Abstract：
:The hippocampal formation is a brain structure essential for higher-order cognitive functions. It has a complex anatomical organization and cellular composition, and hippocampal subregions have different properties and functional roles. In this study, we used SWATH-MS to determine whether the proteomes of hippocampus areas CA1 and CA3 can explain the commonalities or specificities of these subregions in basal conditions and after recognition memory. We show that the proteomes of areas CA1 and CA3 are largely different in basal conditions and that differential changes and dynamics in protein expression are induced in these areas after recognition of an object or object location. While changes are consistent across both recognition paradigms in area CA1, they are not in area CA3, suggesting distinct proteomic responses in areas CA1 and CA3 for memory formation.
journal_name
Cell Repjournal_title
Cell reportsauthors
von Ziegler LM,Selevsek N,Tweedie-Cullen RY,Kremer E,Mansuy IMdoi
10.1016/j.celrep.2018.02.079subject
Has Abstractpub_date
2018-03-20 00:00:00pages
3362-3374issue
12issn
2211-1247pii
S2211-1247(18)30289-4journal_volume
22pub_type
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