Abstract：
:Carbendazim (MBC), the bioactive metabolite of the fungicide benomyl, has been reported to induce a number of testicular alterations in male rats. Since it is possible that extragonadal changes contribute to the appearance of such effects, the present study focused on the presence of concurrent endocrine changes in the hypothalamic and pituitary components of the brain-pituitary-testicular axis. Subchronic administration of MBC (50, 100, 200 or 400 mg/kg) was found to cause a dose-related elevation in serum follicle stimulating hormone (FSH) and pituitary luteinizing hormone (LH). Values for prolactin and thyroid-stimulating hormone remained unchanged. No statistical differences in gonadotropin-releasing hormone concentrations were present in mediobasal hypothalamus, although an elevation in anterior hypothalamic values was found at the low dose, followed by a dose-related decline. These findings demonstrate that previously reported gonadal differences following subchronic exposure to carbendazim are accompanied by alterations elsewhere in the reproductive system which appear to involve both changes in Sertoli cell-pituitary feedback signals and direct effects of the compound on the central nervous system.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Goldman JM,Rehnberg GL,Cooper RL,Gray LE Jr,Hein JF,McElroy WKdoi
10.1016/0300-483x(89)90163-7subject
Has Abstractpub_date
1989-07-17 00:00:00pages
173-82issue
2eissn
0300-483Xissn
1879-3185pii
0300-483X(89)90163-7journal_volume
57pub_type
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