Abstract:
:Cetaben and clofibrate were each administered to groups of 6 rats (3 male and 3 female) by gavage at dosages of 50 mg/kg per day and 200 mg/kg per day for 2 weeks. Cetaben caused 1 death at 200 mg/kg per day and decreases in body weight gain and food consumption at 50 mg/kg per day or more. There were no effects on body weight or food consumption in the clofibrate-treated groups. At 200 mg/kg per day cetaben and clofibrate induced comparable increases in liver weight and in numbers of liver peroxisomes while cetaben caused increases in liver catalase activity as well.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Fort FL,Stein HH,Langenberg K,Lewkowski JP,Heyman IA,Kesterson JWdoi
10.1016/0300-483x(83)90004-5subject
Has Abstractpub_date
1983-11-01 00:00:00pages
305-11issue
4eissn
0300-483Xissn
1879-3185pii
0300-483X(83)90004-5journal_volume
28pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Evidence from epidemiological studies indicates that acute exposure to airborne pollutants is associated with an increased risk of morbidity and mortality attributed to cardiovascular diseases. The present study investigated the effects of combustion-derived ultrafine particles (diesel exhaust particles) as well as en...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.08.018
更新日期:2008-11-20 00:00:00
abstract::We examined the effect of repeated ozone exposure on the respiratory system in mice, sensitized with ovalbumin (OA). OA-sensitized mice and saline-treated control mice were exposed to 1.0 ppm ozone or clean air for 6 h daily and five days weekly for five weeks. Subsequently, these mice were exposed to 1.0 ppm ozone fo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.06.047
更新日期:2004-11-01 00:00:00
abstract::LoVo adenocarcinoma cells are fairly sensitive to cytostatic drugs, e.g. doxorubicin, but can develop drug resistance by expression of a P-glycoprotein-mediated MDR1 phenotype. LoVo cells respond with apoptosis to nanomolar concentrations of okadaic acid and micromolar concentrations of cantharidic acid. Interestingly...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00017-7
更新日期:1999-06-15 00:00:00
abstract::Aniline and its halogenated derivatives are widely used as chemical intermediates. The purpose of this study was to determine the hepatotoxic and nephrotoxic potential of the 2-haloanilines. Male Fischer 344 rats (n > or = 4) were injected (i.p.) with 1.0 or 1.25 mmol/kg of: aniline (A), 2-fluoroaniline (2-FA), 2-chlo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90151-4
更新日期:1992-11-01 00:00:00
abstract::The anticonvulsant, valproic acid (VPA) is a suspected human teratogen. This study, employing the rhesus monkey as an animal model, demonstrates that VPA has a significant teratogenic potential in the monkey. Timed pregnant monkeys were exposed orally to VPA at approx. 1X, 10X, and 30X (20, 200, and 600 mg/kg/day, res...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90129-0
更新日期:1986-05-01 00:00:00
abstract::Long-term cadmium exposure leads to mitochondrial dysfunction in the proximal tubular epithelial cells. Mitochondrial DNA deletion may contribute to the pathogenesis of cadmium-induced nephropathy. The aim of our study is to clarify the accumulation of mitochondrial DNA deletion and mitochondrial dysfunction in the re...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.06.005
更新日期:2004-10-15 00:00:00
abstract::To investigate the mechanism of hepatocarcinogenesis due to dicyclanil (DC), an insect growth regulator for sheep, histopathological and molecular biological analyses were performed in the liver of male ICR mice fed on a diet containing 1500 ppm of DC for 2 weeks (Experiment I; Exp. I). In gene expression analyses usi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.10.011
更新日期:2005-02-28 00:00:00
abstract::This study was designed to evaluate the cardioprotective potential of naringin on lipid peroxides, enzymatic and nonenzymatic antioxidants and histopathological findings in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (85 mg/kg) to male Wistar rats showed a significant ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.09.005
更新日期:2006-12-07 00:00:00
abstract::Since predictive differentiation of photoallergenic from phototoxic reactions, induced by low molecular weight compounds, represents a current problem, we tried to improve the differentiation between the two reactions by using a modified protocol of the local lymph node assay (LLNA). Briefly, groups of female BALB/c m...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00156-x
更新日期:1998-02-06 00:00:00
abstract::This study is aimed to investigate the inflammation and neurological dysfunction induced by tetrachloro-p-benzoquinone (TCBQ) through Toll-like receptor 4 (TLR4) signaling. We also investigated the protective role of melatonin as an antioxidant and anti-inflammatory agent. In vitro model was established by rat pheochr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.02.015
更新日期:2017-04-15 00:00:00
abstract::The toxicity of daily subcutaneously applied 500 mg/kg N-methylformamide (NMF) during a period of 8 days in female CD-mice was ameliorated when 100 mg/kg sodium ascorbate, 60 mg/kg menadione bisulfite or 80 mg/kg pyridoxal hydrochloride were applied simultaneously. The comparison of the daily s.c. application of 360 m...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90008-4
更新日期:1987-02-01 00:00:00
abstract::p-Chloro-m-cresol (PCMC) and p-chloro-m-xylenol (PCMX) are known to cause allergic contact dermatitis. For risk assessment of skin sensitizers, information on dose-response profiles in the induction and elicitation phases and cross-reactivity with analogous chemicals are important. In the non-radioactive local lymph-n...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00161-6
更新日期:2003-08-28 00:00:00
abstract:UNLABELLED:We recently observed a case of digoxin and insulin self-poisoning without cardiac repercussion. We raised the hypothesis that insulin may have a cardio-protective effect in case of digoxin toxicity. We have therefore evaluated the effect of glucose-insulin infusion on mortality and ECG abnormalities during a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.04.035
更新日期:2006-07-25 00:00:00
abstract::We have examined the effect of pretreatment with a potent protein kinase C (PKC) inhibitor, 1-(5-isoquinoline-sulfonyl)-2-methylpiperazine (H-7), against metabolic alterations induced by sodium cyanide (NaCN), 4.2 mg/kg, in brain of anesthetized male micropigs (6-10 kg). Brain high energy phosphates were analyzed usin...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03078-t
更新日期:1995-06-26 00:00:00
abstract::Cell death triggers the release into extracellular spaces of products of chromatin catabolism, particularly of DNA. A sensitive DNA assay has been used to investigate in the mouse whether the quantitation of plasma DNA may be used as an index of in vivo cytotoxicity. It has been found that toxic doses of bacterial lip...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90178-j
更新日期:1990-04-30 00:00:00
abstract::The objective of this study was to compare the disposition and metabolism of [14C]1,2-dichloropropane [( 14C]DCP) following oral and inhalation exposure since these two routes are of interest with regards to occupational and accidental exposure. [14C]DCP was administered orally to groups of four rats of each sex as a ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90076-d
更新日期:1991-01-01 00:00:00
abstract::In the present study, we demonstrated the cytotoxic effect of a dimethylarsenic compound in seaweed, (R)-(2',3'-dihydroxypropyl) 5- deoxy-5-dimethylarsinoyl-beta-D-riboside, namely arsenosugar (AsSug), on mammalian cells, murine macrophages, in comparison with that of an inorganic arsenical, arsenite, in vitro. More t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00101-7
更新日期:1997-10-19 00:00:00
abstract::The synthetic pyrethroid insecticide, cypermethrin, was given during gestation to pregnant rats by gavage in corn oil. Peripheral blood and spleen cytotoxic activity of dams and their offspring were then evaluated at different times (30, 60, 90, 120 days) after birth. Pups showed a significant increase in peripheral b...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)03662-7
更新日期:1997-07-11 00:00:00
abstract::Cadmium (Cd) is a heavy metal with a long biological half-life in humans and is recognized as a toxic pollutant. Cd is also a potential neurotoxicant and its exposure is associated with olfactory impairment in humans. However, the molecular and cellular mechanisms of Cd neurotoxicity are not well defined. Adult neurog...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.01.013
更新日期:2017-04-01 00:00:00
abstract::The effects of lindane on alpha-aminoisobutyric acid and uridine uptake were studied in the rat line C-6 of glial origin. Different levels of modifications could be distinguished by use of 2 modes of investigation. One study, carried out within minutes of contact with lindane, has shown that the inhibition of alpha-am...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(80)90103-1
更新日期:1980-01-01 00:00:00
abstract::Repeated intraperitoneal administration of benzene (1.0 ml/kg body wt) for 3 days produced leucopenia, lymphocytopenia and an increased number of nucleated cells in the bone marrow and significantly decreased organ weights of thymus (P less than 0.001) and spleen (P less than 0.001) in female albino rats. Iron content...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90029-6
更新日期:1986-06-01 00:00:00
abstract::Fischer 344 rats were exposed to filtered air (controls) or to 0.12, 0.5, or 1.0 ppm of ozone for 6 h/day, 5 days/week, for 20 months. We examined lung collagen deposition and metabolism in tissue from these animals to determine whether chronic exposure of rats to ozone causes pulmonary fibrosis. We observed excess st...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90110-e
更新日期:1993-11-12 00:00:00
abstract::Nowadays, very little information concerning the effects on behavior in mammals of perfluorooctane sulfonate (PFOS), a widely distributed persistent environmental pollutant, is available. In the present study, we assessed the behavioral effects of PFOS on 3 months old mice after 1 month of exposure to this pollutant. ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.09.012
更新日期:2007-12-05 00:00:00
abstract::The influence of pretreatment with the drug mixture (pyridostigmine, benactyzine and trihexyphenidyle), and antidotal treatment (the oxime HI-6 in combination with benactyzine) on respiration, circulation and survival of experimental animals poisoned with supralethal doses of soman (2 x LD50) was investigated in a rat...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00186-8
更新日期:1998-06-26 00:00:00
abstract::Maintenance of health is dependent on numerous regulatory interactions between organ systems. This review discusses interorgan communication between the nervous, endocrine, and immune systems and environmental and genetic influences on this neuroendocrine immune circuitry. Stresses of multiple types, including psychol...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(99)00144-4
更新日期:2000-01-17 00:00:00
abstract::The present study was undertaken to investigate the usefulness of stress proteins as early, sensitive indicators of hepatotoxicity. Induction of stress protein synthesis in precision-cut rat liver slices was examined following in vitro exposure to sodium arsenite or heat shock. Precision-cut rat liver slices were incu...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03119-z
更新日期:1995-12-15 00:00:00
abstract::Mitochondria are cellular powerhouses as well as metabolic and signaling hubs regulating diverse cellular functions, from basic physiology to phenotypic fate determination. It is widely accepted that reactive oxygen species (ROS) generated in mitochondria participate in the regulation of cellular signaling, and that s...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2017.07.013
更新日期:2017-11-01 00:00:00
abstract::Asthma, which is primarily an allergic type of respiratory disease, has increased in the U.S. and Europe by 30% over the last decade. Air pollution may play a role in this rise, since during episodes of smog, hospital admissions due to asthma increase. Ambient air quality has generally improved since the Clean Air Act...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(95)03230-d
更新日期:1995-12-28 00:00:00
abstract::Because it had been suggested that alpha-tocopherol might protect protein thiols (PSH) from oxidation, we were interested in determining if alpha-tocopherol could prevent or mitigate nitrofurantoin-induced changes in the glutathione (GSH) or PSH status of the liver. Isolated rat livers were perfused in the single pass...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90140-v
更新日期:1991-04-08 00:00:00
abstract::The involvement of metallothionein (MT) in the nephrotoxicity of cis-diamminedichloroplatinum (c-DDP) was investigated in rats using enzyme excretion and histology as indicators of renal damage. In addition, the effects of renal glutathione (GSH) depletion on the nephrotoxicity of c-DDP was assessed by organic anion t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90129-5
更新日期:1990-11-01 00:00:00