We show that mild chemi...

journal_title：Cell reports

authors： Shao Z,Yao C,Khodadadi-Jamayran A,Xu W,Townes TM,Crowley MR,Hu K

更新日期：2016-09-20 00:00:00

abstract：:The E3 ubiquitin ligase HUWE1, deregulated in carcinoma, has been implicated in tumor formation. Here, we uncover a role for HUWE1 in cell migration and invasion through degrading the RAC activator TIAM1, implying an additional function in malignant progression. In MDCKII cells in response to HGF, HUWE1 catalyzes TIAM...

journal_title：Cell reports

authors： Vaughan L,Tan CT,Chapman A,Nonaka D,Mack NA,Smith D,Booton R,Hurlstone AF,Malliri A

更新日期：2015-01-06 00:00:00

abstract：:The JAK/STAT1 pathway is generally activated by cytokines, providing essential antiviral defense. Here, we identify that STAT1 activation is independent of cytokines and JAKs at the early infection stage of some viruses, including influenza A virus (IAV). Instead, STAT1 is activated mainly through spleen tyrosine kina...

journal_title：Cell reports

authors： Liu S,Liao Y,Chen B,Chen Y,Yu Z,Wei H,Zhang L,Huang S,Rothman PB,Gao GF,Chen JL

更新日期：2021-01-19 00:00:00

abstract：:Neurodegenerative disorders are a major public health problem because of the high frequency of these diseases. Genome editing with the CRISPR/Cas9 system is making it possible to modify the sequence of genes linked to these disorders. We designed the KamiCas9 self-inactivating editing system to achieve transient expre...

journal_title：Cell reports

authors： Merienne N,Vachey G,de Longprez L,Meunier C,Zimmer V,Perriard G,Canales M,Mathias A,Herrgott L,Beltraminelli T,Maulet A,Dequesne T,Pythoud C,Rey M,Pellerin L,Brouillet E,Perrier AL,du Pasquier R,Déglon N

更新日期：2017-09-19 00:00:00

abstract：:Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene ...

journal_title：Cell reports

authors： Hatakeyama H,Wu SY,Lyons YA,Pradeep S,Wang W,Huang Q,Court KA,Liu T,Nie S,Rodriguez-Aguayo C,Shen F,Huang Y,Hisamatsu T,Mitamura T,Jennings N,Shim J,Dorniak PL,Mangala LS,Petrillo M,Petyuk VA,Schepmoes AA,Shukla

更新日期：2016-11-01 00:00:00