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Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex.

Abstract：

:The SWI/SNF chromatin remodeling complex is highly conserved from yeast to human, and aberrant SWI/SNF complexes contribute to human disease. The Snf5/SMARCB1/INI1 subunit of SWI/SNF is a tumor suppressor frequently lost in pediatric rhabdoid cancers. We examined the effects of Snf5 loss on the composition, nucleosome binding, recruitment, and remodeling activities of yeast SWI/SNF. The Snf5 subunit is shown by crosslinking-mass spectrometry (CX-MS) and subunit deletion analysis to interact with the ATPase domain of Snf2 and to form a submodule consisting of Snf5, Swp82, and Taf14. Snf5 promotes binding of the Snf2 ATPase domain to nucleosomal DNA and enhances the catalytic and nucleosome remodeling activities of SWI/SNF. Snf5 is also required for SWI/SNF recruitment by acidic transcription factors. RNA-seq analysis suggests that both the recruitment and remodeling functions of Snf5 are required in vivo for SWI/SNF regulation of gene expression. Thus, loss of SNF5 alters the structure and function of SWI/SNF.

journal_name

Cell Rep

journal_title

Cell reports

authors

Sen P,Luo J,Hada A,Hailu SG,Dechassa ML,Persinger J,Brahma S,Paul S,Ranish J,Bartholomew B

doi

10.1016/j.celrep.2017.02.017

subject

Has Abstract

pub_date

2017-02-28 00:00:00

pages

2135-2147

issue

9

issn

2211-1247

pii

S2211-1247(17)30182-1

journal_volume

18

pub_type

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