Abstract：
:Maintenance of health is dependent on numerous regulatory interactions between organ systems. This review discusses interorgan communication between the nervous, endocrine, and immune systems and environmental and genetic influences on this neuroendocrine immune circuitry. Stresses of multiple types, including psychological and exposure to chemicals and infectious agents, may combine to enhance neuroimmunotoxicology. Altered nervous system functions can alter immunity which could result in exacerbation of infections, cancers or other immune-associated problems. Inversely, aberrant immune system activities could lead to pathologies associated with altered nervous activities, such as Alzheimer's disease, chronic fatigue, or multiple sclerosis. The nervous, endocrine and immune circuitry is multi-directional, and a chemical, physical or emotional stress could upset the homeostasis.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Lawrence DA,Kim Ddoi
10.1016/s0300-483x(99)00144-4keywords:
subject
Has Abstractpub_date
2000-01-17 00:00:00pages
189-201issue
3eissn
0300-483Xissn
1879-3185pii
S0300483X99001444journal_volume
142pub_type
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