Abstract:
:Recently we observed a suppressed delayed-type hypersensitivity (DTH) response to bovine serum albumin (BSA) in the 4-5-month-old offspring of F344 rat dams receiving as little as 1.0 microg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg on gestational day (GD) 14. This study was designed to characterize better this suppression of the DTH response. First, the persistence of the DTH suppression was determined by measuring the DTH response to BSA in the offspring of dams dosed orally with 3.0 microg TCDD/kg on GD14 as well as in age-matched controls at 4, 8, 12 and 19 months of age. TCDD significantly suppressed the males' DTH response through 19 months of age. While the females' DTH response was reduced at 8, 12 and 19 months, significant suppression was observed only at 4 months of age. Secondly, the lowest maternal dose of TCDD that produced DTH suppression was determined by measuring the DTH response to BSA in the 4- and 14-month-old offspring of dams dosed orally with 0, 0.1, 0.3 or 1.0 microg TCDD/kg on GD14. In the males, suppression was observed at a maternal dose as low as 0.1 microg TCDD/kg at 14 months of age, while a maternal dose of 0.3 microg TCDD/kg was necessary to cause suppression in the 14-month-old females. Both males and females were more sensitive to the suppression at 14 months of age than at 4 months of age. Lastly, the DTH response to a second antigen was examined by measuring the DTH response to either BSA or keyhole limpet hemocyanin (KLH) in the 5- or 4-month-old male offspring, respectively, of dams dosed orally with either 0 or 3.0 microg TCDD/kg on GD14. The DTH response to both antigens was suppressed significantly. Phenotypic analysis was performed on thymus and lymph node suspensions. Significant effects in the thymus included an increased percentage of gammadelta TCR+ cells and a decreased percentage of gammadelta TCR+/CD4- CD8- and MHCI- MHCII- cells. In the popliteal lymph node draining the BSA-injected footpad, there was a decreased percentage of gammadelta TCR+ and MHCI- MHCII- cells and an increased percentage of MHCI+ cells. In conclusion, the suppression of the DTH response associated with perinatal TCDD exposure is persistent through late adulthood, occurs at a low dose (i.e. 0.1 microg TCDD/kg) to the dam, and is more pronounced in males than females. While phenotypic analysis identified differences in subsets of thymocytes and lymph node cells between control and TCDD exposed offspring, no clear correlations were established between altered subpopulations and suppressed DTH responses.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Gehrs BC,Smialowicz RJdoi
10.1016/s0300-483x(99)00024-4keywords:
subject
Has Abstractpub_date
1999-05-03 00:00:00pages
79-88issue
1eissn
0300-483Xissn
1879-3185pii
S0300-483X(99)00024-4journal_volume
134pub_type
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