Abstract:
:Stannous chloride (SnCl2) is a reducing chemical agent used in several man-made products. SnCl2 can generate reactive oxygen species (ROS). Therefore, the present study has been carried out to investigate the antioxidant action of l-ascorbic acid (AA) in minimizing SnCl2 toxicity on lipid peroxidation, antioxidant enzyme, and biochemical parameters in male New Zealand white rabbits. Animals were assigned to one of four treatment groups: 0mg AA and 0mg SnCl2/kg BW (control); 40 mg AA/kg BW; 20mg SnCl2/kg BW; 20mg SnCl2 plus 40 mg AA/kg BW. Rabbits were orally administered the respective doses every other day for 12 weeks. Results obtained showed that SnCl2 significantly (P<0.05) induced thiobarbituric acid-reactive substances (TBARS; the marker of lipid peroxidation) in plasma, while the activities of glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT), and the level of sulfhydryl groups (SH-group) were decreased (P<0.05) in blood plasma. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (AlP), acid phosphatase (AcP) and lactate dehydrogenase (LDH) activities were decreased (P<0.05). Stannous chloride significantly (P<0.05) increased the levels of plasma total lipid (TL), cholesterol, triglyceride (TG), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL), glucose, urea and total bilirubin. On the other hand, the level of plasma high-density lipoprotein (HDL), total protein (TP), albumin (A) and globulin (G) were significantly (P<0.05) decreased. Ascorbic acid alone significantly decreased the levels of TBARS, lipids and urea, and increased the activities of GST, SOD and CAT, and the levels of SH-group and proteins. While the rest of the tested parameters were not affected. Also, the presence of AA with SnCl2 alleviated its harmful effects on most of the tested parameters. Therefore, the present results revealed that treatment with AA could minimize the toxic effects of stannous chloride.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Yousef MI,Awad TI,Elhag FA,Khaled FAdoi
10.1016/j.tox.2007.03.017subject
Has Abstractpub_date
2007-06-25 00:00:00pages
194-202issue
3eissn
0300-483Xissn
1879-3185pii
S0300-483X(07)00186-2journal_volume
235pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Glutathione S-transferases and glutathione play an important role in the detoxification of most toxic agents. In the present study, the protective effects of some antioxidants (L-ascorbic acid (AA), vitamin E (VE) or garlic) on carbon tetrachloride-induced changes in the activity of alanine amino transferase (ALT), as...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00429-2
更新日期:2001-08-28 00:00:00
abstract::Transgenic rat mutation assays can be used to assess genotoxic properties of chemicals in target organs for carcinogenicity. Mutations in transgenes are genetically neutral and accumulate during a treatment period; thus, assays are suitable for assessing the genotoxic risk of chemicals using a repeated-dose treatment ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.07.003
更新日期:2014-10-03 00:00:00
abstract::Among exocyclic DNA adducts, etheno (epsilon) bases (epsilond A, epsilond C, N(2),3-epsilond G) are generated by reactions of DNA bases with lipid peroxidation (LPO) products derived from endogenous sources and from the carcinogens vinyl chloride or urethane. The recent development of ultrasensitive methods has made i...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(00)00307-3
更新日期:2000-11-16 00:00:00
abstract::To elucidate factors responsible for altered proliferation of preneoplastic hepatocytes in rat hepatocarcinogenesis in vivo, EGF-stimulated DNA synthesis of normal and nodular hepatocytes in primary culture was studied. In addition, the influence of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated to clari...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00189-4
更新日期:2000-04-03 00:00:00
abstract::Butylated hydroxytoluene (BHT)-induced lung damage in mice is an excellent model system for studying mechanisms of chemically-induced, reversible alveolar injury. Changes in the pulmonary contents of protein kinase C (PKC) and the calcium-dependent protease, calpain, were previously noted during the repair phase follo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)02943-o
更新日期:1995-03-31 00:00:00
abstract::The bioavailability of coplanar 2,3',4,4',5-pentachlorobiphenyl (PCB118) and nonplanar 2,2',5,5'-tetrachlorobiphenyl (PCB52) from soils representing a range in organic carbon (OC), clay content and pH were investigated using an in vivo rat model and an in vitro physiologically based extraction test (PBET) to assess th...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.08.012
更新日期:2006-01-05 00:00:00
abstract::The attempts to use nitroxide free radicals and nitrone spin traps topically in skin requires analysis of their potential cutaneous adverse effects. The objective of this study was to investigate the skin irritation and sensitizing potential of nitroxides and nitrones in the guinea pig. The following unsubstituted nit...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00183-2
更新日期:1998-02-20 00:00:00
abstract::In a Japanese chemical factory, a lung disease like pneumoconiosis appeared at a high rate among workers handling cross-linked water-soluble acrylic acid polymer (CWAAP). To our knowledge, no such case was known in the world until very recently. The present study was designed to elucidate the effect of single intratra...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152647
更新日期:2021-01-30 00:00:00
abstract::CI-959 is an orally effective inhibitor of cellular activation in both in vitro and animal models. To assess the effects of CI-959 on immune function, male Fischer 344 rats were evaluated for splenic T- and B-lymphocyte populations, antibody-forming cell response to sheep red blood cells (sRBC), concanavalin A and pok...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)02985-4
更新日期:1995-04-12 00:00:00
abstract::To establish a paraquat-resistant Wistar rat strain, we carried out continuous sister-brother mating among rats that survived high-dose intraperitoneal administration of paraquat dichloride (360 mg/kg). The percentages of paraquat-resistant rats among wild rats and among the fifth-generations were 7.1% and 20.6%, resp...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00299-7
更新日期:2000-11-23 00:00:00
abstract::We studied the effect of O,S,S-trimethyl phosphorodithioate (OSS-Me) on macrophage function and the immune responses of both T- and B-cells using an in vitro system. The involvement of glutathione (GSH) in the bioactivation of OSS-Me to suppress such responses was investigated after either direct culture with spleen o...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90155-1
更新日期:1986-04-01 00:00:00
abstract::Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2017.07.019
更新日期:2017-11-01 00:00:00
abstract::The possibility that Cd administration could activate the pituitary-adrenal axis has been studied. It was found that acute administration of Cd strongly increased serum corticosterone levels. Adrenocortical activation correlated well with serum Cd levels, suggesting that adrenal activation was dependent on the presenc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90119-3
更新日期:1987-07-01 00:00:00
abstract::The influence of the insertion of a liver into the perfusion circuit of a lung on the availability of benzo[a]pyrene and benzo[a]pyrene metabolites to the lung was examined. Perfused lungs from 5,6-benzoflavone pretreated rats release high quantities of free benzo[a]pyrene metabolites and conjugates into the perfusion...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90100-4
更新日期:1987-08-01 00:00:00
abstract::Chlorpyrifos (CPF) is a commonly used diethylphosphorothionate organophosphorus (OP) insecticide. Diethylphosphate (DEP), diethylthiophosphate (DETP) and 3,5,6-trichloro-2-pyridinol (TCPy) are products of both in vivo metabolism and environmental degradation of CPF and are routinely measured in urine as biomarkers of ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.11.022
更新日期:2010-01-31 00:00:00
abstract::The nephrotoxicant and nephrocarcinogen tris(2,3-dibromopropyl)-phosphate (Tris-BP) is activated to products which bind covalently to microsomal protein by a cytochrome P-450 dependent oxidation reaction. Binding to rat liver microsomes proceeds 15 times faster than with kidney microsomes. The binding in liver microso...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(81)90144-x
更新日期:1981-01-01 00:00:00
abstract::The ability to overcome cellular barriers in the body is crucial for efficient delivery of drugs to the target where intervention is needed. For drugs acting in the brain it is essential to overcome the blood-brain barrier (BBB). Such drugs include antidotes for the treatment of organophosphate poisoning, a current wa...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152541
更新日期:2020-10-01 00:00:00
abstract::Quartz is a well-known occupational fibrogenic agent able to cause fibrosis and other severe pulmonary diseases such as silicosis and lung cancer. The silicotic pathology owes its severity to the structural and chemo-physical properties of the particles such as shape, size and abundance of surface radicals. In earlier...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.07.001
更新日期:2016-06-15 00:00:00
abstract::During the past decade, several assessments have estimated the carcinogenic risk of inhaled 1,3-butadiene (BD) to the general population as well as for occupational exposures. Although most of the risk assessments have been based on inhalation bioassays in mice, some of the assessments have included the 2-year inhalat...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(96)03447-6
更新日期:1996-10-28 00:00:00
abstract::Oxidative stress as a result of excessive generation of reactive oxygen species (ROS) or diminished antioxidative defence is regarded as a main factor in the pathophysiology of various diseases and ageing. Many flavonoids that are present in herbal edibles have antioxidative properties and possess a remarkable spectru...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.02.006
更新日期:2007-05-05 00:00:00
abstract::Tobacco smoking is the largest preventable risk factor for morbidity and mortality in industrialized countries. WHO estimates that tobacco will become the largest single health problem by 2020, causing an estimated 8.4 million deaths annually. Tobacco has central importance in the etiology of cancers of the lung, head...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(01)00445-0
更新日期:2001-09-14 00:00:00
abstract::Within the framework of an EU project on risk assessment of brominated flame retardants, TBBPA was studied for neurobehavioral effects in rats. To permit benchmark dose analysis, eight dose levels were chosen ranging from 0 to 3000mg/kg body weight. Exposure of parental rats started 10 and 2 weeks before mating in mal...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.01.007
更新日期:2008-04-03 00:00:00
abstract::Subcutaneous administration of methyl isocyanate (MIC) in 0.5 LD50 and 1 LD50 doses in female rabbits resulted in significant changes in physiological, clinico-chemical and histological parameters. There was a fall in arterial blood pressure and cardioacceleration in both the 0.5 LD50 and 1 LD50 groups, while the resp...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90152-7
更新日期:1988-10-01 00:00:00
abstract::The consumption of diets rich in plant foods are associated with a reduced risk of cardiovascular diseases. This study was aimed to evaluate the role of S-allylcysteine (SAC) in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (150 mg/kg) to Wistar rats showed a significant...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.04.039
更新日期:2006-07-05 00:00:00
abstract::Although the production of polychlorinated biphenyl 77 (PCB77) has already been banned globally, PCB77 is still used for a wide range of commercial purposes. Previous evidence has demonstrated that the PCB77 administration should be responsible for the gut microbiota variations and the host health risk. However, the h...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.03.011
更新日期:2019-05-15 00:00:00
abstract::The involvement of metallothionein (MT) in the nephrotoxicity of cis-diamminedichloroplatinum (c-DDP) was investigated in rats using enzyme excretion and histology as indicators of renal damage. In addition, the effects of renal glutathione (GSH) depletion on the nephrotoxicity of c-DDP was assessed by organic anion t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90129-5
更新日期:1990-11-01 00:00:00
abstract::Sodium valproate (VPA) is a potentially hepatotoxic antiepileptic drug. Risk of VPA-induced hepatotoxicity is increased in patients with mitochondrial diseases and especially in patients with POLG1 gene mutations. We used a HepG2 cell in vitro model to investigate the effect of VPA on mitochondrial activity. Cells wer...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2015.03.001
更新日期:2015-05-04 00:00:00
abstract::The widespread use of tributyltin (TBT) as biocides in antifouling paints and agricultural chemicals has led to environmental and marine pollution. Human exposure occurs mainly through TBT contaminated seafood and drinking water. It is a well known endocrine disruptor in mammals, but its molecular mechanism in testicu...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2013.09.003
更新日期:2013-12-06 00:00:00
abstract::The development of poisons information centers has in general complied with the actual needs and conditions in the society, and a pragmatic approach and limited funds have been characteristic for these units. To operate in a satisfying way a poisons information center is dependent on two cornerstones-a well educated a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.01.033
更新日期:2004-05-20 00:00:00
abstract::A 20-year-old man on oral substitution of pancreatic enzymes after hemipancreatectomy injected an enzyme preparation of fungal origin intravenously after dissolving it in water. Within a few hours chills, headache, nausea and vomiting, fever of 40.8 degrees C, and shock occurred. The acute illness might have been caus...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90189-3
更新日期:1989-04-01 00:00:00