Evidence of reproductive disruption associated with neuroendocrine changes induced by UV-B filters, phthalates and nonylphenol during sexual maturation in rats of both gender.

abstract：:Cell death triggers the release into extracellular spaces of products of chromatin catabolism, particularly of DNA. A sensitive DNA assay has been used to investigate in the mouse whether the quantitation of plasma DNA may be used as an index of in vivo cytotoxicity. It has been found that toxic doses of bacterial lip...

journal_title：Toxicology

authors： Bret L,Lulé J,Alary C,Appolinaire-Pilipenko S,Pourrat JP,Fournié GJ

更新日期：1990-04-30 00:00:00

abstract：:Exposure to polycyclic aromatic hydrocarbons (PAHs) always involves complex mixtures that may induce synergistic or antagonistic effects on the genotoxic properties and make risk assessment more difficult. In this study, we evaluated how particulate PAHs modulated the formation of DNA damage induced by carcinogenic be...

journal_title：Toxicology

authors： Tarantini A,Maître A,Lefèbvre E,Marques M,Rajhi A,Douki T

更新日期：2011-01-11 00:00:00

abstract：:Many studies have demonstrated that polycyclic aromatic hydrocarbons adversely affect mature mammalian immune systems. However, little is known about the cellular mechanism(s) mediating this immunosuppression or the potential for these ubiquitous environmental chemicals to similarly compromise lymphocyte development (...

journal_title：Toxicology

authors： Hinoshita F,Hardin JA,Sherr DH

更新日期：1992-01-01 00:00:00

abstract：:In order to evaluate the primary DNA damage due to occupational exposure to chromium (VI), DNA strand-breaks and apoptosis in peripheral lymphocytes were measured in a group of 19 chrome-plating workers. DNA strand-breaks was assessed by alkaline (pH>13) single-cell microgel electrophoresis ('comet') assay, while apop...

journal_title：Toxicology

authors： Gambelunghe A,Piccinini R,Ambrogi M,Villarini M,Moretti M,Marchetti C,Abbritti G,Muzi G

更新日期：2003-06-30 00:00:00

abstract：:Bisphenol A (BPA), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. Exposure-related reproductive disorders have been found, but recently it has also been suggested that BPA may be involved in obesity, diabetes, myocardial hypertroph...

journal_title：Toxicology

authors： Ljunggren SA,Iggland M,Rönn M,Lind L,Lind PM,Karlsson H

更新日期：2016-03-10 00:00:00

abstract：:Gulf War Illness (GWI) affects 25% of veterans from the 1990-1991 Gulf War (GW) and is accompanied by damage to the brain regions involved in memory processing. After twenty-five years, the chronic pathobiology of GWI is still unexplained. To address this problem, we examined the long-term consequences of GW exposures...

journal_title：Toxicology

authors： Abdullah L,Evans JE,Joshi U,Crynen G,Reed J,Mouzon B,Baumann S,Montague H,Zakirova Z,Emmerich T,Bachmeier C,Klimas N,Sullivan K,Mullan M,Ait-Ghezala G,Crawford F

更新日期：2016-11-30 00:00:00

abstract：:Several nitrocompounds have been screened for carcinogenicity in rodents, but this is a lengthy and expensive process, taking two years and typically costing 2.5 million dollars, and uses large numbers of animals. There is, therefore, much impetus to develop suitable alternative methods. One possible way of predicting...

journal_title：Toxicology

authors： Morales AH,Pérez MA,Combes RD,González MP

更新日期：2006-03-01 00:00:00

abstract：:Arsenic and cadmium are both priority hazardous substances and human carcinogens. Although there is the potential for simultaneous exposure to both metals, the interactions of cadmium and arsenic are not well defined. We examined the toxicity of these metals when given alone or in alternating sequence to adult male Fi...

journal_title：Toxicology

authors： Hochadel JF,Waalkes MP

更新日期：1997-01-15 00:00:00

abstract：:The present study was undertaken to investigate the involvement of oxidative damage in lead-induced toxicity in humans and to enlighten whether oxidative stress indicators are correlated with the known indices of lead toxicity. For these purposes, selected oxidative stress parameters along with some clinical indices o...

journal_title：Toxicology

authors： Gurer-Orhan H,Sabir HU,Ozgüneş H

更新日期：2004-02-15 00:00:00

abstract：:The trichothecenes are a group of mycotoxins that target leukocytes and have a wide range of immunomodulatory effects. Differential display analysis was applied to assess the effects of the trichothecenes deoxynivalenol (vomitoxin, DON) and satratoxin G (SG), on mRNA in the RAW 264.7 macrophage cell line. Cells were i...

journal_title：Toxicology

authors： Chung YJ,Yang GH,Islam Z,Pestka JJ

更新日期：2003-04-15 00:00:00

abstract：:Pulmonary fibrosis is one of the most common chronic interstitial lung diseases with high mortality rate after diagnosis and limited successful treatment. The present study was designed to assess the potential antifibrotic effect of thymoquinone (TQ) and whether TQ can attenuate the severity of oxidative stress and in...

journal_title：Toxicology

authors： El-Khouly D,El-Bakly WM,Awad AS,El-Mesallamy HO,El-Demerdash E

更新日期：2012-12-16 00:00:00

abstract：:Maize co-contamination with aflatoxin B1 (AFB1) and fumonisin B1 (FB1) is frequently found in several countries. Although the alterations on nutritional and immunologic parameters induced by these mycotoxins, when administered individually, are partially characterised, little is known about the effects induced in anim...

journal_title：Toxicology

authors： Theumer MG,López AG,Masih DT,Chulze SN,Rubinstein HR

更新日期：2003-04-15 00:00:00

abstract：:The free radical scavenging activities and inhibitory effect of lipid peroxidation of a delphinidin derivative in eggplant were investigated. Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside (nasunin), an anthocyanin, was isolated as purple colored crystals from eggplant peels. Using electron spin resonance spectrome...

journal_title：Toxicology

authors： Noda Y,Kneyuki T,Igarashi K,Mori A,Packer L

更新日期：2000-08-07 00:00:00

abstract：:The objective of this study was to establish a hypospadiac rat model by maternal exposure to di-n-butyl phthalate (DBP) and to evaluate the developmental abnormalities of hypospadiac male rats. Timed-pregnant rats were given DBP by gastric intubation at doses of 0, 250, 500, 750 or 1000 mg/kg body weight (bw)/day from...

journal_title：Toxicology

authors： Jiang J,Ma L,Yuan L,Wang X,Zhang W

更新日期：2007-04-11 00:00:00

abstract：:Bisphenol A has been shown to affect the reproduction of male rats and mice. However, the mechanism of action of bisphenol A on the epididymal sperm is not elucidated. The present study was undertaken to evaluate the effect of bisphenol A on the antioxidant system of rat epididymal sperm. Bisphenol A was administered ...

journal_title：Toxicology

authors： Chitra KC,Latchoumycandane C,Mathur PP

更新日期：2003-03-14 00:00:00

abstract：:Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and ...

journal_title：Toxicology

authors： Meyer JN,Leuthner TC,Luz AL

更新日期：2017-11-01 00:00:00

abstract：:Several reports have described the effects of trichloroethylene (TCE) on the microsomal mixed function oxidase system (MFOS). These studies suggest that repeated TCE administration induces MFOS, especially cytochrome P-450 and NADPH-cytochrome c reductase. However, it is uncertain what isozymes are induced by TCE trea...

journal_title：Toxicology

authors： Kawamoto T,Hobara T,Nakamura K,Imamura A,Ogino K,Kobayashi H,Iwamoto S,Sakai T

更新日期：1988-12-30 00:00:00

abstract：:Both 4,4'-dichlorobiphenyl (4,4'-DCB) and 3-methylcholanthrene (3-MC) caused a substantial increase of phenacetin-induced hepatic glutathione (GSH) depletion, whereas phenobarbital (PB) had no effect, suggesting that 4,4'-DCB possesses cytochrome P-448 inducing activity. The O-deethylation of phenacetin by liver micro...

journal_title：Toxicology

authors： van Bree L,Redegeld FA,de Vries J

更新日期：1986-12-15 00:00:00

abstract：:We have determined that the addition of 3-phenylamino-L-alanine (PAA), a recently reported contaminant in L-tryptophan implicated in the eosinophilia-myalgia syndrome, affects tryptophan binding by utilizing an in vitro measurement of 3H-tryptophan binding to hepatic nuclei or nuclear envelopes. PAA (10(-10) to 10(-4)...

journal_title：Toxicology

authors： Sidransky H,Verney E,Cosgrove JW,Latham PS

更新日期：1994-01-26 00:00:00

abstract：:Studies showed that certain cytotoxicity assays were not suitable for assessing nanoparticle (NP) toxicity. We evaluated a lactate dehydrogenase (LDH) assay for assessing copper (Cu-40, 40nm), silver (Ag-35, 35nm; Ag-40, 40nm), and titanium dioxide (TiO(2)-25, 25nm) NPs by examining their potential to inactivate LDH a...

journal_title：Toxicology

authors： Han X,Gelein R,Corson N,Wade-Mercer P,Jiang J,Biswas P,Finkelstein JN,Elder A,Oberdörster G

更新日期：2011-09-05 00:00:00

abstract：:The Comet assay is an often used approach for the assessment of genetic damage in primary cells of exposed populations. In the majority of these studies lymphocytes are used. Therefore, we reviewed human biomonitoring studies of occupational exposure using the Comet assay with lymphocytes. We also tried to elucidate t...

journal_title：Toxicology

authors： Faust F,Kassie F,Knasmüller S,Kevekordes S,Mersch-Sundermann V

更新日期：2004-05-20 00:00:00

abstract：:We have found that incubation of heparin plasma with Ni(2+) or Co(2+) at concentrations below 100 microM can stimulate the conversion of complement factor C3 to C3b faster than magnesium, which is the natural cofactor in the alternative complement activation. This conversion was monitored by light absorbance measureme...

journal_title：Toxicology

authors： Acevedo F,Vesterberg O

更新日期：2003-03-14 00:00:00

abstract：:We examined the role of miRNAs in DNA damage response in HepG2 cells following exposure to 4-aminobiphenyl (4-ABP). The arylamine 4-ABP is a human carcinogen. Using the Comet assay, we showed that 4-ABP (18.75-300μM) induces DNA damage in HepG2 cells after 24h. DNA damage signaling pathway-based PCR arrays were used t...

journal_title：Toxicology

authors： Huan LC,Wu JC,Chiou BH,Chen CH,Ma N,Chang CY,Tsen YK,Chen SC

更新日期：2014-08-01 00:00:00

abstract：:A neuron spinal chord x hybrid (NSC-34) cell culture derived from neonatal mouse was characterized for studies on mercury toxicity. Exposure of NSC-34 cells to methyl mercury chloride (MeHgCl) (0-16 microM) resulted in significant dose-dependent cell damage and death (P < 0.05). MeHgCl was more toxic than inorganic me...

journal_title：Toxicology

authors： Chapman LA,Chan HM

更新日期：1999-02-15 00:00:00

abstract：:The interaction in vivo of four O-alkyl O-2,5-dichlorophenyl phosphoramidates with neural neuropathy target esterase (NTE) and acetylcholinesterase (AChE) and their ability to cause delayed polyneuropathy in hens has been examined. Previous studies in vitro (Vilanova, Johnson & Vicedo, Pestic. Biochem. Physiol., 28 (1...

journal_title：Toxicology

authors： Johnson MK,Vilanova E,Read DJ

更新日期：1989-01-01 00:00:00

abstract：:In our previous study, di-n-butyltin diacetate has been shown to cause malformations such as cleft mandible, ankyloglossia, fused ribs, etc. in rat fetuses after oral treatment of maternal rats on day 8 of gestation. In this study, teratogenic effects of five di-n-butyltin compounds with different anions and also buty...

journal_title：Toxicology

authors： Noda T,Morita S,Baba A

更新日期：1993-12-31 00:00:00

abstract：:Exposure to low-dose benzene may lead to hematotoxicity and cause health problems. Though peripheral blood cell count is widely used in benzene exposure assessment and health risk assessment, the reports regarding the effects of low-dose benzene exposure on blood cell count remain inconsistent. To uncover more sensiti...

journal_title：Toxicology

authors： Liang B,Zhong Y,Chen K,Zeng L,Li G,Zheng J,Jiang L,Xie Z,Que B,Lai G,Wu B,Yang X,Wu J,Xiao Y,Chen W,Huang Z

更新日期：2018-12-01 00:00:00

abstract：:The question as to whether or not the hypotension observed as part of the effect of tricholorofluoromethane (FC11), dichlorofluoromethane (FC 12), dichlorotetrafluoroethane (FC 114) and methyl chloroform was due to a vasodepressor component of action, in addition to the previously documented depression in myocardial c...

journal_title：Toxicology

authors： Simaan JA,Aviado DM

更新日期：1976-03-01 00:00:00

abstract：:Role of chromium(III) in biological systems is controversial and no significant conclusions can be arrived with the available data. Chromium(VI) enters in to the cell readily and gets reduced to form stable chromium(III) complexes. Chromium(III) complexes react slowly and were considered non-toxic. Recent studies sugg...

journal_title：Toxicology

authors： Raja NS,Nair BU

更新日期：2008-09-29 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is a cellular process during which epithelial polarized cells become motile mesenchymal-appearing cells, which in turn promotes carcinoma invasion and metastasis. Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural polyphenolic compound found in grapes, red wine and se...

journal_title：Toxicology

authors： Wang H,Zhang H,Tang L,Chen H,Wu C,Zhao M,Yang Y,Chen X,Liu G

更新日期：2013-01-07 00:00:00