Interaction of air pollutants and pulmonary allergic responses in experimental animals.


:Asthma, which is primarily an allergic type of respiratory disease, has increased in the U.S. and Europe by 30% over the last decade. Air pollution may play a role in this rise, since during episodes of smog, hospital admissions due to asthma increase. Ambient air quality has generally improved since the Clean Air Act was implemented in 1971 however, and has led some investigators to suggest that the increased risk of asthma is associated with a deterioration of indoor air quality through the introduction of closed ventilation systems and constant climate control. Thus, although the direct health effects of acute and chronic air pollutant exposure are not in dispute, emphasis on the sources and location of exposure is changing from outdoors to the home environment and workplace. The few experimental studies which have investigated the interaction of air pollutants with allergic disease have shown that exposure to O3 or NO2 can increase levels of allergen-specific antibody and may augment allergic symptoms. These experiments are reviewed along with a study conducted in our laboratory which demonstrated the enhancing effect of NO2 exposure on immune responses and pulmonary inflammation following sensitization and pulmonary challenge with house dust mite allergen (HDM). In this study, rats exposed to 5 ppm NO2 for 3 h after each immunization had significantly higher levels of serum IgE and local IgA, IgG and IgE antibody than air controls. Lymphocyte activity in the spleen and local lymph nodes, and pulmonary inflammatory cells were also increased in NO2-exposed rats. The results show that exposure to NO2 enhances immune responsiveness and the severity of pulmonary inflammation following antigen challenge. Since allergic individuals and most asthmatics also have increased immunity to these proteins, the possibility that air pollutant exposure enhances immune responses to allergens and thus exacerbates immune-mediated lung disease exists.






Gilmour MI




Has Abstract


1995-12-28 00:00:00














  • Genotoxicity of phenacetin in the kidney and liver of Sprague-Dawley gpt delta transgenic rats in 26-week and 52-week repeated-dose studies.

    abstract::Transgenic rat mutation assays can be used to assess genotoxic properties of chemicals in target organs for carcinogenicity. Mutations in transgenes are genetically neutral and accumulate during a treatment period; thus, assays are suitable for assessing the genotoxic risk of chemicals using a repeated-dose treatment ...


    pub_type: 杂志文章


    authors: Kawamura Y,Hayashi H,Masumura K,Numazawa S,Nohmi T

    更新日期:2014-10-03 00:00:00

  • Increased levels of metallothionein in placenta of smokers.

    abstract::Experiments were designed to evaluate and compare metallothionein (MT), zinc and cadmium levels in human placentas of smoking and non-smoking women. Smoking was assessed by self-reported cigarette consumption and urine cotinine levels before delivery. Smoking pregnant women with urine cotinine levels higher than 130 n...


    pub_type: 临床试验,杂志文章


    authors: Ronco AM,Arguello G,Suazo M,Llanos MN

    更新日期:2005-03-01 00:00:00

  • The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: acute studies.

    abstract::Arsenicals are known to induce ROS, which can lead to DNA damage, oxidative stress, and carcinogenesis. A human urothelial cell line, UROtsa, was used to study the effects of arsenicals on the human bladder. Arsenite [As(III)] and monomethylarsonous acid [MMA(III)] induce oxidative stress in UROtsa cells after exposur...


    pub_type: 杂志文章


    authors: Eblin KE,Hau AM,Jensen TJ,Futscher BW,Gandolfi AJ

    更新日期:2008-08-19 00:00:00

  • The in vivo effects of cyanide and its antidotes on rat brain cytochrome oxidase activity.

    abstract::The in vivo effects of sodium cyanide and its antidotes, sodium nitrite, sodium thiosulfate and 4-dimethylaminophenol (DMAP), as well as the alpha-adrenergic blocking agent phentolamine, on rat brain cytochrome oxidase were studied. The course of inhibition was time-dependent and a peak of 40% was attained between 15 ...


    pub_type: 杂志文章


    authors: Tadić V

    更新日期:1992-11-22 00:00:00

  • Estrogenic effects in fish in The Netherlands: some preliminary results.

    abstract::Recently, a large-scale field study in The Netherlands has focused on the effects of estrogenic contaminants on feral fish populations. The freshwater bream (Abramis brama) and the estuarine flounder (Platichthys flesus) were sampled at a large number of locations in the spring and autumn of 1999. Concentrations of th...


    pub_type: 杂志文章


    authors: Vethaak AD,Lahr J,Kuiper RV,Grinwis GC,Rankouhi TR,Giesy JP,Gerritsen A

    更新日期:2002-12-27 00:00:00

  • Repeated exposure to butenolide vapour: subacute study in Syrian golden hamsters.

    abstract::The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, saliva...


    pub_type: 杂志文章


    authors: Feron VJ,Kruysse A,Immel HR,Til HP

    更新日期:1979-12-01 00:00:00

  • Changes in the mRNA expression of structural proteins, hormone synthesis and secretion from bovine placentome sections after DDT and DDE treatment.

    abstract::Disorders in the barrier function and secretory activity of the placenta can be caused by xenobiotics (XB) present in the environment and their accumulation in tissues of living organisms. Thus, the aim of this study was to investigate the effect of 1,1,1-trichloro-2,2,-bis-4-chlorophenyl-ethane (DDT) and its metaboli...


    pub_type: 杂志文章


    authors: Wojciechowska A,Mlynarczuk J,Kotwica J

    更新日期:2017-01-15 00:00:00

  • Human exposure to PBDEs through the diet in Catalonia, Spain: temporal trend. A review of recent literature on dietary PBDE intake.

    abstract::The mean concentrations of polybrominated diphenyl ethers (PBDEs) (sum tetra- to octaBDEs) were determined in samples of foodstuffs widely consumed by the population of Catalonia, Northeast Spain. The following six tetra-through heptabrominated congeners were also individually analyzed: PBDEs 47, 99, 100, 153, 154 and...


    pub_type: 杂志文章,评审


    authors: Domingo JL,Martí-Cid R,Castell V,Llobet JM

    更新日期:2008-06-03 00:00:00

  • DNA damage induced by alachlor after in vitro activation by rat hepatocytes.

    abstract::We investigated the ability of alachlor to cause DNA damage by measuring single-strand breaks (SSB) in DNA, after metabolic activation by freshly isolated rat hepatocytes. Incubation of different concentrations of alachlor with rat hepatocytes led to numerous metabolites. The majority, isolated and identified by GC-MS...


    pub_type: 杂志文章


    authors: Bonfanti M,Taverna P,Chiappetta L,Villa P,D'Incalci M,Bagnati R,Fanelli R

    更新日期:1992-01-01 00:00:00

  • The dilemma of approving antidotes.

    abstract::Clinical trials with antidotes are difficult to perform for a variety of practical, ethical, and financial reasons. As acute poisoning is a rare event, the commercial interest in basic and clinical research is low. Poisoned patients are usually not available for normal clinical trial procedures and, if they are, they ...


    pub_type: 杂志文章


    authors: Steffen C

    更新日期:2007-04-20 00:00:00

  • The effects of formaldehyde gas in a flow-through rat tracheal implant system.

    abstract::A flow-through rat tracheal implant system is described which permits the quantitative and repetitive exposure of respiratory epithelia to test gaseous substances. To investigate the acute toxicity of formaldehyde gas with this new system, open-ended rat tracheal implants were exposed to the gas for 1 h twice a week f...


    pub_type: 杂志文章


    authors: Shiba M,Marchok AC,Klein-Szanto AJ

    更新日期:1984-04-16 00:00:00

  • Long noncoding RNA-SNHG20 promotes silica-induced pulmonary fibrosis by miR-490-3p/TGFBR1 axis.

    abstract::Silicosis is a universal occupational disease, which is caused by long-term crystalline silica exposure. Recent studies have shown that noncoding RNAs participate in diverse pathological cellular pathways. However, the precise regulation mechanism remains limited in silicosis. Here, we established a silica-induced mou...


    pub_type: 杂志文章


    authors: Cheng D,Xu Q,Liu Y,Li G,Sun W,Ma D,Ni C

    更新日期:2021-01-19 00:00:00

  • Distribution of terbium and increase in calcium concentrations in organs of mice administered with terbium chloride.

    abstract::To investigate the biological effects of terbium (Tb), male mice were intraperitoneally administered with TbCl3 at doses of 10, 50, or 250 mg Tb/kg. The Tb distribution in organs was determined after 18-20 h of injection by using a spectrofluorometer. The concentrations of Ca, Mg, Fe, and Zn in various organs were det...


    pub_type: 杂志文章


    authors: Shinohara A,Chiba M

    更新日期:1991-02-11 00:00:00

  • Regulations on health/functional foods in Korea.

    abstract::The term "health/functional food" (HFF) refers to food supplements containing nutrients or other substances (in a concentrated form) that have a nutritional or physiological effect whose purpose is to supplement the normal diet. The Korean Health/Functional Food Act that came into effect in 2004 requires these product...


    pub_type: 杂志文章


    authors: Kim JY,Kim DB,Lee HJ

    更新日期:2006-04-03 00:00:00

  • Developing and maintaining quality in poisons information centers.

    abstract::The development of poisons information centers has in general complied with the actual needs and conditions in the society, and a pragmatic approach and limited funds have been characteristic for these units. To operate in a satisfying way a poisons information center is dependent on two cornerstones-a well educated a...


    pub_type: 杂志文章


    authors: Persson H,Tempowski J

    更新日期:2004-05-20 00:00:00

  • Oral exposure to atrazine modulates cell-mediated immune function and decreases host resistance to the B16F10 tumor model in female B6C3F1 mice.

    abstract::Atrazine (ATZ) is used throughout North America to control annual broadleaf weeds and grasses in various crops including; corn, sorghum, and sugar cane. Unfortunately, contamination of surface and ground water has occurred as a result of ATZ's chemical and physical properties, and its widespread use throughout the U.S...


    pub_type: 杂志文章


    authors: Karrow NA,McCay JA,Brown RD,Musgrove DL,Guo TL,Germolec DR,White KL Jr

    更新日期:2005-04-01 00:00:00

  • Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite.

    abstract::Exposure of pregnant C3H/HeNCR mice to 42.5- or 85-ppm of arsenic as sodium arsenite in drinking water between days 8 and 18 of gestation markedly increases tumor incidence in their offspring. In the work reported here, distribution of inorganic arsenic and its metabolites, methyl arsenic and dimethyl arsenic, were de...


    pub_type: 杂志文章


    authors: Devesa V,Adair BM,Liu J,Waalkes MP,Diwan BA,Styblo M,Thomas DJ

    更新日期:2006-07-05 00:00:00

  • Diethyl 2-phenyl-2 tellurophenyl vinylphosphonate: an organotellurium compound with low toxicity.

    abstract::It is well-known that organotellurium compounds can have antioxidant activity in vitro, but in vivo these compounds can be potentially toxic to rodents. Here we investigated the potential in vitro and ex vivo toxicity of a new beta-organochalcogenyl vinylphosphonate, the diethyl 2-phenyl-2 tellurophenyl vinylphosphona...


    pub_type: 杂志文章


    authors: de Avila DS,Beque MC,Folmer V,Braga AL,Zeni G,Nogueira CW,Soares FA,Rocha JB

    更新日期:2006-07-05 00:00:00

  • Chemotactic activity of human polymorphonuclear leukocytes and industrial xenobiotics: a brief review.

    abstract::This review deals with some of our contributions to the use of chemotaxis, as a tool in evaluating effects of industrial xenobiotics on PMN, either in vitro or ex vivo. In vitro experiments have shown that lead, arsenic, styrene and 2,5-hexanedione, a major neurotoxicant metabolite of n-hexane, reduce chemotaxis. The ...


    pub_type: 杂志文章,评审


    authors: Governa M,Valentino M,Visonà I

    更新日期:1994-07-01 00:00:00

  • Nutritional claims for functional foods and supplements.

    abstract::Food labels are an important educational tool to assist consumers in making healthy food choices. In addition to mandatory nutritional labeling information, manufacturers have a variety of options on the food/supplement packages to communicate the nutrition/health benefits of their products. This paper describes the d...


    pub_type: 杂志文章


    authors: Agarwal S,Hordvik S,Morar S

    更新日期:2006-04-03 00:00:00

  • Technical pentabromodiphenyl ether and hexabromocyclododecane as activators of the pregnane-X-receptor (PXR).

    abstract::Technical pentabrominated diphenyl ether (pentaBDE mix) is a mixture of polybrominated diphenyl ethers (PBDEs) which has been widely used as a flame retardant. Since its ban in several countries it has been replaced by other brominated flame retardants such as hexabromocyclododecane (HBCD). Both certain PBDE congeners...


    pub_type: 杂志文章


    authors: Fery Y,Buschauer I,Salzig C,Lang P,Schrenk D

    更新日期:2009-10-01 00:00:00

  • Preventive effect of S-allylcysteine on lipid peroxides and antioxidants in normal and isoproterenol-induced cardiotoxicity in rats: a histopathological study.

    abstract::The consumption of diets rich in plant foods are associated with a reduced risk of cardiovascular diseases. This study was aimed to evaluate the role of S-allylcysteine (SAC) in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (150 mg/kg) to Wistar rats showed a significant...


    pub_type: 杂志文章


    authors: Padmanabhan M,Prince PS

    更新日期:2006-07-05 00:00:00

  • In-vitro toxicity of molybdenum trioxide nanoparticles on human keratinocytes.

    abstract::Molybdenum trioxide (MoO3) nanoparticles (NPs) embedded in polymer films have been proposed as a cheap way of producing antibacterial coatings on external surfaces. Recently, we synthesized MoO3 nanowires in a unique shape and degree of anisotropy, which enables their fast water dissolution and quick antimicrobial rea...


    pub_type: 杂志文章


    authors: Božinović K,Nestić D,Centa UG,Ambriović-Ristov A,Dekanić A,de Bisschop L,Remškar M,Majhen D

    更新日期:2020-11-01 00:00:00

  • Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4.

    abstract::Preclinical drug safety assessment includes in vitro studies with physiologically relevant cell cultures. As an in vitro system for hepatic toxicology testing, we have been generating cell clones of human hepatoblastoma cell line HepG2 by lentiviral transduction of phase I cytochrome P450 (CYP) enzymes. Here, we prese...


    pub_type: 杂志文章


    authors: Steinbrecht S,König R,Schmidtke KU,Herzog N,Scheibner K,Krüger-Genge A,Jung F,Kammerer S,Küpper JH

    更新日期:2019-01-15 00:00:00

  • Effect of intratracheal injection of zinc oxide dust in guinea pigs.

    abstract::Intratracheal injection of zinc oxide dust, a component of many cosmetic preparations caused elevation of alkaline phosphatase and lactate dehydrogenase in serum and lung of guinea pigs. Clearance of zinc oxide dust from lungs through zinc-carrying proteins was evident. ...


    pub_type: 杂志文章


    authors: Gupta S,Pandey SD,Misra V,Viswanathan PN

    更新日期:1986-02-01 00:00:00

  • Benzoyl peroxide cytotoxicity evaluated in vitro with the human keratinocyte cell line, RHEK-1.

    abstract::The human keratinocyte cell line, RHEK-1, was used to evaluate the cytotoxicity of benzoyl peroxide (BZP). As determined with the neutral red (NR) cytotoxicity assay, the 24-h midpoint (NR50) toxicity values, in mM, were 0.11 for BZP and 29.5 for benzoic acid, the stable metabolite of BZP. Irreversible cytotoxicity oc...


    pub_type: 杂志文章


    authors: Babich H,Zuckerbraun HL,Wurzburger BJ,Rubin YL,Borenfreund E,Blau L

    更新日期:1996-01-08 00:00:00

  • Influence of dosage regimen on responses of the arcuate nucleus to subcutaneous injection of a protein hydrolysate.

    abstract::The effect of administration of a glutamate-containing protein hydrolysate on the arcuate nucleus of 10-day-old mice was studied by two methods. Arcuate nucleus damage resulted when administration was by a single large subcutaneous dose (100 ml/kg). When the same total dose was administered subcutaneously in five smal...


    pub_type: 杂志文章


    authors: Guzman RJ,Irwin RG,Hansen DM,Hidalgo J

    更新日期:1975-09-01 00:00:00

  • The protective effect of epigallocatechin-3-gallate on testicular oxidative stress in lead-induced toxicity mediated by Cyp19 gene / estradiol level.

    abstract::Exposure to heavy metals contributes to most of the unexplained male infertility. Lead (Pb) is a well- known heavy metal, which disrupt the male reproductive system. This study was conducted to investigate the therapeutic and protective effects of green tea active principle, epigallocatechin gallate (EGCG), on the lea...


    pub_type: 杂志文章


    authors: Hassan E,Kahilo K,Kamal T,Hassan M,Saleh Elgawish M

    更新日期:2019-06-15 00:00:00

  • Mechanism of DNA damage induced by bromate differs from general types of oxidative stress.

    abstract::A representative reactive oxygen species (ROS), hydroxyl radical (*OH), is a highly reactive species and induces DNA backbone breakage. *OH also oxidizes every DNA base. The interaction of *OH with guanine leads to the generation of not only piperidine-resistant 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) but also v...


    pub_type: 杂志文章


    authors: Kawanishi S,Murata M

    更新日期:2006-04-17 00:00:00

  • Profile of nonprotein thiols, lipid peroxidation and delta-aminolevulinate dehydratase activity in mouse kidney and liver in response to acute exposure to mercuric chloride and sodium selenite.

    abstract::The effects of mercury (Hg(2+)) and selenite (Se(4+)) on delta-aminolevulinic acid dehydratase (delta-ALA-D) activity, 2-thiobarbituric acid reactive substances (TBARS) and nonprotein sulfhydryl content (NPSH) in mouse kidney and liver were investigated. Male mice were given a single i.p. injection of Hg(2+) and/or Se...


    pub_type: 杂志文章


    authors: Farina M,Brandão R,de Lara FS,Pagliosa LB,Soares FA,Souza DO,Rocha JB

    更新日期:2003-03-03 00:00:00