Abstract：
:The central mechanism by which neurotensin (Nts) potentiates weight loss has remained elusive. We leveraged chemogenetics to reveal that Nts-expressing neurons of the lateral hypothalamic area (LHA) promote weight loss in mice by increasing volitional activity and restraining food intake. Intriguingly, these dual weight loss behaviors are mediated by distinct signaling pathways: Nts action via NtsR1 is essential for the anorectic effect of the LHA Nts circuit, but not for regulation of locomotor or drinking behavior. Furthermore, although LHA Nts neurons cannot reduce intake of freely available obesogenic foods, they effectively restrain motivated feeding in hungry, weight-restricted animals. LHA Nts neurons are thus vital mediators of central Nts action, particularly in the face of negative energy balance. Enhanced action via LHA Nts neurons may, therefore, be useful to suppress the increased appetitive drive that occurs after lifestyle-mediated weight loss and, hence, to prevent weight regain.
journal_name
Cell Repjournal_title
Cell reportsauthors
Woodworth HL,Beekly BG,Batchelor HM,Bugescu R,Perez-Bonilla P,Schroeder LE,Leinninger GMdoi
10.1016/j.celrep.2017.11.068subject
Has Abstractpub_date
2017-12-12 00:00:00pages
3116-3128issue
11issn
2211-1247pii
S2211-1247(17)31720-5journal_volume
21pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:STAT5, a member of the family of signal transducers and activators of transcription, senses cytokines and controls the biology of cell lineages, including mammary, liver, and T cells. Here, we show that STAT5 activates lineage-specific and widely expressed genes through different mechanisms. STAT5 preferentially binds...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.11.079
更新日期：2016-12-20 00:00:00
abstract：:DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How DNA methylation is regulated in developmental and cellular processes and ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.11.082
更新日期：2017-12-19 00:00:00
abstract：:Here, we propose an approach to identify active metabolic pathways by integrating gene essentiality analysis and protein abundance. We use two bacterial species (Mycoplasma pneumoniae and Mycoplasma agalactiae) that share a high gene content similarity yet show significant metabolic differences. First, we build detail...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107722
更新日期：2020-06-02 00:00:00
abstract：:Centromeric nucleosomes are critical for chromosome attachment to the mitotic spindle. In this issue of Cell Reports, Diaz-Ingelmo et al. (2015) propose that the yeast centromeric nucleosome is stabilized by a positively supercoiled loop formed by the sequence-specific CBF3 complex. ...
journal_title：Cell reports
pub_type： 评论,杂志文章
doi：10.1016/j.celrep.2015.10.007
更新日期：2015-10-27 00:00:00
abstract：:In Drosophila larvae, the class IV dendritic arborization (da) neurons are polymodal nociceptors. Here, we show that ppk26 (CG8546) plays an important role in mechanical nociception in class IV da neurons. Our immunohistochemical and functional results demonstrate that ppk26 is specifically expressed in class IV da ne...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.10.020
更新日期：2014-11-20 00:00:00
abstract：:Hypoxia-inducible factors (HIFs) are crucial for cellular and organismal adaptation to hypoxia. The mitochondrial respiratory chain is the largest consumer of oxygen in most mammalian cells; however, it is unknown whether the respiratory chain is necessary for in vivo activation of HIFs and organismal adaptation to hy...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.03.044
更新日期：2016-04-19 00:00:00
abstract：:CD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties. However, how Treg's differentiation and functional specification are regulated remains incompletely understood. Here, we report that gradient exp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.05.061
更新日期：2019-06-18 00:00:00
abstract：:Trithorax proteins and long-intergenic noncoding RNAs are critical regulators of embryonic stem cell pluripotency; however, how they cooperatively regulate germ layer mesoderm specification remains elusive. We report here that HoxBlinc RNA first specifies Flk1(+) mesoderm and then promotes hematopoietic differentiatio...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.12.007
更新日期：2016-01-05 00:00:00
abstract：:Altering the redox state of cysteine residues on protein surfaces is an important response to environmental challenges. Although aging and fasting alter many redox processes, the role of cysteine residues is uncertain. To address this, we used a redox proteomic technique, oxidative isotope-coded affinity tags (OxICAT)...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.05.033
更新日期：2015-06-30 00:00:00
abstract：:In the absence of low-level ER-to-mitochondrial Ca(2+) transfer, ATP levels fall, and AMPK-dependent, mTOR-independent autophagy is induced as an essential survival mechanism in many cell types. Here, we demonstrate that tumorigenic cancer cell lines, transformed primary human fibroblasts, and tumors in vivo respond s...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.02.030
更新日期：2016-03-15 00:00:00
abstract：:The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During the onset of acute inflammation, CD38 levels are increased, leading to the pr...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.12.090
更新日期：2020-01-28 00:00:00
abstract：:Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate and are thus essential for glutamatergic neurotransmission. However, VGLUTs were originally discovered as members of a transporter subfamily specific for inorganic phosphate (Pi). It is still unclear how VGLUTs accommodate glutamate transp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.055
更新日期：2018-04-10 00:00:00
abstract：:The innate immune system senses cytosolic dsDNA and bacterial cyclic dinucleotides and initiates signaling via the adaptor STING to induce type 1 interferon (IFN) response. We demonstrate here that BTK-deficient cells have impaired IFN-β production and TBK1/IRF3 activation when stimulated with agonists or infected wit...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.01.039
更新日期：2015-02-24 00:00:00
abstract：:Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of new unmodified histones during each cell cycle, and the principl...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.12.060
更新日期：2020-01-28 00:00:00
abstract：:Meiotic progression in S. pombe is regulated by stage-specific gene expression and translation, changes in RNA stability, expression of anti-sense transcripts, and targeted proteolysis of regulatory proteins. We have used SILAC labeling to examine the relative levels of proteins in diploid S. pombe cells during meiosi...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.12.075
更新日期：2019-01-22 00:00:00
abstract：:Most current tumor immunotherapy strategies leverage cytotoxic CD8+ T cells. Despite evidence for clinical potential of CD4+ tumor-infiltrating lymphocytes (TILs), their functional diversity limits our ability to harness their activity. Here, we use single-cell mRNA sequencing to analyze the response of tumor-specific...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.10.131
更新日期：2019-12-03 00:00:00
abstract：:Although bacterial cell morphology is tightly controlled, the principles of size regulation remain elusive. In Escherichia coli, perturbation of cell-wall synthesis often results in similar morphologies, making it difficult to deconvolve the complex genotype-phenotype relationships underlying morphogenesis. Here we mo...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.10.027
更新日期：2014-11-20 00:00:00
abstract：:DC-SIGN+ monocyte-derived dendritic cells (mo-DCs) play important roles in bacterial infections and inflammatory diseases, but the factors regulating their differentiation and proinflammatory status remain poorly defined. Here, we identify a microRNA, miR-181a, and a molecular mechanism that simultaneously regulate th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.02.077
更新日期：2020-03-17 00:00:00
abstract：:The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2. PRC2-mediated di- and tri-methylation (H3K27me2/H3K27me3) have been interchangeably associated with gene repression. However, it remains unclear whether these two degrees of H3K27 methylation have di...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.09.087
更新日期：2016-10-25 00:00:00
abstract：:Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer's disease (AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and synapse loss. We hypothesize that one mechanism of Aβ-induced synaptic injury is related to the cleavage of amyloid β precursor protein (AP...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107839
更新日期：2020-06-30 00:00:00
abstract：:Cockayne syndrome (CS) is a severe neurodevelopmental disorder characterized by growth abnormalities, premature aging, and photosensitivity. Mutation of Cockayne syndrome B (CSB) affects neuronal gene expression and differentiation, so we attempted to bypass its function by expressing downstream target genes. Intrigui...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.02.051
更新日期：2016-03-22 00:00:00
abstract：:TRBP functions as both a Dicer cofactor and a PKR inhibitor. However, the role of TRBP in microRNA (miRNA) biogenesis is controversial and its regulation of PKR in mitosis remains unexplored. Here, we generate TRBP knockout cells and find altered Dicer-processing sites in a subset of miRNAs but no effect on Dicer stab...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.09.039
更新日期：2014-11-06 00:00:00
abstract：:The asymmetric distribution of auxin leads to the bending growth of hypocotyls during gravitropic and phototropic responses, but the signaling events downstream of auxin remain unclear. Here, we identify many SAUR genes showing asymmetric expression in soybean hypocotyls during gravistimulation and then study their ho...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107529
更新日期：2020-04-21 00:00:00
abstract：:The neural network of the temporal lobe is thought to provide a cognitive map of our surroundings. Functional analysis of this network has been hampered by coarse tools that often result in collateral damage to other circuits. We developed a chemogenetic system to temporally control electrical input into the hippocamp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.032
更新日期：2016-07-19 00:00:00
abstract：:Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, their functions, and their relation to both normal development and dise...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.05.050
更新日期：2014-07-10 00:00:00
abstract：:Mcm2-7 helicase is loaded onto double-stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling that trigger helicase activation in S phase remain unknown. Here, we develop an approach to detect and purify the endogenous DHs directly. Through cellular fractionation, we pro...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.11.018
更新日期：2015-12-22 00:00:00
abstract：:In Escherichia coli, bidirectional chromosomal replication is accompanied by the colocalization of sister replication forks. However, the biological significance of this mechanism and the key factors involved are still largely unknown. In this study, we found that a protein, termed CrfC, helps sustain the colocalizati...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.07.040
更新日期：2013-09-12 00:00:00
abstract：:Embryonic stem cells (ESCs) hold promise for the treatment of many medical conditions; however, their utility is limited by immune rejection. The objective of our study is to establish tolerance or promote engraftment of transplanted ESCs as well as mature cell populations derived from ESCs. Luciferase (luc(+))-expres...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.02.050
更新日期：2015-03-24 00:00:00
abstract：:Monkeys are an optimal model species for developing stem cell therapies. We previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (dESCs). However, conventional primed pluripotent stem cells (pPSCs) lack chimera competency. Here, by altering the media in which injecte...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.11.001
更新日期：2018-11-27 00:00:00
abstract：:Ependymomas exist within distinct genetic subgroups, but the molecular diversity within individual ependymomas is unknown. We perform multiplatform molecular profiling of 6 spatially distinct samples from an ependymoma with C11orf95-RELA fusion. DNA methylation and RNA sequencing distinguish clusters of samples accord...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.01.018
更新日期：2020-02-04 00:00:00
