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Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature.

Abstract：

:Mural cells (pericytes and vascular smooth muscle cells) are essential for the regulation of vascular networks and maintenance of vascular integrity, but their origins are diverse in different tissues and not known in the organs that arise from the ectoderm, such as skin. Here, we show that tissue-localized myeloid progenitors contribute to pericyte development in embryonic skin vasculature. A series of in vivo fate-mapping experiments indicates that tissue myeloid progenitors differentiate into pericytes. Furthermore, depletion of tissue myeloid cells and their progenitors in PU.1 (also known as Spi1) mutants results in defective pericyte development. Fluorescence-activated cell sorting (FACS)-isolated myeloid cells and their progenitors from embryonic skin differentiate into pericytes in culture. At the molecular level, transforming growth factor-β (TGF-β) induces pericyte differentiation in culture. Furthermore, type 2 TGF-β receptor (Tgfbr2) mutants exhibit deficient pericyte development in skin vasculature. Combined, these data suggest that pericytes differentiate from tissue myeloid progenitors in the skin vasculature through TGF-β signaling.

journal_name

Cell Rep

journal_title

Cell reports

authors

Yamazaki T,Nalbandian A,Uchida Y,Li W,Arnold TD,Kubota Y,Yamamoto S,Ema M,Mukouyama YS

doi

10.1016/j.celrep.2017.02.069

subject

Has Abstract

pub_date

2017-03-21 00:00:00

pages

2991-3004

issue

12

issn

2211-1247

pii

S2211-1247(17)30287-5

journal_volume

18

pub_type

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