Abstract：
:Age-related differences in susceptibility to cephaloridine nephrotoxicity were evaluated in male Fischer-344 rats. Rats, 2.5, 4, 10-12 and 27-29 months old, were administered a single intraperitoneal dose of cephaloridine and renal function evaluated 24 h later. Susceptibility to cephaloridine-induced nephrotoxicity was age-related. Older rats (10-12 and 27-29 months) were the most susceptible to cephaloridine nephrotoxicity as indicated by a dose-related increase in relative kidney weight, elevation in blood urea nitrogen concentrations and a diminished capacity of renal cortical slices to accumulate the organic anion, p-aminohippurate (PAH) and the organic cation, tetraethylammonium (TEA). Impaired renal function following cephaloridine treatment was not detected in 2.5-month-old, apparent to a slight extent in 4-month-old, and most pronounced in 10-12- and 27-29-month-old rats. Serum and renal cortical concentrations of cephaloridine tended to be greater in older rats compared to that of young adults. Thus, the enhanced susceptibility of older rats to cephaloridine nephrotoxicity may be related in part to the increased renal cortical accumulation of cephaloridine.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Goldstein RS,Pasino DA,Hook JBdoi
10.1016/0300-483x(86)90171-xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
43-53issue
1eissn
0300-483Xissn
1879-3185pii
0300-483X(86)90171-Xjournal_volume
38pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Alkylfurans inflict toxicity in several mammalian species to lung, liver and kidney. Organ specificity of the alkylfurans is a sensitive function of the nature of the alkyl group. To determine if this toxicity requires an aromatic ring in the compound, we synthesized 4-methyl-2,3-dihydrofuran, 4-ethyl-2,3-dihydrofuran...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90006-3
更新日期：1990-03-30 00:00:00
abstract：:This study reviews current understanding of mechanisms of biotransformation of organophosphorus compounds (OPC). The first part of this article covers chemical aspects of biotransformation describing reactions that lead to activation or detoxication of OPC. The second part explains biochemical mechanisms of biotransfo...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(01)00463-2
更新日期：2001-09-25 00:00:00
abstract：:When Xenopus laevis embryos were treated with fenitrothion, a substantial proportion failed to survive to hatching only when the concentration approached saturation. However, after exposure to 10 ppm of fenitrothion, most were abnormal and did not survive past feeding stage. Different embryonic stages were not equally...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90026-3
更新日期：1981-01-01 00:00:00
abstract：:Because occupational hazards of small-scale industries were severe and the occupational health management lagged behind in Shanghai, we selected some districts as experimental units to explore a model of community management and service for the occupational health in small-scale industries for controlling occupational...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.01.019
更新日期：2004-05-20 00:00:00
abstract：:Ozone (O3), a pulmonary irritant, and a major toxic component of photochemical smog, is capable of inducing pulmonary inflammation characterized by recruitment of polymorphonuclear leukocytes (PMNs) into the lung. The recruited PMNs, in turn, can release toxic mediators and produce lung injury. The mechanism of ozone-...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00024-9
更新日期：1998-05-15 00:00:00
abstract：:Previous studies have shown that excess dietary Al during development can affect neurobehavioral measures and decrease tissue Mn of 21-day-old weanling mice without a corresponding increase in tissue Al concentrations. Al and Mn have similar tissue concentrations and similar affinities for transferrin, which is the ma...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90154-k
更新日期：1993-07-11 00:00:00
abstract：:Reactions of ethenyloxirane with amino (RNH2) and thiol (R'SH) nucleophiles occur by an SN2 mechanism involving competing ring cleavage at C-2 and C-3. In contrast, 2-ethenyl-2-methyloxirane reacts with amino (RNH2) and thiolate (R'S-) nucleophiles in methanol by regioselective SN2 attack at C-3 ("neo-pentyl" position...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(96)03458-0
更新日期：1996-10-28 00:00:00
abstract：:Although manufactured magnetic nanoparticles (NPs) are currently used in many fields, NPs have potential toxicity on cardiovascular system especially atherosclerosis. In our previous study, we prepared novel Fe3O4 nanoparticles surface-coated with aminoguanidine (Fe3O4-AG NPs) which could remove acid dyes from aqueous...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2019.03.002
更新日期：2019-05-01 00:00:00
abstract：:In vitro stimulation of bronchoalveolar lavage cells from patients with chronic beryllium disease (CBD) induces the production of TNF-alpha. We tested the hypothesis that beryllium (Be)-stimulated TNF-alpha might induce apoptosis in mouse and human macrophage cell lines. These cell lines were selected because they pro...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00237-7
更新日期：2000-08-21 00:00:00
abstract：:During the past decade, several assessments have estimated the carcinogenic risk of inhaled 1,3-butadiene (BD) to the general population as well as for occupational exposures. Although most of the risk assessments have been based on inhalation bioassays in mice, some of the assessments have included the 2-year inhalat...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(96)03447-6
更新日期：1996-10-28 00:00:00
abstract：:An in vitro model of the rat nasal cavity has been used to compare the responses of nasal tissues in vitro, using loss of intracellular ATP and potassium as indices of toxicity, with the pathological changes occurring following in vivo exposure to four test compounds. Turbinates were incubated in vitro with the test c...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00180-8
更新日期：2000-04-07 00:00:00
abstract：:Calf thymus DNA was reacted with 1,2-epoxybutene (BDO) in phosphate buffered saline at 37 degrees C for 12 h. DNA was ethanol precipitated and hydrolyzed with 1 M HCl to release DNA bases. Adenine (A)-BDO and guanine (Gua)-BDO adducts were analyzed in the ethanol supernatant and DNA hydrolysate using LC/ESI MS/MS. Rea...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(96)03468-3
更新日期：1996-10-28 00:00:00
abstract：:In the present work was analyzed whether sulforaphane (SFN) may protect against cisplatin (CIS)-induced hepatic damage, oxidant stress and mitochondrial dysfunction. Four groups of male Wistar rats were studied: control, CIS, CIS+SFN and SFN. SFN was given i.p. (500 μg/kg/d × 3 days) before CIS administration (single ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.04.014
更新日期：2011-08-15 00:00:00
abstract：:Oxidative DNA damage is emerging as an biomarker of effect in studies assessing the health risks of occupational chemicals. Trichloroethylene (TCE) and perchloroethylene (PERC) are used in the dry cleaning industry and their metabolism can produce reactive oxygen compounds. The present study examined the potential for...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00083-9
更新日期：1999-10-29 00:00:00
abstract：:The pharmacokinetics of selected aluminum-hydroxypyridinone (Al-HP complexes were determined in rats to better understand the relationship between their disposition and elimination parameters and the safety of HPs in the chelation therapy of Al intoxication. Five complexes were administered as i.v. bolus doses of Al-H...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)90177-5
更新日期：1994-09-06 00:00:00
abstract：:Presently, many consumer products contain nano-sized materials (NMs) to improve material properties, product quality and ease of use. NMs in food additives and in cosmetic articles (e.g., tooth paste) may be taken up by the oral route. As adverse effects of environmental nanoparticles, like ultrafine particles, have b...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2011.11.004
更新日期：2012-01-27 00:00:00
abstract：:Polycyclic aromatic hydrocarbons (PAHs) including benzo[a]pyrene (B[a]P) and 7,12-dimethylbenz[a]anthracene (DMBA) are environmental pollutants, which undergo metabolic activation to exert their carcinogenic effects. Our earlier studies showed that naturally occurring plant phenols, protocatechuic, chlorogenic, tannic...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.07.047
更新日期：2008-09-29 00:00:00
abstract：:Several studies indicated that chloral hydrate can prolong the disappearance time of ethanol from blood in mice. This seems to result from inhibition of the enzyme alcohol dehydrogenase by chloral hydrate and trichloroethanol, its main metabolite. We examined the effect of both these compounds on the disappearance tim...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(98)00108-5
更新日期：1998-11-02 00:00:00
abstract：:Endocrine disruptors (EDs) are exogenous substances or xenoestrogens natural or synthetic, capable of interacting with different systems and altering their normal hormonal regulation, being the reproductive system one of the most affected. EDs produce their effects not only by acting on nuclear steroid receptors, but ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2013.05.014
更新日期：2013-09-06 00:00:00
abstract：:The objective of this study was to further evaluate the developmental toxicity of tributyltin chloride (TBTCl) in rats. Pregnant rats were given TBTCl by gastric intubation at a dose of 25, 50 or 100 mg/kg on days 7-9, days 10-12 or days 13-15 of pregnancy. A significant increase in the incidence of post-implantation ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)02920-p
更新日期：1995-02-27 00:00:00
abstract：:The reproductive toxicity of vanadium was studied in mice. Male Swiss mice were exposed to sodium metavanadate at doses of 0, 20, 40, 60, and 80 mg/kg per day given in the drinking water for 64 days. To evaluate the fertility of the vanadium-treated animals, males were mated with untreated females for 4 days. A signif...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90181-q
更新日期：1993-06-11 00:00:00
abstract：:Hexavalent chromium [Cr(VI)] compounds (e.g. chromates) are strong oxidants that readily enter cells where they are reduced to reactive Cr intermediates that can directly oxidize some cell components and can promote the generation of reactive oxygen and nitrogen species. Inhalation is a major route of exposure which d...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.01.001
更新日期：2011-03-15 00:00:00
abstract：:The effect of amyl nitrite on the erythrocytes of adult and cord hemoglobin was examined in vitro. This study revealed that amyl nitrite caused oxyhemoglobin to become oxidized to methemoglobin wherein a rectangular hyperbolic curve was generated as the reaction progressed. This curve consisted of a reactionary log ph...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90003-4
更新日期：1985-07-01 00:00:00
abstract：:Disorders in the barrier function and secretory activity of the placenta can be caused by xenobiotics (XB) present in the environment and their accumulation in tissues of living organisms. Thus, the aim of this study was to investigate the effect of 1,1,1-trichloro-2,2,-bis-4-chlorophenyl-ethane (DDT) and its metaboli...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.11.016
更新日期：2017-01-15 00:00:00
abstract：:Gambogic acid (GA), a major active component of gamboge, exhibits potent anticancer activity in many kinds of cancer cells. However, the anticancer mechanism of GA is not clearly understood. Here we showed that GA could cause growth inhibition, induce the G0/G1 phase cell cycle arrest and apoptosis in human chronic my...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.04.059
更新日期：2009-08-03 00:00:00
abstract：:Deltamethrin is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control, protection of foodstuff and disease vector control. The objective of this study was to investigate the propensity of deltamethrin to induce oxidative stress and changes in biochemical parameters and enzyme activities i...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.08.008
更新日期：2006-10-29 00:00:00
abstract：:We have found that incubation of heparin plasma with Ni(2+) or Co(2+) at concentrations below 100 microM can stimulate the conversion of complement factor C3 to C3b faster than magnesium, which is the natural cofactor in the alternative complement activation. This conversion was monitored by light absorbance measureme...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00590-5
更新日期：2003-03-14 00:00:00
abstract：:This study compares changes in cardiopulmonary function, selected endpoints in exhaled breath, blood, and bronchoalveolar lavage fluid (BAL) following a single, high-level 30-min nose-only exposure of rats to chlorine and phosgene gas. The time-course of lung injury was systematically examined up to 1-day post-exposur...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.10.010
更新日期：2014-12-04 00:00:00
abstract：:Life-threatening acute lung injury potentially occurs following high-level accidental exposures to phosgene gas. This situation was mirrored in rats exposed nose-only at 900-1000 mg phosgene/m(3)min. At this exposure level, previous studies on rats demonstrated sustained reflexively induced cardiopulmonary dysfunction...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.11.005
更新日期：2014-01-06 00:00:00
abstract：:A single high dose, 75 mg/kg, of clotrimazole (CloTZ) was administered intragastrically (i.g.) to adult male Sprague-Dawley rats. Hepatic CloTZ concentrations were determined in organic extracts of whole liver homogenate, by high-performance liquid chromatography (HPLC). The peak liver CloTZ concentration was found at...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90074-3
更新日期：1993-06-04 00:00:00
