Abstract:
:The intravenous toxicity of phytic acid (inositol hexakisphosphate, IHP) has recently become of interest because of the potential for IHP incorporation into red blood cells to achieve a therapeutically useful shift in the hemoglobin-oxygen dissociation curve (Gersonde, K. and Nicolau, C., Blut, 39 (1979) 1). The observed acute intravenous toxicity of IHP in rodents is consistent with its recognized capacity to bind calcium. The toxic manifestations of intravenous IHP are a function of rate of infusion as well as total dose, with some seemingly anomalous variations which may related to compensatory mechanisms. The data suggest that significant alterations of plasma calcium and the toxic potential of such alterations are not likely to result from the administration of red blood cells with IHP incorporated.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Gersonde K,Weiner Mdoi
10.1016/0300-483x(81)90022-6subject
Has Abstractpub_date
1981-01-01 00:00:00pages
279-86issue
4eissn
0300-483Xissn
1879-3185pii
0300-483X(81)90022-6journal_volume
22pub_type
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