Abstract：
:To investigate whether sensitivity to the induction of micronuclei by acetaldehyde is associated with genetic polymorphisms of the aldehyde dehydrogenase-2 (ALDH2) gene, cytokinesis-block micronucleus (CBMN) assays were performed on peripheral lymphocytes from 47 healthy human subjects exposed to acetaldehyde in vitro. Facial flushing following alcohol intake was analyzed to determine if it was correlated with ALDH2 gene polymorphisms. The frequencies of the ALDH2 genotypes ALDH2(1)/ALDH2(1), ALDH2(1)/ALDH2(2), and ALDH2(2)/ALDH2(2) were 66.0, 27.7, and 6.4%, respectively, in the 47 subjects. Therefore, 34% of the studied subjects carried the mutant allele ALDH2(2), which is associated with the lack of enzyme activity. The frequency of micronuclei induced by acetaldehyde increased in a dose-dependent manner with the largest increase seen in subjects that were homozygous for the ALDH2(2) allele. A significant association was observed between the ALDH2 genotype and alcohol-induced facial flushing. Average alcohol consumption of the study subjects was also associated with the ALDH2 genotype. The frequency of heavy drinking was significantly higher among subjects with the ALDH2(1)/ALDH2(1) genotype than among subjects with the ALDH2(2) allele (ALDH2(1)/ALDH2(2) and ALDH2(2)/ALDH2(2) genotypes). Alcohol-induced facial flushing was also associated with an increased frequency of micronuclei in lymphocytes treated with acetaldehyde. The results suggest that the ALDH2 genotype is significantly associated with acetaldehyde-induced micronuclei and alcohol-induced facial flushing.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Kim JS,Kim YJ,Kim TY,Song JY,Cho YH,Park YC,Chung HWdoi
10.1016/j.tox.2005.01.016keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
169-74issue
2-3eissn
0300-483Xissn
1879-3185pii
S0300-483X(05)00085-5journal_volume
210pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:A major goal in modern pharmacotechnology is to increase the therapeutic index of drugs by using nanoparticulate vehicle systems in order to ensure slow release or targeted delivery of drugs. With all great benefits, however, these innovative therapies can carry a risk for acute immune toxicity manifested in hypersens...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2005.07.023
更新日期：2005-12-15 00:00:00
abstract：:Double-stranded RNA-dependent protein kinase (PKR) is a component of signal transduction pathways mediating various stress signals including oxidative stress and endoplasmic reticulum (ER) stress and is suggested to be implicated in several neurodegenerative diseases. Cell death in neurodegenerative conditions has bee...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2019.02.012
更新日期：2019-04-15 00:00:00
abstract：:It has been suggested that the measurement of DNA-protein cross-links (DPCs) may be of value in the assessment of an individual's exposure to specific environmental insults. For a biomarker to be reliable, its results should be consistent and specific. In the present study, the precision and specificity of the K(+)-SD...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(96)03318-5
更新日期：1996-06-17 00:00:00
abstract：:Thimerosal (TH), an ethylmercury complex of thiosalicylic acid has been used as preservative in vaccines. In vitro neurotoxicity of TH at high nM concentrations has been reported. Although a number of toxicological experiments demonstrated high affinity of mercury to thiol groups of the extracellular amino acids and p...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2010.07.023
更新日期：2010-10-29 00:00:00
abstract：:Bisphenol A has been shown to affect the reproduction of male rats and mice. However, the mechanism of action of bisphenol A on the epididymal sperm is not elucidated. The present study was undertaken to evaluate the effect of bisphenol A on the antioxidant system of rat epididymal sperm. Bisphenol A was administered ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00597-8
更新日期：2003-03-14 00:00:00
abstract：:Mature rats were dosed with T3 by different routes and dose-levels at either 0.1 mg/kg for 14 days s.c. (Group A), 1 mg/kg for 3 alternative days i.p. (Group B), 5 mg/kg for 14 days p.o. (Group C), or with propylthiouracil (PTU 50 mg/day for 14 days p.o.-Group D). Measurement of cerebellar and striatal NA+,K+-ATPase a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(87)90075-8
更新日期：1987-01-01 00:00:00
abstract：:Trichloroacetic acid, TCA, is a water chlorination by-product similar to dichloroacetic acid, DCA. Because DCA has been shown to have effects on intermediary metabolism, TCA was tested to determine if it possesses similar capabilities. The effects were more pronounced in females. High doses of TCA (2.45 mumol/kg three...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90069-s
更新日期：1990-07-01 00:00:00
abstract：:Inorganic arsenic (iAs), a ubiquitous element and a natural drinking water contaminant, has been found to impair male reproductive function. However, the effect of long-term exposure to arsenic on testis damage and its underlying mechanisms still require further evaluation. In the study, male C57BL/6 mice (4 weeks) we...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2018.09.010
更新日期：2019-01-01 00:00:00
abstract：:In the current study, we used pathway-specific cDNA arrays to detect the transcriptional signature induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in vivo by studying simultaneously the expression profiles of 83 genes involved in apoptosis, cytokine production and angiogenesis. To this end, C57BL/6 mice were inj...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00230-5
更新日期：2002-09-16 00:00:00
abstract：:Exposure to low-dose benzene may lead to hematotoxicity and cause health problems. Though peripheral blood cell count is widely used in benzene exposure assessment and health risk assessment, the reports regarding the effects of low-dose benzene exposure on blood cell count remain inconsistent. To uncover more sensiti...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2018.09.004
更新日期：2018-12-01 00:00:00
abstract：:The objective of this study was to further evaluate the developmental toxicity of tributyltin chloride (TBTCl) in rats. Pregnant rats were given TBTCl by gastric intubation at a dose of 25, 50 or 100 mg/kg on days 7-9, days 10-12 or days 13-15 of pregnancy. A significant increase in the incidence of post-implantation ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)02920-p
更新日期：1995-02-27 00:00:00
abstract：OBJECTIVES:Infusion phlebitis is a common clinical problem associated with some antimicrobial agents. The pathomechanism of infusion phlebitis has not yet been elucidated, however, it has been proposed that chemical irritation of the endothelium leads to subsequent sterile inflammation with recruitment and migration of...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.09.014
更新日期：2006-01-20 00:00:00
abstract：:Inhibition of fungal lanosterol-14 alpha-demethylase (CYP51) is the working principle of the antifungal activity of azoles used in agriculture and medicine. Inhibition of human CYP51 may result in endocrine disruption since follicular fluid-meiosis activating steroid (FF-MAS), the direct product of lanosterol demethyl...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.08.007
更新日期：2006-11-10 00:00:00
abstract：:Rats were treated with a single dose of thallium acetate (32 mg/kg i.p.) and the antidotal effect of D-penicillamine and prussian blue given alone or in combination was assessed by means of evaluation of the thallium-induced cerebellar histological lesions. After thallium poisoning (24 h), antidotes were administered ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90129-5
更新日期：1994-03-25 00:00:00
abstract：:Epidemiological studies have implicated fine particulate matter (PM2.5) as a risk factor for neurodegenerative diseases and neurodevelopmental disorders. However, the underlying molecular mechanisms and the influences of different components remain largely elusive. Here, we extended our previous work to investigate th...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2017.01.017
更新日期：2017-04-01 00:00:00
abstract：:Envenoming by the pitviper Bothrops jararacussu produces cardiovascular alterations, including coagulopathy, systemic hemorrhage, hypotension, circulatory shock and renal failure. In this work, we examined the activity of this venom in rat isolated right atria. Incubation with venom (0.025, 0.05, 0.1 and 0.2mg/ml) cau...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.06.010
更新日期：2014-09-02 00:00:00
abstract：:There are reports of alterations in the number and functions of the cells of the immune system in patients with metal-on-metal (MOM) orthopaedic implants. These effects have been correlated with elevated chromium levels in the patients' blood. We have investigated the interactions of clinically relevant concentrations...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.04.002
更新日期：2007-07-01 00:00:00
abstract：:Oral administration of sodium pyridinethione together with 63Ni2+, 109Cd2+ or 65Zn2+ to non-pregnant mice resulted in very markedly increased levels of the metals in several tissues in comparison with animals given the metals alone. For 63Ni2+ the sodium pyridinethione induced a strong labelling of the pancreatic isle...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90148-4
更新日期：1986-03-01 00:00:00
abstract：:The free radical scavenging activities and inhibitory effect of lipid peroxidation of a delphinidin derivative in eggplant were investigated. Delphinidin-3-(p-coumaroylrutinoside)-5-glucoside (nasunin), an anthocyanin, was isolated as purple colored crystals from eggplant peels. Using electron spin resonance spectrome...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00202-x
更新日期：2000-08-07 00:00:00
abstract：:Cetaben and clofibrate were each administered to groups of 6 rats (3 male and 3 female) by gavage at dosages of 50 mg/kg per day and 200 mg/kg per day for 2 weeks. Cetaben caused 1 death at 200 mg/kg per day and decreases in body weight gain and food consumption at 50 mg/kg per day or more. There were no effects on bo...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(83)90004-5
更新日期：1983-11-01 00:00:00
abstract：:Consequences of exposure of rats for 2 days or less to O3 at various concentrations between 0.12 and 0.96 ppm were measured using several assays performed on bronchoalveolar lavage fluid. Changes in apparent lung permeability were assessed by measurement of recovery of labelled bovine serum albumin in lung lavage flui...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90074-0
更新日期：1986-08-01 00:00:00
abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dioxin-like compounds (DLC) as well as some drugs and endogenous tryptophan metabolites. Short-term activation of AhR can lead to hepatocellular s...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.07.005
更新日期：2015-10-02 00:00:00
abstract：:The mechanism underlying the induction of micronuclei induced by rifampicin and nicotine in mouse bone marrow was investigated by fluorescence in situ hybridization assay using mouse minor satellite DNA probe. Colchicine and mitomycin, known to be predominantly clastogenic and aneugenic, respectively were used as posi...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.03.011
更新日期：2007-06-03 00:00:00
abstract：:Malthion, DDT, kelthane and their mixture (3 : 10 : 5) were applied to pear fruits at the rate recommended by the Ministry of Agriculture. The rate of disappearance of their residues on pear fruits was investigated under refrigerated conditions (2 +/- 1 degree and 47% relative humidity (RH)). The same insecticides wer...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(75)90094-3
更新日期：1975-05-01 00:00:00
abstract：:Ozone (O3), a pulmonary irritant, and a major toxic component of photochemical smog, is capable of inducing pulmonary inflammation characterized by recruitment of polymorphonuclear leukocytes (PMNs) into the lung. The recruited PMNs, in turn, can release toxic mediators and produce lung injury. The mechanism of ozone-...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00024-9
更新日期：1998-05-15 00:00:00
abstract：:V79 Chinese hamster cells are being genetically engineered for stable expression of cytochromes P450 using a SV40 early promoter containing plasmid as the eukaryotic expression vector. V79 cells lack endogenous cytochrome P450 activity. Therefore, genetically engineered V79 cell lines are defined for the cytochrome P4...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(93)90063-x
更新日期：1993-10-05 00:00:00
abstract：:Bisphenol A (BPA), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. Exposure-related reproductive disorders have been found, but recently it has also been suggested that BPA may be involved in obesity, diabetes, myocardial hypertroph...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.02.007
更新日期：2016-03-10 00:00:00
abstract：:Ochratoxin A (OTA) is a mycotoxin produced by several fungi which grow on human food source material. Consumption of OTA is almost unavoidable. The consumption leads to low but detectable amounts of OTA in human blood. Risk assessment of OTA is based on studies performed either in animals or cultured cells. So far, ma...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.12.008
更新日期：2007-03-22 00:00:00
abstract：:As a new method, support vector machine (SVM) were applied for prediction of toxicity of different data sets compared with other two common methods, multiple linear regression (MLR) and RBFNN. Quantitative structure-activity relationships (QSAR) models based on calculated molecular descriptors have been clearly establ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.08.019
更新日期：2006-01-16 00:00:00
abstract：:(1) Following the administration of the highly toxic agent 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to pregnant mice, exceedingly low concentrations of this substance were found in the embryo and fetus between gestational days 11 and 18 (between 0.04 and 0.14% of the maternal dose/g tissue). (2) Tissue levels of tCD...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90037-8
更新日期：1981-01-01 00:00:00
