Abstract：
:Prior studies have shown that aversive olfactory memory is acquired by dopamine acting on a specific receptor, dDA1, expressed by mushroom body neurons. Active forgetting is mediated by dopamine acting on another receptor, Damb, expressed by the same neurons. Surprisingly, prior studies have shown that both receptors stimulate cyclic AMP (cAMP) accumulation, presenting an enigma of how mushroom body neurons distinguish between acquisition and forgetting signals. Here, we surveyed the spectrum of G protein coupling of dDA1 and Damb, and we confirmed that both receptors can couple to Gs to stimulate cAMP synthesis. However, the Damb receptor uniquely activates Gq to mobilize Ca2+ signaling with greater efficiency and dopamine sensitivity. The knockdown of Gαq with RNAi in the mushroom bodies inhibits forgetting but has no effect on acquisition. Our findings identify a Damb/Gq-signaling pathway that stimulates forgetting and resolves the opposing effects of dopamine on acquisition and forgetting.
journal_name
Cell Repjournal_title
Cell reportsauthors
Himmelreich S,Masuho I,Berry JA,MacMullen C,Skamangas NK,Martemyanov KA,Davis RLdoi
10.1016/j.celrep.2017.10.108subject
Has Abstractpub_date
2017-11-21 00:00:00pages
2074-2081issue
8issn
2211-1247pii
S2211-1247(17)31588-7journal_volume
21pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:The neural network of the temporal lobe is thought to provide a cognitive map of our surroundings. Functional analysis of this network has been hampered by coarse tools that often result in collateral damage to other circuits. We developed a chemogenetic system to temporally control electrical input into the hippocamp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.032
更新日期：2016-07-19 00:00:00
abstract：:Obesity modifies T cell populations in adipose tissue, thereby contributing to adipose tissue inflammation and insulin resistance. Here, we show that Rab4b, a small GTPase governing endocytic trafficking, is pivotal in T cells for the development of these pathological events. Rab4b expression is decreased in adipose T...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.11.083
更新日期：2018-12-18 00:00:00
abstract：:Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level of initiation and is under strict cell-cycle regulation. Importantly,...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.10.005
更新日期：2014-11-06 00:00:00
abstract：:Metazoan genomes are partitioned into modular chromosomal domains containing active or repressive chromatin. In flies, Polycomb group (PcG) response elements (PREs) recruit PHO and other DNA-binding factors and act as nucleation sites for the formation of Polycomb repressive domains. The sequence specificity of PREs i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.08.072
更新日期：2014-10-09 00:00:00
abstract：:Inhibitory receptors (IRs) function as critical regulators of immune responses by tempering T cell activity. In humans, several persisting viruses as well as cancers exploit IR signaling by upregulating IR ligands, resulting in suppression of T cell function (i.e., exhaustion). This allows escape from immune surveilla...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.10.119
更新日期：2019-12-03 00:00:00
abstract：:Evidence suggests that Polycomb (Pc) is present at chromatin loop anchors in Drosophila. Pc is recruited to DNA through interactions with the GAGA binding factors GAF and Pipsqueak (Psq). Using HiChIP in Drosophila cells, we find that the psq gene, which has diverse roles in development and tumorigenesis, encodes dist...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.096
更新日期：2019-09-03 00:00:00
abstract：:Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to b...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.08.054
更新日期：2018-09-25 00:00:00
abstract：:Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant to these functions. Here, we show ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2011.12.002
更新日期：2012-02-23 00:00:00
abstract：:Synapse elimination is crucial for precise neural circuit formation during postnatal development. We examined how relative differences in synaptic strengths among competing inputs and/or absolute synaptic strengths contribute to climbing fiber (CF) to Purkinje cell (PC) synapse elimination in the cerebellum. We genera...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.07.014
更新日期：2014-08-21 00:00:00
abstract：:Neurons exhibit dynamic structural changes in response to extracellular stimuli. Microtubules (MTs) provide rapid and dramatic cytoskeletal changes within the structural framework. However, the molecular mechanisms and signaling networks underlying MT dynamics remain unknown. Here, we have applied a comprehensive and ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.018
更新日期：2015-09-22 00:00:00
abstract：:We examined the effect of Bone Morphogenetic Protein 4 (BMP4) on energy expenditure in adult mature mice by targeting the liver with adeno-associated viral (AAV) BMP4 vectors to increase circulating levels. We verified the direct effect of BMP4 in inducing a brown oxidative phenotype in differentiating preadipocytes i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.07.020
更新日期：2017-08-01 00:00:00
abstract：:Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased expression of NRG1 in the brains of schizophrenia patients, given that both findings have been reported from autopsy studies. To study NRG1 functions in vivo...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.07.026
更新日期：2014-08-21 00:00:00
abstract：:Virus infection is sensed by pattern recognition receptors (PRRs) detecting virus nucleic acids and initiating an innate immune response. DNA-dependent protein kinase (DNA-PK) is a PRR that binds cytosolic DNA and is antagonized by vaccinia virus (VACV) protein C16. Here, VACV protein C4 is also shown to antagonize DN...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.10.034
更新日期：2018-11-13 00:00:00
abstract：:During development, two cell types born from closely related progenitor pools often express identical transcriptional regulators despite their completely distinct characteristics. This phenomenon implies the need for a mechanism that operates to segregate the identities of the two cell types throughout differentiation...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.100
更新日期：2016-08-09 00:00:00
abstract：:Manipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host AMPK activity due to the energetic demands placed on the infected cell. Here,...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.08.001
更新日期：2016-09-06 00:00:00
abstract：:The patterns of neuronal connectivity underlying multisensory integration, a fundamental property of many brains, remain poorly characterized. The Drosophila melanogaster mushroom body-an associative center-is an ideal system to investigate how different sensory channels converge in higher order brain centers. The neu...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108138
更新日期：2020-09-15 00:00:00
abstract：:Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high degree of sequence and structural similarity; still, however, they often mediate distinct functional...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.08.053
更新日期：2019-09-24 00:00:00
abstract：:Epithelial tissues, such as the skin, rely on cellular plasticity of stem cells (SCs) from different niches to restore tissue function after injury. How these molecularly and functionally diverse SC populations respond to injury remains elusive. Here, we genetically labeled Lgr5- or Lgr6-expressing cells from the hair...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.09.059
更新日期：2018-10-16 00:00:00
abstract：:Salivary proteins are essential for maintaining health in the oral cavity and proximal digestive tract, and they serve as potential diagnostic markers for monitoring human health and disease. However, their precise organ origins remain unclear. Through transcriptomic analysis of major adult and fetal salivary glands a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108402
更新日期：2020-11-17 00:00:00
abstract：:Embryonic cells transcriptionally repress the expression of endogenous and exogenous retroelements. Trim28, a key player in this silencing, is known to act in a large DNA-bound complex, but the other components of the complex are not fully characterized. Here, we show that the zinc finger protein Yin Yang 1 (YY1) is o...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.06.003
更新日期：2013-07-11 00:00:00
abstract：:Mitochondrial respiratory chain disorders are characterized by loss of electron transport chain (ETC) activity. Although the causes of many such diseases are known, there is a lack of effective therapies. To identify genes that confer resistance to severe ETC dysfunction when inactivated, we performed a genome-wide ge...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.02.046
更新日期：2014-04-10 00:00:00
abstract：:GPR116 is an orphan seven-pass transmembrane receptor whose function has been unclear. Global disruption of the Gpr116 gene in mice revealed an unexpected, critical role for this receptor in lung surfactant homeostasis, resulting in progressive accumulation of surfactant lipids and proteins in the alveolar space, labo...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.04.019
更新日期：2013-05-30 00:00:00
abstract：:It is currently assumed that 3D chromosomal organization plays a central role in transcriptional control. However, depletion of cohesin and CTCF affects the steady-state levels of only a minority of transcripts. Here, we use high-resolution Capture Hi-C to interrogate the dynamics of chromosomal contacts of all annota...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107929
更新日期：2020-07-21 00:00:00
abstract：:Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which remains unclear. Here, we report that the noxious stimulus receptor TRPV1 is ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.10.063
更新日期：2017-11-07 00:00:00
abstract：:Two hallmarks of cancer cells are their resistance to apoptosis and ability to thrive despite reduced levels of vital serum components. c-jun N-terminal kinase (JNK) activation is crucial for apoptosis triggered by serum starvation (SS), and isocitrate dehydrogenase 1 (IDH1) mutations are tumorigenic, in part, because...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.03.053
更新日期：2017-04-11 00:00:00
abstract：:We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirm...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108448
更新日期：2020-12-08 00:00:00
abstract：:The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs). Many FA proteins are recruited to ICLs in a timely fashion so that coordinated repair can occur. However, the mechanism of this process is poorly understood. Here, we report the purification of a FANCD2-containing protein complex with multiple ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107850
更新日期：2020-07-07 00:00:00
abstract：:Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis. Precisely how these phenomena are linked, however, remains unclear. Using a cortico-hip...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107865
更新日期：2020-07-07 00:00:00
abstract：:Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently, the transcription of long noncoding RNAs often overlaps with coding gene promoters, triggering potential gene repression through a poorly characterized mechanism of transcription interference. Here, we propose a comprehensive model ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107612
更新日期：2020-05-05 00:00:00
abstract：:The t(8;21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO disrupts normal hematopoietic differentiation. Here, we have investigated its effects on the transcriptome and epigenome in t(8,21) patient cells. AML1-ETO binding was found at promoter regions of active genes with high levels of histone acetylat...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.08.082
更新日期：2016-11-15 00:00:00
