Cetaben versus clofibrate: comparison of toxicity and peroxisome proliferation in rats.

Abstract:

:Cetaben and clofibrate were each administered to groups of 6 rats (3 male and 3 female) by gavage at dosages of 50 mg/kg per day and 200 mg/kg per day for 2 weeks. Cetaben caused 1 death at 200 mg/kg per day and decreases in body weight gain and food consumption at 50 mg/kg per day or more. There were no effects on body weight or food consumption in the clofibrate-treated groups. At 200 mg/kg per day cetaben and clofibrate induced comparable increases in liver weight and in numbers of liver peroxisomes while cetaben caused increases in liver catalase activity as well.

journal_name

Toxicology

journal_title

Toxicology

authors

Fort FL,Stein HH,Langenberg K,Lewkowski JP,Heyman IA,Kesterson JW

doi

10.1016/0300-483x(83)90004-5

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

305-11

issue

4

eissn

0300-483X

issn

1879-3185

pii

0300-483X(83)90004-5

journal_volume

28

pub_type

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