当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.

PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.

Abstract：

:Virtually all organisms seek to maximize fitness by matching fuel availability with energy expenditure. In vertebrates, glucose homeostasis is central to this process, with glucose levels finely tuned to match changing energy requirements. To discover new pathways regulating glucose levels in vivo, we performed a large-scale chemical screen in live zebrafish and identified the small molecule alexidine as a potent glucose-lowering agent. We found that alexidine inhibits the PTEN-like mitochondrial phosphatase PTPMT1 and that other pharmacological and genetic means of inactivating PTPMT1 also decrease glucose levels in zebrafish. Mutation of ptpmt1 eliminates the effect of alexidine, further confirming it as the glucose-lowering target of alexidine. We then identified succinate dehydrogenase (SDH) as a substrate of PTPMT1. Inactivation of PTPMT1 causes hyperphosphorylation and activation of SDH, providing a possible mechanism by which PTPMT1 coordinates glucose homeostasis. Therefore, PTPMT1 appears to be an important regulator of SDH phosphorylation status and glucose concentration.

journal_name

Cell Rep

journal_title

Cell reports

authors

Nath AK,Ryu JH,Jin YN,Roberts LD,Dejam A,Gerszten RE,Peterson RT

doi

10.1016/j.celrep.2015.01.010

subject

Has Abstract

pub_date

2015-02-10 00:00:00

pages

694-701

issue

5

issn

2211-1247

pii

S2211-1247(15)00023-6

journal_volume

10

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Stratum, a Homolog of the Human GEF Mss4, Partnered with Rab8, Controls the Basal Restriction of Basement Membrane Proteins in Epithelial Cells.

    abstract：:The basement membrane (BM), a sheet of extracellular matrix lining the basal side of epithelia, is essential for epithelial cell function and integrity, yet the mechanisms that control the basal restriction of BM proteins are poorly understood. In epithelial cells, a specialized pathway is dedicated to restrict the de...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.02.002

    authors： Devergne O,Sun GH,Schüpbach T

    更新日期：2017-02-21 00:00:00

  • Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice.

    abstract：:Exercise has been argued to enhance cognitive function and slow progressive neurodegenerative disease. Although exercise promotes neurogenesis, oligodendrogenesis and adaptive myelination are also significant contributors to brain repair and brain health. Nonetheless, the molecular details underlying these effects rem...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.09.030

    authors： Alvarez-Saavedra M,De Repentigny Y,Yang D,O'Meara RW,Yan K,Hashem LE,Racacho L,Ioshikhes I,Bulman DE,Parks RJ,Kothary R,Picketts DJ

    更新日期：2016-10-11 00:00:00

  • Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma.

    abstract：:Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (NMC) cells are specifically killed by CDK9 inhibition (CDK9i) an...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.082

    authors： Brägelmann J,Dammert MA,Dietlein F,Heuckmann JM,Choidas A,Böhm S,Richters A,Basu D,Tischler V,Lorenz C,Habenberger P,Fang Z,Ortiz-Cuaran S,Leenders F,Eickhoff J,Koch U,Getlik M,Termathe M,Sallouh M,Greff Z,Varga Z

    更新日期：2017-09-19 00:00:00

  • A De Novo Mutation in the Sodium-Activated Potassium Channel KCNT2 Alters Ion Selectivity and Causes Epileptic Encephalopathy.

    abstract：:Early infantile epileptic encephalopathies (EOEE) are a debilitating spectrum of disorders associated with cognitive impairments. We present a clinical report of a KCNT2 mutation in an EOEE patient. The de novo heterozygous variant Phe240Leu SLICK was identified by exome sequencing and confirmed by Sanger sequencing. ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.09.088

    authors： Gururaj S,Palmer EE,Sheehan GD,Kandula T,Macintosh R,Ying K,Morris P,Tao J,Dias KR,Zhu Y,Dinger ME,Cowley MJ,Kirk EP,Roscioli T,Sachdev R,Duffey ME,Bye A,Bhattacharjee A

    更新日期：2017-10-24 00:00:00

  • Exosome secretion is enhanced by invadopodia and drives invasive behavior.

    abstract：:Unconventional secretion of exosome vesicles from multivesicular endosomes (MVEs) occurs across a broad set of systems and is reported to be upregulated in cancer, where it promotes aggressive behavior. However, regulatory control of exosome secretion is poorly understood. Using cancer cells, we identified specialized...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.10.050

    authors： Hoshino D,Kirkbride KC,Costello K,Clark ES,Sinha S,Grega-Larson N,Tyska MJ,Weaver AM

    更新日期：2013-12-12 00:00:00

  • Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity.

    abstract：:Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased expression of NRG1 in the brains of schizophrenia patients, given that both findings have been reported from autopsy studies. To study NRG1 functions in vivo...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.07.026

    authors： Agarwal A,Zhang M,Trembak-Duff I,Unterbarnscheidt T,Radyushkin K,Dibaj P,Martins de Souza D,Boretius S,Brzózka MM,Steffens H,Berning S,Teng Z,Gummert MN,Tantra M,Guest PC,Willig KI,Frahm J,Hell SW,Bahn S,Rossner MJ

    更新日期：2014-08-21 00:00:00

  • Motile axonal mitochondria contribute to the variability of presynaptic strength.

    abstract：:One of the most notable characteristics of synaptic transmission is the wide variation in synaptic strength in response to identical stimulation. In hippocampal neurons, approximately one-third of axonal mitochondria are highly motile, and some dynamically pass through presynaptic boutons. This raises a fundamental qu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.06.040

    authors： Sun T,Qiao H,Pan PY,Chen Y,Sheng ZH

    更新日期：2013-08-15 00:00:00

  • Measurement of Rapid Protein Diffusion in the Cytoplasm by Photo-Converted Intensity Profile Expansion.

    abstract：:The fluorescence microscopy methods presently used to characterize protein motion in cells infer protein motion from indirect observables, rather than measuring protein motion directly. Operationalizing these methods requires expertise that can constitute a barrier to their broad utilization. Here, we have developed P...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.02.063

    authors： Gura Sadovsky R,Brielle S,Kaganovich D,England JL

    更新日期：2017-03-14 00:00:00

  • Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells.

    abstract：:The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS colorectal cancer (CRC) cells release extracellular vesicles (EVs) containing distinct proteomes, microRNAs (miRNAs), and circular RNAs. Here, we comprehensively ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.054

    authors： Hinger SA,Cha DJ,Franklin JL,Higginbotham JN,Dou Y,Ping J,Shu L,Prasad N,Levy S,Zhang B,Liu Q,Weaver AM,Coffey RJ,Patton JG

    更新日期：2018-10-16 00:00:00

  • Opiates modulate thermosensation by internalizing cold receptor TRPM8.

    abstract：:Stimulation of μ-opioid receptors (OPRMs) brings powerful pain relief, but it also leads to the development of tolerance and addiction. Ensuing withdrawal in abstinent patients manifests itself with severe symptoms, including cold hyperalgesia, often preventing addicted patients from successfully completing the rehabi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.07.002

    authors： Shapovalov G,Gkika D,Devilliers M,Kondratskyi A,Gordienko D,Busserolles J,Bokhobza A,Eschalier A,Skryma R,Prevarskaya N

    更新日期：2013-08-15 00:00:00

  • TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages.

    abstract：:Macrophages exist predominantly in two distinct states, G0 and a G1-like state that is accompanied by phosphorylation of SAMHD1 at T592. Here, we demonstrate that Toll-like receptor 4 (TLR4) activation can potently induce G0 arrest and SAMHD1 antiretroviral activity by an interferon (IFN)-independent pathway. This pat...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.03.008

    authors： Mlcochova P,Winstone H,Zuliani-Alvarez L,Gupta RK

    更新日期：2020-03-24 00:00:00

  • Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation.

    abstract：:Hypermethylation-mediated tumor suppressor gene (TSG) silencing is a central epigenetic alteration in RAS-dependent tumorigenesis. Ten-eleven translocation (TET) enzymes can depress DNA methylation by hydroxylation of 5-methylcytosine (5mC) bases to 5-hydroxymethylcytosine (5hmC). Here, we report that suppression of T...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.10.063

    authors： Wu BK,Brenner C

    更新日期：2014-12-11 00:00:00

  • IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.

    abstract：:Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is highly expressed in the skin and downregulated in psoriasis patients. We report an investigation in cellular targets of IL-38 during the progression of ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.03.082

    authors： Han Y,Mora J,Huard A,da Silva P,Wiechmann S,Putyrski M,Schuster C,Elwakeel E,Lang G,Scholz A,Scholz T,Schmid T,de Bruin N,Billuart P,Sala C,Burkhardt H,Parnham MJ,Ernst A,Brüne B,Weigert A

    更新日期：2019-04-16 00:00:00

  • Chd5 requires PHD-mediated histone 3 binding for tumor suppression.

    abstract：:Chromodomain Helicase DNA binding protein 5 (CHD5) is a tumor suppressor mapping to 1p36, a genomic region that is frequently deleted in human cancer. Although CHD5 belongs to the CHD family of chromatin-remodeling proteins, whether its tumor-suppressive role involves an interaction with chromatin is unknown. Here we ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.12.009

    authors： Paul S,Kuo A,Schalch T,Vogel H,Joshua-Tor L,McCombie WR,Gozani O,Hammell M,Mills AA

    更新日期：2013-01-31 00:00:00

  • miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.

    abstract：:Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells, whose precursors are formed during the initial immunological insult, provide protection from future encounters, and their generation is the goal of many vaccin...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.07.064

    authors： Gagnon JD,Kageyama R,Shehata HM,Fassett MS,Mar DJ,Wigton EJ,Johansson K,Litterman AJ,Odorizzi P,Simeonov D,Laidlaw BJ,Panduro M,Patel S,Jeker LT,Feeney ME,McManus MT,Marson A,Matloubian M,Sanjabi S,Ansel KM

    更新日期：2019-08-20 00:00:00

  • Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites.

    abstract：:Memories are believed to be stored in distributed neuronal assemblies through activity-induced changes in synaptic and intrinsic properties. However, the specific mechanisms by which different memories become associated or linked remain a mystery. Here, we develop a simplified, biophysically inspired network model tha...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.10.015

    authors： Kastellakis G,Silva AJ,Poirazi P

    更新日期：2016-11-01 00:00:00

  • Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory Synapse.

    abstract：:GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of the release sensor contributes to these signaling properties remains unclear. Here, we examined the Ca2+ sensor of exocytosis at GABAergic basket cell (BC) to Pu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.12.067

    authors： Chen C,Arai I,Satterfield R,Young SM Jr,Jonas P

    更新日期：2017-01-17 00:00:00

  • GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

    abstract：:Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11Q209L with and without h...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.01.081

    authors： Moore AR,Ran L,Guan Y,Sher JJ,Hitchman TD,Zhang JQ,Hwang C,Walzak EG,Shoushtari AN,Monette S,Murali R,Wiesner T,Griewank KG,Chi P,Chen Y

    更新日期：2018-02-27 00:00:00

  • DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing.

    abstract：:Virus infection is sensed by pattern recognition receptors (PRRs) detecting virus nucleic acids and initiating an innate immune response. DNA-dependent protein kinase (DNA-PK) is a PRR that binds cytosolic DNA and is antagonized by vaccinia virus (VACV) protein C16. Here, VACV protein C4 is also shown to antagonize DN...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.10.034

    authors： Scutts SR,Ember SW,Ren H,Ye C,Lovejoy CA,Mazzon M,Veyer DL,Sumner RP,Smith GL

    更新日期：2018-11-13 00:00:00

  • The PP2A-like Protein Phosphatase Ppg1 and the Far Complex Cooperatively Counteract CK2-Mediated Phosphorylation of Atg32 to Inhibit Mitophagy.

    abstract：:Mitophagy plays an important role in mitochondrial quality control. In yeast, phosphorylation of the mitophagy receptor Atg32 by casein kinase 2 (CK2) upon induction of mitophagy is a prerequisite for interaction of Atg32 with Atg11 (an adaptor protein for selective autophagy) and following delivery of mitochondria to...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.05.064

    authors： Furukawa K,Fukuda T,Yamashita SI,Saigusa T,Kurihara Y,Yoshida Y,Kirisako H,Nakatogawa H,Kanki T

    更新日期：2018-06-19 00:00:00

  • Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis.

    abstract：:Pneumonias caused by influenza A virus (IAV) co- and secondary bacterial infections are characterized by their severity and high mortality rate. Previously, we have shown that bacterial pore-forming toxin (PFT)-mediated necroptosis is a key driver of acute lung injury during bacterial pneumonia. Here, we evaluate the ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108062

    authors： Gonzalez-Juarbe N,Riegler AN,Jureka AS,Gilley RP,Brand JD,Trombley JE,Scott NR,Platt MP,Dube PH,Petit CM,Harrod KS,Orihuela CJ

    更新日期：2020-08-25 00:00:00

  • Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle.

    abstract：:The transcriptional coactivators PGC-1α and PGC-1β are widely thought to be required for mitochondrial biogenesis and fiber typing in skeletal muscle. Here, we show that mice lacking both PGC-1s in myocytes do indeed have profoundly deficient mitochondrial respiration but, surprisingly, have preserved mitochondrial co...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.04.023

    authors： Rowe GC,Patten IS,Zsengeller ZK,El-Khoury R,Okutsu M,Bampoh S,Koulisis N,Farrell C,Hirshman MF,Yan Z,Goodyear LJ,Rustin P,Arany Z

    更新日期：2013-05-30 00:00:00

  • Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures.

    abstract：:Complex febrile seizures (FSs) lead to a high risk of intractable temporal lobe epilepsy during adulthood, yet the pathological process of complex FSs is largely unknown. Here, we demonstrate that activated microglia extensively associated with glutamatergic neuronal soma displace surrounding GABAergic presynapses in ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108346

    authors： Wan Y,Feng B,You Y,Yu J,Xu C,Dai H,Trapp BD,Shi P,Chen Z,Hu W

    更新日期：2020-11-03 00:00:00

  • Anterior Cingulate Cortex Modulation of the Ventral Tegmental Area in an Effort Task.

    abstract：:Information gained during goal pursuit motivates adaptive behavior. The anterior cingulate cortex (ACC) supports adaptive behavior, but how ACC signals are translated into motivational signals remains unclear. Rats with implants in the ACC and ventral tegmental area (VTA), a dopaminergic brain area implicated in motiv...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.05.062

    authors： Elston TW,Bilkey DK

    更新日期：2017-06-13 00:00:00

  • A Simple Grammar Defines Activating and Repressing cis-Regulatory Elements in Photoreceptors.

    abstract：:Transcription factors often activate and repress different target genes in the same cell. How activation and repression are encoded by different arrangements of transcription factor binding sites in cis-regulatory elements is poorly understood. We investigated how sites for the transcription factor CRX encode both act...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.09.066

    authors： White MA,Kwasnieski JC,Myers CA,Shen SQ,Corbo JC,Cohen BA

    更新日期：2016-10-25 00:00:00

  • PIAS1 Promotes Lymphomagenesis through MYC Upregulation.

    abstract：:The MYC proto-oncogene is a transcription factor implicated in a broad range of cancers. MYC is regulated by several post-translational modifications including SUMOylation, but the functional impact of this post-translational modification is still unclear. Here, we report that the SUMO E3 ligase PIAS1 SUMOylates MYC. ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.05.015

    authors： Rabellino A,Melegari M,Tompkins VS,Chen W,Van Ness BG,Teruya-Feldstein J,Conacci-Sorrell M,Janz S,Scaglioni PP

    更新日期：2016-06-07 00:00:00

  • Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks.

    abstract：:Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms to tolerate DNA lesions. The Smc5/6 complex, together with the Nse2/Mms21 SUMO ligase, plays essential roles in genome stability through undefined tasks at damaged replication forks. Various subunits...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.10.123

    authors： Zapatka M,Pociño-Merino I,Heluani-Gahete H,Bermúdez-López M,Tarrés M,Ibars E,Solé-Soler R,Gutiérrez-Escribano P,Apostolova S,Casas C,Aragon L,Wellinger R,Colomina N,Torres-Rosell J

    更新日期：2019-12-03 00:00:00

  • Sensory Afferents Use Different Coding Strategies for Heat and Cold.

    abstract：:Primary afferents transduce environmental stimuli into electrical activity that is transmitted centrally to be decoded into corresponding sensations. However, it remains unknown how afferent populations encode different somatosensory inputs. To address this, we performed two-photon Ca2+ imaging from thousands of dorsa...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.04.065

    authors： Wang F,Bélanger E,Côté SL,Desrosiers P,Prescott SA,Côté DC,De Koninck Y

    更新日期：2018-05-15 00:00:00

  • Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation.

    abstract：:Clinical transplantation of tissue fragments, including islets, faces a critical challenge because of a lack of effective strategies that ensure efficient engraftment through the timely integration of vascular networks. We recently developed a complex organoid engineering method by "self-condensation" culture based on...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.123

    authors： Takahashi Y,Sekine K,Kin T,Takebe T,Taniguchi H

    更新日期：2018-05-08 00:00:00

  • Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription.

    abstract：:Chromatin posttranslational modifications (PTMs), including monoubiquitylation of histone H2B on lysine 120 (H2Bub1), play a major role in regulating genome functions. To elucidate the molecular mechanisms of H2Bub1 activity, a chromatin template uniformly containing H2Bub1 was used as an affinity matrix to identify p...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.07.014

    authors： Shema-Yaacoby E,Nikolov M,Haj-Yahya M,Siman P,Allemand E,Yamaguchi Y,Muchardt C,Urlaub H,Brik A,Oren M,Fischle W

    更新日期：2013-08-15 00:00:00