Abstract：
:Clarifying the participation of oxidative stress among possible contributing factors in potassium bromate (KBrO(3))-induced carcinogenesis is of importance from the perspective of human health protection. In the present study, utilizing the antioxidative effects of alpha-tocopherol (alpha-TP) or sodium ascorbic acid (SAA) to attenuate oxidative stress, alterations in bromodeoxyuridine labeling indices (BrdU-LIs) and reporter gene mutations in kidneys of male and female gpt delta rats given KBrO(3) were examined. Five male and female gpt delta rats in each group were given KBrO(3) at a concentration of 500ppm in the drinking water for 9 weeks, with 1% of alpha-TP or SAA administered in the diet from 1 week prior to the KBrO(3) treatment until the end of the experiment. Increases in 8-hydroxydeoxyguanosine levels in kidney DNA of both sexes of rats given KBrO(3) were significantly inhibited by SAA, but not alpha-TP. While BrdU-LIs in the proximal tubules of female rats were also significantly reduced by SAA, those in the males and gpt mutant frequencies in kidney DNA of both sexes were not affected by SAA or alpha-TP. Immunohistochemical and Western blot analyses for alpha(2u)-globulin strongly suggested that induction of cell proliferation observed in the males might primarily result from accumulation of this protein, independent of oxidative stress. The overall data indicated that while oxidative stress well correlates with induction of cell proliferation in females, its role in males and in generation of in vivo mutagenicity by KBrO(3) in both sexes is limited.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Umemura T,Tasaki M,Kijima A,Okamura T,Inoue T,Ishii Y,Suzuki Y,Masui N,Nohmi T,Nishikawa Adoi
10.1016/j.tox.2008.12.007subject
Has Abstractpub_date
2009-03-04 00:00:00pages
46-52issue
1-2eissn
0300-483Xissn
1879-3185pii
S0300-483X(08)00597-0journal_volume
257pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This ...
journal_title：Toxicology
pub_type：
doi：10.1016/j.tox.2020.152421
更新日期：2020-04-30 00:00:00
abstract：:The intravenous toxicity of phytic acid (inositol hexakisphosphate, IHP) has recently become of interest because of the potential for IHP incorporation into red blood cells to achieve a therapeutically useful shift in the hemoglobin-oxygen dissociation curve (Gersonde, K. and Nicolau, C., Blut, 39 (1979) 1). The obser...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90022-6
更新日期：1981-01-01 00:00:00
abstract：:Ursodeoxycholic acid (UDCA) has been widely used for treating cholestatic liver diseases. However, in a recent review of clinical trial articles, its therapeutic benefits were not proven. Therefore, we investigated whether UDCA prevents or potentiates glycochenodeoxycholic acid (GCDCA)-induced apoptosis in isolated ra...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.05.025
更新日期：2005-10-15 00:00:00
abstract：:Within the framework of an EU project on risk assessment of brominated flame retardants, TBBPA was studied for neurobehavioral effects in rats. To permit benchmark dose analysis, eight dose levels were chosen ranging from 0 to 3000mg/kg body weight. Exposure of parental rats started 10 and 2 weeks before mating in mal...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.01.007
更新日期：2008-04-03 00:00:00
abstract：:The present study was examined whether or not 2-bromoethyamine, a semicarbazide-sensitive amine oxidase (SSAO, EC; 1.4.3.6) inhibitor, would increase an active dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical ((*)OH) generation in the rat striatum. Rats were anesthetized, and ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.09.012
更新日期：2006-01-20 00:00:00
abstract：:Mitochondrial dysfunction with exposure to anthropogenic contaminants is a critical concern in biomedical and ecological health. Importantly, understanding the role of mitotoxicants in modulating organismal fitness and survival, particularly in the context of species' resilience to shifts in abiotic factors with clima...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2017.07.015
更新日期：2017-11-01 00:00:00
abstract：:One of the most sensitive and reproducible immunotoxic endpoints of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure is suppression of the antibody response to sheep red blood cells (SRBCs) in mice. Immunosuppression occurs in concert with hepatomegaly and associated induction of several hepatic cytochrome P450 enz...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2003.11.016
更新日期：2004-04-01 00:00:00
abstract：:Microcystins are cyclic heptapeptide toxins produced by certain strains of Microcystis aeruginosa and microcystin-LR (MC-LR) is the most toxic among the 70 variants isolated so far. These toxins have been implicated in both human and livestock mortality. In the present study we investigated the microcystin-LR induced ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.12.007
更新日期：2006-03-15 00:00:00
abstract：:The nerve agent tabun inhibits the essential enzyme acetylcholinesterase (AChE) by a rapid phosphoramidation of the catalytic serine residue. Oximes, such as K027 and HLö-7, can reactivate tabun-inhibited human AChE (tabun-hAChE) whereas the activity of their close structural analogue HI-6 is notably low. To investiga...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.09.002
更新日期：2009-11-30 00:00:00
abstract：:Immunohistochemical methods have been widely used to determine the histogenesis of spontaneous and chemically-induced mouse lung tumors. Typically, antigens for either alveolar Type II cells or bronchiolar epithelial Clara cells are studied. In the present work, the morphological and immunohistochemical phenotype of a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(03)00060-x
更新日期：2003-05-03 00:00:00
abstract：:In this study, we examined the relationship between maternal weight gain deficits induced by protein-and-energy restriction (PER) and pregnancy outcome. We also evaluated whether PER would potentiate the developmental toxicity of cyclophosphamide (CP) and hydroxyurea (HU). Two independent experiments--employing two di...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00373-6
更新日期：2002-09-30 00:00:00
abstract：:Cadmium (Cd) is a heavy metal with a long biological half-life in humans and is recognized as a toxic pollutant. Cd is also a potential neurotoxicant and its exposure is associated with olfactory impairment in humans. However, the molecular and cellular mechanisms of Cd neurotoxicity are not well defined. Adult neurog...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2017.01.013
更新日期：2017-04-01 00:00:00
abstract：:LoVo adenocarcinoma cells are fairly sensitive to cytostatic drugs, e.g. doxorubicin, but can develop drug resistance by expression of a P-glycoprotein-mediated MDR1 phenotype. LoVo cells respond with apoptosis to nanomolar concentrations of okadaic acid and micromolar concentrations of cantharidic acid. Interestingly...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00017-7
更新日期：1999-06-15 00:00:00
abstract：:Exposure of cultured rat mesangial cells to CdCl2 caused a dose- and time-dependent increase in intracellular glutathione that was significant at 0.5 microM and maximal at 1 microM Cd2+. The effect depended on glutathione synthesis and was masked by inhibiting synthesis with buthionine sulfoximine. The cells responded...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90145-i
更新日期：1993-01-29 00:00:00
abstract：:The influence of the known hepatotoxic agent, cerium (Ce) on the activity of liver microsomal monoxygenases, especially coumarin 7-hydroxylase (COH) was investigated in two inbred strains of male mice, DBA/2N and C57BL/6N. Ce was injected intravenously in three doses (0.5, 1.0 and 2.0 mg/kg body wt) and the animals we...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90148-t
更新日期：1991-01-01 00:00:00
abstract：:Recent studies have demonstrated that mammalian sperm are capable of generating reactive oxygen species (ROS) and that this activity is significantly accelerated in subfertile subjects. The observed decrease in penetration of zona-intact oocyte might be explained by chemical-induced ROS-related early onset of capacita...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00107-9
更新日期：1999-11-29 00:00:00
abstract：:Phensuximide (PSX) is an antiepileptic agent which has been shown to induce hemorrhagic cystitis and mild nephrotoxicity following repeated administration in man or rats or when acutely administered to phenobarbital-pretreated rats. The purpose of this study was to explore the role of para-hydroxylation of the phenyl ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90045-g
更新日期：1992-08-01 00:00:00
abstract：:The expanding use of innovative botanical ingredients in dietary supplements and foods has resulted in a flurry of research aimed at the development and validation of analytical methods for accurate measurement of active ingredients. The pressing need for these methods is being met through an expansive collaborative i...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.12.020
更新日期：2006-04-03 00:00:00
abstract：:A number of clinical reports and experimental studies have shown that autoimmune responses and/or autoimmune diseases are induced in humans and laboratory animals by chronic exposure to various chemicals. The present review is focused on the most frequent groups of chemically induced human disorders. Results obtained ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(96)03591-3
更新日期：1997-04-11 00:00:00
abstract：:Intraperitoneal administration of Thimet (0.6 mg/kg) on alternate days for a period of 30 days produced various pathological and biochemical changes in the liver and testes of male gerbils. Histology of the liver showed necrosis, enlarged hepatocytes and fatty degeneration. Histological changes seen in the testes were...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90076-1
更新日期：1980-01-01 00:00:00
abstract：:Considerable evidence has demonstrated that women are more vulnerable than men to the toxic effects of alcohol, although the results as to whether gender differences exist in ethanol-induced brain damage are contradictory. We have reported that ethanol, by activating the neuroimmune system and Toll-like receptors 4 (T...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.03.001
更新日期：2013-09-06 00:00:00
abstract：:The effect of tamoxifen on cytosolic free Ca2+ concentrations ([Ca2+]i) and viability has not been explored in corneal epithelial cells. This study examined whether tamoxifen altered [Ca2+]i and viability in SIRC corneal epithelial cells. Tamoxifen at concentrations > or = 1 microM increased [Ca2+]i in a concentration...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.10.001
更新日期：2009-01-08 00:00:00
abstract：:Testicular injury is often observed in drug development. Serum hormones are usually used as noninvasive biomarkers for testicular injury; however, their sensitivities are low. Therefore, it is difficult to monitor testicular injury in drug development. In recent years, molecules in body fluid exosomes have attracted a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152490
更新日期：2020-07-01 00:00:00
abstract：:The in vivo effects of sodium cyanide and its antidotes, sodium nitrite, sodium thiosulfate and 4-dimethylaminophenol (DMAP), as well as the alpha-adrenergic blocking agent phentolamine, on rat brain cytochrome oxidase were studied. The course of inhibition was time-dependent and a peak of 40% was attained between 15 ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90018-a
更新日期：1992-11-22 00:00:00
abstract：:A flow-through rat tracheal implant system is described which permits the quantitative and repetitive exposure of respiratory epithelia to test gaseous substances. To investigate the acute toxicity of formaldehyde gas with this new system, open-ended rat tracheal implants were exposed to the gas for 1 h twice a week f...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90142-2
更新日期：1984-04-16 00:00:00
abstract：:Chlorination of drinking water containing organic materials is known to generate toxic by-products. We suggested that such compounds may also be produced by interactions between chlorine and bacteria present in water. To confirm this hypothesis, a method based on RNA synthesis inhibition of HeLa S3 human cells in the ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00317-6
更新日期：2000-11-16 00:00:00
abstract：:Pregnant M. ochrogaster received single intraperitoneal (i.p.) doses of 0.06, 0.125, 0.25, 0.5, 1,2, or 5 mg phenyl mercuric acetate (PMA/kg of body weight on day 8, 9, or 10 of gestation or 0.5 mg PMA/kg on day 7, 8, 9, 10, 11, or 12 of gestation. No toxicity was exhibited, and no abnormal fetuses were observed in an...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(76)90031-7
更新日期：1976-11-01 00:00:00
abstract：:There is a close relationship between the central nervous system activity and bone metabolism. Therefore, methamphetamine (METH), which stimulates the central nervous system, is expected to affect bone turnover. The aim of this study was to investigate the role of METH in bone metabolism. Mice were divided into 3 grou...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.01.014
更新日期：2014-05-07 00:00:00
abstract：:It is reported that diesel exhaust particles contain more 1-nitropyrene (1-NP) than benzo[a]pyrene (B[a]P), both of which are potent carcinogenic compounds. In this study, we show that 1-NP is more potent in reducing cell viability than B[a]P, pyrene, nitrobenzene, and nitromethane. Aldo-keto reductases (AKRs) are enz...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.11.022
更新日期：2008-02-28 00:00:00
abstract：:Hesperidin (HDN) is a flavanone glycoside abundantly found in citrus fruits. HDN has been reported to possess significant activities against allergy, haemorrhoids, hormonal disorders and ulcers. Other reported activities include anti-inflammatory, analgesic, antibacterial, antifungal, antiviral, antioxidant and free r...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.06.018
更新日期：2006-09-21 00:00:00
