abstract：:In a Japanese chemical factory, a lung disease like pneumoconiosis appeared at a high rate among workers handling cross-linked water-soluble acrylic acid polymer (CWAAP). To our knowledge, no such case was known in the world until very recently. The present study was designed to elucidate the effect of single intratra...

journal_title：Toxicology

authors： Suka M,Kido T,Yoshioka W,Hachisuka E,Okoshi H,Yamauchi T,Hano H,Okano T,Yokoyama M,Yanagisawa H

更新日期：2021-01-30 00:00:00

abstract：:The neurotoxicity and developmental effects of a widely applied insecticide (methomyl) was investigated by a multi-level approach (behavior and biometry, biochemical alterations and neurodegeneration) in Caenorhabditis elegans upon a short-term exposure (1 h) and a post-exposure period (48 h). The 1-h exposure to sub-...

journal_title：Toxicology

authors： Queirós L,Martins AC,Krum BN,Ke T,Aschner M,Pereira JL,Gonçalves FJM,Milne GL,Pereira P

更新日期：2021-01-25 00:00:00

abstract：:Hydrogen sulfide (H2S) as the third gasotransmitter molecule serves various biological regulatory roles in health and disease. Acrylonitrile (AN) is a common occupational toxicant and environmental pollutant, causing brain and liver damage in mammals. The biotransformation of AN is dependent-upon reduced glutathione (...

journal_title：Toxicology

authors： Yang B,Zhao W,Yin C,Bai Y,Wang S,Xing G,Li F,Bian J,Aschner M,Cai J,Shi H,Lu R

更新日期：2021-01-21 00:00:00

abstract：:Silicosis is a universal occupational disease, which is caused by long-term crystalline silica exposure. Recent studies have shown that noncoding RNAs participate in diverse pathological cellular pathways. However, the precise regulation mechanism remains limited in silicosis. Here, we established a silica-induced mou...

journal_title：Toxicology

authors： Cheng D,Xu Q,Liu Y,Li G,Sun W,Ma D,Ni C

更新日期：2021-01-19 00:00:00

abstract：:Urinary dialkylphosphates (DAPs) are measured to assess exposure to organophosphorus pesticides (OPs), but they are common metabolites of OPs and not specific indices for individual agents. Biomonitoring (BM) of urinary DAPs has been widely adopted as an assessment of individual exposure in general environments, howev...

journal_title：Toxicology

authors： Sato H,Ito Y,Hanai C,Nishimura M,Ueyama J,Kamijima M

更新日期：2021-01-15 00:00:00

abstract：OBJECTIVE:Ozone has become a major air pollutant in recent years, which leading to a variety of lung diseases. This study aimed to explore the mechanisms of pyroptosis and related signaling pathways in ozone-induced lung injury. METHODS:We exposed 120 Wistar rats to ozone, 20 in each group (half male and half female)....

journal_title：Toxicology

authors： Tian L,Yan J,Li K,Zhang W,Lin B,Lai W,Bian L,Liu H,Xi Z,Liu X

更新日期：2020-12-28 00:00:00

abstract：:As an important cholesterol oxide, 7-ketocholesterol plays a deleterious role in the occurrence of cancer. Although the fact had been proved that 7-ketocholesterol could induce several biological phenomena, including apoptosis, DNA damage, et al., this issue whether 7-ketocholesterol led to mutagenesis in mammalian ce...

journal_title：Toxicology

authors： Wang X,Li Y,Xia X,Zhang M,Ge C,Xia X,Xiao H,Xu S

更新日期：2020-12-15 00:00:00

abstract：PURPOSE:The environmental endocrine disruptors, bisphenol A (BPA) and bisphenol S (BPS) are associated with the development of type 2 diabetes. We aim to study the effects of BPA or BPS exposure on adipokine expression in human adipose tissue and on adipocyte glucose uptake. METHODS:Human subcutaneous adipose tissue w...

journal_title：Toxicology

authors： Ahmed F,Sarsenbayeva A,Katsogiannos P,Aguer C,Pereira MJ

更新日期：2020-12-01 00:00:00

abstract：:Molybdenum trioxide (MoO3) nanoparticles (NPs) embedded in polymer films have been proposed as a cheap way of producing antibacterial coatings on external surfaces. Recently, we synthesized MoO3 nanowires in a unique shape and degree of anisotropy, which enables their fast water dissolution and quick antimicrobial rea...

journal_title：Toxicology

authors： Božinović K,Nestić D,Centa UG,Ambriović-Ristov A,Dekanić A,de Bisschop L,Remškar M,Majhen D

更新日期：2020-11-01 00:00:00

abstract：:The ability to overcome cellular barriers in the body is crucial for efficient delivery of drugs to the target where intervention is needed. For drugs acting in the brain it is essential to overcome the blood-brain barrier (BBB). Such drugs include antidotes for the treatment of organophosphate poisoning, a current wa...

journal_title：Toxicology

authors： Kobrlova T,Soukup O

更新日期：2020-10-01 00:00:00

abstract：:Long-term exposure to isoflurane may induce long-term developmental neurotoxicity and cognitive impairments in the neonatal brains. Trilobatin, a leaf extract from the Chinese traditional sweet tea Lithocarpus polystachyus Rehd, possesses various biological properties including anti-inflammatory and anti-oxidant prope...

journal_title：Toxicology

authors： Shen T,Shang Y,Wu Q,Ren H

更新日期：2020-09-01 00:00:00

abstract：:Heavy metal neurotoxicity is one of the major challenges in today's era due to the large scale and widespread mechanisation of the production. However, the causative factors responsible for neurotoxicity are neither known nor do we have the availability of therapeutic approaches to deal with it. One of the major causa...

journal_title：Toxicology

authors： Namgyal D,Ali S,Mehta R,Sarwat M

更新日期：2020-09-01 00:00:00

abstract：:There is considerable interest in gene and environment interactions in neurodegenerative diseases. The HFE (homeostatic iron regulator) gene variant (H63D) is highly prevalent in the population and has been investigated as a disease modifier in multiple neurodegenerative diseases. We have developed a mouse model to in...

journal_title：Toxicology

authors： Song IY,Snyder AM,Kim Y,Neely EB,Wade QW,Connor JR

更新日期：2020-08-01 00:00:00

abstract：:Testicular injury is often observed in drug development. Serum hormones are usually used as noninvasive biomarkers for testicular injury; however, their sensitivities are low. Therefore, it is difficult to monitor testicular injury in drug development. In recent years, molecules in body fluid exosomes have attracted a...

journal_title：Toxicology

authors： Kawata R,Kagawa T,Koya Y,Kajiyama H,Oda S,Yokoi T

更新日期：2020-07-01 00:00:00

abstract：:Synthetic pyrethroids are used as insecticides in agriculture and a variety of household applications worldwide. Pyrethroids are widely distributed in all environmental compartments and the general populations are exposed to pyrethroids through various routes. Pyrethroids have been identified as endocrine-disrupting c...

journal_title：Toxicology

authors： Wang Q,Shen JY,Zhang R,Hong JW,Li Z,Ding Z,Wang HX,Zhang JP,Zhang MR,Xu LC

更新日期：2020-05-30 00:00:00

abstract：:Arsenic is an endocrine disruptor that promotes breast cancer (BCa) development. Estrogen synthesis, through aromatase activation, is essential for BCa promotion and progression through activating the G-coupled estrogen receptor 1 (GPER1), regulating rapid nongenomic effects involved in cell proliferation and migratio...

journal_title：Toxicology

authors： Reyes-Vázquez L,Hernández AJA,Calderón-Aranda ES

更新日期：2020-05-15 00:00:00

abstract：:Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This ...

journal_title：Toxicology

authors： Rogiers V,Benfenati E,Bernauer U,Bodin L,Carmichael P,Chaudhry Q,Coenraads PJ,Cronin MTD,Dent M,Dusinska M,Ellison C,Ezendam J,Gaffet E,Galli CL,Goebel C,Granum B,Hollnagel HM,Kern PS,Kosemund-Meynen K,Ouédraogo G,

更新日期：2020-04-30 00:00:00

abstract：:An impaired gut-liver axis is a potential factor that contributes to alcoholic liver disease. Specifically, ethanol decreases intestinal integrity and causes gut dysbiosis. Butyrate, a fermentation byproduct of gut microbiota, is negatively altered following acute ethanol exposure. This study aimed to determine whethe...

journal_title：Toxicology

authors： Chen J,Xuan YH,Luo MX,Ni XG,Ling LQ,Hu SJ,Chen JQ,Xu JY,Jiang LY,Si WZ,Xu L,Gao H,Liu Z,Li H

更新日期：2020-01-15 00:00:00

abstract：:Exposure to heavy metals contributes to most of the unexplained male infertility. Lead (Pb) is a well- known heavy metal, which disrupt the male reproductive system. This study was conducted to investigate the therapeutic and protective effects of green tea active principle, epigallocatechin gallate (EGCG), on the lea...

journal_title：Toxicology

authors： Hassan E,Kahilo K,Kamal T,Hassan M,Saleh Elgawish M

更新日期：2019-06-15 00:00:00

abstract：:Dental resin systems have been in use for several decades. (Meth)acrylic monomers are an important part of the matrix system and are either based on BPA while others lack the BPA core. The degree of conversion during restoration is in general between 50-70 % allowing leaching from unreacted monomers to the oral cavity...

journal_title：Toxicology

authors： Vervliet P,Den Plas JV,De Nys S,Duca RC,Boonen I,Elskens M,Van Landuyt KL,Covaci A

更新日期：2019-05-15 00:00:00

abstract：:Although the production of polychlorinated biphenyl 77 (PCB77) has already been banned globally, PCB77 is still used for a wide range of commercial purposes. Previous evidence has demonstrated that the PCB77 administration should be responsible for the gut microbiota variations and the host health risk. However, the h...

journal_title：Toxicology

authors： Chi Y,Wang H,Lin Y,Lu Y,Huang Q,Ye G,Dong S

更新日期：2019-05-15 00:00:00

abstract：:Although manufactured magnetic nanoparticles (NPs) are currently used in many fields, NPs have potential toxicity on cardiovascular system especially atherosclerosis. In our previous study, we prepared novel Fe3O4 nanoparticles surface-coated with aminoguanidine (Fe3O4-AG NPs) which could remove acid dyes from aqueous...

journal_title：Toxicology

authors： Qu G,Wu Q,Zhao B,Miao J,Su L

更新日期：2019-05-01 00:00:00

abstract：:Double-stranded RNA-dependent protein kinase (PKR) is a component of signal transduction pathways mediating various stress signals including oxidative stress and endoplasmic reticulum (ER) stress and is suggested to be implicated in several neurodegenerative diseases. Cell death in neurodegenerative conditions has bee...

journal_title：Toxicology

authors： Hirata Y,Iwasaki T,Makimura Y,Okajima S,Oh-Hashi K,Takemori H

更新日期：2019-04-15 00:00:00

abstract：:Malathion is one of the most widely used organophosphorus insecticides in agriculture. However, malathion may be involved in the etiology of human brain dysfunction. Induction of ROS has been proposed as a mechanism of malathion-induced poisoning cases, but there are few data regarding the effects of malathion on oxid...

journal_title：Toxicology

authors： Shieh P,Jan CR,Liang WZ

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Carbamates physostigmine and pyridostigmine have been used as a pretreatment against poisoning with nerve agents in order to reversibly inhibit and thus protect from irreversible inhibition a portion of acetylcholinesterase (AChE) in brain and respiratory muscles that is crucial for survival. Memantine, an a...

journal_title：Toxicology

authors： Stojiljković MP,Škrbić R,Jokanović M,Bokonjić D,Kilibarda V,Vulović M

更新日期：2019-03-15 00:00:00

abstract：:Prostaglandin E2 (PGE2) is a critical factor in the pathogenesis of dioxin-induced neonatal hydronephrosis. Since the PGE2 receptor has four subtypes, EP1 - EP4, this study was aimed to challenge the hypothesis that at least one of the four subtypes is responsible for the pathogenesis of dioxin-induced hydronephrosis....

journal_title：Toxicology

authors： Aida-Yasuoka K,Nishimura N,Fujisawa N,Endo N,Narumiya S,Tohyama C

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:This study was designed to investigate whether the mice treated with triptolide (TP) could disrupt the liver immune homeostasis, resulting in the inability of the liver to eliminate the harmful response induced by lipopolysaccharide (LPS). In addition, we explored whether apoptosis and necroptosis played a cr...

journal_title：Toxicology

authors： Yuan Z,Zhang H,Hasnat M,Ding J,Chen X,Liang P,Sun L,Zhang L,Jiang Z

更新日期：2019-02-15 00:00:00

abstract：:Preclinical drug safety assessment includes in vitro studies with physiologically relevant cell cultures. As an in vitro system for hepatic toxicology testing, we have been generating cell clones of human hepatoblastoma cell line HepG2 by lentiviral transduction of phase I cytochrome P450 (CYP) enzymes. Here, we prese...

journal_title：Toxicology

authors： Steinbrecht S,König R,Schmidtke KU,Herzog N,Scheibner K,Krüger-Genge A,Jung F,Kammerer S,Küpper JH

更新日期：2019-01-15 00:00:00

abstract：:Inorganic arsenic (iAs), a ubiquitous element and a natural drinking water contaminant, has been found to impair male reproductive function. However, the effect of long-term exposure to arsenic on testis damage and its underlying mechanisms still require further evaluation. In the study, male C57BL/6 mice (4 weeks) we...

journal_title：Toxicology

authors： Zeng Q,Yi H,Huang L,An Q,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Some effects of organophosphorus compounds (OPs) esters cannot be explained by action on currently recognized targets acetylcholinesterase or neuropathy target esterase (NTE). In previous studies, in membrane chicken brain fractions, four components (EPα, EPβ, EPγ and EPδ) of phenyl valerate esterase activity (PVase) ...

journal_title：Toxicology

authors： Estévez J,Benabent M,Selva V,Mangas I,Sogorb MÁ,Del Rio E,Vilanova E

更新日期：2018-12-01 00:00:00

abstract：:Exposure to low-dose benzene may lead to hematotoxicity and cause health problems. Though peripheral blood cell count is widely used in benzene exposure assessment and health risk assessment, the reports regarding the effects of low-dose benzene exposure on blood cell count remain inconsistent. To uncover more sensiti...

journal_title：Toxicology

authors： Liang B,Zhong Y,Chen K,Zeng L,Li G,Zheng J,Jiang L,Xie Z,Que B,Lai G,Wu B,Yang X,Wu J,Xiao Y,Chen W,Huang Z

更新日期：2018-12-01 00:00:00

abstract：:Prenatal dexamethasone exposure (PDE) could induce testicular developmental toxicity in adults. The present study aims to confirm its intrauterine origination, and to explore its potential intrauterine programming mechanism. The pregnant rats were respectively injected subcutaneously with 0.2 and 0.8 mg/kg d dexametha...

journal_title：Toxicology

authors： Liu M,Chen B,Pei L,Zhang Q,Zou Y,Xiao H,Zhou J,Chen L,Wang H

更新日期：2018-09-01 00:00:00

abstract：:Groundwater arsenic contamination has become a serious global concern due to its adverse effects on human health. Arsenic-induced reactive oxygen species trigger oxidative stress inside mitochondria, which initiate a cascade of events including altered mitochondrial (mt) membrane potential, uncoupling of electron tran...

journal_title：Toxicology

authors： Sanyal T,Bhattacharjee P,Bhattacharjee S,Bhattacharjee P

更新日期：2018-09-01 00:00:00

abstract：:The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents. Understanding their interactions within the active site of phosphylated AChE is of great significance for the search for mo...

journal_title：Toxicology

authors： Katalinić M,Šinko G,Maček Hrvat N,Zorbaz T,Bosak A,Kovarik Z

更新日期：2018-08-01 00:00:00

abstract：:The aim of this study is to explore the potent neuroprotective effect of calpeptin (CP) on neuron damage induced by acrylamide (ACR) and its mechanism. Behavioural indicators such as hind limb splay, rota-rod performance, and gait analysis were assessed weekly to evaluate neurobehavioural changes after ACR and/or CP a...

journal_title：Toxicology

authors： Su B,Guan Q,Wang M,Liu N,Wei X,Wang S,Yang X,Jiang W,Xu M,Yu S

更新日期：2018-05-01 00:00:00

abstract：:This study aimed to prove that prenatal ethanol exposure (PEE) can induce nephrotic syndrome in male rat offspring and to explore the underlying intrauterine programming mechanisms. Pregnant Wistar rats were intragastrically administered ethanol (4 g/kg d) from gestational day (GD) 9 to GD 20, and the male fetuses wer...

journal_title：Toxicology

authors： Zhu Y,Zuo N,Li B,Xiong Y,Chen H,He H,Sun Z,Hu S,Cheng H,Ao Y,Wang H

更新日期：2018-05-01 00:00:00

abstract：:Cadmium, an environmental neurotoxic compound, produces cognitive disorders, although the mechanism remains unknown. Previously, we described that cadmium induces a more pronounced cell death on cholinergic neurons from basal forebrain (BF). This effect, partially mediated by M1 receptor blockade, triggering it throug...

journal_title：Toxicology

authors： Moyano P,de Frias M,Lobo M,Anadon MJ,Sola E,Pelayo A,Díaz MJ,Frejo MT,Del Pino J

更新日期：2018-02-01 00:00:00

abstract：:Cigarette smoking is a significant risk factor for cataract. However, the mechanism by which cigarette smoke (CS) causes cataract remains poorly understood. We had earlier shown that in CS-exposed guinea pig, p-benzoquinone (p-BQ) derived from CS in the lungs is carried by the circulatory system to distant organs and ...

journal_title：Toxicology

authors： Chowdhury A,Choudhury A,Chakraborty S,Ghosh A,Banerjee V,Ganguly S,Bhaduri G,Banerjee R,Das K,Chatterjee IB

更新日期：2018-02-01 00:00:00

abstract：:Methylmercury (MeHg) is a ubiquitous environmental toxicant, best known for its selective targeting of the developing nervous system. MeHg exposure has been shown to cause motor deficits such as impaired gait and coordination, muscle weakness, and muscle atrophy, which have been associated with disruption of motor neu...

journal_title：Toxicology

authors： Prince LM,Rand MD

更新日期：2018-01-15 00:00:00

abstract：:Novel dexrazoxane derivative JR-311 was prepared to investigate structure-activity relationships and mechanism(s) of protection against anthracycline cardiotoxicity. Its cardioprotective, antiproliferative, iron (Fe) chelation and inhibitory and/or depletory activities on topoisomerase IIbeta (TOP2B) were examined and...

journal_title：Toxicology

authors： Bures J,Jirkovska A,Sestak V,Jansova H,Karabanovich G,Roh J,Sterba M,Simunek T,Kovarikova P

更新日期：2017-12-01 00:00:00