The protective effect of epigallocatechin-3-gallate on testicular oxidative stress in lead-induced toxicity mediated by Cyp19 gene / estradiol level.

abstract：:Calf thymus DNA was reacted with 1,2-epoxybutene (BDO) in phosphate buffered saline at 37 degrees C for 12 h. DNA was ethanol precipitated and hydrolyzed with 1 M HCl to release DNA bases. Adenine (A)-BDO and guanine (Gua)-BDO adducts were analyzed in the ethanol supernatant and DNA hydrolysate using LC/ESI MS/MS. Rea...

journal_title：Toxicology

authors： Kambouris SJ,Chaudhary AK,Blair IA

更新日期：1996-10-28 00:00:00

abstract：:Zinc (Zn) is an essential nutrient that is required in humans and animals for many physiological functions, including immune and antioxidant function, growth and reproduction. The present study was conducted to investigate the effects of adequate Zn level (38 mg/kg diet, as a control) and two low levels that create Zn...

journal_title：Toxicology

authors： Yousef MI,El-Hendy HA,El-Demerdash FM,Elagamy EI

更新日期：2002-06-14 00:00:00

abstract：:Rats were exposed to isopropanol by inhalation of 200,2000 and 8000 ppm for 2 weeks with a daily exposure of 6 h. A pilot group exposed to 8000 ppm was given a recovery period of 4 weeks. Kidney and liver microsomal metabolism of n-hexane was investigated in vitro concomitant with activities of cytochrome P-450 and GS...

journal_title：Toxicology

authors： Zahlsen K,Aarstad K,Nilsen OG

更新日期：1985-01-01 00:00:00

abstract：:The effects of zinc and copper on delta-aminolaevulinic acid dehydratase were studied in vitro and in vivo. The in vitro addition of zinc alone to whole blood resulted in a highly significant increase in enzyme activity. The addition of copper alone had the opposite effect with a significant decrease in enzyme activit...

journal_title：Toxicology

authors： Nelson HM,Hughes MA,Meredith PA

更新日期：1981-01-01 00:00:00

abstract：:The anticonvulsant, valproic acid (VPA) is a suspected human teratogen. This study, employing the rhesus monkey as an animal model, demonstrates that VPA has a significant teratogenic potential in the monkey. Timed pregnant monkeys were exposed orally to VPA at approx. 1X, 10X, and 30X (20, 200, and 600 mg/kg/day, res...

journal_title：Toxicology

authors： Mast TJ,Cukierski MA,Nau H,Hendrickx AG

更新日期：1986-05-01 00:00:00

abstract：:Enantioselectivity in toxicology, and health risk of chiral xenobiotics have become important topics at the forefront of chemistry and toxicology research. Our previous results showed that cis-bifenthrin (cis-BF) induced cytotoxicity and genotoxicity in human amnion epithelial (FL) cells, in an enantioselective manner...

journal_title：Toxicology

authors： Liu H,Xu L,Zhao M,Liu W,Zhang C,Zhou S

更新日期：2009-07-10 00:00:00

abstract：:We have previously shown that young guinea pigs repeatedly exposed to sidestream cigarette smoke (SS) develop decreased airway reactivity of the C-fiber system without changing reactivity to one of its neurotransmitters, substance P (SP). This study was designed to determine whether the decreased reactivity was due to...

journal_title：Toxicology

authors： Joad JP,Avadhanam KP,Watt KC,Kott KS,Bric JM,Pinkerton KE

更新日期：1996-09-02 00:00:00

abstract：:The Internet = s global reach offers new powerful tools to professionals in Occupational and Environmental Health (OEH). The World Wide Web includes extensive free and commercially available reference materials on toxicology, regulatory issues, environmental epidemiology and prevention programs. Much of this especiall...

journal_title：Toxicology

authors： Greenberg GN

更新日期：2002-04-25 00:00:00

abstract：:The protective effect of telmisartan, the angiotensin II-receptor antagonist, against liver toxicity induced by sodium arsenite (5 mg/kg/day, p.o., for 30 days) was investigated in mice. Telmisartan treatment (10 mg/kg/day, p.o.) was applied for 30 days, starting on the same day of arsenic administration. Telmisartan ...

journal_title：Toxicology

authors： Fouad AA,Al-Mulhim AS,Jresat I

更新日期：2012-10-28 00:00:00

abstract：:Trans-1,2-dichloroethylene (t-DCE), an industrial solvent, proved to be moderately toxic when studied in small laboratory animals. In adult female rats brief (8 h) and prolonged (8 h daily, on 5 consecutive days a week, for more than 16 weeks) inhalation of 200 ppm--the current TLV/MAC in various countries--produced h...

journal_title：Toxicology

authors： Freundt KJ,Liebaldt GP,Lieberwirth E

更新日期：1977-04-01 00:00:00

abstract：:Deltamethrin is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control, protection of foodstuff and disease vector control. The objective of this study was to investigate the propensity of deltamethrin to induce oxidative stress and changes in biochemical parameters and enzyme activities i...

journal_title：Toxicology

authors： Yousef MI,Awad TI,Mohamed EH

更新日期：2006-10-29 00:00:00

abstract：:In our previous study, di-n-butyltin diacetate has been shown to cause malformations such as cleft mandible, ankyloglossia, fused ribs, etc. in rat fetuses after oral treatment of maternal rats on day 8 of gestation. In this study, teratogenic effects of five di-n-butyltin compounds with different anions and also buty...

journal_title：Toxicology

authors： Noda T,Morita S,Baba A

更新日期：1993-12-31 00:00:00

abstract：:The present study was conducted in order to study the effect of the PCB congener 3,3', 4,4'-tetrachlorobiphenyl (CB-77) on fetal thyroxin homeostasis in the mouse, and to examine a possible underlying mechanism behind the effect. C57BL mice were treated with 14C-labelled or unlabelled CB-77 (1 or 10 mg/kg body wt.) on...

journal_title：Toxicology

authors： Darnerud PO,Morse D,Klasson-Wehler E,Brouwer A

更新日期：1996-01-08 00:00:00

abstract：:The attempts to use nitroxide free radicals and nitrone spin traps topically in skin requires analysis of their potential cutaneous adverse effects. The objective of this study was to investigate the skin irritation and sensitizing potential of nitroxides and nitrones in the guinea pig. The following unsubstituted nit...

journal_title：Toxicology

authors： Fuchs J,Groth N,Herrling T

更新日期：1998-02-20 00:00:00

abstract：:A major goal in modern pharmacotechnology is to increase the therapeutic index of drugs by using nanoparticulate vehicle systems in order to ensure slow release or targeted delivery of drugs. With all great benefits, however, these innovative therapies can carry a risk for acute immune toxicity manifested in hypersens...

journal_title：Toxicology

authors： Szebeni J

更新日期：2005-12-15 00:00:00

abstract：:The present study was undertaken to investigate the involvement of oxidative damage in lead-induced toxicity in humans and to enlighten whether oxidative stress indicators are correlated with the known indices of lead toxicity. For these purposes, selected oxidative stress parameters along with some clinical indices o...

journal_title：Toxicology

authors： Gurer-Orhan H,Sabir HU,Ozgüneş H

更新日期：2004-02-15 00:00:00

abstract：:The effects of N-acetylcysteine (NAC), 2-mercaptopropionylglycine (MPG) and dithiothreitol (DTT) on the metabolism and toxicity of acetaminophen (APAP) were examined in isolated mouse hepatocytes maintained in primary culture on collagen-coated dishes. Both NAC and MPG increased the formation of the glutathione and su...

journal_title：Toxicology

authors： Harman AW,Self G

更新日期：1986-10-01 00:00:00

abstract：:Chalcones are phenolic compounds that can be isolated from plants. Previous studies have described some pharmacological applications for these compounds. Making use of our established reporter gene system, we determined the effect of five hydroxychalcones--2-hydroxychalcone, 2'-hydroxychalcone, 4-hydroxychalcone, 4,2'...

journal_title：Toxicology

authors： Wang H,Wang Y,Chen ZY,Chan FL,Leung LK

更新日期：2005-02-14 00:00:00

abstract：:The effect of sodium metavanadate (NaVO3) consumption on trace element metabolism, components of the antioxidant defense system and lipid oxidative damage were studied in control (CON) and streptozotocin-induced diabetic (DIAB) rats. Ten days after injection, CON and DIAB rats received either 0 mM NaVO3/80 mM NaCl (0 ...

journal_title：Toxicology

authors： Oster MH,Llobet JM,Domingo JL,German JB,Keen CL

更新日期：1993-10-25 00:00:00

abstract：:This study evaluated a single intradermal injection model in the guinea pig with subsequent inhalation challenge and serological analysis as a method to predict the potential of chemicals to induce respiratory allergy. Four known respiratory allergens (trimellitic anhydride, diphenyl methane diisocyanate, phthalic anh...

journal_title：Toxicology

authors： Blaikie L,Morrow T,Wilson AP,Hext P,Hartop PJ,Rattray NJ,Woodcock D,Botham PA

更新日期：1995-01-19 00:00:00

abstract：:Flame retardants such as polybrominated diphenyl ethers (PBDE) and tetrabromobisphenol A are used as flame retardants and detected in the environmental, wildlife species and human tissues. Exposure to PBDEs during the neonatal development of the brain has been shown to affect behavior and learning and memory in adult ...

journal_title：Toxicology

authors： Viberg H,Eriksson P

更新日期：2011-10-28 00:00:00

abstract：:The carcinogenic response of NZO/BlGd inbred mice of both sexes to oral N-nitrosohexamethyleneimine (NHEX) was investigated at 2 differing dose rates, but equal cumulative doses. Mice received 52 mg NHEX (2 mg/g body wt) in drinking water over either an 8-week period (200 mg/l) or a 32-week period (50 mg/l), and were ...

journal_title：Toxicology

authors： Goodall CM,Lijinsky W

更新日期：1984-12-01 00:00:00

abstract：:Organochalcogens are important intermediates and useful reagents in organic synthesis, which can increase human exposure risk to these chemicals in the workplace. As well, there are a number of reported cases of acute toxicity following organochalcogen ingestion of vitamins and dietary supplements. Since, the erythroc...

journal_title：Toxicology

authors： Nogueira CW,Borges VC,Zeni G,Rocha JB

更新日期：2003-09-30 00:00:00

abstract：:Static and rotary cultures of adult rabbit hepatocytes can be produced reproducibly following their isolation by means of a simplified, inexpensive recycling perfusion system. Light and electron microscopic examination of the cultures showed that these hepatocytes retained the morphological characteristics of fully di...

journal_title：Toxicology

authors： Poole A,Chasseaud LF,Bridges JW

更新日期：1982-01-01 00:00:00

abstract：:Spores of actinomycetes, mesophilic gram-positive bacteria, isolated from moldy houses, induced the expression of inducible NO-synthase (iNOS) with a subsequent NO-production in RAW264.7 macrophages. No differences were detected between production of nitric oxide (NO) by alive or irradiated spores of different strains...

journal_title：Toxicology

authors： Hirvonen MR,Ruotsalainen M,Savolainen K,Nevalainen A

更新日期：1997-12-26 00:00:00

abstract：OBJECTIVES:Infusion phlebitis is a common clinical problem associated with some antimicrobial agents. The pathomechanism of infusion phlebitis has not yet been elucidated, however, it has been proposed that chemical irritation of the endothelium leads to subsequent sterile inflammation with recruitment and migration of...

journal_title：Toxicology

authors： Kilic B,Kruse M,Stahlmann R

更新日期：2006-01-20 00:00:00

abstract：:The intravenous toxicity of phytic acid (inositol hexakisphosphate, IHP) has recently become of interest because of the potential for IHP incorporation into red blood cells to achieve a therapeutically useful shift in the hemoglobin-oxygen dissociation curve (Gersonde, K. and Nicolau, C., Blut, 39 (1979) 1). The obser...

journal_title：Toxicology

authors： Gersonde K,Weiner M

更新日期：1981-01-01 00:00:00

abstract：:Drug-induced liver injury (DILI) is a major safety concern in drug development and clinical drug therapy. The pathogenesis of DILI usually involves the participation of the parent drug or metabolites that either directly affect the cell biochemistry or elicit an immune response. However, in most cases the mechanisms a...

journal_title：Toxicology

authors： Kobayashi M,Higuchi S,Mizuno K,Tsuneyama K,Fukami T,Nakajima M,Yokoi T

更新日期：2010-09-10 00:00:00

abstract：:Fifteen Chinchilla rabbits were treated by seven daily i.v. injections of two doses (25 or 50 mg/kg body wt.) of sodium borocaptate (Na2B12H11SH), an agent now widely investigated for potential use in Boron Neutron Capture Therapy (BNCT) of malignant brain tumors. Definite nephrotoxic lesions hyperemic and dilated glo...

journal_title：Toxicology

authors： Janků I,Buchar E,Jiricka Z

更新日期：1993-04-30 00:00:00

abstract：:Unfortunately, the principal routine toxicology methods employed for the safety assessment of new products are over 40 years old and rely primarily on histopathological evaluation. It is difficult to introduce newer immunotoxicology or molecular toxicology methods into toxicity assessment without extensive and time co...

journal_title：Toxicology

authors： Dean JH

更新日期：1997-04-11 00:00:00