Evaluation of cadmium-induced transcriptome alterations by three color cDNA labeling microarray analysis on a T-cell line.

abstract：:Use of the fluoroquinolone antibiotic trovafloxacin (TVX) was restricted due to idiosyncratic, drug-induced liver injury (IDILI). Previous studies demonstrated that tumor necrosis factor-alpha (TNF) and TVX interact to cause death of hepatocytes in vitro that was associated with prolonged activation of c-Jun N-termina...

journal_title：Toxicology

authors： Beggs KM,Maiuri AR,Fullerton AM,Poulsen KL,Breier AB,Ganey PE,Roth RA

更新日期：2015-05-04 00:00:00

abstract：:A major goal in modern pharmacotechnology is to increase the therapeutic index of drugs by using nanoparticulate vehicle systems in order to ensure slow release or targeted delivery of drugs. With all great benefits, however, these innovative therapies can carry a risk for acute immune toxicity manifested in hypersens...

journal_title：Toxicology

authors： Szebeni J

更新日期：2005-12-15 00:00:00

abstract：:(1) Following the administration of the highly toxic agent 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to pregnant mice, exceedingly low concentrations of this substance were found in the embryo and fetus between gestational days 11 and 18 (between 0.04 and 0.14% of the maternal dose/g tissue). (2) Tissue levels of tCD...

journal_title：Toxicology

authors： Nau H,Bass R

更新日期：1981-01-01 00:00:00

abstract：:No clinical data are available on the acute cutaneous toxicity of spin traps which are frequently used in combination with the electron paramagnetic resonance (EPR) technique for detection of free radicals and reactive oxygen/nitrogen species. The purpose of this study was to evaluate the acute dermatotoxicity of the ...

journal_title：Toxicology

authors： Fuchs J,Groth N,Herrling T

更新日期：2000-10-26 00:00:00

abstract：:This review concerns some of the cell culture systems that are most frequently used in toxicology investigations. In particular, it sets out to evaluate the effectiveness of these cell culture systems in assessing the toxic potential of chemicals. Metabolic studies and general and specific toxicology investigations ar...

journal_title：Toxicology

authors： Stammati AP,Silano V,Zucco F

更新日期：1981-01-01 00:00:00

abstract：:Many studies have demonstrated that polycyclic aromatic hydrocarbons adversely affect mature mammalian immune systems. However, little is known about the cellular mechanism(s) mediating this immunosuppression or the potential for these ubiquitous environmental chemicals to similarly compromise lymphocyte development (...

journal_title：Toxicology

authors： Hinoshita F,Hardin JA,Sherr DH

更新日期：1992-01-01 00:00:00

abstract：:Indomethacin (IMC) has been shown to reduce post-operative inflammation and to decrease intraocular irritation after cataract extraction and in cystoid macular edema; however, the clinical use of its most commonly used eye drops is limited due to topical side-effects that include burning sensation, irritation and epit...

journal_title：Toxicology

authors： Nagai N,Ito Y,Okamoto N,Shimomura Y

更新日期：2014-05-07 00:00:00

abstract：:Paracetamol, in toxic doses, is associated with extensive liver damage. This represents one of the common causes of morbidity and mortality in drug poisoning cases. This study was undertaken to investigate the possible potentiation of the hepatoprotective action of N-acetylcysteine (NAC) by cimetidine (CMD), an inhibi...

journal_title：Toxicology

authors： Al-Mustafa ZH,Al-Ali AK,Qaw FS,Abdul-Cader Z

更新日期：1997-09-05 00:00:00

abstract：:A 20-year-old man on oral substitution of pancreatic enzymes after hemipancreatectomy injected an enzyme preparation of fungal origin intravenously after dissolving it in water. Within a few hours chills, headache, nausea and vomiting, fever of 40.8 degrees C, and shock occurred. The acute illness might have been caus...

journal_title：Toxicology

authors： Seitz R,Adler G,Koop I,Koop H,Egbring R

更新日期：1989-04-01 00:00:00

abstract：:Neonatal rat hearts were separated into separate cultures of beating myocytes (M cells), endothelial cells (E cells) and fibroblasts (F cells). Their susceptibilities to the toxic effects of emetine, chloroquine and metronidazole were then compared using a quantitative metabolic inhibition test (QMIT) and morphologic ...

journal_title：Toxicology

authors： Wenzel DG,Cosma GN

更新日期：1984-11-01 00:00:00

abstract：:The present study investigates the influence of different levels of Schistosoma mansoni infection (60, 120, 180, 300, 600 cercariae per mice) after 33 days on the activity of aryl hydrocarbon hydroxylase (AHH) and the formation of hepatic hydrogen peroxide (H(2)O(2)) during the metabolic activation of benzo(a)pyrene [...

journal_title：Toxicology

authors： Awney HA,Ghzlan HE,Sheweita SA,Mostafa MH

更新日期：2001-06-21 00:00:00

abstract：:Several nitrocompounds have been screened for carcinogenicity in rodents, but this is a lengthy and expensive process, taking two years and typically costing 2.5 million dollars, and uses large numbers of animals. There is, therefore, much impetus to develop suitable alternative methods. One possible way of predicting...

journal_title：Toxicology

authors： Morales AH,Pérez MA,Combes RD,González MP

更新日期：2006-03-01 00:00:00

abstract：:We examined the effect of repeated ozone exposure on the respiratory system in mice, sensitized with ovalbumin (OA). OA-sensitized mice and saline-treated control mice were exposed to 1.0 ppm ozone or clean air for 6 h daily and five days weekly for five weeks. Subsequently, these mice were exposed to 1.0 ppm ozone fo...

journal_title：Toxicology

authors： Funabashi H,Shima M,Kuwaki T,Hiroshima K,Kuriyama T

更新日期：2004-11-01 00:00:00

abstract：:Technical pentabrominated diphenyl ether (pentaBDE mix) is a mixture of polybrominated diphenyl ethers (PBDEs) which has been widely used as a flame retardant. Since its ban in several countries it has been replaced by other brominated flame retardants such as hexabromocyclododecane (HBCD). Both certain PBDE congeners...

journal_title：Toxicology

authors： Fery Y,Buschauer I,Salzig C,Lang P,Schrenk D

更新日期：2009-10-01 00:00:00

abstract：:The anticonvulsant, valproic acid (VPA) is a suspected human teratogen. This study, employing the rhesus monkey as an animal model, demonstrates that VPA has a significant teratogenic potential in the monkey. Timed pregnant monkeys were exposed orally to VPA at approx. 1X, 10X, and 30X (20, 200, and 600 mg/kg/day, res...

journal_title：Toxicology

authors： Mast TJ,Cukierski MA,Nau H,Hendrickx AG

更新日期：1986-05-01 00:00:00

abstract：:Ozone (O3), a pulmonary irritant, and a major toxic component of photochemical smog, is capable of inducing pulmonary inflammation characterized by recruitment of polymorphonuclear leukocytes (PMNs) into the lung. The recruited PMNs, in turn, can release toxic mediators and produce lung injury. The mechanism of ozone-...

journal_title：Toxicology

authors： Reinhart PG,Bassett DJ,Bhalla DK

更新日期：1998-05-15 00:00:00

abstract：:Though, oxidative stress has been implicated in silica nanoparticles induced toxicity both in vitro and in vivo, but no similarities exist regarding dose-response relationship. This discrepancy may, partly, be due to associated impurities of trace metals that may present in varying amounts. Here, cytotoxicity and oxid...

journal_title：Toxicology

authors： Akhtar MJ,Ahamed M,Kumar S,Siddiqui H,Patil G,Ashquin M,Ahmad I

更新日期：2010-10-09 00:00:00

abstract：:Manganese (II) bis(glycinate)dichloride (Mn(glycinate)2) is a coordination complex of manganese with application as a contrast enhancement agent for magnetic resonance imaging in the heart. To determine the cardioactivity of the manganese ion in this chelation cage, the effects of Mn(glycinate)2 on Ca channel function...

journal_title：Toxicology

authors： Tan W,Barnett JV,Hehn GM,Quay SC,Galper JB

更新日期：1991-01-01 00:00:00

abstract：:Aniline and its halogenated derivatives are widely used as chemical intermediates. The purpose of this study was to determine the hepatotoxic and nephrotoxic potential of the 2-haloanilines. Male Fischer 344 rats (n > or = 4) were injected (i.p.) with 1.0 or 1.25 mmol/kg of: aniline (A), 2-fluoroaniline (2-FA), 2-chlo...

journal_title：Toxicology

authors： Valentovic MA,Ball JG,Anestis DK,Beers KW,Madan E,Hubbard JL,Rankin GO

更新日期：1992-11-01 00:00:00

abstract：:Antidepressants are generally used for treatment of various mood and anxiety disorders. Several studies have shown the anti-tumor and cytotoxic activities of some antidepressants, but the underlying mechanisms were unclear. Maprotiline is a tetracyclic antidepressant and possesses a highly selective norepinephrine reu...

journal_title：Toxicology

authors： Jan CR,Su JA,Teng CC,Sheu ML,Lin PY,Chi MC,Chang CH,Liao WC,Kuo CC,Chou CT

更新日期：2013-02-08 00:00:00

abstract：:Arsenic and cadmium are both priority hazardous substances and human carcinogens. Although there is the potential for simultaneous exposure to both metals, the interactions of cadmium and arsenic are not well defined. We examined the toxicity of these metals when given alone or in alternating sequence to adult male Fi...

journal_title：Toxicology

authors： Hochadel JF,Waalkes MP

更新日期：1997-01-15 00:00:00

abstract：:Ochratoxin A (OCT A) has the potential to cause myelotoxicity in addition to the well-known toxic effects on the liver and kidney. Whereas in previous studies the bone marrow parameters were examined shortly after injection, experiments reported here were designed to determine whether mice would recover from the myelo...

journal_title：Toxicology

authors： Hong HH,Jameson CW,Boorman GA

更新日期：1988-12-16 00:00:00

abstract：:The objective of this study was to establish a hypospadiac rat model by maternal exposure to di-n-butyl phthalate (DBP) and to evaluate the developmental abnormalities of hypospadiac male rats. Timed-pregnant rats were given DBP by gastric intubation at doses of 0, 250, 500, 750 or 1000 mg/kg body weight (bw)/day from...

journal_title：Toxicology

authors： Jiang J,Ma L,Yuan L,Wang X,Zhang W

更新日期：2007-04-11 00:00:00

abstract：:Three new natural mycotoxins, analogues of ochratoxin A, in which the phenylalanine moiety is replaced by serine, hydroxyproline or lysine, were isolated from cultures of Aspergillus ochraceus by TLC followed by HPLC column chromatography. Their structures were determined after acidic hydrolysis by the characterisatio...

journal_title：Toxicology

authors： Hadidane R,Bacha H,Creppy EE,Hammami M,Ellouze F,Dirheimer G

更新日期：1992-12-04 00:00:00

abstract：:The osteolathyrogenic agent semicarbazide was assayed for its toxicity and teratogenicity using early embryos of the frog Xenopus laevis. The 96-h LC50 is 1504.20 mg/l while the 96-h EC50 is 76.28 mg/l. Embryo length is altered prior to the onset of other effects indicated by a reduction in stage of development. The m...

journal_title：Toxicology

authors： Schultz TW,Dumont JN,Epler RG

更新日期：1985-08-01 00:00:00

abstract：:An embryotoxicity study on Ponceau 4 R was carried out in SPF Wistar rats. The substance was given by gavage from day 1 to 20 of the gestation period in doses of 0, 1000, 2000, and 4000 mg/kg bw per day, dissolved in distilled water. The foetuses were removed on day 21. No effect due to the treatment with the dye was ...

journal_title：Toxicology

authors： Meyer O,Hansen EV

更新日期：1975-11-01 00:00:00

abstract：:Several inhibitors of cytochrome P-450 mediated oxidative transformations, ethyl 2-diethylaminoethyl-2-phenyl-2-ethylmalonate, ethyl-2-diethyl-aminoethyl-2-ethyl-2-buthylmalonate, 2,4 dichloro-6-phenoxyethyl diethylamine, 2-diethylaminoethyl-2-phenyl- (2-propene)-4-penten-1-oate or 3-amino,1,2,4 triazole were not able...

journal_title：Toxicology

authors： de Ferreyra EC,de Fenos OM,Castro JA

更新日期：1980-01-01 00:00:00

abstract：:The human keratinocyte cell line, RHEK-1, was used to evaluate the cytotoxicity of benzoyl peroxide (BZP). As determined with the neutral red (NR) cytotoxicity assay, the 24-h midpoint (NR50) toxicity values, in mM, were 0.11 for BZP and 29.5 for benzoic acid, the stable metabolite of BZP. Irreversible cytotoxicity oc...

journal_title：Toxicology

authors： Babich H,Zuckerbraun HL,Wurzburger BJ,Rubin YL,Borenfreund E,Blau L

更新日期：1996-01-08 00:00:00

abstract：:The administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to a variety of cultured cells may alter their ability to proliferate and die. In a previous study we demonstrated that TCDD induced proliferation in Madin-Darby Bovine Kidney (MDBK) cells where no signs of apoptosis were observed, but herein, analysis o...

journal_title：Toxicology

authors： Fiorito F,Ciarcia R,Granato GE,Marfe G,Iovane V,Florio S,De Martino L,Pagnini U

更新日期：2011-12-18 00:00:00

abstract：:Endocrine disruptors (EDs) are exogenous substances or xenoestrogens natural or synthetic, capable of interacting with different systems and altering their normal hormonal regulation, being the reproductive system one of the most affected. EDs produce their effects not only by acting on nuclear steroid receptors, but ...

journal_title：Toxicology

authors： Ponzo OJ,Silvia C

更新日期：2013-09-06 00:00:00