Abstract：
:Several studies indicated that chloral hydrate can prolong the disappearance time of ethanol from blood in mice. This seems to result from inhibition of the enzyme alcohol dehydrogenase by chloral hydrate and trichloroethanol, its main metabolite. We examined the effect of both these compounds on the disappearance time of methanol in mice. Also the effect of a combination of ethanol and chloral hydrate on the disappearance time of methanol was examined. Several groups of six mice each received methanol (1 g/kg i.p.) followed immediately by one of the following treatments: saline (10 ml/kg); chloral hydrate (0.4 g/kg); trichloroethanol (0.36 g/kg); ethanol (4 g/kg); or a combination of chloral hydrate (0.2 g/kg) and ethanol (4 g/kg). The concentrations of methanol in blood were measured at 1, 2, 4, and 8 h after its administration and were used to calculate some approximate indicators of methanol elimination in each group. The results show that all the above treatments do prolong the disappearance time of methanol in the blood of mice to varying extents. The ethanol-chloral hydrate combination produced the most pronounced effect.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Faci A,Plaa GL,Sharkawi Mdoi
10.1016/s0300-483x(98)00108-5subject
Has Abstractpub_date
1998-11-02 00:00:00pages
1-7issue
1eissn
0300-483Xissn
1879-3185pii
S0300-483X(98)00108-5journal_volume
131pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Deoxynivalenol (DON) is one of the major mycotoxic contaminants of grains, which causes reduced weight gain in pigs. The cytotoxicity of DON to porcine hepatocytes was examined in this study. DON was added at the final concentration of 100, 10, 1, 0.1 or 0.01 microg/ml to the medium of primary cultured hepatocytes. Ce...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.07.001
更新日期：2004-11-15 00:00:00
abstract：:The prime factors influencing survivability from 10 major fire-related public transport aircraft accidents were assessed. Regulatory requirements were assessed against derived criteria and alternate concepts evaluated to identify a preferred strategy for enhanced survival; the provision of passenger protective breathi...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(96)03494-4
更新日期：1996-12-31 00:00:00
abstract：:The present research examines the effects of 4-nonylphenol (4-NP) on mouse primary calvarial osteoblasts (COBs). Incubation of the cells with 4-NP at 10(-5)M and 10(-6)M striking decreased osteoblasts viability and phosphatidylserine (PS) exposure, measured by Annexin V, was greatly enhanced. In addition, an up-regula...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.10.014
更新日期：2011-12-18 00:00:00
abstract：:To investigate the biological effects of terbium (Tb), male mice were intraperitoneally administered with TbCl3 at doses of 10, 50, or 250 mg Tb/kg. The Tb distribution in organs was determined after 18-20 h of injection by using a spectrofluorometer. The concentrations of Ca, Mg, Fe, and Zn in various organs were det...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90181-y
更新日期：1991-02-11 00:00:00
abstract：:Cruciferous vegetable consumption correlates with reduced risk of cancer. This chemopreventative activity may involve glucosinolates and their hydrolysis products. Glucosinolate-derived isothiocyanates have been studied for their toxicity and chemopreventative properties, but other hydrolysis products (epithionitriles...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.06.002
更新日期：2015-08-06 00:00:00
abstract：:Urinary dialkylphosphates (DAPs) are measured to assess exposure to organophosphorus pesticides (OPs), but they are common metabolites of OPs and not specific indices for individual agents. Biomonitoring (BM) of urinary DAPs has been widely adopted as an assessment of individual exposure in general environments, howev...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2021.152679
更新日期：2021-01-15 00:00:00
abstract：:V79 Chinese hamster cells are being genetically engineered for stable expression of cytochromes P450 using a SV40 early promoter containing plasmid as the eukaryotic expression vector. V79 cells lack endogenous cytochrome P450 activity. Therefore, genetically engineered V79 cell lines are defined for the cytochrome P4...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(93)90063-x
更新日期：1993-10-05 00:00:00
abstract：:Static and rotary cultures of adult rabbit hepatocytes can be produced reproducibly following their isolation by means of a simplified, inexpensive recycling perfusion system. Light and electron microscopic examination of the cultures showed that these hepatocytes retained the morphological characteristics of fully di...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(82)90052-x
更新日期：1982-01-01 00:00:00
abstract：:In the present study, we demonstrated the cytotoxic effect of a dimethylarsenic compound in seaweed, (R)-(2',3'-dihydroxypropyl) 5- deoxy-5-dimethylarsinoyl-beta-D-riboside, namely arsenosugar (AsSug), on mammalian cells, murine macrophages, in comparison with that of an inorganic arsenical, arsenite, in vitro. More t...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)00101-7
更新日期：1997-10-19 00:00:00
abstract：:The consumption of diets rich in plant foods are associated with a reduced risk of cardiovascular diseases. This study was aimed to evaluate the role of S-allylcysteine (SAC) in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (150 mg/kg) to Wistar rats showed a significant...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.04.039
更新日期：2006-07-05 00:00:00
abstract：:Subacute exposure of male rats to various concentrations (70-1000 ppm) of dichloromethane (DCM) produces a selective reduction of dopamine (DA) levels without a change of DA turnover in certain types of forebrain DA nerve terminal systems. In the low concentration (70 ppm) a selective reduction of DA turnover was obse...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90161-6
更新日期：1984-02-01 00:00:00
abstract：:In mice, styrene is hepatotoxic, pneumotoxic, and causes lung tumors. One explanation for the mechanism of toxicity is oxidative stress/damage. Previous studies have shown decreased glutathione levels, linked to increased apoptosis, in lung homogenates and isolated Clara cells 3 h following styrene or styrene oxide (S...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.08.001
更新日期：2009-10-29 00:00:00
abstract：:Aluminum (Al) is recognized worldwide as serious inorganic contaminants. Exposure to Al is associated with low BMD and an increased risk of osteoporosis. However, the precise molecular mechanisms remains unclear. Thus, in this study, rats were orally exposed to 0 (control group, CG) and 0.4g/L AlCl3 (AlCl3 treated gro...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.10.002
更新日期：2016-09-14 00:00:00
abstract：:Extract and fractions of city smog collected from a heavy industrialized area caused in vitro dose-dependent reduction of cell survival of mouse macrophages and a growth inhibition of human fetal diploid lung fibroblasts. Great differences were observed in both cell systems between the total extract and its different ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90091-8
更新日期：1980-01-01 00:00:00
abstract：:A single oral dose of 50 mg/kg of [14C]TOCP was administered in corn oil to male rats. Three animals were sacrificed at each of 2, 6 and 12 h and 1, 2 and 5 days following dosing, and tissues and excreta were analyzed for 14C. Within 5 days, 63 and 36% of the dose were recovered in the urine and feces, respectively. I...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90079-v
更新日期：1990-12-17 00:00:00
abstract：:Hexachlorobenzene (HCB) is an organochlorine pesticide that acts as an endocrine disruptor in humans and rodents. The development of breast cancer strongly depends on endocrine conditions modulated by environmental factors. We have demonstrated that HCB is a tumor co-carcinogen in rats and an inducer of proliferation ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.12.012
更新日期：2012-03-11 00:00:00
abstract：:The effects of di-(2-ethylhexyl)adipate (DEHA) have been compared in female F344 rats and female B6C3F1 mice fed diets containing 0-4.0% DEHA and 0-2.5% DEHA, respectively, for periods of 1, 4 and 13 weeks. In both the rat and mouse treatment with DEHA at all time points produced a dose-dependent increase in relative ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)00125-x
更新日期：1997-12-05 00:00:00
abstract：:Deltamethrin, an alpha-cyano type II synthetic pyrethroid insecticide is used to control a wide range of insects on a variety of crops. Deltamethrin is reported to cause many adverse effects on non-target species. Deltamethrin is reported to cause DNA damage and micronuclei induction in human lymphocytes. It is highly...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00416-9
更新日期：2001-05-28 00:00:00
abstract：:Maintenance of health is dependent on numerous regulatory interactions between organ systems. This review discusses interorgan communication between the nervous, endocrine, and immune systems and environmental and genetic influences on this neuroendocrine immune circuitry. Stresses of multiple types, including psychol...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(99)00144-4
更新日期：2000-01-17 00:00:00
abstract：:Recently we observed a suppressed delayed-type hypersensitivity (DTH) response to bovine serum albumin (BSA) in the 4-5-month-old offspring of F344 rat dams receiving as little as 1.0 microg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg on gestational day (GD) 14. This study was designed to characterize better this su...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00024-4
更新日期：1999-05-03 00:00:00
abstract：:NLRC5, a newly found member of the NLR family and the largest member of nucleotide-binding, has been reported to regulate immune responses and is associated with hepatocellular carcinoma (HCC). We investigated the mechanisms and signaling pathways of NLRC5 in HCC progression. Increased expression of NLRC5, vascular en...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.06.012
更新日期：2016-06-01 00:00:00
abstract：:The most commonly used assays designed to detect either skin or systemic immune-based hypersensitivity reactions are those using guinea pigs (GP). We obtained data from various FDA records to evaluate the correlation between GP assay results and reported post-marketing systemic hypersensitivity reactions. We examined ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(03)00267-1
更新日期：2003-12-01 00:00:00
abstract：:Evidence from epidemiological studies indicates that acute exposure to airborne pollutants is associated with an increased risk of morbidity and mortality attributed to cardiovascular diseases. The present study investigated the effects of combustion-derived ultrafine particles (diesel exhaust particles) as well as en...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.08.018
更新日期：2008-11-20 00:00:00
abstract：:The nerve agent tabun inhibits the essential enzyme acetylcholinesterase (AChE) by a rapid phosphoramidation of the catalytic serine residue. Oximes, such as K027 and HLö-7, can reactivate tabun-inhibited human AChE (tabun-hAChE) whereas the activity of their close structural analogue HI-6 is notably low. To investiga...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.09.002
更新日期：2009-11-30 00:00:00
abstract：:The nitric oxide (NO) donor, O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), is metabolized by P450 enzymes to release NO in the liver and possibly other tissues. V-PYRRO/NO has been shown to be hepatoprotective, but little is known about its effect in the kidney, another organ rich in P450s. Thus...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(03)00129-x
更新日期：2003-08-01 00:00:00
abstract：:Trans-1,2-dichloroethylene (t-DCE), an industrial solvent, proved to be moderately toxic when studied in small laboratory animals. In adult female rats brief (8 h) and prolonged (8 h daily, on 5 consecutive days a week, for more than 16 weeks) inhalation of 200 ppm--the current TLV/MAC in various countries--produced h...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(77)90059-2
更新日期：1977-04-01 00:00:00
abstract：:Solar radiation induces acute and chronic reactions in human and animal skin. Chronic repeated exposures are the primary cause of benign and malignant skin tumors, including malignant melanoma. Among types of solar radiation, ultraviolet B (290-320 nm) radiation is highly mutagenic and carcinogenic in animal experimen...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(03)00150-1
更新日期：2003-07-15 00:00:00
abstract：:In the present work was analyzed whether sulforaphane (SFN) may protect against cisplatin (CIS)-induced hepatic damage, oxidant stress and mitochondrial dysfunction. Four groups of male Wistar rats were studied: control, CIS, CIS+SFN and SFN. SFN was given i.p. (500 μg/kg/d × 3 days) before CIS administration (single ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.04.014
更新日期：2011-08-15 00:00:00
abstract：:The interaction in vivo of four O-alkyl O-2,5-dichlorophenyl phosphoramidates with neural neuropathy target esterase (NTE) and acetylcholinesterase (AChE) and their ability to cause delayed polyneuropathy in hens has been examined. Previous studies in vitro (Vilanova, Johnson & Vicedo, Pestic. Biochem. Physiol., 28 (1...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(89)90081-4
更新日期：1989-01-01 00:00:00
abstract：:The activity of the haem biosynthetic enzymes delta-aminolaevulinic acid synthetase (ALA.S) and delta-aminolaevulinic acid dehydratase (ALA.D) were measured in the peripheral blood of a group of lead workers and control subjects. The haem precursor delta-aminolaevulinic acid (ALA) was measured in blood and urine, whil...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(78)90026-4
更新日期：1978-02-01 00:00:00
