Abstract:
:The histogenesis of coumarin-induced cholangiofibrosis in the rat has been determined. Proliferation of ductal structures was preceded by extensive damage to hepatocytes in the centrilobular region. Focal proliferation of ducts and fibrous tissue was present at 3 months and typical areas of cholangiofibrosis at 6 months. By 18 months the lesion was extensive and contained areas showing bizarre histological features suggestive of malignancy although no evidence of extra-hepatic metastasis was found. The lesion in animals returned to standard diet showed varying degrees of involution with extensive atrophy and fibrosis. A number of parameters of hepatic mixed function oxidase activity were reduced during the initial treatment period, at later times there was recovery of some microsomal enzyme activities. The activity of gamma-glutamyltransferase and the hepatic content of non-protein sulphydryl groups, in contrast, were raised throughout the treatment period.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Evans JG,Appleby EC,Lake BG,Conning DMdoi
10.1016/0300-483x(89)90187-xsubject
Has Abstractpub_date
1989-04-01 00:00:00pages
207-24issue
1-2eissn
0300-483Xissn
1879-3185pii
0300-483X(89)90187-Xjournal_volume
55pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Ultrafine titanium dioxide (TiO(2)) particles have been shown to exhibit strong cytotoxicity when exposed to UVA radiation, but are regarded as a biocompatible material in the absence of photoactivation. In contrast to this concept, the present results indicate that anatase-sized (10 and 20 nm) TiO(2) particles in the...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.05.007
更新日期:2005-09-15 00:00:00
abstract::There is a close relationship between the central nervous system activity and bone metabolism. Therefore, methamphetamine (METH), which stimulates the central nervous system, is expected to affect bone turnover. The aim of this study was to investigate the role of METH in bone metabolism. Mice were divided into 3 grou...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.01.014
更新日期:2014-05-07 00:00:00
abstract::Several epidemiological studies have shown that acute exposure to particulate air pollution is associated with increases in cardiovascular morbidity and mortality, and that these effects are especially exacerbated among individuals with pre-existing compromised cardiovascular function such as hypertension. This study ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.03.018
更新日期:2011-07-11 00:00:00
abstract::This study was undertaken to investigate whether treatment with vitamin E (VE) and/or vitamin C (VC) protects rat sperm by inhibiting reactive oxygen species generation induced by lead (Pb) exposure. Male Sprague-Dawley rats were assigned to the following five groups: vitamin-unsupplemented; 150 mg VE/kg chow suppleme...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00068-7
更新日期:1998-07-17 00:00:00
abstract::The intravenous toxicity of phytic acid (inositol hexakisphosphate, IHP) has recently become of interest because of the potential for IHP incorporation into red blood cells to achieve a therapeutically useful shift in the hemoglobin-oxygen dissociation curve (Gersonde, K. and Nicolau, C., Blut, 39 (1979) 1). The obser...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(81)90022-6
更新日期:1981-01-01 00:00:00
abstract::Food labels are an important educational tool to assist consumers in making healthy food choices. In addition to mandatory nutritional labeling information, manufacturers have a variety of options on the food/supplement packages to communicate the nutrition/health benefits of their products. This paper describes the d...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.12.021
更新日期:2006-04-03 00:00:00
abstract::Pregnant M. ochrogaster received single intraperitoneal (i.p.) doses of 0.06, 0.125, 0.25, 0.5, 1,2, or 5 mg phenyl mercuric acetate (PMA/kg of body weight on day 8, 9, or 10 of gestation or 0.5 mg PMA/kg on day 7, 8, 9, 10, 11, or 12 of gestation. No toxicity was exhibited, and no abnormal fetuses were observed in an...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(76)90031-7
更新日期:1976-11-01 00:00:00
abstract::Arsenicals are known to induce ROS, which can lead to DNA damage, oxidative stress, and carcinogenesis. A human urothelial cell line, UROtsa, was used to study the effects of arsenicals on the human bladder. Arsenite [As(III)] and monomethylarsonous acid [MMA(III)] induce oxidative stress in UROtsa cells after exposur...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.05.018
更新日期:2008-08-19 00:00:00
abstract::When Xenopus laevis embryos were treated with fenitrothion, a substantial proportion failed to survive to hatching only when the concentration approached saturation. However, after exposure to 10 ppm of fenitrothion, most were abnormal and did not survive past feeding stage. Different embryonic stages were not equally...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(81)90026-3
更新日期:1981-01-01 00:00:00
abstract::Effects of methylmercury on the cell growth of mouse glioma in vitro were studied in relation to the microtubules as a possible target. The electron microscopic observation revealed that methylmercury added in culture medium specifically attacked microtubules in the cells at growth inhibitory concentration, while merc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90101-8
更新日期:1980-01-01 00:00:00
abstract::Some chemicals are harmful in to light-exposed tissues such as skin and eyes. The 3T3 Neutral Red Uptake Phototoxicity Test has been validated and adopted by the Organization of Economic and Community Development (OECD) as a method of evaluating chemical phototoxicity using mouse 3T3 fibroblasts. However, the high rat...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.01.003
更新日期:2017-03-01 00:00:00
abstract::Rats which were treated intraperitoneally (i.p.) with FeCl2 X 4H2O expired ethane which increased with increasing doses of iron. The same amount of ethane was expired by animals exposed to 20% or 100% oxygen. The mobilization by FeCl2 of stored ethane from the body was excluded. Propane expiration was also stimulated ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90103-8
更新日期:1983-09-01 00:00:00
abstract::The safety of an açai (Euterpe oleracea Mart.) pulp enriched fruit and berry juice, MonaVie Active®, fortified with the functional ingredient, glucosamine, was studied. The beverage was found not to be mutagenic, clastogenic, cytotoxic, or genotoxic, as determined by the bacterial reverse mutation assay, chromosomal a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.04.017
更新日期:2010-11-28 00:00:00
abstract::Deltamethrin is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control, protection of foodstuff and disease vector control. The objective of this study was to investigate the propensity of deltamethrin to induce oxidative stress and changes in biochemical parameters and enzyme activities i...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.08.008
更新日期:2006-10-29 00:00:00
abstract::Exposure to cadmium (Cd) can cause a variety of biological effects including alterations of immune responses in animals and humans. Both immunosuppression and immunoenhancement have been reported. The present study was aimed at investigating the consequences of exposure to Cd on the human immunoglobulin (Ig) E synthes...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00044-1
更新日期:2003-06-03 00:00:00
abstract::Disorders in the barrier function and secretory activity of the placenta can be caused by xenobiotics (XB) present in the environment and their accumulation in tissues of living organisms. Thus, the aim of this study was to investigate the effect of 1,1,1-trichloro-2,2,-bis-4-chlorophenyl-ethane (DDT) and its metaboli...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.11.016
更新日期:2017-01-15 00:00:00
abstract::Ketamine, an anaesthetic agent used in newborns and toddlers, has been shown to induce neurodegeneration and alter adult behavior in mice, when administered during the neonatal period. Mammals have a marked period of rapid brain growth and development (BGS), which is postnatal in mice and rats, spanning the first 3-4 ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.04.019
更新日期:2008-07-30 00:00:00
abstract::This study was designed to evaluate the cardioprotective potential of naringin on lipid peroxides, enzymatic and nonenzymatic antioxidants and histopathological findings in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (85 mg/kg) to male Wistar rats showed a significant ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.09.005
更新日期:2006-12-07 00:00:00
abstract::We have investigated in the current study, the possible modulatory effects of dexamethasone on cisplatin cytotoxicity in Ehrlich ascites carcinoma (EAC)-bearing female Swiss albino mice. Cisplatin (3.5mg/kg) was injected IP for 3 consecutive days in mice previously inoculated SC with EAC cells in the right flank. Dexa...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.02.007
更新日期:2006-05-01 00:00:00
abstract::The effects of triethyl lead chloride (TEL) on the expression of two detoxication enzyme families, glutathione S-transferases (GSTs) and NAD(P)H:quinone oxidoreductase (QR) were determined in rat liver and kidney. Fischer 344 rats were given one intraperitoneal (i.p.) injection of TEL. GST activity, GST isoenzyme leve...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03555-x
更新日期:1997-02-14 00:00:00
abstract::Considerable evidence has demonstrated that women are more vulnerable than men to the toxic effects of alcohol, although the results as to whether gender differences exist in ethanol-induced brain damage are contradictory. We have reported that ethanol, by activating the neuroimmune system and Toll-like receptors 4 (T...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2013.03.001
更新日期:2013-09-06 00:00:00
abstract::In the current study, we used pathway-specific cDNA arrays to detect the transcriptional signature induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in vivo by studying simultaneously the expression profiles of 83 genes involved in apoptosis, cytokine production and angiogenesis. To this end, C57BL/6 mice were inj...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00230-5
更新日期:2002-09-16 00:00:00
abstract::Aniline and its halogenated derivatives are widely used as chemical intermediates. The purpose of this study was to determine the hepatotoxic and nephrotoxic potential of the 2-haloanilines. Male Fischer 344 rats (n > or = 4) were injected (i.p.) with 1.0 or 1.25 mmol/kg of: aniline (A), 2-fluoroaniline (2-FA), 2-chlo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90151-4
更新日期:1992-11-01 00:00:00
abstract::Inhibition of regulated exocytosis by botulinum toxins type A and B was studied in chromaffin cells. Both virtually abolished catecholamine release triggered from intact cells by depolarising stimuli, whereas the blockade by type A, but not B, was only partial after cell permeabilisation and direct stimulation of exoc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00453-5
更新日期:2002-12-27 00:00:00
abstract::p-Chloro-m-cresol (PCMC) and p-chloro-m-xylenol (PCMX) are known to cause allergic contact dermatitis. For risk assessment of skin sensitizers, information on dose-response profiles in the induction and elicitation phases and cross-reactivity with analogous chemicals are important. In the non-radioactive local lymph-n...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00161-6
更新日期:2003-08-28 00:00:00
abstract::Simultaneous exposure to cadmium and arsenic is highly probable in the urban area of San Luis Potosi, Mexico due to common localization of copper and zinc smelters. Therefore, in this work, rats were intraperitoneally exposed either to cadmium or arsenic alone, or simultaneously to both metals. The effects of these tr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90135-4
更新日期:1990-11-01 00:00:00
abstract::Sensitivity to the toxic effects of xenobiotic agents is influenced by a number of factors. Recent evidence derived from studies using experimental animals suggests that inflammation is one of these factors. For example, induction of inflammation by coexposure to bacterial endotoxin, vitamin A or Corynebacterium parvu...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(01)00523-6
更新日期:2001-12-28 00:00:00
abstract::To check the possible toxicity risks of the meat from swine fed with a residue producing feed additive: Carbadox, a new methodology was used. It is the "Relay Toxicity". Swine were fed with a high dose of the additive and sacrificed without any withdrawal. In such conditions meat contains a high level of residues. The...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(78)91039-9
更新日期:1978-10-01 00:00:00
abstract::Male and female B6C3F1 mice were administered dichloroacetate (DCA) and trichloroacetate (TCA) in their drinking water at concentrations of 1 or 2 g/l for up to 52 weeks. Both compounds induced hepatoproliferative lesions (HPL) in male mice, including hepatocellular nodules, adenomas and hepatocellular carcinomas with...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90195-m
更新日期:1990-09-01 00:00:00
abstract::Challenges to improve toxicological risk assessment to meet the demands of the EU chemical's legislation, REACH, and the EU 7th Amendment of the Cosmetics Directive have accelerated the development of non-animal based methods. Unfortunately, uncertainties remain surrounding the power of alternative methods such as in ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2013.08.012
更新日期:2015-06-05 00:00:00