Abstract：
:Ketamine, an anaesthetic agent used in newborns and toddlers, has been shown to induce neurodegeneration and alter adult behavior in mice, when administered during the neonatal period. Mammals have a marked period of rapid brain growth and development (BGS), which is postnatal in mice and rats, spanning the first 3-4 weeks of life and reaching its peak around postnatal day 10. CaMKII and GAP-43 play important roles during the BGS in mammals. In the present study, 10 days old mice were exposed to 5-25 mg ketamine/kg bw and 24 h later brains were analyzed for calcium/calmodulin-dependent protein kinase II (CaMKII) and growth associated protein-43 (GAP-43) and at an age of 2 and 4 months the animals were tested for spontaneous behavior. The protein analysis showed that CaMKII increased significantly in hippocampus, but not in cortex, in animals 24h after exposure to ketamine. GAP-43 showed a significant increase in hippocampus, but a significant decrease in cortex for the highest ketamine dose. When looking at the adult behavior it was clear that neonatal ketamine exposure affected spontaneous behavior and habituation in a dose-response-related manner and that these behavioral disturbances were not transient but still persisted 2 months later. Taken together, this shows that ketamine affects important proteins involved in normal maturation of the brain and induce functional deficits in the adult individual, which further strengthen our findings concerning ketamine as a developmental neurotoxicological agent.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Viberg H,Pontén E,Eriksson P,Gordh T,Fredriksson Adoi
10.1016/j.tox.2008.04.019subject
Has Abstractpub_date
2008-07-30 00:00:00pages
153-9issue
2-3eissn
0300-483Xissn
1879-3185pii
S0300-483X(08)00210-2journal_volume
249pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:The possible juvenilizing effects of Dimilin and Altosid against larvae of Culex pipiens L. were studied. Apart from delayed lethal action, possible effect on the mean number of basal follicles developed per female has been considered. A baseline exposure was found which caused only low mortalities of the early 4th la...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90137-2
更新日期：1981-01-01 00:00:00
abstract：:The effects of 2,2,2-trichloro-1-(3,4-dichlorophenyl)ethyl acetate (Penfenate) on hepatic, renal and small intestinal drug-metabolizing enzyme activities, hepatic reduced glutathione content and urinary excretion of thioethers were studied in the rat. A single i.p. dose of Penfenate (500 mg/kg) decreased the body weig...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(83)90028-8
更新日期：1983-07-01 00:00:00
abstract：:Cruciferous vegetable consumption correlates with reduced risk of cancer. This chemopreventative activity may involve glucosinolates and their hydrolysis products. Glucosinolate-derived isothiocyanates have been studied for their toxicity and chemopreventative properties, but other hydrolysis products (epithionitriles...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.06.002
更新日期：2015-08-06 00:00:00
abstract：:Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), a major constituent of marijuana, has been shown to stimulate the growth of MCF-7 breast cancer cells through cannabinoid receptor-independent signaling [Takeda, S., Yamaori, S., Motoya, E., Matsunaga, T., Kimura, T., Yamamoto, I., Watanabe, K., 2008. Delta(9)-Tetrahydroca...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.01.024
更新日期：2009-05-02 00:00:00
abstract：:The effects of ethanol on hamster hepatic and extrahepatic monooxygenases were determined in the present study. Chronic ethanol administration increased cytochrome P-450 (P-450) content and monooxygenase activities towards aniline, N-nitrosodimethylamine, and 7-ethoxyresorufin. In contrast, benzphetamine and benzo(a)p...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90006-e
更新日期：1993-07-28 00:00:00
abstract：:Effects of metallothionein (MT) synthesis inhibiting compounds (actinomycin D, cycloheximide), MT synthesis stimulating compounds (dexamethasone, dibu-cAMP) and interfering metals (Cd, Zn) on copper accumulation were investigated in rat hepatoma tissue culture cells. Copper-metallothionein (Cu-MT) and MT-associated co...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90168-6
更新日期：1994-09-06 00:00:00
abstract：:Cell death triggers the release into extracellular spaces of products of chromatin catabolism, particularly of DNA. A sensitive DNA assay has been used to investigate in the mouse whether the quantitation of plasma DNA may be used as an index of in vivo cytotoxicity. It has been found that toxic doses of bacterial lip...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90178-j
更新日期：1990-04-30 00:00:00
abstract：:The anticonvulsant, valproic acid (VPA) is a suspected human teratogen. This study, employing the rhesus monkey as an animal model, demonstrates that VPA has a significant teratogenic potential in the monkey. Timed pregnant monkeys were exposed orally to VPA at approx. 1X, 10X, and 30X (20, 200, and 600 mg/kg/day, res...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90129-0
更新日期：1986-05-01 00:00:00
abstract：:This study compares changes in cardiopulmonary function, selected endpoints in exhaled breath, blood, and bronchoalveolar lavage fluid (BAL) following a single, high-level 30-min nose-only exposure of rats to chlorine and phosgene gas. The time-course of lung injury was systematically examined up to 1-day post-exposur...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.10.010
更新日期：2014-12-04 00:00:00
abstract：:The action of various manganese organic compounds, which are structural analogs of methylcyclopentadienyl manganese tricarbonyl (MMT), was investigated. Only the cyclopentadienyl manganese tricarbonyl compounds are effective inhibitors of mitochondrial respiration, but only when associated with NAD+-linked substrates....
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(77)90001-4
更新日期：1977-10-01 00:00:00
abstract：:Chemical carcinogens are generally classified as genotoxic or non-genotoxic. However, weak genotoxicity at high concentrations is sometimes observed and interpretation is often problematic. In addition, certain rodent carcinogens exert their effects at doses associated with cytotoxicity and compensatory hyperplasia ma...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(03)00058-1
更新日期：2003-05-03 00:00:00
abstract：:An increasing body of data has been demonstrating that mammalian cells have elaborate networks of molecular signalling in counteracting heat shock and in developing adaptation to oxidative stress to avoid cell death. However, the precise mechanisms linking heat shock, oxidative stress and cell survival/cell death mech...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.04.028
更新日期：2006-07-25 00:00:00
abstract：:Pilinskaya showed that the fungicide ziram induced chrocosome aberrations in the lymphocytes of exposed industrial workers and also in lymphocyte cultures treated in vitro. Ziram is chemically similar to the drug Antabuse (disulfirm) which is used in the treatment of alcoholics. To establish whether disulfirm can also...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(75)90055-4
更新日期：1975-07-01 00:00:00
abstract：:The usefulness of cDNA-directed expression of human hepatic P450s in yeast for the in vitro study of drug metabolism is emphasized. The major advantages of yeast expression are: (i) relatively high yields of heterologous P450 (approximately 5-10 nmol/l of culture medium) can be obtained; (ii) the expressed P450s are d...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(93)90058-z
更新日期：1993-10-05 00:00:00
abstract：:Diesel exhaust particles (DEP) affect health adversely. Our previous studies revealed that DEP extracts up-regulated expression of genes related to drug metabolism, antioxidant enzymes, cell cycle/apoptosis and coagulation, and in addition, n-hexane soluble fraction (n-HSF) of DEP extracts contains aliphatic and polyc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.05.012
更新日期：2009-07-28 00:00:00
abstract：:Osteoporosis is associated with many etiological causes such as nutrition, cytokines, hormones, and aging. Recently, reactive oxygen species (ROS) are considered to be responsible for the aging process and osteoporosis. We investigated the relationship between ROS and bone metabolism in young female and postmenopausal...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2003.12.006
更新日期：2004-04-15 00:00:00
abstract：:The possibility that Cd administration could activate the pituitary-adrenal axis has been studied. It was found that acute administration of Cd strongly increased serum corticosterone levels. Adrenocortical activation correlated well with serum Cd levels, suggesting that adrenal activation was dependent on the presenc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(87)90119-3
更新日期：1987-07-01 00:00:00
abstract：:The ability to overcome cellular barriers in the body is crucial for efficient delivery of drugs to the target where intervention is needed. For drugs acting in the brain it is essential to overcome the blood-brain barrier (BBB). Such drugs include antidotes for the treatment of organophosphate poisoning, a current wa...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152541
更新日期：2020-10-01 00:00:00
abstract：:Hexachlorobenzene (HCB) is an organochlorine pesticide that acts as an endocrine disruptor in humans and rodents. The development of breast cancer strongly depends on endocrine conditions modulated by environmental factors. We have demonstrated that HCB is a tumor co-carcinogen in rats and an inducer of proliferation ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.12.012
更新日期：2012-03-11 00:00:00
abstract：:Inorganic arsenic (iAs) and its metabolites are transferred to the foetus through the placental barrier and this exposure can compromise the normal development of the unborn. For this reason, we assessed the toxicity of sodium arsenite (iAs(III)) and its metabolites dimethylarsinic acid (DMA(V)), monomethylarsonic aci...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.04.008
更新日期：2008-07-30 00:00:00
abstract：:The mouse lymphoma thymidine kinase assay (MLA) has been optimized to quantitatively determine the in vitro mutagenicity of cigarette mainstream smoke particulate phase. To test whether the MLA is able to discriminate between different cigarette types, specially constructed cigarettes each containing a single tobacco ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.07.019
更新日期：2006-10-29 00:00:00
abstract：:Recently, chimeric mice with humanized liver were established by transplanting human hepatocytes into an urokinase-type plasminogen activator(+/+)/severe combined immunodeficient transgenic mouse line. The replacement with human hepatocytes is more than 80-90% and is higher than any other chimeric mouse reported previ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2007.11.012
更新日期：2008-04-03 00:00:00
abstract：:Asthma, which is primarily an allergic type of respiratory disease, has increased in the U.S. and Europe by 30% over the last decade. Air pollution may play a role in this rise, since during episodes of smog, hospital admissions due to asthma increase. Ambient air quality has generally improved since the Clean Air Act...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(95)03230-d
更新日期：1995-12-28 00:00:00
abstract：:Rats which were treated intraperitoneally (i.p.) with FeCl2 X 4H2O expired ethane which increased with increasing doses of iron. The same amount of ethane was expired by animals exposed to 20% or 100% oxygen. The mobilization by FeCl2 of stored ethane from the body was excluded. Propane expiration was also stimulated ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(83)90103-8
更新日期：1983-09-01 00:00:00
abstract：:Previous reports from this laboratory have established the propensity of chlordecone to potentiate the hepatotoxicity and lethality in male and female rats. The present study was designed to investigate the hepatotoxicity of CCl4 in chlordecone (CD) pretreated, ovariectomized rats. Ten days after bilateral ovariectomy...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90163-x
更新日期：1984-02-01 00:00:00
abstract：:BHK21 fibroblastic cells were exposed in vitro to lead microparticles produced by pyrolysis of the organic lead used as an antiknock agent in gasoline. Although non-cytolethal, 10 micrograms of lead/10(6) cells rapidly inhibited cell growth kinetics as well as [3H]thymidine and L-[3H]leucine incorporation by the BHK21...
journal_title：Toxicology
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
abstract：:Ochratoxin A (OTA) is a mycotoxin produced by several fungi which grow on human food source material. Consumption of OTA is almost unavoidable. The consumption leads to low but detectable amounts of OTA in human blood. Risk assessment of OTA is based on studies performed either in animals or cultured cells. So far, ma...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.12.008
更新日期：2007-03-22 00:00:00
abstract：:Fischer 344 rats were exposed to filtered air (controls) or to 0.12, 0.5, or 1.0 ppm of ozone for 6 h/day, 5 days/week, for 20 months. We examined lung collagen deposition and metabolism in tissue from these animals to determine whether chronic exposure of rats to ozone causes pulmonary fibrosis. We observed excess st...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90110-e
更新日期：1993-11-12 00:00:00
abstract：:Potassium dichromate was given to female Swiss mice (25 mg/kg per day) orally in water for 1-3 days. Brain homogenates were prepared to evaluate the occurrence of oxidative stress in this organ through the measurement of the antioxidant defense levels, and the extent of lipid peroxidation. In addition, mitochondrial f...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00254-7
更新日期：2000-09-07 00:00:00
abstract：:Insulin and dexamethasone are potent inhibitors of apoptosis induced by transforming growth factor-beta1 (TGF-beta) in hepatoma cells. Using FTO-2B rat hepatoma cells, we determined whether the anti-apoptotic effects of these agents result from interference within or upstream of the TGF-beta-induced caspase cascade. A...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.06.020
更新日期：2004-11-15 00:00:00
