Abstract：
:The effects of di-(2-ethylhexyl)adipate (DEHA) have been compared in female F344 rats and female B6C3F1 mice fed diets containing 0-4.0% DEHA and 0-2.5% DEHA, respectively, for periods of 1, 4 and 13 weeks. In both the rat and mouse treatment with DEHA at all time points produced a dose-dependent increase in relative liver weight and hepatic peroxisome proliferation as demonstrated by the induction of peroxisomal (cyanide-insensitive palmitoyl-CoA oxidation) and microsomal (lauric acid 12-hydroxylase) fatty acid oxidising enzyme activities. The magnitude of induction of peroxisome proliferation was similar in both species. Replicative DNA synthesis was studied by implanting osmotic pumps containing 5-bromo-2'-deoxyuridine during study weeks 0-1, 3-4 and 12-13. After 1 week DEHA treatment hepatocyte labelling index values were increased in rats given 2.5 and 4.0% DEHA and mice given 0.6-2.5% DEHA. While DEHA treatment for 4 and 13 weeks did not increase labelling index values in the rat, a sustained stimulation of replicative DNA synthesis was observed in mice given 1.2 and 2.5% DEHA. The results of this study demonstrate a species difference in the hepatic effects of DEHA, in that at some dose levels DEHA can produce a sustained stimulation of replicative DNA synthesis in mouse but not in rat liver. Sustained cell replication provides a better correlation with the observed formation of liver tumours in chronic studies with DEHA in female mice, but not in female rats, than the magnitude of stimulation of hepatic peroxisome proliferation.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Lake BG,Price RJ,Cunninghame ME,Walters DGdoi
10.1016/s0300-483x(97)00125-xsubject
Has Abstractpub_date
1997-12-05 00:00:00pages
217-26issue
3eissn
0300-483Xissn
1879-3185pii
S0300483X9700125Xjournal_volume
123pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:The present study was undertaken to examine the effects of iodoacetic acid, a non-phorbol tumor promoter, on metabolic cooperation between mutant human fibroblasts as measured by [14C]citrulline incorporation. Other thiol-reactive polyphenolic compounds such as hydroquinone and 2-hydroxyestrone were also examined. 12-...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(87)90047-3
更新日期：1987-04-01 00:00:00
abstract：:The 4 S polycyclic aromatic hydrocarbon (PAH)-binding protein had been implicated in regulating the expression of rat cytochrome P450IA1 which is most closely associated with aryl hydrocarbon hydroxylase (AHH). We have now investigated the presence of both the 4 S PAH-binding protein and the 8 S Ah receptor in rat hep...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90217-o
更新日期：1991-02-01 00:00:00
abstract：:Acute and subchronic toxicities of VRCTC-310, a combination product of crotoxin (CT) and cardiotoxin (CD), which has shown antitumor activity in vivo, have been studied in Beagle dogs. Single i.m. doses of 0.25, 0.5 and 1.0 mg/kg resulted in dose-dependent local muscular toxicity consisting of myofiber atrophy, inters...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)02995-7
更新日期：1995-05-05 00:00:00
abstract：:Tobacco smoking is the largest preventable risk factor for morbidity and mortality in industrialized countries. WHO estimates that tobacco will become the largest single health problem by 2020, causing an estimated 8.4 million deaths annually. Tobacco has central importance in the etiology of cancers of the lung, head...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(01)00445-0
更新日期：2001-09-14 00:00:00
abstract：:In living organisms both chemical agents and physical factors [16] may produce neurophysiological change that affects EEG activity. EEG signals are very suitable for non-invasive measurement of CNS reactions, but quite complicated equipment is necessary for measurement and analysis. We have implemented a system that p...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90004-2
更新日期：1988-05-01 00:00:00
abstract：:Maintenance of health is dependent on numerous regulatory interactions between organ systems. This review discusses interorgan communication between the nervous, endocrine, and immune systems and environmental and genetic influences on this neuroendocrine immune circuitry. Stresses of multiple types, including psychol...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(99)00144-4
更新日期：2000-01-17 00:00:00
abstract：:To establish a paraquat-resistant Wistar rat strain, we carried out continuous sister-brother mating among rats that survived high-dose intraperitoneal administration of paraquat dichloride (360 mg/kg). The percentages of paraquat-resistant rats among wild rats and among the fifth-generations were 7.1% and 20.6%, resp...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00299-7
更新日期：2000-11-23 00:00:00
abstract：:Mechanisms responsible for resistance to Cd-induced testicular necrosis in inbred mice were investigated using strains resistant (A/J) or susceptible (129/J) to Cd-induced testicular damage. Cadmium accumulation was measured in testes of both strains 15 min, 30 min, 1 h, 2 h, 6 h, 12 h and 24 h after intravenous injec...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90126-4
更新日期：1984-03-01 00:00:00
abstract：:Nonylphenol (NP) has been identified at low levels in surface waters throughout North America. This industrial chemical is primarily used for the production of certain non-ionic surfactants, and has been reported to have weak estrogen-like activity. As estrogen has immunoregulatory properties and is crucial for normal...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2003.11.009
更新日期：2004-03-15 00:00:00
abstract：:Mutagenicity analysis of urine from rats treated by oral gavage with MX at a dose of 64 mg/kg for 14 days revealed that only 0.3% of the administered compound was excreted in a genotoxically active form. At lower doses, mutagenicity was not detectable. No evidence of micronucleus induction in peripheral blood erythroc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(96)03336-7
更新日期：1996-06-17 00:00:00
abstract：:Between the DNA sequences of two randomly-selected human genomes, which consist of over 3 billion base pairs and twenty five thousand genes, there exists only 0.1% variation and 99.9% sequence identity. During the last couple of decades, extensive genome-wide studies have investigated the association between single-nu...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2017.03.020
更新日期：2017-05-15 00:00:00
abstract：:The mouse lymphoma thymidine kinase assay (MLA) has been optimized to quantitatively determine the in vitro mutagenicity of cigarette mainstream smoke particulate phase. To test whether the MLA is able to discriminate between different cigarette types, specially constructed cigarettes each containing a single tobacco ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.07.019
更新日期：2006-10-29 00:00:00
abstract：:The effects of thallous cation (Tl(+)) on: (a) the production of oxidant species and (b) membrane fluidity were evaluated in human leukemia T cells (Jurkat). After 72 h of incubation in the presence of Tl(+) (5-100 microM), no significant changes in cell viability were observed, although the average cell size was decr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.01.028
更新日期：2006-05-01 00:00:00
abstract：:The promoting effects of a combined exposure to two pollutants (NO2, O3 or H2SO4-aerosol) at near ambient levels on lung tumorigenesis induced by N-bis(2-hydroxypropyl) nitrosamine (BHPN) were investigated in male Wistar rats. The rats were given a single intraperitoneal injection of BHPN (0.5 g per kg body wt.) at 6 ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90137-4
更新日期：1992-09-01 00:00:00
abstract：:This paper presents an overview of issues related to surface water contamination arising from uranium mining activities in the Alligator Rivers Region (ARR) of northern Australia, and a program of research and monitoring that must assess the potential and actual effects on ecosystem and human health. The program of as...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(02)00470-5
更新日期：2002-12-27 00:00:00
abstract：:There is considerable interest in gene and environment interactions in neurodegenerative diseases. The HFE (homeostatic iron regulator) gene variant (H63D) is highly prevalent in the population and has been investigated as a disease modifier in multiple neurodegenerative diseases. We have developed a mouse model to in...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2020.152525
更新日期：2020-08-01 00:00:00
abstract：:To investigate mechanisms of chemical-induced congenital heart defects (CHD) we have developed a rat model using dimethadione (DMO), the N-demethylated metabolite of the anticonvulsant, trimethadione (TMD). Dosing pregnant rats with 300mg/kg DMO every 12h from the evening of gestational day (GD) 8 until the morning of...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2014.10.014
更新日期：2014-12-04 00:00:00
abstract：UNLABELLED:We recently observed a case of digoxin and insulin self-poisoning without cardiac repercussion. We raised the hypothesis that insulin may have a cardio-protective effect in case of digoxin toxicity. We have therefore evaluated the effect of glucose-insulin infusion on mortality and ECG abnormalities during a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.04.035
更新日期：2006-07-25 00:00:00
abstract：:Ultrafine titanium dioxide (TiO(2)) particles have been shown to exhibit strong cytotoxicity when exposed to UVA radiation, but are regarded as a biocompatible material in the absence of photoactivation. In contrast to this concept, the present results indicate that anatase-sized (10 and 20 nm) TiO(2) particles in the...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.05.007
更新日期：2005-09-15 00:00:00
abstract：:For quantitative in vitro-in vivo extrapolation (QIVIVE) of metabolism for the purposes of toxicokinetics prediction, a precise and robust analytical technique for identifying and measuring a chemical and its metabolites is an absolute prerequisite. Currently, high-resolution mass spectrometry (HR-MS) is a tool of cho...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2013.08.010
更新日期：2015-06-05 00:00:00
abstract：:Manganese (II) bis(glycinate)dichloride (Mn(glycinate)2) is a coordination complex of manganese with application as a contrast enhancement agent for magnetic resonance imaging in the heart. To determine the cardioactivity of the manganese ion in this chelation cage, the effects of Mn(glycinate)2 on Ca channel function...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90062-6
更新日期：1991-01-01 00:00:00
abstract：:This review concerns some of the cell culture systems that are most frequently used in toxicology investigations. In particular, it sets out to evaluate the effectiveness of these cell culture systems in assessing the toxic potential of chemicals. Metabolic studies and general and specific toxicology investigations ar...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90046-9
更新日期：1981-01-01 00:00:00
abstract：:A mixture of 55% tallow alkyl ethoxylate sulfate (TAE3S) and 45% of linear alkylbenzene sulfonate (LAS) was fed to two generations of rats at dietary levels of 0.1, 0.5 or 1.0%. The rats were fed the surfactant mixture either continuously or during the organogenesis (days 6-15) period of six pregnancies. In addition,...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(75)90103-1
更新日期：1975-05-01 00:00:00
abstract：:The ability of urban oxidant and acid air pollutants to induce heat shock proteins (HSPs) in the mammalian lung is not known. Such proteins are known to be correlated with environmental stress and pathophysiological conditions. In this study, stress-inducible HSP 70 was assessed by slot-blotting in rat lungs (N=10 per...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(95)03250-j
更新日期：1996-02-22 00:00:00
abstract：:Hydroquinone (HQ) is naturally found in the diet, drugs, as an environmental contaminant and endogenously generated after benzene exposure. Considering that HQ alters the immune system and its several source of exposures in the environment, we hypothesized that prolonged exposure of HQ could affect the course of an im...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.08.085
更新日期：2007-11-20 00:00:00
abstract：:In our previous study, di-n-butyltin diacetate has been shown to cause malformations such as cleft mandible, ankyloglossia, fused ribs, etc. in rat fetuses after oral treatment of maternal rats on day 8 of gestation. In this study, teratogenic effects of five di-n-butyltin compounds with different anions and also buty...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90039-u
更新日期：1993-12-31 00:00:00
abstract：:L-695,256 is a novel 2-fluorenonyl carbapenem antibiotic with significant antimicrobial activity against strains of methicillin-resistant Staphylococci. This prototype compound was administered intravenously to rhesus monkeys (Macaca mulatta) at does of 50 or 200 mg/kg/day for 2 weeks to assess toxicity and found to i...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(96)03305-7
更新日期：1996-04-30 00:00:00
abstract：:Exposure to polychlorinated biphenyls (PCBs) is associated with numerous adverse health effects. Although the main route of exposure to PCBs is through the gastrointestinal tract, little is known about the contribution of the gut to the health effects of PCBs. We hypothesize that PCBs can disrupt intestinal integrity,...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.08.001
更新日期：2012-12-16 00:00:00
abstract：:Recent attention to methanol (MeOH) as a potential alternative fuel prompted an evaluation of the chemical's effects during early pregnancy. Rats were dosed by gavage during Days 1-8 of pregnancy at 0, 1.6, 2.4, or 3.2 g MeOH/kg/day. Groups of animals were killed on Days 9, 11, or 20 of pregnancy, and maternal, embryo...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90212-b
更新日期：1993-05-24 00:00:00
abstract：:Potassium dichromate was given to female Swiss mice (25 mg/kg per day) orally in water for 1-3 days. Brain homogenates were prepared to evaluate the occurrence of oxidative stress in this organ through the measurement of the antioxidant defense levels, and the extent of lipid peroxidation. In addition, mitochondrial f...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00254-7
更新日期：2000-09-07 00:00:00
