Abstract：
:The ability of urban oxidant and acid air pollutants to induce heat shock proteins (HSPs) in the mammalian lung is not known. Such proteins are known to be correlated with environmental stress and pathophysiological conditions. In this study, stress-inducible HSP 70 was assessed by slot-blotting in rat lungs (N=10 per group) following inhalation exposures for 4 h per day, 3 days per week for 40 weeks to the following pollutants: (a) purified air;(b) 0.15 ppm ozone (O3);(c)50 micrograms/m3 nitric acid (HNO3); or(d) a combination of both 0.15 ppm O3 and 50 micrograms/m3 HNO3. At 24 h following the last exposure, samples from the right apical lobe of the lung were obtained for either slot-blotting or gel electrophoretic separation, subsequent protein immunoblotting, and chemiluminescence detection of HSP 70 levels. Experiments demonstrate that stress-inducible HSP 70 was present constitutively in the control lungs and was separable from the constitutive form of HSP 70. Slot-blotting analysis demonstrate that the O3 and HNO3 exposures alone produced significant elevations of HSP70. Specifically, either O3 or HNO3 alone significantly elevated lung stress-inducible HSP 70 levels by 277% and 221% respectively, above control levels. The group exposed to combined O3 and HNO3 showed a 177% elevation in lung stress-inducible HSP 70 that was significantly greater that the group inhaling purified air, but this effect was less than the effects of either pollutant component alone. Moreover, all exposure groups were significantly different from one another. These results indicate that stress-inducible HSP 70 in the rat lung is highly elevated after chronic inhalation exposures to both O3 and HNO3 when administered either alone or in combination within the range of urban ambient concentrations.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Wong CG,Bonakdar M,Mautz WJ,Kleinman MTdoi
10.1016/0300-483x(95)03250-jsubject
Has Abstractpub_date
1996-02-22 00:00:00pages
111-9issue
2eissn
0300-483Xissn
1879-3185pii
0300483X9503250Jjournal_volume
107pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:In the present study, we demonstrated the cytotoxic effect of a dimethylarsenic compound in seaweed, (R)-(2',3'-dihydroxypropyl) 5- deoxy-5-dimethylarsinoyl-beta-D-riboside, namely arsenosugar (AsSug), on mammalian cells, murine macrophages, in comparison with that of an inorganic arsenical, arsenite, in vitro. More t...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(97)00101-7
更新日期：1997-10-19 00:00:00
abstract：:Proliferation and differentiation of cells in female reproductive organs, the oviduct, uterus and vagina, are regulated by endogenous estrogen. In utero exposure to a synthetic estrogen, diethylstilbestrol (DES), induces vaginal clear-cell adenocarcinoma in humans. In mice, perinatal exposure to DES results in abnorma...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.02.010
更新日期：2012-06-14 00:00:00
abstract：:Pulmonary fibrosis is one of the most common chronic interstitial lung diseases with high mortality rate after diagnosis and limited successful treatment. The present study was designed to assess the potential antifibrotic effect of thymoquinone (TQ) and whether TQ can attenuate the severity of oxidative stress and in...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.09.001
更新日期：2012-12-16 00:00:00
abstract：:Ghrelin stimulates growth hormone (GH) release and induces positive energy balances. Previous studies have reported that ghrelin inhibits apoptosis in several cell types but the precise underlying protective mechanisms in pancreatic beta cells are poorly understood. Therefore, we investigated which pathway was related...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.05.013
更新日期：2007-07-31 00:00:00
abstract：:Polycyclic aromatic hydrocarbons (PAHs) and N-nitrosamines (NNA) are mainly activated by cytochrome P450s, and their associated enzyme activities such as aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH), N-nitrosdimethylamine N-demethylase I (NDMA-dI), NADPH-cytochrome C reductase, and detoxified by glutathione S-t...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00048-3
更新日期：2002-05-24 00:00:00
abstract：:The objective of this study was to further evaluate the developmental toxicity of tributyltin chloride (TBTCl) in rats. Pregnant rats were given TBTCl by gastric intubation at a dose of 25, 50 or 100 mg/kg on days 7-9, days 10-12 or days 13-15 of pregnancy. A significant increase in the incidence of post-implantation ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(94)02920-p
更新日期：1995-02-27 00:00:00
abstract：:Organochalcogens are important intermediates and useful reagents in organic synthesis, which can increase human exposure risk to these chemicals in the workplace. As well, there are a number of reported cases of acute toxicity following organochalcogen ingestion of vitamins and dietary supplements. Since, the erythroc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(03)00250-6
更新日期：2003-09-30 00:00:00
abstract：:We compared the results of the multiple-dose guinea pig maximization test (GPMT) and the non-radioactive murine local lymph-node assay (LLNA) for various biocides. Thirteen out of 17 positive biocides in the GPMT gave positive results in the LLNA. In the GPMT, the minimum first induction doses ranged over four orders ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.02.014
更新日期：2005-07-01 00:00:00
abstract：:Cetaben and clofibrate were each administered to groups of 6 rats (3 male and 3 female) by gavage at dosages of 50 mg/kg per day and 200 mg/kg per day for 2 weeks. Cetaben caused 1 death at 200 mg/kg per day and decreases in body weight gain and food consumption at 50 mg/kg per day or more. There were no effects on bo...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(83)90004-5
更新日期：1983-11-01 00:00:00
abstract：:The protective effect of telmisartan, the angiotensin II-receptor antagonist, against liver toxicity induced by sodium arsenite (5 mg/kg/day, p.o., for 30 days) was investigated in mice. Telmisartan treatment (10 mg/kg/day, p.o.) was applied for 30 days, starting on the same day of arsenic administration. Telmisartan ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2012.06.015
更新日期：2012-10-28 00:00:00
abstract：:The function of the neuromuscular transmission in rats dosed with phoxim (P), methomyl (M), fenvalerate (F), and mixtures of P+M and P+F was studied by using both the stimulation single fiber electromyography (SSFEMG) and repetitive nerve stimulations (RNS) to determine the single muscle fiber action potential and com...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00339-0
更新日期：2001-03-21 00:00:00
abstract：:An in vitro model of the rat nasal cavity has been used to compare the responses of nasal tissues in vitro, using loss of intracellular ATP and potassium as indices of toxicity, with the pathological changes occurring following in vivo exposure to four test compounds. Turbinates were incubated in vitro with the test c...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00180-8
更新日期：2000-04-07 00:00:00
abstract：:Treatment of rats with beta-alanine increases the urinary taurine levels and markedly reduces the concentration of taurine in the liver. Dosing with carbon tetrachloride (CCl4) during treatment with beta-alanine results in a marked decrease in urinary taurine concomitant with a decrease in food intake. Treatment of an...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90133-d
更新日期：1993-01-29 00:00:00
abstract：:Many scientists and doctors are not aware that the level of certainty for litigation purposes differs from that usually associated with scientific studies. Although the 0.05 probability level is commonly used in scientific studies ("beyond a reasonable doubt"), in U.S. civil litigation the diagnostic criteria is "more...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(88)90025-x
更新日期：1988-05-01 00:00:00
abstract：:Natural antioxidants like catechin are now known to have a modulatory role on physiological functions and biotransformation reactions involved in the detoxification process, thereby affording protection from toxic metabolic actions of xenobiotics. Reactive oxygen intermediates have been demonstrated to play an etiolog...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.05.009
更新日期：2006-08-15 00:00:00
abstract：:Chalcones are phenolic compounds that can be isolated from plants. Previous studies have described some pharmacological applications for these compounds. Making use of our established reporter gene system, we determined the effect of five hydroxychalcones--2-hydroxychalcone, 2'-hydroxychalcone, 4-hydroxychalcone, 4,2'...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.10.005
更新日期：2005-02-14 00:00:00
abstract：:Numerous dietary compounds, ubiquitous in fruits, vegetables and spices have been isolated and evaluated during recent years for their therapeutic potential. These compounds include flavonoid and non-flavonoid polyphenols, which describe beneficial effects against a variety of ailments. The notion that these plant pro...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2009.11.008
更新日期：2010-11-28 00:00:00
abstract：:Treatment of Chinese hamster cells with 1 mM tertiary-butylhydroperoxide (t-BuOOH) for 1 h markedly inhibited the activity of glutathione peroxidase (GSH-Px). However, the activity returned to pre-inhibition levels within 1-2 h with post-treatment incubation. The inhibition of the activity of GSH-Px by t-BuOOH was enh...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(92)90058-m
更新日期：1992-01-01 00:00:00
abstract：:Potassium dichromate was given to female Swiss mice (25 mg/kg per day) orally in water for 1-3 days. Brain homogenates were prepared to evaluate the occurrence of oxidative stress in this organ through the measurement of the antioxidant defense levels, and the extent of lipid peroxidation. In addition, mitochondrial f...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00254-7
更新日期：2000-09-07 00:00:00
abstract：:Age-related differences in susceptibility to cephaloridine nephrotoxicity were evaluated in male Fischer-344 rats. Rats, 2.5, 4, 10-12 and 27-29 months old, were administered a single intraperitoneal dose of cephaloridine and renal function evaluated 24 h later. Susceptibility to cephaloridine-induced nephrotoxicity w...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90171-x
更新日期：1986-01-01 00:00:00
abstract：:Nitrated-polycyclic aromatic hydrocarbons (nitro-PAHs) and diesel exhaust particle extracts (DEPE) induced apoptosis in Hepa1c1c7 cells with the following potency: 1,3-dinitropyrene (1,3-DNP)>1-nitropyrene (1-NP) > DEPE > 1,8-dinitropyrene (1,8-DNP). The compounds induced cyp1a1, and activated various intracellular si...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.12.009
更新日期：2007-03-07 00:00:00
abstract：:The nerve agent tabun inhibits the essential enzyme acetylcholinesterase (AChE) by a rapid phosphoramidation of the catalytic serine residue. Oximes, such as K027 and HLö-7, can reactivate tabun-inhibited human AChE (tabun-hAChE) whereas the activity of their close structural analogue HI-6 is notably low. To investiga...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.09.002
更新日期：2009-11-30 00:00:00
abstract：:A flow-limited physiologically based toxicokinetic model was constructed for uptake, metabolism, and clearance of butadiene (BD) and its principal metabolite 1,2-epoxy-3-butene (EB), using physiological and biochemical parameters from the literature where available. The model includes compartments for blood, liver, lu...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(96)03424-5
更新日期：1996-10-28 00:00:00
abstract：:Mitochondrial dysfunction with exposure to anthropogenic contaminants is a critical concern in biomedical and ecological health. Importantly, understanding the role of mitotoxicants in modulating organismal fitness and survival, particularly in the context of species' resilience to shifts in abiotic factors with clima...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2017.07.015
更新日期：2017-11-01 00:00:00
abstract：:Rats were treated for 4 weeks with chlorphentermine hydrochloride (30 mg/kg, i.p., 5 days/seek), a regimen which causes a profound phospholipidosis in the alveolar macrophages (AMs). The susceptibility of these lipid-laden cells to lipid peroxidation was examined and compared to AMs from control (untreated) rats. Lipi...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90078-5
更新日期：1980-01-01 00:00:00
abstract：:The intravenous LD50 of cefuroxime sodium for mice was 10.4 g/kg. The maximum dosage administered in other acute toxicity tests was well tolerated by mice (10 g/kg, subcutaneous), by rats (4 g/kg, intravenous, 5 g/kg, subcutaneous) and by cats, dogs and monkeys (2 g/kg, intramuscularly). Cefuroxime sodium was administ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(79)80003-7
更新日期：1979-05-01 00:00:00
abstract：:Malathion is one of the most widely used organophosphorus insecticides in agriculture. However, malathion may be involved in the etiology of human brain dysfunction. Induction of ROS has been proposed as a mechanism of malathion-induced poisoning cases, but there are few data regarding the effects of malathion on oxid...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2019.02.004
更新日期：2019-04-01 00:00:00
abstract：:This paper introduces the special issue on quantitative in vitro-in vivo extrapolations (QIVIVE). It highlights important issues in the development of in vitro toxicology towards its implementation in toxicological risk assessment. ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/j.tox.2014.04.004
更新日期：2015-06-05 00:00:00
abstract：:Pregnant CD-1 mice were administered a commercial 2,4-dichlorophenoxyacetic acid (2,4-D) formulation on days 6-16 days of gestation, in drinking water at concentrations ranging from 0 to 1.0% of the formulated product, equivalent to approximately 0-650 mg/kg per day expressed as the amine derivative. The effect of 2,4...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00403-6
更新日期：2001-08-13 00:00:00
abstract：:Mycotoxins (frequently referred to as secondary metabolites of toxigenic fungi) are commonly found in foodstuffs and are important because of their association with disease. The mycotoxin diacetoxyscirpenol, or 3-hydroxy-4,15-diacetoxy-12,13-epoxytrichothec-9-ene (DAS), is produced by numerous species of Fusarium and ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(87)90016-3
更新日期：1987-09-01 00:00:00
