Interaction of air pollutants and pulmonary allergic responses in experimental animals.


:Asthma, which is primarily an allergic type of respiratory disease, has increased in the U.S. and Europe by 30% over the last decade. Air pollution may play a role in this rise, since during episodes of smog, hospital admissions due to asthma increase. Ambient air quality has generally improved since the Clean Air Act was implemented in 1971 however, and has led some investigators to suggest that the increased risk of asthma is associated with a deterioration of indoor air quality through the introduction of closed ventilation systems and constant climate control. Thus, although the direct health effects of acute and chronic air pollutant exposure are not in dispute, emphasis on the sources and location of exposure is changing from outdoors to the home environment and workplace. The few experimental studies which have investigated the interaction of air pollutants with allergic disease have shown that exposure to O3 or NO2 can increase levels of allergen-specific antibody and may augment allergic symptoms. These experiments are reviewed along with a study conducted in our laboratory which demonstrated the enhancing effect of NO2 exposure on immune responses and pulmonary inflammation following sensitization and pulmonary challenge with house dust mite allergen (HDM). In this study, rats exposed to 5 ppm NO2 for 3 h after each immunization had significantly higher levels of serum IgE and local IgA, IgG and IgE antibody than air controls. Lymphocyte activity in the spleen and local lymph nodes, and pulmonary inflammatory cells were also increased in NO2-exposed rats. The results show that exposure to NO2 enhances immune responsiveness and the severity of pulmonary inflammation following antigen challenge. Since allergic individuals and most asthmatics also have increased immunity to these proteins, the possibility that air pollutant exposure enhances immune responses to allergens and thus exacerbates immune-mediated lung disease exists.






Gilmour MI




Has Abstract


1995-12-28 00:00:00














  • The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.

    abstract::This study is aimed to investigate the inflammation and neurological dysfunction induced by tetrachloro-p-benzoquinone (TCBQ) through Toll-like receptor 4 (TLR4) signaling. We also investigated the protective role of melatonin as an antioxidant and anti-inflammatory agent. In vitro model was established by rat pheochr...


    pub_type: 杂志文章


    authors: Fu J,Xia X,Liu Z,Wang Y,Wang Y,Shi Q,Song X,Song E,Song Y

    更新日期:2017-04-15 00:00:00

  • Doxorubicin-resistant LoVo adenocarcinoma cells display resistance to apoptosis induction by some but not all inhibitors of ser/thr phosphatases 1 and 2A.

    abstract::LoVo adenocarcinoma cells are fairly sensitive to cytostatic drugs, e.g. doxorubicin, but can develop drug resistance by expression of a P-glycoprotein-mediated MDR1 phenotype. LoVo cells respond with apoptosis to nanomolar concentrations of okadaic acid and micromolar concentrations of cantharidic acid. Interestingly...


    pub_type: 杂志文章


    authors: Sieder S,Richter E,Becker K,Heins R,Steinfelder HJ

    更新日期:1999-06-15 00:00:00

  • Developmental exposure of aflatoxin B1 reversibly affects hippocampal neurogenesis targeting late-stage neural progenitor cells through suppression of cholinergic signaling in rats.

    abstract::To elucidate the maternal exposure effects of aflatoxin B1 (AFB1) and its metabolite aflatoxin M1, which is transferred into milk, on postnatal hippocampal neurogenesis, pregnant Sprague-Dawley rats were provided a diet containing AFB1 at 0, 0.1, 0.3, or 1.0 ppm from gestational day 6 to day 21 after delivery on weani...


    pub_type: 杂志文章


    authors: Tanaka T,Mizukami S,Hasegawa-Baba Y,Onda N,Sugita-Konishi Y,Yoshida T,Shibutani M

    更新日期:2015-10-02 00:00:00

  • Sodium benzoate attenuates D-serine induced nephrotoxicity in the rat.

    abstract::D-Serine causes selective necrosis to the straight portion of the rat renal proximal tubules. The onset is rapid, occurring within 3-4 h and accompanied by proteinuria, glucosuria and aminoaciduria. The metabolism of D-serine by D-amino acid oxidase (D-AAO) may be involved in the mechanism of toxicity. D-AAO is locali...


    pub_type: 杂志文章


    authors: Williams RE,Lock EA

    更新日期:2005-02-01 00:00:00

  • Repeated exposure to butenolide vapour: subacute study in Syrian golden hamsters.

    abstract::The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, saliva...


    pub_type: 杂志文章


    authors: Feron VJ,Kruysse A,Immel HR,Til HP

    更新日期:1979-12-01 00:00:00

  • Lung injury induced by trichloroethylene.

    abstract::Trichloroethylene (TCE) produced bronchiolar damage when administered to mice. Administration of 2000 mg/kg caused injury in Clara cells of the bronchiolar epithelium, which was observed at 24 h following TCE treatment; increase of the dosage to 2500 mg/kg induced additionally, alterations in alveolar Type II cells of...


    pub_type: 杂志文章


    authors: Forkert PG,Sylvestre PL,Poland JS

    更新日期:1985-05-01 00:00:00

  • Acute cardiovascular toxicity of trazodone, etoperidone and imipramine in rats.

    abstract::The cardiovascular effects of trazodone, a broad-spectrum antidepressant and its analogue etoperidone, were compared with imipramine, following intravenous infusion in rats. Their effects on electrocardiogram and blood pressure were simultaneously recorded until cardiac arrest. Hypotension was the primary effect of tr...


    pub_type: 杂志文章


    authors: Lisciani R,Baldini A,Benedetti D,Campana A,Barcellona PS

    更新日期:1978-06-01 00:00:00

  • Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver.

    abstract::Phthalate esters belong to a large class of compounds known as peroxisome proliferators (PP). PP include chemicals that activate different subtypes of the peroxisome proliferator-activated receptor (PPAR) family. The ability of phthalate esters and their metabolites to activate responses through different PPAR subtype...


    pub_type: 杂志文章


    authors: Lapinskas PJ,Brown S,Leesnitzer LM,Blanchard S,Swanson C,Cattley RC,Corton JC

    更新日期:2005-02-01 00:00:00

  • Suspended particulate matter in indoor air: adjuvants and allergen carriers.

    abstract::The overall purpose of this study was to investigate how airborne house dust particles may contribute to an allergic immune response, and thereby also to asthma and other respiratory symptoms. The following aims were set: first, to quantify and characterize indoor suspended particulate matter (SPM) with regard to amou...


    pub_type: 杂志文章


    authors: Ormstad H

    更新日期:2000-11-02 00:00:00

  • Gut microbiota characterization and lipid metabolism disorder found in PCB77-treated female mice.

    abstract::Although the production of polychlorinated biphenyl 77 (PCB77) has already been banned globally, PCB77 is still used for a wide range of commercial purposes. Previous evidence has demonstrated that the PCB77 administration should be responsible for the gut microbiota variations and the host health risk. However, the h...


    pub_type: 杂志文章


    authors: Chi Y,Wang H,Lin Y,Lu Y,Huang Q,Ye G,Dong S

    更新日期:2019-05-15 00:00:00

  • Involvement of CaM-CaMKII-ERK in bisphenol A-induced Sertoli cell apoptosis.

    abstract::Bisphenol A (BPA), one of the most prevalent chemicals for daily use, has been reported as a xenoestrogen to induce reproductive toxicity, but its mechanism is poorly understood. In the present study, we aimed to explore whether CaM-CaMKII-ERK1/2 signaling pathway was involved in BPA-induced Sertoli cells injury via t...


    pub_type: 杂志文章


    authors: Qian W,Zhu J,Mao C,Liu J,Wang Y,Wang Q,Liu Y,Gao R,Xiao H,Wang J

    更新日期:2014-10-03 00:00:00

  • Cumene hydroperoxide-mediated lipid peroxidation in rat alveolar macrophages following induction of phospholipidosis with chlorphentermine.

    abstract::Rats were treated for 4 weeks with chlorphentermine hydrochloride (30 mg/kg, i.p., 5 days/seek), a regimen which causes a profound phospholipidosis in the alveolar macrophages (AMs). The susceptibility of these lipid-laden cells to lipid peroxidation was examined and compared to AMs from control (untreated) rats. Lipi...


    pub_type: 杂志文章


    authors: Reasor MJ

    更新日期:1980-01-01 00:00:00

  • Triorganotin-induced cytotoxicity to rat thymus, bone marrow and red blood cells as determined by several in vitro assays.

    abstract::To further investigate the immunotoxic effects of tri-n-propyltin chloride (TPTC), tri-n-butyltin chloride (TBTC) and triphenyltin chloride (TPhTC) several cytotoxicity tests with a series of trialkyltin chlorides and TPhTC were carried out, using isolated rat thymocytes as target cells. Thymocytes, cultured in a seru...


    pub_type: 杂志文章


    authors: Snoeij NJ,van Iersel AA,Penninks AH,Seinen W

    更新日期:1986-04-01 00:00:00

  • Time-course of toxicity of reactive sulfonamide metabolites.

    abstract::It has been suggested, on the basis of work in cell-free systems, that sulfonamide hydroxy-lamines are metabolized to nitroso metabolites which may be the proximate toxins mediating sulfonamide hypersensitivity reactions. We performed time-course experiments investigating the toxicity of the hydroxylamine and nitroso ...


    pub_type: 杂志文章


    authors: Rieder MJ,Krause R,Bird IA

    更新日期:1995-01-06 00:00:00

  • Exposure to tetrabromobisphenol A (TBBPA) in Wistar rats: neurobehavioral effects in offspring from a one-generation reproduction study.

    abstract::Within the framework of an EU project on risk assessment of brominated flame retardants, TBBPA was studied for neurobehavioral effects in rats. To permit benchmark dose analysis, eight dose levels were chosen ranging from 0 to 3000mg/kg body weight. Exposure of parental rats started 10 and 2 weeks before mating in mal...


    pub_type: 杂志文章


    authors: Lilienthal H,Verwer CM,van der Ven LT,Piersma AH,Vos JG

    更新日期:2008-04-03 00:00:00

  • Iodoacetic acid and related sulfhydryl reagents fail to inhibit cell-cell communication: mechanisms of immunotoxicity in vitro.

    abstract::The present study was undertaken to examine the effects of iodoacetic acid, a non-phorbol tumor promoter, on metabolic cooperation between mutant human fibroblasts as measured by [14C]citrulline incorporation. Other thiol-reactive polyphenolic compounds such as hydroquinone and 2-hydroxyestrone were also examined. 12-...


    pub_type: 杂志文章


    authors: Si EC,Pfeifer RW,Yim GK

    更新日期:1987-04-01 00:00:00

  • Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells.

    abstract::In an attempt to ameliorate the chemotherapy associated normal cell toxicity, in this study a known antioxidant, grape seed proanthocyanidin extract (GSPE) using Chang liver cells has been used. Chang liver cells were treated in vitro with idarubicin (Ida) (30 nM) and 4-hydroxyperoxycyclophosphamide (4-HC) (1 microg/m...


    pub_type: 杂志文章


    authors: Joshi SS,Kuszynski CA,Bagchi M,Bagchi D

    更新日期:2000-11-30 00:00:00

  • Territrems B and C metabolism in human liver microsomes: major role of CYP3A4 and CYP3A5.

    abstract::Human liver microsomes, supersomes from baculovirus-transformed insect cells expressing different human CYP450 isoforms, and control and CYP3A4 cDNA-transfected V79 Chinese hamster cells were tested for their ability to metabolize territrem B (TRB) and territrem C (TRC). Two TRB metabolites, designated MB(2) and MB(4)...


    pub_type: 杂志文章


    authors: Peng FC,Chang CC,Yang CY,Edwards RJ,Doehmer J

    更新日期:2006-02-01 00:00:00

  • Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus.

    abstract::In this study, some biochemical features and the extent of inhibition induced by the organophosphorous pesticide azinphos-methyl on the cholinesterase (ChE) activity present in whole soft tissue of two freshwater invertebrate species, the gastropod Biomphalaria glabrata and the oligochaete Lumbriculus variegatus were ...


    pub_type: 杂志文章


    authors: Kristoff G,Guerrero NV,de D'Angelo AM,Cochón AC

    更新日期:2006-05-15 00:00:00

  • Predictive drug allergy testing: an alternative viewpoint.

    abstract::T- and B-cells recognise drugs when bound as haptens to carrier molecules. Recent studies suggest that drugs might also bind in a non-covalent form to MHC-peptide complexes and T cell receptors, and are thereby able to stimulate T cells. This has, however, only been shown for drug-specific T cell clones. Functional an...


    pub_type: 杂志文章,评审


    authors: Pichler WJ

    更新日期:2001-02-02 00:00:00

  • Elucidation of the mechanism of atorvastatin-induced myopathy in a rat model.

    abstract::Myopathy is among the well documented and the most disturbing adverse effects of statins. The underlying mechanism is still unknown. Mitochondrial dysfunction related to coenzyme Q10 decline is one of the proposed theories. The present study aimed to investigate the mechanism of atorvastatin-induced myopathy in rats. ...


    pub_type: 杂志文章


    authors: El-Ganainy SO,El-Mallah A,Abdallah D,Khattab MM,Mohy El-Din MM,El-Khatib AS

    更新日期:2016-06-01 00:00:00

  • Possible participation of oxidative stress in causation of cell proliferation and in vivo mutagenicity in kidneys of gpt delta rats treated with potassium bromate.

    abstract::Clarifying the participation of oxidative stress among possible contributing factors in potassium bromate (KBrO(3))-induced carcinogenesis is of importance from the perspective of human health protection. In the present study, utilizing the antioxidative effects of alpha-tocopherol (alpha-TP) or sodium ascorbic acid (...


    pub_type: 杂志文章


    authors: Umemura T,Tasaki M,Kijima A,Okamura T,Inoue T,Ishii Y,Suzuki Y,Masui N,Nohmi T,Nishikawa A

    更新日期:2009-03-04 00:00:00

  • Benzene: a case study in parent chemical and metabolite interactions.

    abstract::Benzene, an important industrial solvent, is also present in unleaded gasoline and cigarette smoke. The hematotoxic effects of benzene in humans are well documented and include aplastic anemia and pancytopenia, and acute myelogenous leukemia. A combination of metabolites (hydroquinone and phenol for example) is appare...


    pub_type: 杂志文章


    authors: Medinsky MA,Kenyon EM,Schlosser PM

    更新日期:1995-12-28 00:00:00

  • Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals.

    abstract::We performed a reporter gene assay for ERalpha-mediated transcriptional activation and an immature rat uterotrophic assay of 23 chemicals, to study the relationship between these two assays and to examine the usefulness of the reporter gene assay. The chemicals analyzed in the study were as follows: benzophenone, bisp...


    pub_type: 杂志文章


    authors: Yamasaki K,Takeyoshi M,Yakabe Y,Sawaki M,Imatanaka N,Takatsuki M

    更新日期:2002-01-15 00:00:00

  • Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations.

    abstract::The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents. Understanding their interactions within the active site of phosphylated AChE is of great significance for the search for mo...


    pub_type: 杂志文章


    authors: Katalinić M,Šinko G,Maček Hrvat N,Zorbaz T,Bosak A,Kovarik Z

    更新日期:2018-08-01 00:00:00

  • The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat.

    abstract::Ammonium perfluorooctanoate (APFO) is a surfactant used primarily as an aid in processing various fluoropolymers. Many toxicology and epidemiological studies have been conducted with APFO; however, no specific information regarding functional reproduction was previously available. Therefore, the potential reproductive...


    pub_type: 杂志文章


    authors: Butenhoff JL,Kennedy GL Jr,Frame SR,O'Connor JC,York RG

    更新日期:2004-03-01 00:00:00

  • The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced nephrotoxicity in mice.

    abstract::The nitric oxide (NO) donor, O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), is metabolized by P450 enzymes to release NO in the liver and possibly other tissues. V-PYRRO/NO has been shown to be hepatoprotective, but little is known about its effect in the kidney, another organ rich in P450s. Thus...


    pub_type: 杂志文章


    authors: Li C,Liu J,Saavedra JE,Keefer LK,Waalkes MP

    更新日期:2003-08-01 00:00:00

  • CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy.

    abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is highly toxic in experimental animals, and is known to induce cytochrome P450 (CYP) gene expression. We investigated the effect of CYP1A1 and CYP1B1 variant genotypes and haplotypes on CYP1A1 and CYP1B1 mRNA expression and ethoxyresorufin-O-deethylase (EROD) activity in lym...


    pub_type: 杂志文章


    authors: Landi MT,Bergen AW,Baccarelli A,Patterson DG Jr,Grassman J,Ter-Minassian M,Mocarelli P,Caporaso N,Masten SA,Pesatori AC,Pittman GS,Bell DA

    更新日期:2005-02-14 00:00:00

  • Protective elevations of glutathione and metallothionein in cadmium-exposed mesangial cells.

    abstract::Exposure of cultured rat mesangial cells to CdCl2 caused a dose- and time-dependent increase in intracellular glutathione that was significant at 0.5 microM and maximal at 1 microM Cd2+. The effect depended on glutathione synthesis and was masked by inhibiting synthesis with buthionine sulfoximine. The cells responded...


    pub_type: 杂志文章


    authors: Chin TA,Templeton DM

    更新日期:1993-01-29 00:00:00

  • Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells.

    abstract::Cytochrome P450 (CYP) 2A13 is mainly expressed in the respiratory system and has the ability to metabolize aflatoxin B(1) (AFB(1)). However, the role of CYP2A13-mediated AFB(1) metabolism and its consequences in human lung epithelial cell is not clear. Therefore, the objectives of this study were to investigate the si...


    pub_type: 杂志文章


    authors: Yang XJ,Lu HY,Li ZY,Bian Q,Qiu LL,Li Z,Liu Q,Li J,Wang X,Wang SL

    更新日期:2012-10-28 00:00:00