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Data-Driven Modeling of Intracellular Auxin Fluxes Indicates a Dominant Role of the ER in Controlling Nuclear Auxin Uptake.

Abstract：

:In plants, the phytohormone auxin acts as a master regulator of developmental processes and environmental responses. The best characterized process in the auxin regulatory network occurs at the subcellular scale, wherein auxin mediates signal transduction into transcriptional programs by triggering the degradation of Aux/IAA transcriptional repressor proteins in the nucleus. However, whether and how auxin movement between the nucleus and the surrounding compartments is regulated remain elusive. Using a fluorescent auxin analog, we show that its diffusion into the nucleus is restricted. By combining mathematical modeling with time course assays on auxin-mediated nuclear signaling and quantitative phenotyping in single plant cell systems, we show that ER-to-nucleus auxin flux represents a major subcellular pathway to directly control nuclear auxin levels. Our findings propose that the homeostatically regulated auxin pool in the ER and ER-to-nucleus auxin fluxes underpin auxin-mediated downstream responses in plant cells.

journal_name

Cell Rep

journal_title

Cell reports

authors

Middleton AM,Dal Bosco C,Chlap P,Bensch R,Harz H,Ren F,Bergmann S,Wend S,Weber W,Hayashi KI,Zurbriggen MD,Uhl R,Ronneberger O,Palme K,Fleck C,Dovzhenko A

doi

10.1016/j.celrep.2018.02.074

subject

Has Abstract

pub_date

2018-03-13 00:00:00

pages

3044-3057

issue

11

issn

2211-1247

pii

S2211-1247(18)30269-9

journal_volume

22

pub_type

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