Abstract：
:The present study investigates the influence of different levels of Schistosoma mansoni infection (60, 120, 180, 300, 600 cercariae per mice) after 33 days on the activity of aryl hydrocarbon hydroxylase (AHH) and the formation of hepatic hydrogen peroxide (H(2)O(2)) during the metabolic activation of benzo(a)pyrene [B(a)p]. Also, it shows the mutagenic effect of B(a)p at different levels of S. mansoni infection using Salmonella typhimurium TA 98 and TA 102 as a tester strains. High levels of H(2)O(2) production (222 nmol/mg protein) and AHH activity (240 pmol 3-OH B(a)p per mg protein) were seen at 300 cercariae per mice. Increasing histidine revertant colonies at TA98 and TA102 were detected at different levels of S. mansoni infection. These data clearly demonstrate that S. mansoni infection changes the mutagenicity of B(a)p, AHH activity, as well as enhancing the formation of hepatic H(2)O(2) generated during the metabolic activation of B(a)p in infected mice.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Awney HA,Ghzlan HE,Sheweita SA,Mostafa MHdoi
10.1016/s0300-483x(01)00372-9keywords:
subject
Has Abstractpub_date
2001-06-21 00:00:00pages
213-8issue
2-3eissn
0300-483Xissn
1879-3185pii
S0300483X01003729journal_volume
163pub_type
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