Abstract:
:There are reports of alterations in the number and functions of the cells of the immune system in patients with metal-on-metal (MOM) orthopaedic implants. These effects have been correlated with elevated chromium levels in the patients' blood. We have investigated the interactions of clinically relevant concentrations of Cr VI with macrophages in vitro, and the mechanisms responsible for its toxicity. Cr VI causes a concentration dependent decrease in macrophage viability above 1 microM as measured by the MTT and Neutral Red assays. This falls well within the range of circulating chromium serum concentrations measured in patients with MOM. Intracellular reduced glutathione (GSH) levels fall as a result, and most of the loss (86%) is accounted for by oxidation to the dimer, GSSG. Prior depletion of GSH does not sensitise the cells to Cr VI toxicity, implying that it is not involved in protecting the cells against the effects of Cr VI. During the metabolism of Cr VI, glutathione reductase activity is inhibited. In contrast, the activities of catalase and superoxide dismutase are not significantly altered. Prior inhibition of glutathione reductase activity protects against the toxicity of Cr VI to a significant extent, suggesting that it reduces Cr VI to a toxic metabolite.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Lalaouni A,Henderson C,Kupper C,Grant MHdoi
10.1016/j.tox.2007.04.002subject
Has Abstractpub_date
2007-07-01 00:00:00pages
76-81issue
1-2eissn
0300-483Xissn
1879-3185pii
S0300-483X(07)00211-9journal_volume
236pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Challenges to improve toxicological risk assessment to meet the demands of the EU chemical's legislation, REACH, and the EU 7th Amendment of the Cosmetics Directive have accelerated the development of non-animal based methods. Unfortunately, uncertainties remain surrounding the power of alternative methods such as in ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2013.08.012
更新日期:2015-06-05 00:00:00
abstract::Short term exposure of cultured chick ganglia nerve fibers and neuroglia to selenite produced half maximal inhibitory growth effects in concentrations of 6.2 (2.9--13.0) X 10(-5) M and 1.1 (0.7--1.7) X 10(-4) M, respectively. Complete inhibition of growth for both cell types was apparent at 1 X 10(-3) M, while slight ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(78)90041-0
更新日期:1978-02-01 00:00:00
abstract::The toxicity of daily subcutaneously applied 500 mg/kg N-methylformamide (NMF) during a period of 8 days in female CD-mice was ameliorated when 100 mg/kg sodium ascorbate, 60 mg/kg menadione bisulfite or 80 mg/kg pyridoxal hydrochloride were applied simultaneously. The comparison of the daily s.c. application of 360 m...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90008-4
更新日期:1987-02-01 00:00:00
abstract::Following carbon tetrachloride-induced liver injury, hepatotrophic factors are synthesized and released into the serum to facilitate the regeneration of damaged hepatic tissue. We investigated the possibility that immunosuppression could be mediated through induction of a serum factor(s) because in vivo exposure of B6...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90083-5
更新日期:1993-12-15 00:00:00
abstract::Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showe...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90137-5
更新日期:1987-10-12 00:00:00
abstract::The term "health/functional food" (HFF) refers to food supplements containing nutrients or other substances (in a concentrated form) that have a nutritional or physiological effect whose purpose is to supplement the normal diet. The Korean Health/Functional Food Act that came into effect in 2004 requires these product...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.01.016
更新日期:2006-04-03 00:00:00
abstract:OBJECTIVE:This study was designed to investigate whether the mice treated with triptolide (TP) could disrupt the liver immune homeostasis, resulting in the inability of the liver to eliminate the harmful response induced by lipopolysaccharide (LPS). In addition, we explored whether apoptosis and necroptosis played a cr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.01.005
更新日期:2019-02-15 00:00:00
abstract::The immunohistochemical localization of G alpha q/G alpha 11 was studied in the olfactory neuroepithelium of the channel catfish. Antigenicity in the rosette was found at the apical surfaces of cells, within the apical neck regions of some cells, and within the area of the basal nerve tracts. Specific labeling was eli...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03558-5
更新日期:1997-02-28 00:00:00
abstract::The nonsteroidal anti-inflammatory drug (NSAID) diclofenac (DF) is associated with idiosyncratic hepatotoxicity and several other distinct hypersensitivity reactions. The mechanism(s) are unknown but evidence suggests both cell-mediated and antibody-mediated immune effector systems may be involved. In the present stud...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00008-2
更新日期:2002-04-02 00:00:00
abstract::The effect of tert-butyl hydroperoxide (tBH) on the nucleotide level in isolated cardiomyocytes from adult rats was examined. Incubation of myocytes with the hydroperoxide resulted in loss of both ATP and NAD from mitochondria and cytosol. In contrast, only the cytosolic level of NADP was increased. The effect on myoc...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03158-c
更新日期:1996-01-08 00:00:00
abstract::Chlorpyrifos (CPF) has been widely used around the world as a pesticide for both agricultural and residential application. Although various studies have reported toxicity and health-related effects from CPF exposure, the molecular mechanism of CPF toxicity to skin has not been well-characterized. The present study det...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2015.09.006
更新日期:2015-12-02 00:00:00
abstract::Novel substituted phenoxyalkyl pyridinium oximes, previously shown to reactivate brain cholinesterase in rats treated with high sublethal dosages of surrogates of sarin and VX, were tested for their ability to prevent mortality from lethal doses of these two surrogates. Rats were treated subcutaneously with 0.6mg/kg n...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2015.12.001
更新日期:2016-01-02 00:00:00
abstract::Incubation of rat platelets with organotins inhibited their capacity to take up 5-hydroxytryptamine-14C (5-HT-14C) and stimulated the release of preloaded 5-HT-14C as well as endogenous 5-HT. Similar but less pronounced effects also were observed when platelets from rats treated intraperitoneally with organotins were ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90037-9
更新日期:1983-12-01 00:00:00
abstract::Chalcones are phenolic compounds that can be isolated from plants. Previous studies have described some pharmacological applications for these compounds. Making use of our established reporter gene system, we determined the effect of five hydroxychalcones--2-hydroxychalcone, 2'-hydroxychalcone, 4-hydroxychalcone, 4,2'...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.10.005
更新日期:2005-02-14 00:00:00
abstract::The effects of cadmium on some mitochondrial enzymes of kidney, testis and lung were investigated in male rats. Rats were injected intraperitoneally with 3 mg Cd/kg body weight and its effects were studied 24, 72 and 144 h later. Succinic dehydrogenase and cytochrome c oxidase activities were significantly inhibited i...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(83)90077-x
更新日期:1983-05-01 00:00:00
abstract::To elucidate the maternal exposure effects of aflatoxin B1 (AFB1) and its metabolite aflatoxin M1, which is transferred into milk, on postnatal hippocampal neurogenesis, pregnant Sprague-Dawley rats were provided a diet containing AFB1 at 0, 0.1, 0.3, or 1.0 ppm from gestational day 6 to day 21 after delivery on weani...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2015.08.001
更新日期:2015-10-02 00:00:00
abstract::Heavy metal neurotoxicity is one of the major challenges in today's era due to the large scale and widespread mechanisation of the production. However, the causative factors responsible for neurotoxicity are neither known nor do we have the availability of therapeutic approaches to deal with it. One of the major causa...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152542
更新日期:2020-09-01 00:00:00
abstract::In 1975, in cooperation with 8 County Hygienic Stations, total mercury content in fish from rivers and lakes in Hungary was measured. The mercury content in fish muscle-tissue from 164 fish samples averaged 0.36 mg/kg. Average levels in different fish species ranged from 0.10 to 0.57 mg/kg. The amount of mercury in fi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(77)90052-x
更新日期:1977-06-01 00:00:00
abstract::This paper presents an overview of issues related to surface water contamination arising from uranium mining activities in the Alligator Rivers Region (ARR) of northern Australia, and a program of research and monitoring that must assess the potential and actual effects on ecosystem and human health. The program of as...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(02)00470-5
更新日期:2002-12-27 00:00:00
abstract::Many studies have demonstrated that polycyclic aromatic hydrocarbons adversely affect mature mammalian immune systems. However, little is known about the cellular mechanism(s) mediating this immunosuppression or the potential for these ubiquitous environmental chemicals to similarly compromise lymphocyte development (...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90103-l
更新日期:1992-01-01 00:00:00
abstract::The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dioxin-like compounds (DLC) as well as some drugs and endogenous tryptophan metabolites. Short-term activation of AhR can lead to hepatocellular s...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2015.07.005
更新日期:2015-10-02 00:00:00
abstract::Bisphenol A (BPA) is a commonly used endocrine-disrupting chemical used as a component of polycarbonates plastics that has potential adverse effects on human health. Exposure to BPA during development has been implicated in memory deficits, but the mechanism of action underlying the effect is not fully understood. In ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.01.010
更新日期:2016-02-03 00:00:00
abstract::Glutathione S-transferases (GSTs) are important as drug metabolizing enzymes mainly in the detoxication process. To assess individual differences in susceptibility to different chemicals, it would be useful to know the activity of specific GST isozymes in individuals. In order to study individual variability, typical ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90120-1
更新日期:1994-03-11 00:00:00
abstract::In this study, we examined the relationship between maternal weight gain deficits induced by protein-and-energy restriction (PER) and pregnancy outcome. We also evaluated whether PER would potentiate the developmental toxicity of cyclophosphamide (CP) and hydroxyurea (HU). Two independent experiments--employing two di...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00373-6
更新日期:2002-09-30 00:00:00
abstract::We determined the threshold concentration of sarin vapor exposure producing miosis in African green monkeys (Chlorocebus aethiops). Monkeys (n=8) were exposed to a single concentration of sarin (0.069-0.701mg/m3) for 10min. Changes in pupil size were measured from photographs taken before and after the exposure. Sarin...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.11.004
更新日期:2008-02-28 00:00:00
abstract::The cytochrome P-450 enzymes are responsible for the oxidation of xenobiotic chemicals including drugs, pesticides, and carcinogens. These enzymes include cytochrome P450, cytochrome b(5), arylhydrocarbon (benzo[a]pyrene) hydroxylase (AHH), NADPH-cytochrome C reductase and dimethylnitrosamine N-demethylase I (DMN-dI)....
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00473-5
更新日期:2001-12-14 00:00:00
abstract::Simultaneous exposure to cadmium and arsenic is highly probable in the urban area of San Luis Potosi, Mexico due to common localization of copper and zinc smelters. Therefore, in this work, rats were intraperitoneally exposed either to cadmium or arsenic alone, or simultaneously to both metals. The effects of these tr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90135-4
更新日期:1990-11-01 00:00:00
abstract::Resistance to chemotherapy is a major obstacle for the effective treatment of cancers. The mechanism of chemo-resistance is still poorly understood, however, mounting evidence supports a role for microRNAs (miRNAs) in modulating key cellular pathways mediating response to chemotherapy. microRNA-21 (miR-21) has been im...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2013.02.014
更新日期:2013-04-05 00:00:00
abstract::Butachlor is a systemic herbicide widely applied on rice, tea, wheat, beans and other crops; however, it concurrently exerts toxic effects on beneficial organisms like earthworms, aquatic invertebrates and other non-target animals including humans. Owing to the associated risk to humans, this chloroacetanilide class o...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2012.07.014
更新日期:2012-12-08 00:00:00
abstract::Aluminium has been implicated in various neurodegenerative diseases but exact mechanism of action is still not known. Mitochondria being a major site of reactive oxygen species production are considered to be target of oxidative stress and it seems that the oxidative damage to mitochondrial proteins may underlie the p...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.10.009
更新日期:2009-01-31 00:00:00