Abstract：
:Deltamethrin, an alpha-cyano type II synthetic pyrethroid insecticide is used to control a wide range of insects on a variety of crops. Deltamethrin is reported to cause many adverse effects on non-target species. Deltamethrin is reported to cause DNA damage and micronuclei induction in human lymphocytes. It is highly toxic for other organisms such as aquatic invertebrates, fish and Daphnia. About the tumorigenic risk (both tumour initiating and promoting) associated with deltamethrin exposure, very few reports are available in literature. In the present set of investigations, deltamethrin has been evaluated for its tumorigenic and co-carcinogenic (tumour initiating and tumour promoting) potential following long term dermal exposure in Swiss albino mice. The results revealed that deltamethrin has only tumour initiating potential in both the sexes of Swiss albino mice, initiated with deltamethrin and promoted by standard tumour promoter, 12-O-tetra decanoyl phorbol-13-acetate (TPA). In the single dose initiated mice (deltamethrin 4 mg/kg body weight, once only), 44% males and 43% females developed benign skin tumours. A much higher incidence of tumorigenesis was recorded in multiple dose initiated animals (deltamethrin 4 mg/kg body weight, three times per week for 3 weeks), where 71% male and 75% female mice developed tumours at the site of application of deltamethrin. Deltamethrin exposure failed to show any tumour promoting and complete tumorigenic potential at all the three tested dose levels.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Shukla Y,Arora A,Singh Adoi
10.1016/s0300-483x(00)00416-9keywords:
subject
Has Abstractpub_date
2001-05-28 00:00:00pages
1-9issue
1eissn
0300-483Xissn
1879-3185pii
S0300483X00004169journal_volume
163pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Previously, we evaluated the effects of lactational exposure to a representative mixture of the six indicator non-dioxin-like polychlorinated biphenyls (∑6 NDL-PCBs) at low levels on the neurobiological changes and developmental/behavioral performances in mice. In this study, we analyzed the global gene expression pro...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.12.011
更新日期：2015-02-03 00:00:00
abstract：:Extract and fractions of city smog collected from a heavy industrialized area caused in vitro dose-dependent reduction of cell survival of mouse macrophages and a growth inhibition of human fetal diploid lung fibroblasts. Great differences were observed in both cell systems between the total extract and its different ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90091-8
更新日期：1980-01-01 00:00:00
abstract：:Organochalcogens are important intermediates and useful reagents in organic synthesis, which can increase human exposure risk to these chemicals in the workplace. As well, there are a number of reported cases of acute toxicity following organochalcogen ingestion of vitamins and dietary supplements. Since, the erythroc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(03)00250-6
更新日期：2003-09-30 00:00:00
abstract：:Injection of insulin into mice and rabbit has been reported to convert the latent form of phosphoglucomutase (E X Zn) to an active form (E X Mg) without any net increase in the protein associated with this enzyme (Hashimoto et al., Biochem. Biophys. Res. Commun., 27 (1967) 369 and Peck et al., J. Biol. Chem. 242 (1971...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90050-2
更新日期：1985-08-01 00:00:00
abstract：:Numerous dietary compounds, ubiquitous in fruits, vegetables and spices have been isolated and evaluated during recent years for their therapeutic potential. These compounds include flavonoid and non-flavonoid polyphenols, which describe beneficial effects against a variety of ailments. The notion that these plant pro...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2009.11.008
更新日期：2010-11-28 00:00:00
abstract：:Young adult male and female Wistar rats were inhalationally exposed head-only for 1 or 4 h to different anticholinesterase aerosols. The compounds tested were dichlorvos, fenamiphos, methamidophos, parathion, a pyrimidine thiophosphate and the carbamate propoxur. These compounds are direct or indirect inhibitors of ch...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(87)90126-0
更新日期：1987-10-30 00:00:00
abstract：:A recent epidemiological study showed an increased risk for bone fractures after chronic low-level cadmium exposure. This finding agrees with those of cadmium accumulation in rat bones after chronic oral exposure which reduced the mechanical strength of the bones. There are indications that ossicular cadmium uptake ma...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00364-4
更新日期：2001-02-21 00:00:00
abstract：:Methoxy-, ethoxy- and n-butoxy acetic acids, known urinary metabolites of the corresponding alkoxyethanol solvents, were administered by gavage to rats as a single oral dose equimolar with 500, 250 or 100 mg 2-methoxyethanol/kg body weight. Testicular weight and morphology were monitored over a 14-day period post-trea...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(87)90071-0
更新日期：1987-01-01 00:00:00
abstract：:Acrylonitrile (AN) is widely used in the manufacturing of fibers, plastics and pharmaceuticals. Free radical-mediated lipid peroxidation is implicated in the toxicity of AN. The present study was designed to examine the ability of curcumin, a natural polyphenolic compound, to attenuate acute AN-induced lipid peroxidat...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.11.001
更新日期：2010-01-12 00:00:00
abstract：:Hydrogen sulfide (H2S) as the third gasotransmitter molecule serves various biological regulatory roles in health and disease. Acrylonitrile (AN) is a common occupational toxicant and environmental pollutant, causing brain and liver damage in mammals. The biotransformation of AN is dependent-upon reduced glutathione (...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2021.152685
更新日期：2021-01-21 00:00:00
abstract：:Troglitazone is a thiazolidinedione antidiabetic agent with insulin-sensitizing activities that was withdrawn from the market in 2000 due to its association with idiosyncratic hepatotoxicity. To address the suspected autoantibody production associated with troglitazone, we investigated autoantibodies in sera from pati...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.07.012
更新日期：2005-12-01 00:00:00
abstract：:Antimony compounds are widely used in various manufacturing and semiconducting industries. Previously, it has been shown that antimony trichloride (SbCl3) elevates sister chromatid exchange (SCE) rates in V79 cells after a 28-h incubation. However, only limited data on its genotoxic effects are available so far. The p...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00073-0
更新日期：1998-08-21 00:00:00
abstract：:Spores of actinomycetes, mesophilic gram-positive bacteria, isolated from moldy houses, induced the expression of inducible NO-synthase (iNOS) with a subsequent NO-production in RAW264.7 macrophages. No differences were detected between production of nitric oxide (NO) by alive or irradiated spores of different strains...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)00141-8
更新日期：1997-12-26 00:00:00
abstract：:Paraquat, a quarternary nitrogen herbicide, is a highly toxic compound for humans and animals and many cases of acute poisoning and death have been reported over the past few decades. The mechanisms of paraquat toxicity involve: the generation of the superoxide anion, which can lead to the formation of more toxic reac...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(02)00382-7
更新日期：2002-10-30 00:00:00
abstract：:When Xenopus laevis embryos were treated with fenitrothion, a substantial proportion failed to survive to hatching only when the concentration approached saturation. However, after exposure to 10 ppm of fenitrothion, most were abnormal and did not survive past feeding stage. Different embryonic stages were not equally...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90026-3
更新日期：1981-01-01 00:00:00
abstract：:Measurement of lymphocyte proliferation to detect hypersensitivity to beryllium (Be-LPT) in vitro is done presently using a method based on tritiated thymidine incorporation. Although this method is sensitive it gives no information on cell viability or responding lymphocyte subsets. We have developed reliable and sim...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00167-5
更新日期：2000-02-21 00:00:00
abstract：:The mean concentrations of polybrominated diphenyl ethers (PBDEs) (sum tetra- to octaBDEs) were determined in samples of foodstuffs widely consumed by the population of Catalonia, Northeast Spain. The following six tetra-through heptabrominated congeners were also individually analyzed: PBDEs 47, 99, 100, 153, 154 and...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2008.03.006
更新日期：2008-06-03 00:00:00
abstract：:Renal markers were investigated over 96 h in male Sprague-Dawley rats after i.v. administration of 10.7 mg kg(-1) of digoxin-specific Fab fragments (DSFab). The dose was calculated by an allometric equation as equivalent to a high clinical dose. DSFab both alone and pre-incubated with digoxin were tested. None of the ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00022-5
更新日期：1998-04-03 00:00:00
abstract：:Leflunomide, used for the treatment of rheumatoid arthritis, has been reported to cause severe liver problems and liver failure; however, the underlying mechanisms are not clear. In this study, we used multiple approaches including genomic analysis to investigate and characterize the possible molecular mechanisms of t...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2017.10.002
更新日期：2017-12-01 00:00:00
abstract：:To investigate whether sensitivity to the induction of micronuclei by acetaldehyde is associated with genetic polymorphisms of the aldehyde dehydrogenase-2 (ALDH2) gene, cytokinesis-block micronucleus (CBMN) assays were performed on peripheral lymphocytes from 47 healthy human subjects exposed to acetaldehyde in vitro...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.01.016
更新日期：2005-06-01 00:00:00
abstract：:Adrenocortical carcinoma (ACC) is an extremely rare and aggressive endocrine malignancy with a poor prognosis. The most common symptom of ACC is hypercortisolism (Cushing's syndrome), which has the highest mortality. Mitotane is used as a steroidogenesis inhibitor for Cushing's syndrome or as a chemical adrenalectomy ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.04.007
更新日期：2012-08-16 00:00:00
abstract：:Sodium fluoride (NaF) is widely used for the treatment of dental caries and dentin hypersensitivity. However, its pro-apoptotic effect on odontoblasts may lead to harmful side-effects. The purpose of this study was to evaluate the pro-apoptotic effects of NaF in odontoblasts and elucidate the possible underlying molec...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.03.016
更新日期：2013-06-07 00:00:00
abstract：:Ochratoxin A (OCT A) has the potential to cause myelotoxicity in addition to the well-known toxic effects on the liver and kidney. Whereas in previous studies the bone marrow parameters were examined shortly after injection, experiments reported here were designed to determine whether mice would recover from the myelo...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90236-3
更新日期：1988-12-16 00:00:00
abstract：:Carbon monoxide (CO) is a dangerous exogenous poison and an essential endogenous neurotransmitter. This gas when inhaled has an anaesthetic effect, which is poorly understood, but which may be fatal if compensatory mechanisms are exhausted, if cardiac oxygen (O(2)) needs exceed myocardial oxygenation and/or if apnoea ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(03)00005-2
更新日期：2003-05-01 00:00:00
abstract：:The organophosphorus nerve agent soman is an irreversible cholinesterase (ChE) inhibitor that can produce long-lasting seizures and seizure-related brain damage (SRBD) in which acetylcholine and glutamate are involved. Since these neurotransmitters play a key-role in the auditory function, it was hypothesized that a h...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2010.08.014
更新日期：2010-11-09 00:00:00
abstract：:Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This ...
journal_title：Toxicology
pub_type：
doi：10.1016/j.tox.2020.152421
更新日期：2020-04-30 00:00:00
abstract：:We have found that incubation of heparin plasma with Ni(2+) or Co(2+) at concentrations below 100 microM can stimulate the conversion of complement factor C3 to C3b faster than magnesium, which is the natural cofactor in the alternative complement activation. This conversion was monitored by light absorbance measureme...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00590-5
更新日期：2003-03-14 00:00:00
abstract：:Extracts from the leaves of Ginkgo biloba L. belong to the most widely used phytopharmaceuticals. In crude Ginkgo extracts, ginkgolic acids (GA) and related alkylphenols (e.g. cardanols and cardols) have been recognized as hazardous compounds with suspected cytotoxic, allergenic, mutagenic and carcinogenic properties....
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00189-0
更新日期：2002-08-15 00:00:00
abstract：:Rats were treated for 4 weeks with chlorphentermine hydrochloride (30 mg/kg, i.p., 5 days/seek), a regimen which causes a profound phospholipidosis in the alveolar macrophages (AMs). The susceptibility of these lipid-laden cells to lipid peroxidation was examined and compared to AMs from control (untreated) rats. Lipi...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90078-5
更新日期：1980-01-01 00:00:00
abstract：:Multidrug resistance type 1 P-glycoproteins (P-gp) and multidrug resistance associated proteins (MRP) were studied in differentiated primary human lung cells in culture, in comparison with permanent human lung cell lines and primary alveolar type II cells from rat lung. AII cells exhibited low basal levels of mdr1b mR...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00458-9
更新日期：2001-10-05 00:00:00
