Abstract:
:Different affinities of blood for CO were observed in in vivo and in vitro experiments. Hamsters showed the greatest relative affinity (1.0), the corresponding value for rats was 0.8, for pigs 0.74 and for rabbits 0.58. The upward shift of the saturation curves was dependent on the rate of respiratory exchange per unit of body weight, e.g. the curves were less steep for pigs than for rabbits. After increased motor activity the equilibrium saturation of CO in blood is reached more rapidly. From the results of in vitro experiments the following affinity constants for the blood of different species could be calculated: pig K = 130, hamster K = 181, rat I = 141, rabbit K = 109. For equal atmospheric CO concentrations the saturation values were lower (37-40%) in experiments in vitro than in vivo. Similar saturation values were obtained with light excluded, when O2 concentration was decreased to the level of alveolar oxygen concentration. With regard to the affinity of blood for CO, the blood of domestic pigs did not differ from that of minature pigs in in vitro experiments.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Klimisch HJ,Chevalier HJ,Harke HP,Dontenwill Wdoi
10.1016/0300-483x(75)90031-1keywords:
subject
Has Abstractpub_date
1975-01-01 00:00:00pages
301-10issue
3eissn
0300-483Xissn
1879-3185pii
0300-483X(75)90031-1journal_volume
3pub_type
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