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Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase that targets PCNA and is linked to the DNA damage response.

Abstract：

:Recent evidence supports the presence of an L-glutamyl methyltransferase(s) in eukaryotic cells, but this enzyme class has been defined only in certain prokaryotic species. Here, we characterize the human C6orf211 gene product as "acidic residue methyltransferase-1" (Armt1), an enzyme that specifically targets proliferating cell nuclear antigen (PCNA) in breast cancer cells, predominately methylating glutamate side chains. Armt1 homologs share structural similarities with the SAM-dependent methyltransferases, and negative regulation of activity by automethylation indicates a means for cellular control. Notably, shRNA-based knockdown of Armt1 expression in two breast cancer cell lines altered survival in response to genotoxic stress. Increased sensitivity to UV, adriamycin, and MMS was observed in SK-Br-3 cells, while in contrast, increased resistance to these agents was observed in MCF7 cells. Together, these results lay the foundation for defining the mechanism by which this post-translational modification operates in the DNA damage response (DDR).

journal_name

Cell Rep

journal_title

Cell reports

authors

Perry JJ,Ballard GD,Albert AE,Dobrolecki LE,Malkas LH,Hoelz DJ

doi

10.1016/j.celrep.2015.01.054

subject

Has Abstract

pub_date

2015-03-03 00:00:00

pages

1288-96

issue

8

issn

2211-1247

pii

S2211-1247(15)00079-0

journal_volume

10

pub_type

杂志文章

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