Abstract:
:The effects of thallous cation (Tl(+)) on: (a) the production of oxidant species and (b) membrane fluidity were evaluated in human leukemia T cells (Jurkat). After 72 h of incubation in the presence of Tl(+) (5-100 microM), no significant changes in cell viability were observed, although the average cell size was decreased as evaluated by steady-state light scattering. Tl(+) (5-100 microM) caused a significant increase in the concentration of cellular oxidants as measured with the probe 5(6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate (DCDCDHF). Similarly, a higher lipid oxidation products release was observed as measured by TBARS production. Both Tl(+)-mediated DCDCDHF oxidation and TBARS production were prevented when cells were supplemented with 2mM Trolox. Tl(+) (5-100 microM) also induced a concentration-dependent increase in plasma membrane fluidity, evaluated with the probe 6-(9-anthroyloxy)stearic acid (6-AS). This effect of Tl(+) was neither associated to the externalization of phosphatidylserine, nor observed in Trolox-supplemented cells. Significant correlations were found between the increase in plasma membrane fluidity and TBARS production and DCDCDHF oxidation. Together, the present results suggest that the increase in cellular oxidants caused by Tl(+) could oxidize membrane fatty acids, resulting in an increase in membrane fluidity. These effects could underlie the pathology associated with Tl(+) toxicity.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Verstraeten SVdoi
10.1016/j.tox.2006.01.028keywords:
subject
Has Abstractpub_date
2006-05-01 00:00:00pages
95-102issue
1-2eissn
0300-483Xissn
1879-3185pii
S0300-483X(06)00083-7journal_volume
222pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Ethanol is able to cross the placenta, which may cause teratogenicity. Here we investigated whether ethanol consumption during pregnancy (ECDP), even at doses unable to cause malformation, might increase the susceptibility of fetal rat liver to oxidative insults. Since cholestasis is a common condition in alcoholic li...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.05.015
更新日期:2006-08-15 00:00:00
abstract::The overall purpose of this study was to investigate how airborne house dust particles may contribute to an allergic immune response, and thereby also to asthma and other respiratory symptoms. The following aims were set: first, to quantify and characterize indoor suspended particulate matter (SPM) with regard to amou...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00292-4
更新日期:2000-11-02 00:00:00
abstract::Prenatal dexamethasone exposure (PDE) could induce testicular developmental toxicity in adults. The present study aims to confirm its intrauterine origination, and to explore its potential intrauterine programming mechanism. The pregnant rats were respectively injected subcutaneously with 0.2 and 0.8 mg/kg d dexametha...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2018.06.005
更新日期:2018-09-01 00:00:00
abstract::Ammonium perfluorooctanoate (APFO) is a surfactant used primarily as an aid in processing various fluoropolymers. Many toxicology and epidemiological studies have been conducted with APFO; however, no specific information regarding functional reproduction was previously available. Therefore, the potential reproductive...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2003.11.005
更新日期:2004-03-01 00:00:00
abstract::In the rat the hepatotoxicity of bromobenzene is greatly enhanced by the introduction of a cyano group adjacent to the bromine (i.e. o-bromobenzonitrile). Epoxide metabolites of these aryl halides are believed to be the actual toxic species, but epoxides of the latter compound also possess a second site of chemical re...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90106-9
更新日期:1984-06-01 00:00:00
abstract::It has been suggested, on the basis of work in cell-free systems, that sulfonamide hydroxy-lamines are metabolized to nitroso metabolites which may be the proximate toxins mediating sulfonamide hypersensitivity reactions. We performed time-course experiments investigating the toxicity of the hydroxylamine and nitroso ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)02900-f
更新日期:1995-01-06 00:00:00
abstract::Chronic ethanol intake affects various organ systems of the body. The present study evaluated modifications of fatty acid concentrations both in brain and striated skeletal muscles of rats genetically selected for voluntary high ethanol intake. Three groups of rats were tracked for 10 weeks of access to ethanol only a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.02.023
更新日期:2004-07-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) and N-nitrosamines (NNA) are mainly activated by cytochrome P450s, and their associated enzyme activities such as aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH), N-nitrosdimethylamine N-demethylase I (NDMA-dI), NADPH-cytochrome C reductase, and detoxified by glutathione S-t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00048-3
更新日期:2002-05-24 00:00:00
abstract::To elucidate the maternal exposure effects of aflatoxin B1 (AFB1) and its metabolite aflatoxin M1, which is transferred into milk, on postnatal hippocampal neurogenesis, pregnant Sprague-Dawley rats were provided a diet containing AFB1 at 0, 0.1, 0.3, or 1.0 ppm from gestational day 6 to day 21 after delivery on weani...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2015.08.001
更新日期:2015-10-02 00:00:00
abstract::For quantitative in vitro-in vivo extrapolation (QIVIVE) of metabolism for the purposes of toxicokinetics prediction, a precise and robust analytical technique for identifying and measuring a chemical and its metabolites is an absolute prerequisite. Currently, high-resolution mass spectrometry (HR-MS) is a tool of cho...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2013.08.010
更新日期:2015-06-05 00:00:00
abstract::The ability of 27 compounds to mediate depletion of glutathione (GSH) in a fortified liver microsome incubation via production of reactive metabolites generated by microsomal mono-oxygenase (MMO) metabolism has been studied. The majority of compounds tested of this type were positive in this assay, with the exception ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90082-6
更新日期:1989-01-01 00:00:00
abstract::The brominated flame retardants tetrabromobisphenol A (TBBPA) and hexabromocyclododecane (HBCD) are found in the environment, e.g., in sediments and organisms, in food items, human blood samples and mother's milk. In this study, the effects of both compounds on rat hepatic cytochrome P450 (CYP) levels and activities w...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.10.019
更新日期:2006-02-01 00:00:00
abstract::Female mice were given nutrient-sufficient, purified diets containing cadmium at either 0.25, 5, or 50 ppm, as described in the accompanying publication. One-half of the females were bred for 6 consecutive 42-day rounds of pregnancy/lactation (PL mice); remaining females were non-pregnant controls (NP mice). PL mice a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90092-3
更新日期:1988-07-01 00:00:00
abstract::The effects of mercury (Hg(2+)) and selenite (Se(4+)) on delta-aminolevulinic acid dehydratase (delta-ALA-D) activity, 2-thiobarbituric acid reactive substances (TBARS) and nonprotein sulfhydryl content (NPSH) in mouse kidney and liver were investigated. Male mice were given a single i.p. injection of Hg(2+) and/or Se...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00576-0
更新日期:2003-03-03 00:00:00
abstract::Toluene is a widely abused inhaled solvent. This study was designed to determine whether toluene abuse affects the reproductive functions or general health of males. Seven-week-old male Sprague-Dawley rats were exposed to toluene vapor inhalation (0, 4000, or 6000 ppm; 2 h/day) daily for 5 weeks. Exposure-related supp...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00120-1
更新日期:1999-12-06 00:00:00
abstract::Three new natural mycotoxins, analogues of ochratoxin A, in which the phenylalanine moiety is replaced by serine, hydroxyproline or lysine, were isolated from cultures of Aspergillus ochraceus by TLC followed by HPLC column chromatography. Their structures were determined after acidic hydrolysis by the characterisatio...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90192-h
更新日期:1992-12-04 00:00:00
abstract::Rats were exposed to isopropanol by inhalation of 200,2000 and 8000 ppm for 2 weeks with a daily exposure of 6 h. A pilot group exposed to 8000 ppm was given a recovery period of 4 weeks. Kidney and liver microsomal metabolism of n-hexane was investigated in vitro concomitant with activities of cytochrome P-450 and GS...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(85)90078-2
更新日期:1985-01-01 00:00:00
abstract::Aluminum (Al) is recognized worldwide as serious inorganic contaminants. Exposure to Al is associated with low BMD and an increased risk of osteoporosis. However, the precise molecular mechanisms remains unclear. Thus, in this study, rats were orally exposed to 0 (control group, CG) and 0.4g/L AlCl3 (AlCl3 treated gro...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.10.002
更新日期:2016-09-14 00:00:00
abstract::The effects of N-acetylcysteine (NAC), 2-mercaptopropionylglycine (MPG) and dithiothreitol (DTT) on the metabolism and toxicity of acetaminophen (APAP) were examined in isolated mouse hepatocytes maintained in primary culture on collagen-coated dishes. Both NAC and MPG increased the formation of the glutathione and su...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90106-x
更新日期:1986-10-01 00:00:00
abstract::Oxidative stress as a result of excessive generation of reactive oxygen species (ROS) or diminished antioxidative defence is regarded as a main factor in the pathophysiology of various diseases and ageing. Many flavonoids that are present in herbal edibles have antioxidative properties and possess a remarkable spectru...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.02.006
更新日期:2007-05-05 00:00:00
abstract::Flame retardants such as polybrominated diphenyl ethers (PBDE) and tetrabromobisphenol A are used as flame retardants and detected in the environmental, wildlife species and human tissues. Exposure to PBDEs during the neonatal development of the brain has been shown to affect behavior and learning and memory in adult ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.07.010
更新日期:2011-10-28 00:00:00
abstract::The mean concentrations of polybrominated diphenyl ethers (PBDEs) (sum tetra- to octaBDEs) were determined in samples of foodstuffs widely consumed by the population of Catalonia, Northeast Spain. The following six tetra-through heptabrominated congeners were also individually analyzed: PBDEs 47, 99, 100, 153, 154 and...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2008.03.006
更新日期:2008-06-03 00:00:00
abstract::The function of the neuromuscular transmission in rats dosed with phoxim (P), methomyl (M), fenvalerate (F), and mixtures of P+M and P+F was studied by using both the stimulation single fiber electromyography (SSFEMG) and repetitive nerve stimulations (RNS) to determine the single muscle fiber action potential and com...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00339-0
更新日期:2001-03-21 00:00:00
abstract::Salicylate has been found to be an inhibitor of fatty acid synthesis in isolated rat hepatocytes. Half-maximal inhibition of fatty acid synthesis occurs at approximately 2 mM. The inhibitory effect of salicylate on fatty acid synthesis is not relieve by the addition of acetate, suggesting that salicylate inhibits the ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(82)90060-9
更新日期:1982-01-01 00:00:00
abstract::The cardiovascular toxin allylamine (3-aminopropene) has been shown to concentrate in elastic and muscular tissues. In this study the 14C-moiety of [14C]allylamine was traced in aortas of adult Sprague-Dawley rats after intravenously injecting 30 microCi of [14C]allylamine (spec. act. = 0.4 mCi/mM). At 5, 10, 15 and 2...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(85)90014-9
更新日期:1985-06-14 00:00:00
abstract::Fenvalerate is a widely used synthetic pyrethroid insecticide and is reported to disrupt reproductive function in humans and animals. However, little is known about its influence on follicular development. In this study, rat preantral follicles were primary cultured to investigate the effects of fenvalerate on follicu...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.10.022
更新日期:2010-01-12 00:00:00
abstract::The question as to whether or not the hypotension observed as part of the effect of tricholorofluoromethane (FC11), dichlorofluoromethane (FC 12), dichlorotetrafluoroethane (FC 114) and methyl chloroform was due to a vasodepressor component of action, in addition to the previously documented depression in myocardial c...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(76)90048-2
更新日期:1976-03-01 00:00:00
abstract::The mechanism underlying the induction of micronuclei induced by rifampicin and nicotine in mouse bone marrow was investigated by fluorescence in situ hybridization assay using mouse minor satellite DNA probe. Colchicine and mitomycin, known to be predominantly clastogenic and aneugenic, respectively were used as posi...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.03.011
更新日期:2007-06-03 00:00:00
abstract::The current Organisation for Economic Co-operation and Development (OECD) guidelines for evaluating organophosphorus-induced delayed neuropathy (OPIDN) require the observation of dosed animals over several days and the sacrifice of 48 hens. Adhering to these protocols in tests with enantiomers is difficult because lar...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.12.004
更新日期:2012-02-26 00:00:00
abstract::Myopathy is among the well documented and the most disturbing adverse effects of statins. The underlying mechanism is still unknown. Mitochondrial dysfunction related to coenzyme Q10 decline is one of the proposed theories. The present study aimed to investigate the mechanism of atorvastatin-induced myopathy in rats. ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2016.06.015
更新日期:2016-06-01 00:00:00