Preventing Allograft Rejection by Targeting Immune Metabolism.

abstract：:Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet factors dictating the balance between innate and adaptive anti-tumor immunity are unclear. Here, clinical candidate STING agonist ADU-S100 (S100) is used in an IT dosing regimen optimized for adaptive immunity to uncover requirem...

journal_title：Cell reports

authors： Sivick KE,Desbien AL,Glickman LH,Reiner GL,Corrales L,Surh NH,Hudson TE,Vu UT,Francica BJ,Banda T,Katibah GE,Kanne DB,Leong JJ,Metchette K,Bruml JR,Ndubaku CO,McKenna JM,Feng Y,Zheng L,Bender SL,Cho CY,Leong ML

更新日期：2018-12-11 00:00:00

abstract：:Glioblastoma (GBM) harbors subpopulations of therapy-resistant tumor-initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC maintenance and identified ZFHX4, a 397 kDa transcription factor. ZFHX4 is ...

journal_title：Cell reports

authors： Chudnovsky Y,Kim D,Zheng S,Whyte WA,Bansal M,Bray MA,Gopal S,Theisen MA,Bilodeau S,Thiru P,Muffat J,Yilmaz OH,Mitalipova M,Woolard K,Lee J,Nishimura R,Sakata N,Fine HA,Carpenter AE,Silver SJ,Verhaak RG,Califano

更新日期：2014-01-30 00:00:00

abstract：:Early infantile epileptic encephalopathies (EOEE) are a debilitating spectrum of disorders associated with cognitive impairments. We present a clinical report of a KCNT2 mutation in an EOEE patient. The de novo heterozygous variant Phe240Leu SLICK was identified by exome sequencing and confirmed by Sanger sequencing. ...

journal_title：Cell reports

authors： Gururaj S,Palmer EE,Sheehan GD,Kandula T,Macintosh R,Ying K,Morris P,Tao J,Dias KR,Zhu Y,Dinger ME,Cowley MJ,Kirk EP,Roscioli T,Sachdev R,Duffey ME,Bye A,Bhattacharjee A

更新日期：2017-10-24 00:00:00

abstract：:Lineage analysis of autoreactive B cells can reveal the origins of autoimmunity. In the autoimmune disease pemphigus vulgaris (PV), desmoglein 3 (DSG3) and DSG1 autoantibodies are predominantly of the IgG4 subclass and less frequently of IgG1 and IgA subclasses, prompting us to investigate whether anti-DSG IgG4 B cell...

journal_title：Cell reports

authors： Ellebrecht CT,Mukherjee EM,Zheng Q,Choi EJ,Reddy SG,Mao X,Payne AS

更新日期：2018-08-28 00:00:00

abstract：:Antiangiogenic drugs are used clinically for treatment of renal cell carcinoma (RCC) as a standard first-line treatment. Nevertheless, these agents primarily serve to stabilize disease, and resistance eventually develops concomitant with progression. Here, we implicate metabolic symbiosis between tumor cells distal an...

journal_title：Cell reports

authors： Jiménez-Valerio G,Martínez-Lozano M,Bassani N,Vidal A,Ochoa-de-Olza M,Suárez C,García-Del-Muro X,Carles J,Viñals F,Graupera M,Indraccolo S,Casanovas O

更新日期：2016-05-10 00:00:00

abstract：:Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and progression of fibr...

journal_title：Cell reports

authors： Vila IK,Badin PM,Marques MA,Monbrun L,Lefort C,Mir L,Louche K,Bourlier V,Roussel B,Gui P,Grober J,Štich V,Rossmeislová L,Zakaroff-Girard A,Bouloumié A,Viguerie N,Moro C,Tavernier G,Langin D

更新日期：2014-05-22 00:00:00

abstract：:We recently reported an autosomal dominant form of renal Fanconi syndrome caused by a missense mutation in the third codon of the peroxisomal protein EHHADH. The mutation mistargets EHHADH to mitochondria, thereby impairing mitochondrial energy production and, consequently, reabsorption of electrolytes and low-molecul...

journal_title：Cell reports

authors： Assmann N,Dettmer K,Simbuerger JMB,Broeker C,Nuernberger N,Renner K,Courtneidge H,Klootwijk ED,Duerkop A,Hall A,Kleta R,Oefner PJ,Reichold M,Reinders J

更新日期：2016-05-17 00:00:00

abstract：:Interleukin (IL)-17 signaling to the intestinal epithelium regulates the intestinal microbiome. Given the reported links between intestinal dysbiosis, bacterial translocation, and liver disease, we hypothesize that intestinal IL-17R signaling plays a critical role in mitigating hepatic inflammation. To test this, we s...

journal_title：Cell reports

authors： Castillo-Dela Cruz P,Wanek AG,Kumar P,An X,Elsegeiny W,Horne W,Fitch A,Burr AHP,Gopalakrishna KP,Chen K,Methé BA,Canna SW,Hand TW,Kolls JK

更新日期：2019-11-19 00:00:00

abstract：:Reduced eukaryotic Initiation Factor 2 (eIF2)α phosphorylation (p-eIF2α) enhances protein synthesis, memory formation, and addiction-like behaviors. However, p-eIF2α has not been examined with regard to psychoactive cannabinoids and cross-sensitization. Here, we find that a cannabinoid receptor agonist (WIN 55,212-2 m...

journal_title：Cell reports

authors： Melas PA,Qvist JS,Deidda M,Upreti C,Wei YB,Sanna F,Fratta W,Scherma M,Fadda P,Kandel DB,Kandel ER

更新日期：2018-03-13 00:00:00

abstract：:Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we observe repression of host glycolysis in Mtb-infected macrophages, which is dependent on sustained u...

journal_title：Cell reports

authors： Hackett EE,Charles-Messance H,O'Leary SM,Gleeson LE,Muñoz-Wolf N,Case S,Wedderburn A,Johnston DGW,Williams MA,Smyth A,Ouimet M,Moore KJ,Lavelle EC,Corr SC,Gordon SV,Keane J,Sheedy FJ

更新日期：2020-01-07 00:00:00

abstract：:Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the s...

journal_title：Cell reports

authors： Munanairi A,Liu XY,Barry DM,Yang Q,Yin JB,Jin H,Li H,Meng QT,Peng JH,Wu ZY,Yin J,Zhou XY,Wan L,Mo P,Kim S,Huo FQ,Jeffry J,Li YQ,Bardoni R,Bruchas MR,Chen ZF

更新日期：2018-04-17 00:00:00

abstract：:The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies and autoimmune diseases. G6 is an anti-idiotypic monoclonal Ab that selectively binds to IGHV1-6...

journal_title：Cell reports

authors： Avnir Y,Prachanronarong KL,Zhang Z,Hou S,Peterson EC,Sui J,Zayed H,Kurella VB,McGuire AT,Stamatatos L,Hilbert BJ,Bohn MF,Kowalik TF,Jensen JD,Finberg RW,Wang JP,Goodall M,Jefferis R,Zhu Q,Kurt Yilmaz N,Schiffer CA

更新日期：2017-12-12 00:00:00

abstract：:Stringent targeting of membrane proteins to corresponding organelles is essential for organelle identity and functions. In addition to molecular pathways that target proteins to appropriate organelles, surveillance mechanisms clear mistargeted proteins from undesired destinations. Although Msp1 functions on the mitoch...

journal_title：Cell reports

authors： Qin Q,Zhao T,Zou W,Shen K,Wang X

更新日期：2020-11-10 00:00:00

abstract：:PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila...

journal_title：Cell reports

authors： Matsumoto N,Sato K,Nishimasu H,Namba Y,Miyakubi K,Dohmae N,Ishitani R,Siomi H,Siomi MC,Nureki O

更新日期：2015-04-21 00:00:00

abstract：:The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive. Liver kinase B1 (LKB1) acts as a coordinator by linking cellular metabolism to substrate AMP-activated protein kinase (AMPK). We show th...

journal_title：Cell reports

authors： Timilshina M,You Z,Lacher SM,Acharya S,Jiang L,Kang Y,Kim JA,Chang HW,Kim KJ,Park B,Song JH,Ko HJ,Park YY,Ma MJ,Nepal MR,Jeong TC,Chung Y,Waisman A,Chang JH

更新日期：2019-06-04 00:00:00

abstract：:During an infection the antigen-nonspecific memory CD8 T cell compartment is not simply an inert pool of cells, but becomes activated and cytotoxic. It is unknown how these cells contribute to the clearance of an infection. We measured the strength of T cell receptor (TCR) signals that bystander-activated, cytotoxic C...

journal_title：Cell reports

authors： Chu T,Tyznik AJ,Roepke S,Berkley AM,Woodward-Davis A,Pattacini L,Bevan MJ,Zehn D,Prlic M

更新日期：2013-03-28 00:00:00

abstract：:Vitamin D (VD) is a known differentiating agent, but the role of VD receptor (VDR) is still incompletely described in acute myeloid leukemia (AML), whose treatment is based mostly on antimitotic chemotherapy. Here, we present an unexpected role of VDR in normal hematopoiesis and in leukemogenesis. Limited VDR expressi...

journal_title：Cell reports

authors： Paubelle E,Zylbersztejn F,Maciel TT,Carvalho C,Mupo A,Cheok M,Lieben L,Sujobert P,Decroocq J,Yokoyama A,Asnafi V,Macintyre E,Tamburini J,Bardet V,Castaigne S,Preudhomme C,Dombret H,Carmeliet G,Bouscary D,Ginzburg YZ

更新日期：2020-01-21 00:00:00

abstract：:Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors. These processes govern mitochondria subcellular distribution, whose defects are emphasized in neurons because of their polarized structure. We have studie...

journal_title：Cell reports

authors： Trevisan T,Pendin D,Montagna A,Bova S,Ghelli AM,Daga A

更新日期：2018-05-08 00:00:00

abstract：:Lysosomes play a critical role in maintenance of the integrity of neuronal function, and mutations in genes that contribute to lysosome formation, transport, and activity are associated with neurodegenerative disorders. Recently, the multisubunit complex, BLOC-one-related complex (BORC), has been shown to be involved ...

journal_title：Cell reports

authors： Snouwaert JN,Church RJ,Jania L,Nguyen M,Wheeler ML,Saintsing A,Mieczkowski P,Manuel de Villena FP,Armao D,Moy SS,Lorenzo DN,Koller BH

更新日期：2018-07-31 00:00:00

abstract：:Histone H3 lysine 79 (H3K79) methylation is enriched on actively transcribed genes, and its misregulation is a hallmark of leukemia. Methylation of H3K79, which resides on the structured disk face of the nucleosome, is mediated by the Dot1L methyltransferase. Dot1L activity is part of a trans-histone crosstalk pathway...

journal_title：Cell reports

authors： Anderson CJ,Baird MR,Hsu A,Barbour EH,Koyama Y,Borgnia MJ,McGinty RK

更新日期：2019-02-12 00:00:00

abstract：:Alzheimer's disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J20) mutations to investigate transcriptional changes associated with the progress...

journal_title：Cell reports

authors： Castanho I,Murray TK,Hannon E,Jeffries A,Walker E,Laing E,Baulf H,Harvey J,Bradshaw L,Randall A,Moore K,O'Neill P,Lunnon K,Collier DA,Ahmed Z,O'Neill MJ,Mill J

更新日期：2020-02-11 00:00:00

abstract：:Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) or directly reprogrammed from non-myocytes (induced cardiomyocytes [iCMs]) are promising sources for heart regeneration or disease modeling. However, the similarities and differences between iPSC-CMs and iCMs are still unknown. Here, we performed tr...

journal_title：Cell reports

authors： Zhou Y,Wang L,Liu Z,Alimohamadi S,Yin C,Liu J,Qian L

更新日期：2017-09-26 00:00:00

abstract：:Although our understanding of centromere maintenance, marked by the histone H3 variant CenH3(CENP-A) in most eukaryotes, has progressed, the mechanism underlying the de novo formation of centromeres remains unclear. We used a synthetic system to dissect how CenH3(CENP-A) contributes to the accumulation of CENP-C and C...

journal_title：Cell reports

authors： Tachiwana H,Müller S,Blümer J,Klare K,Musacchio A,Almouzni G

更新日期：2015-04-07 00:00:00

abstract：:Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant to these functions. Here, we show ...

journal_title：Cell reports

authors： Hammachi F,Morrison GM,Sharov AA,Livigni A,Narayan S,Papapetrou EP,O'Malley J,Kaji K,Ko MS,Ptashne M,Brickman JM

更新日期：2012-02-23 00:00:00

abstract：:A new influenza-like virus genome (H17N10) was recently discovered in bats and offers a new perspective about the origin and evolution of influenza viruses. The viral envelope glycoprotein hemagglutinin (HA) is responsible for influenza virus receptor binding, fusion, and entry into the cell; therefore, the structure ...

journal_title：Cell reports

authors： Sun X,Shi Y,Lu X,He J,Gao F,Yan J,Qi J,Gao GF

更新日期：2013-03-28 00:00:00

abstract：:Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear. We show that LSD1, interacting with CoREST, associates with and coactivates androgen receptor (AR) ...

journal_title：Cell reports

authors： Cai C,He HH,Gao S,Chen S,Yu Z,Gao Y,Chen S,Chen MW,Zhang J,Ahmed M,Wang Y,Metzger E,Schüle R,Liu XS,Brown M,Balk SP

更新日期：2014-12-11 00:00:00

abstract：:Many infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens that activate naive T cells. How preexisting memory T cells impact th...

journal_title：Cell reports

authors： Oberle SG,Hanna-El-Daher L,Chennupati V,Enouz S,Scherer S,Prlic M,Zehn D

更新日期：2016-10-11 00:00:00

abstract：:Elevated levels of the free amino acid L-tryptophan (L-Trp) trigger expression of the tryptophanase tnaCAB operon in E. coli. Activation depends on tryptophan-dependent ribosomal stalling during translation of the upstream TnaC peptide. Here, we present a cryoelectron microscopy (cryo-EM) reconstruction at 3.8 Å resol...

journal_title：Cell reports

authors： Bischoff L,Berninghausen O,Beckmann R

更新日期：2014-10-23 00:00:00

abstract：:Mitochondrial respiratory chain disorders are characterized by loss of electron transport chain (ETC) activity. Although the causes of many such diseases are known, there is a lack of effective therapies. To identify genes that confer resistance to severe ETC dysfunction when inactivated, we performed a genome-wide ge...

journal_title：Cell reports

authors： Chen WW,Birsoy K,Mihaylova MM,Snitkin H,Stasinski I,Yucel B,Bayraktar EC,Carette JE,Clish CB,Brummelkamp TR,Sabatini DD,Sabatini DM

更新日期：2014-04-10 00:00:00

abstract：:The role of CD4+ T cells in the ischemic tissues of T2D patients remains unclear. Here, we report that T2D patients' vascular density was negatively correlated with the number of infiltrating CD4+ T cells after ischemic injury. Th1 was the predominant subset, and Th1-derived IFN-γ and TNF-α directly impaired human ang...

journal_title：Cell reports

authors： Leung OM,Li J,Li X,Chan VW,Yang KY,Ku M,Ji L,Sun H,Waldmann H,Tian XY,Huang Y,Lau J,Zhou B,Lui KO

更新日期：2018-08-07 00:00:00