Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence.

abstract：:The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are attracting considerable attention for treating obesity. Current experiments in rats investigate whether GDF15 induces an aversive visceral malaise-based state that mediates its acute anorectic effect and, through aversion cond...

journal_title：Cell reports

authors： Borner T,Wald HS,Ghidewon MY,Zhang B,Wu Z,De Jonghe BC,Breen D,Grill HJ

更新日期：2020-04-21 00:00:00

abstract：:CD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties. However, how Treg's differentiation and functional specification are regulated remains incompletely understood. Here, we report that gradient exp...

journal_title：Cell reports

authors： Yang BH,Wang K,Wan S,Liang Y,Yuan X,Dong Y,Cho S,Xu W,Jepsen K,Feng GS,Lu LF,Xue HH,Fu W

更新日期：2019-06-18 00:00:00

abstract：:The mechanisms by which the major Polycomb group (PcG) complexes PRC1 and PRC2 are recruited to target sites in vertebrate cells are not well understood. Building on recent studies that determined a reciprocal relationship between DNA methylation and Polycomb activity, we demonstrate that, in methylation-deficient emb...

journal_title：Cell reports

authors： Cooper S,Dienstbier M,Hassan R,Schermelleh L,Sharif J,Blackledge NP,De Marco V,Elderkin S,Koseki H,Klose R,Heger A,Brockdorff N

更新日期：2014-06-12 00:00:00

abstract：:MicroRNA (miRNA) transfer via exosomes may mediate cell-to-cell communication. Interestingly, specific miRNAs are enriched in exosomes in a cell-type-dependent fashion. However, the mechanisms whereby miRNAs are sorted to exosomes and the significance of miRNA transfer to acceptor cells are unclear. We used macrophage...

journal_title：Cell reports

authors： Squadrito ML,Baer C,Burdet F,Maderna C,Gilfillan GD,Lyle R,Ibberson M,De Palma M

更新日期：2014-09-11 00:00:00

abstract：:Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a gene desert flanking the HoxD cluster. The start site of two opp...

journal_title：Cell reports

authors： Delpretti S,Montavon T,Leleu M,Joye E,Tzika A,Milinkovitch M,Duboule D

更新日期：2013-10-17 00:00:00

abstract：:We have previously found that UV irradiation promotes RNA polymerase II (RNAPII) hyperphosphorylation and subsequent changes in alternative splicing (AS). We show now that UV-induced DNA damage is not only necessary but sufficient to trigger the AS response and that photolyase-mediated removal of the most abundant cla...

journal_title：Cell reports

authors： Muñoz MJ,Nieto Moreno N,Giono LE,Cambindo Botto AE,Dujardin G,Bastianello G,Lavore S,Torres-Méndez A,Menck CFM,Blencowe BJ,Irimia M,Foiani M,Kornblihtt AR

更新日期：2017-03-21 00:00:00

abstract：:Senescence is a cellular response preventing tumorigenesis. The Ras oncogene is frequently activated or mutated in human cancers, but Ras activation is insufficient to transform primary cells. In a search for cooperating oncogenes, we identify the lysine demethylase JMJD2A/KDM4A. We show that JMJD2A functions as a neg...

journal_title：Cell reports

authors： Mallette FA,Richard S

更新日期：2012-11-29 00:00:00

abstract：:Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction. Here we show that TLR2 induces complement factors C3 and CFB, the common and rate-limiting fac...

journal_title：Cell reports

authors： Mulfaul K,Ozaki E,Fernando N,Brennan K,Chirco KR,Connolly E,Greene C,Maminishkis A,Salomon RG,Linetsky M,Natoli R,Mullins RF,Campbell M,Doyle SL

更新日期：2020-02-18 00:00:00

abstract：:Human brain imaging studies have revealed the anterior cingulate cortex (ACC) as a key brain region for mediating visceral-pain-cognitive interactions. Recently, we characterized impairments of long-term potentiation and spike-field coherence in the basolateral amygdala (BLA)-ACC network in association with a decision...

journal_title：Cell reports

authors： Wang J,Tu J,Cao B,Mu L,Yang X,Cong M,Ramkrishnan AS,Chan RHM,Wang L,Li Y

更新日期：2017-11-28 00:00:00

abstract：:Antiangiogenic therapy is commonly used in the clinic, but its beneficial effects are short-lived, leading to tumor relapse within months. Here, we found that the efficacy of angiogenic inhibitors targeting the VEGF/VEGFR pathway was dependent on induction of the angiostatic and immune-stimulatory chemokine CXCL14 in ...

journal_title：Cell reports

authors： Rivera LB,Meyronet D,Hervieu V,Frederick MJ,Bergsland E,Bergers G

更新日期：2015-04-28 00:00:00

abstract：:Simultaneous expression of Oct4, Klf4, Sox2, and cMyc induces pluripotency in somatic cells (iPSCs). Replacing Oct4 with the neuro-specific factor Brn4 leads to transdifferentiation of fibroblasts into induced neural stem cells (iNSCs). However, Brn4 was recently found to induce transient acquisition of pluripotency b...

journal_title：Cell reports

authors： Velychko S,Kang K,Kim SM,Kwak TH,Kim KP,Park C,Hong K,Chung C,Hyun JK,MacCarthy CM,Wu G,Schöler HR,Han DW

更新日期：2019-04-02 00:00:00

abstract：:Stable unannotated transcripts (SUTs), some of which overlap protein-coding genes in antisense direction, are a class of non-coding RNAs. While case studies have reported important regulatory roles for several of such RNAs, their general impact on protein abundance regulation of the overlapping gene is not known. To t...

journal_title：Cell reports

authors： Huber F,Bunina D,Gupta I,Khmelinskii A,Meurer M,Theer P,Steinmetz LM,Knop M

更新日期：2016-06-21 00:00:00

abstract：:Cell polarity arises through the spatial segregation of polarity regulators. PAR proteins are polarity regulators that localize asymmetrically to two opposing cortical domains. However, it is unclear how the spatially segregated PAR proteins interact to maintain their mutually exclusive partitioning. Here, single-mole...

journal_title：Cell reports

authors： Arata Y,Hiroshima M,Pack CG,Ramanujam R,Motegi F,Nakazato K,Shindo Y,Wiseman PW,Sawa H,Kobayashi TJ,Brandão HB,Shibata T,Sako Y

更新日期：2016-08-23 00:00:00

abstract：:The cerebral cortex is organized in vertical columns that contain neurons with similar functions. The cellular micro-architecture of such columns is an essential determinant of brain dynamics and cortical information processing. However, a detailed understanding of columns is incomplete, even in the best studied corti...

journal_title：Cell reports

authors： Tischbirek CH,Noda T,Tohmi M,Birkner A,Nelken I,Konnerth A

更新日期：2019-04-30 00:00:00

abstract：:We recently reported an autosomal dominant form of renal Fanconi syndrome caused by a missense mutation in the third codon of the peroxisomal protein EHHADH. The mutation mistargets EHHADH to mitochondria, thereby impairing mitochondrial energy production and, consequently, reabsorption of electrolytes and low-molecul...

journal_title：Cell reports

authors： Assmann N,Dettmer K,Simbuerger JMB,Broeker C,Nuernberger N,Renner K,Courtneidge H,Klootwijk ED,Duerkop A,Hall A,Kleta R,Oefner PJ,Reichold M,Reinders J

更新日期：2016-05-17 00:00:00

abstract：:Ischemic stroke is a well-recognized disease of aging, yet it is unclear how the age-dependent vulnerability occurs and what are the underlying mechanisms. To address these issues, we perform a comprehensive RNA-seq analysis of aging, ischemic stroke, and their interaction in 3- and 18-month-old mice. We assess differ...

journal_title：Cell reports

authors： Androvic P,Kirdajova D,Tureckova J,Zucha D,Rohlova E,Abaffy P,Kriska J,Valny M,Anderova M,Kubista M,Valihrach L

更新日期：2020-06-16 00:00:00

abstract：:The transcription factor NKX2-1 is best known for its role in the specification of subsets of cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and intersectional focal septal deletion that NKX2-1 is selectively required in the embryonic septal neuroepithelium for the development of...

journal_title：Cell reports

authors： Magno L,Barry C,Schmidt-Hieber C,Theodotou P,Häusser M,Kessaris N

更新日期：2017-08-15 00:00:00

abstract：:Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and progression of fibr...

journal_title：Cell reports

authors： Vila IK,Badin PM,Marques MA,Monbrun L,Lefort C,Mir L,Louche K,Bourlier V,Roussel B,Gui P,Grober J,Štich V,Rossmeislová L,Zakaroff-Girard A,Bouloumié A,Viguerie N,Moro C,Tavernier G,Langin D

更新日期：2014-05-22 00:00:00

abstract：:The subgranular zone (SGZ) of the adult hippocampus contains a pool of quiescent neural progenitor cells (QNPs) that are capable of entering the cell cycle and producing newborn neurons. The mechanisms that control the timing and extent of adult neurogenesis are not well understood. Here, we show that QNPs of the adul...

journal_title：Cell reports

authors： Bouchard-Cannon P,Mendoza-Viveros L,Yuen A,Kærn M,Cheng HY

更新日期：2013-11-27 00:00:00

abstract：:The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies and autoimmune diseases. G6 is an anti-idiotypic monoclonal Ab that selectively binds to IGHV1-6...

journal_title：Cell reports

authors： Avnir Y,Prachanronarong KL,Zhang Z,Hou S,Peterson EC,Sui J,Zayed H,Kurella VB,McGuire AT,Stamatatos L,Hilbert BJ,Bohn MF,Kowalik TF,Jensen JD,Finberg RW,Wang JP,Goodall M,Jefferis R,Zhu Q,Kurt Yilmaz N,Schiffer CA

更新日期：2017-12-12 00:00:00

abstract：:Mitophagy plays an important role in mitochondrial quality control. In yeast, phosphorylation of the mitophagy receptor Atg32 by casein kinase 2 (CK2) upon induction of mitophagy is a prerequisite for interaction of Atg32 with Atg11 (an adaptor protein for selective autophagy) and following delivery of mitochondria to...

journal_title：Cell reports

authors： Furukawa K,Fukuda T,Yamashita SI,Saigusa T,Kurihara Y,Yoshida Y,Kirisako H,Nakatogawa H,Kanki T

更新日期：2018-06-19 00:00:00

abstract：:To survive adverse and ever-changing environmental conditions, an organism must be able to adapt. It has long been established that the cellular reaction to stress includes the upregulation of genes coding for specific stress-responsive factors. In the present study, we demonstrate that during the early steps of the h...

journal_title：Cell reports

authors： Merret R,Descombin J,Juan YT,Favory JJ,Carpentier MC,Chaparro C,Charng YY,Deragon JM,Bousquet-Antonelli C

更新日期：2013-12-12 00:00:00

abstract：:Cellular translation surveillance rescues ribosomes that stall on problematic mRNAs. During translation surveillance, endonucleolytic cleavage of the problematic mRNA is a critical step in rescuing stalled ribosomes. Here we identify NONU-1 as a factor required for translation surveillance pathways including no-go and...

journal_title：Cell reports

authors： Glover ML,Burroughs AM,Monem PC,Egelhofer TA,Pule MN,Aravind L,Arribere JA

更新日期：2020-03-31 00:00:00

abstract：:In plants, the phytohormone auxin acts as a master regulator of developmental processes and environmental responses. The best characterized process in the auxin regulatory network occurs at the subcellular scale, wherein auxin mediates signal transduction into transcriptional programs by triggering the degradation of ...

journal_title：Cell reports

authors： Middleton AM,Dal Bosco C,Chlap P,Bensch R,Harz H,Ren F,Bergmann S,Wend S,Weber W,Hayashi KI,Zurbriggen MD,Uhl R,Ronneberger O,Palme K,Fleck C,Dovzhenko A

更新日期：2018-03-13 00:00:00

abstract：:Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1). In addition to numerous other targets, core histone tails are primary acceptors of Ser-ADPr in the DNA damage response. Here, we s...

journal_title：Cell reports

authors： Bartlett E,Bonfiglio JJ,Prokhorova E,Colby T,Zobel F,Ahel I,Matic I

更新日期：2018-09-25 00:00:00

abstract：:During postnatal development, cerebellar climbing fibers alter their innervation strengths onto supernumerary Purkinje cell targets, generating a one-to-few connectivity pattern in adulthood. To get insight about the processes responsible for this remapping, we reconstructed serial electron microscopy datasets from mi...

journal_title：Cell reports

authors： Wilson AM,Schalek R,Suissa-Peleg A,Jones TR,Knowles-Barley S,Pfister H,Lichtman JW

更新日期：2019-11-26 00:00:00

abstract：:Loss of metabolic homeostasis is a hallmark of aging and is commonly characterized by the deregulation of adaptive signaling interactions that coordinate energy metabolism with dietary changes. The mechanisms driving age-related changes in these adaptive responses remain unclear. Here, we characterize the deregulation...

journal_title：Cell reports

authors： Karpac J,Biteau B,Jasper H

更新日期：2013-09-26 00:00:00

abstract：:5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC and its writers, ten-eleven translocation (Tet) proteins, in stress-induced response have yet to be elucidated. Here, we show that chronic restraint stress (CRS) induced depression-l...

journal_title：Cell reports

authors： Cheng Y,Sun M,Chen L,Li Y,Lin L,Yao B,Li Z,Wang Z,Chen J,Miao Z,Xin N,Huang L,Allen EG,Wu H,Xu X,Jin P

更新日期：2018-12-11 00:00:00

abstract：:In humans, Vγ9Vδ2 T cells respond to self and pathogen-associated, diphosphate-containing isoprenoids, also known as phosphoantigens (pAgs). However, activation and homeostasis of Vγ9Vδ2 T cells remain incompletely understood. Here, we show that pAgs induced expression of the ecto-ATPase CD39, which, however, not only...

journal_title：Cell reports

authors： Gruenbacher G,Gander H,Rahm A,Idzko M,Nussbaumer O,Thurnher M

更新日期：2016-07-12 00:00:00

abstract：:Mutations in WNK kinases cause the human hypertensive disease pseudohypoaldosteronism type II (PHAII), but the regulatory mechanisms of the WNK kinases are not well understood. Mutations in kelch-like 3 (KLHL3) and Cullin3 were also recently identified as causing PHAII. Therefore, new insights into the mechanisms of h...

journal_title：Cell reports

authors： Wakabayashi M,Mori T,Isobe K,Sohara E,Susa K,Araki Y,Chiga M,Kikuchi E,Nomura N,Mori Y,Matsuo H,Murata T,Nomura S,Asano T,Kawaguchi H,Nonoyama S,Rai T,Sasaki S,Uchida S

更新日期：2013-03-28 00:00:00