Ferrous ion-stimulated alkane expiration in rats treated with carbon tetrachloride.

Abstract:

:Rats which were treated intraperitoneally (i.p.) with FeCl2 X 4H2O expired ethane which increased with increasing doses of iron. The same amount of ethane was expired by animals exposed to 20% or 100% oxygen. The mobilization by FeCl2 of stored ethane from the body was excluded. Propane expiration was also stimulated by FeCl2 treatment, whereas n-pentane expiration could not be detected. Rats which were treated i.p. with 500 mg CCl4/kg expired ethane, propane, and n-pentane, the amounts being higher in the presence of 20% than in the presence of 100% oxygen. The treatment of rats with FeCl2 30 min after giving CCl4 resulted in a 2-5-fold increase in ethane, propane and n-pentane expiration, the total amounts depending on the oxygen concentration in the respired air (higher under 20% and lower under 100% oxygen). This increase was due to a minor extent to FeCl2-initiated alkane formation. Therefore, we suggest that in vivo Fe2+, besides its ability to initiate lipid peroxidation, influences the CCl4-induced lipid peroxidation process. The possible relevance for CCl4 toxicity is discussed.

journal_name

Toxicology

journal_title

Toxicology

authors

Muliawan H,Kappus H

doi

10.1016/0300-483x(83)90103-8

subject

Has Abstract

pub_date

1983-09-01 00:00:00

pages

29-36

issue

1-2

eissn

0300-483X

issn

1879-3185

pii

0300-483X(83)90103-8

journal_volume

28

pub_type

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