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The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons.

Abstract：

:Striatal medium-sized spiny neurons (MSNs), composed of striatonigral and striatopallidal neurons, are derived from the lateral ganglionic eminence (LGE). We find that the transcription factor Sp9 is expressed in LGE progenitors that generate nearly all striatal MSNs and that Sp9 expression is maintained in postmitotic striatopallidal MSNs. Sp9-null mice lose most striatopallidal MSNs because of decreased proliferation of striatopallidal MSN progenitors and increased Bax-dependent apoptosis, whereas the development of striatonigral neurons is largely unaffected. ChIP qPCR provides evidence that Ascl1 directly binds the Sp9 promoter. RNA-seq and in situ hybridization reveal that Sp9 promotes expression of Adora2a, P2ry1, Gpr6, and Grik3 in the LGE and striatum. Thus, Sp9 is crucial for the generation, differentiation, and survival of striatopallidal MSNs.

journal_name

Cell Rep

journal_title

Cell reports

authors

Zhang Q,Zhang Y,Wang C,Xu Z,Liang Q,An L,Li J,Liu Z,You Y,He M,Mao Y,Chen B,Xiong ZQ,Rubenstein JL,Yang Z

doi

10.1016/j.celrep.2016.06.090

subject

Has Abstract

pub_date

2016-08-02 00:00:00

pages

1431-1444

issue

5

issn

2211-1247

pii

S2211-1247(16)30859-2

journal_volume

16

pub_type

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