Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G.

abstract：:The usefulness of measuring serum bile acid concentrations by RIA in a number of acute experimental liver injuries of rats was assessed by comparing the concentrations with the results of some of the routinely employed methods of examining hepatotoxic changes. Centrilobular liver cell injury produced by CCl4 revealed ...

journal_title：Toxicology

authors： Gopinath C,Prentice DE,Street AE,Crook D

更新日期：1980-01-01 00:00:00

abstract：:The tissue uptake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during infection was studied in a mouse model using the common human virus Coxsackievirus B3 (CB3), adapted here to the mouse. Male A/J-mice were infected with the CB3 virus and subsequently, on days 4 and 7 of the infection, injected with 0.5 microCi [14...

journal_title：Toxicology

authors： Funseth E,Ilbäck NG

更新日期：1994-05-31 00:00:00

abstract：:As an important cholesterol oxide, 7-ketocholesterol plays a deleterious role in the occurrence of cancer. Although the fact had been proved that 7-ketocholesterol could induce several biological phenomena, including apoptosis, DNA damage, et al., this issue whether 7-ketocholesterol led to mutagenesis in mammalian ce...

journal_title：Toxicology

authors： Wang X,Li Y,Xia X,Zhang M,Ge C,Xia X,Xiao H,Xu S

更新日期：2020-12-15 00:00:00

abstract：:Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), a major constituent of marijuana, has been shown to stimulate the growth of MCF-7 breast cancer cells through cannabinoid receptor-independent signaling [Takeda, S., Yamaori, S., Motoya, E., Matsunaga, T., Kimura, T., Yamamoto, I., Watanabe, K., 2008. Delta(9)-Tetrahydroca...

journal_title：Toxicology

authors： Takeda S,Yamamoto I,Watanabe K

更新日期：2009-05-02 00:00:00

abstract：:Calf thymus DNA was reacted with 1,2-epoxybutene (BDO) in phosphate buffered saline at 37 degrees C for 12 h. DNA was ethanol precipitated and hydrolyzed with 1 M HCl to release DNA bases. Adenine (A)-BDO and guanine (Gua)-BDO adducts were analyzed in the ethanol supernatant and DNA hydrolysate using LC/ESI MS/MS. Rea...

journal_title：Toxicology

authors： Kambouris SJ,Chaudhary AK,Blair IA

更新日期：1996-10-28 00:00:00

abstract：:Excretion and organ distribution of mercury and susceptibility to methylmercury (MeHg) toxicity were compared between strains and sexes after successive oral administration of MeHg chloride (5 mg/kg per day) using BALB/cA (C) and C57BL/6N (B6) mice. Every mouse died several days after initiation of toxic symptoms, and...

journal_title：Toxicology

authors： Yasutake A,Hirayama K

更新日期：1988-09-01 00:00:00

abstract：:Following carbon tetrachloride-induced liver injury, hepatotrophic factors are synthesized and released into the serum to facilitate the regeneration of damaged hepatic tissue. We investigated the possibility that immunosuppression could be mediated through induction of a serum factor(s) because in vivo exposure of B6...

journal_title：Toxicology

authors： Delaney B,Kaminski NE

更新日期：1993-12-15 00:00:00

abstract：:The present work includes a study on the glycosaminoglycanuric condition induced by adriamycin (ADR, a chemotherapeutic agent) and the accompanying secondary hyperlipidemia, wherein the treatment with a low-molecular-weight heparin-derivative (LMWH), certoparin, is evaluated for its protective role (if any) on these p...

journal_title：Toxicology

authors： Deepa PR,Varalakshmi P

更新日期：2005-07-01 00:00:00

abstract：:To investigate the toxic effect of terephthalic acid (TPA) on testicular functions of rats, male Sprague-Dawley rats were orally administered TPA in diet at the levels 0 (control), 0.2, 1 and 5% for 90 days. Testicular functions were assessed by histopathology, testicular sperm head counts, daily sperm production, spe...

journal_title：Toxicology

authors： Cui L,Dai G,Xu L,Wang S,Song L,Zhao R,Xiao H,Zhou J,Wang X

更新日期：2004-09-01 00:00:00

abstract：:The histogenesis of coumarin-induced cholangiofibrosis in the rat has been determined. Proliferation of ductal structures was preceded by extensive damage to hepatocytes in the centrilobular region. Focal proliferation of ducts and fibrous tissue was present at 3 months and typical areas of cholangiofibrosis at 6 mont...

journal_title：Toxicology

authors： Evans JG,Appleby EC,Lake BG,Conning DM

更新日期：1989-04-01 00:00:00

abstract：:Cultures of the human cell line NHIK 3025 were exposed over an 18-month period to 0.5 mumol/1 potassium dichromate (K2Cr2O7) containing 1 mumol/1 hexavalent chromium. The chronically exposed cells increased their tolerance to K2Cr2O7 in comparison to control populations. The doubling time of the chronically exposed ce...

journal_title：Toxicology

authors： White LR,Jakobsen K,Eik-Nes KB

更新日期：1981-01-01 00:00:00

abstract：:The effects of 2,2,2-trichloro-1-(3,4-dichlorophenyl)ethyl acetate (Penfenate) on hepatic, renal and small intestinal drug-metabolizing enzyme activities, hepatic reduced glutathione content and urinary excretion of thioethers were studied in the rat. A single i.p. dose of Penfenate (500 mg/kg) decreased the body weig...

journal_title：Toxicology

authors： Mäntylä E,Ahotupa M,Hietanen E,Vainio H

更新日期：1983-07-01 00:00:00

abstract：:Effects of methylmercury on the cell growth of mouse glioma in vitro were studied in relation to the microtubules as a possible target. The electron microscopic observation revealed that methylmercury added in culture medium specifically attacked microtubules in the cells at growth inhibitory concentration, while merc...

journal_title：Toxicology

authors： Imura N,Miura K,Inokawa M,Nakada S

更新日期：1980-01-01 00:00:00

abstract：:T- and B-cells recognise drugs when bound as haptens to carrier molecules. Recent studies suggest that drugs might also bind in a non-covalent form to MHC-peptide complexes and T cell receptors, and are thereby able to stimulate T cells. This has, however, only been shown for drug-specific T cell clones. Functional an...

journal_title：Toxicology

authors： Pichler WJ

更新日期：2001-02-02 00:00:00

abstract：:Databases in science and technology dealing with toxicology subjects are of great and increasing interest to the scientific community. International hosts pay their tribute in creating toxicology clusters as a user-aid. Toxicology clusters of DataStar, DIALOG, DIMDI and STN are listed and compared. At the German Natio...

journal_title：Toxicology

authors： Voigt K,Brüggemann R

更新日期：1995-06-26 00:00:00

abstract：:Several mechanisms are postulated to be responsible for nephrotoxic and nephrocarcinogenic activities of mycotoxin and food contaminant, ochratoxin A (OTA). Although Nrf2 transcription factor was suggested to be involved in OTA-mediated renal injury, comprehensive study evaluating the effect of OTA toxicity in Nrf2 kn...

journal_title：Toxicology

authors： Loboda A,Stachurska A,Sobczak M,Podkalicka P,Mucha O,Jozkowicz A,Dulak J

更新日期：2017-08-15 00:00:00

abstract：:There is a close relationship between the central nervous system activity and bone metabolism. Therefore, methamphetamine (METH), which stimulates the central nervous system, is expected to affect bone turnover. The aim of this study was to investigate the role of METH in bone metabolism. Mice were divided into 3 grou...

journal_title：Toxicology

authors： Tomita M,Katsuyama H,Watanabe Y,Okuyama T,Fushimi S,Ishikawa T,Nata M,Miyamoto O

更新日期：2014-05-07 00:00:00

abstract：:Induction of lung aryl hydrocarbon hydroxylase (AHH) activity has been studied in rats following their exposure to different regimes of cigarette smoke produced from tobacco and the tobacco substitute NSM. The rate of induction of AHH was maximal during the first 3 days of exposure to tobacco smoke. The frequency of e...

journal_title：Toxicology

authors： Down WH,Chasseaud LF,Sacharin RM

更新日期：1981-01-01 00:00:00

abstract：:Chemicals can increase carcinogenic risk by either directly damaging DNA or increasing cell replication or they can do both. These effects have different implications for a biologically-based extrapolation from rodent bioassays to humans. 2-Acetylaminofluorene (2-AAF) administered at low doses to mice for a lifetime h...

journal_title：Toxicology

authors： Cohen SM

更新日期：1995-09-01 00:00:00

abstract：:Inorganic arsenic (iAs), a ubiquitous element and a natural drinking water contaminant, has been found to impair male reproductive function. However, the effect of long-term exposure to arsenic on testis damage and its underlying mechanisms still require further evaluation. In the study, male C57BL/6 mice (4 weeks) we...

journal_title：Toxicology

authors： Zeng Q,Yi H,Huang L,An Q,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Pregnant CD-1 mice were administered a commercial 2,4-dichlorophenoxyacetic acid (2,4-D) formulation on days 6-16 days of gestation, in drinking water at concentrations ranging from 0 to 1.0% of the formulated product, equivalent to approximately 0-650 mg/kg per day expressed as the amine derivative. The effect of 2,4...

journal_title：Toxicology

authors： Lee K,Johnson VL,Blakley BR

更新日期：2001-08-13 00:00:00

abstract：:Paraquat, a quarternary nitrogen herbicide, is a highly toxic compound for humans and animals and many cases of acute poisoning and death have been reported over the past few decades. The mechanisms of paraquat toxicity involve: the generation of the superoxide anion, which can lead to the formation of more toxic reac...

journal_title：Toxicology

authors： Suntres ZE

更新日期：2002-10-30 00:00:00

abstract：UNLABELLED:We recently observed a case of digoxin and insulin self-poisoning without cardiac repercussion. We raised the hypothesis that insulin may have a cardio-protective effect in case of digoxin toxicity. We have therefore evaluated the effect of glucose-insulin infusion on mortality and ECG abnormalities during a...

journal_title：Toxicology

authors： Oubaassine R,Bilbault P,Roegel JC,Alexandre E,Sigrist S,Lavaux T,Jaeger A,Pinget M,Kessler L

更新日期：2006-07-25 00:00:00

abstract：:We have reported that excessive nitric oxide (NO), like other reactive oxygen species (ROS), causes a decrease in cytochrome c oxidase (CCO) activity and ATP levels (mitochondrial damage) resulting in lens opacity. In addition, previous reports have shown that oxidative stress caused by ROS enhances amyloid β (Aβ) pro...

journal_title：Toxicology

authors： Nagai N,Ito Y,Shibata T,Kubo E,Sasaki H

更新日期：2017-04-15 00:00:00

abstract：:Measurement of lymphocyte proliferation to detect hypersensitivity to beryllium (Be-LPT) in vitro is done presently using a method based on tritiated thymidine incorporation. Although this method is sensitive it gives no information on cell viability or responding lymphocyte subsets. We have developed reliable and sim...

journal_title：Toxicology

authors： Farris GM,Newman LS,Frome EL,Shou Y,Barker E,Habbersett RC,Maier L,Smith HN,Marrone BL

更新日期：2000-02-21 00:00:00

abstract：:This review deals with some of our contributions to the use of chemotaxis, as a tool in evaluating effects of industrial xenobiotics on PMN, either in vitro or ex vivo. In vitro experiments have shown that lead, arsenic, styrene and 2,5-hexanedione, a major neurotoxicant metabolite of n-hexane, reduce chemotaxis. The ...

journal_title：Toxicology

authors： Governa M,Valentino M,Visonà I

更新日期：1994-07-01 00:00:00

abstract：:Cytochrome P450 (CYP) 2A13 is mainly expressed in the respiratory system and has the ability to metabolize aflatoxin B(1) (AFB(1)). However, the role of CYP2A13-mediated AFB(1) metabolism and its consequences in human lung epithelial cell is not clear. Therefore, the objectives of this study were to investigate the si...

journal_title：Toxicology

authors： Yang XJ,Lu HY,Li ZY,Bian Q,Qiu LL,Li Z,Liu Q,Li J,Wang X,Wang SL

更新日期：2012-10-28 00:00:00

abstract：:For half of the 30-odd years that diacetyl-exposed workers have developed disabling lung disease, obliterative bronchiolitis was unrecognized as an occupational risk. Delays in its recognition as an occupational lung disease are attributable to the absence of a work-related temporal pattern of symptoms; failure to rec...

journal_title：Toxicology

authors： Kreiss K

更新日期：2017-08-01 00:00:00

abstract：:Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...

journal_title：Toxicology

authors： Carpanini FM,Gaunt IF,Hardy J,Gangolli SD,Butterworth KR,Lloyd AG

更新日期：1978-02-01 00:00:00

abstract：:The murine local lymph node assay (LLNA) has been proposed as a predictive test for the identification of sensitizing agents. We used this test to compare the sensitization potential of NiSO4, K2Cr2O7, CoCl2, Na2PtCl6 and BeSO4, salts of metals which have all been associated with allergic contact dermatitis and either...

journal_title：Toxicology

authors： Mandervelt C,Clottens FL,Demedts M,Nemery B

更新日期：1997-06-06 00:00:00