Immune-related gene polymorphisms in pulmonary diseases.

abstract：:To check the possible toxicity risks of the meat from swine fed with a residue producing feed additive: Carbadox, a new methodology was used. It is the "Relay Toxicity". Swine were fed with a high dose of the additive and sacrificed without any withdrawal. In such conditions meat contains a high level of residues. The...

journal_title：Toxicology

authors： Ferrando R,Truhaut R,Raynaud JP,Spanoghe JP

更新日期：1978-10-01 00:00:00

abstract：:Deltamethrin, an alpha-cyano type II synthetic pyrethroid insecticide is used to control a wide range of insects on a variety of crops. Deltamethrin is reported to cause many adverse effects on non-target species. Deltamethrin is reported to cause DNA damage and micronuclei induction in human lymphocytes. It is highly...

journal_title：Toxicology

authors： Shukla Y,Arora A,Singh A

更新日期：2001-05-28 00:00:00

abstract：:In our previous study, di-n-butyltin diacetate has been shown to cause malformations such as cleft mandible, ankyloglossia, fused ribs, etc. in rat fetuses after oral treatment of maternal rats on day 8 of gestation. In this study, teratogenic effects of five di-n-butyltin compounds with different anions and also buty...

journal_title：Toxicology

authors： Noda T,Morita S,Baba A

更新日期：1993-12-31 00:00:00

abstract：:The reproductive toxicity of vanadium was studied in mice. Male Swiss mice were exposed to sodium metavanadate at doses of 0, 20, 40, 60, and 80 mg/kg per day given in the drinking water for 64 days. To evaluate the fertility of the vanadium-treated animals, males were mated with untreated females for 4 days. A signif...

journal_title：Toxicology

authors： Llobet JM,Colomina MT,Sirvent JJ,Domingo JL,Corbella J

更新日期：1993-06-11 00:00:00

abstract：:Chlordecone (CD) impairs biliary excretion of organic anions (including phenolphthalein glucuronide (PG), imipramine polar metabolites, and taurocholate) without evidence of hepatocellular necrosis in rats. In this study we investigated the hypothesis that CD-induced hepatobiliary dysfunction is dependent on CD concen...

journal_title：Toxicology

authors： Rochelle LG,Curtis LR

更新日期：1994-01-26 00:00:00

abstract：:The majority of insecticides currently in use throughout the world belong to the class of the organophosphorus insecticides. Many of these compounds, such as the phosphorothioate insecticides, exert their mammalian toxicity only after undergoing metabolic activation by a variety of cytochrome P450 isoforms to produce ...

journal_title：Toxicology

authors： Ramos S,Sultatos L

更新日期：1998-11-16 00:00:00

abstract：:The combined effects of ethyl alcohol (ETOH) intoxication and carbon monoxide (CO) poisoning were studied in the Levine-prepared rat. Infusion or injection of ETOH before and during 90 min of CO exposure to blood levels 2-4 times those considered legally drunk in humans, increased survival at 2400 ppm, and extended th...

journal_title：Toxicology

authors： Sharma P,Penney DG

更新日期：1990-05-31 00:00:00

abstract：:As an important cholesterol oxide, 7-ketocholesterol plays a deleterious role in the occurrence of cancer. Although the fact had been proved that 7-ketocholesterol could induce several biological phenomena, including apoptosis, DNA damage, et al., this issue whether 7-ketocholesterol led to mutagenesis in mammalian ce...

journal_title：Toxicology

authors： Wang X,Li Y,Xia X,Zhang M,Ge C,Xia X,Xiao H,Xu S

更新日期：2020-12-15 00:00:00

abstract：:Immunohistochemical methods have been widely used to determine the histogenesis of spontaneous and chemically-induced mouse lung tumors. Typically, antigens for either alveolar Type II cells or bronchiolar epithelial Clara cells are studied. In the present work, the morphological and immunohistochemical phenotype of a...

journal_title：Toxicology

authors： Hicks SM,Vassallo JD,Dieter MZ,Lewis CL,Whiteley LO,Fix AS,Lehman-McKeeman LD

更新日期：2003-05-03 00:00:00

abstract：:The Salmonella mutagenicity assay was utilized to compare hepatic S9 fractions derived from wild and laboratory reared woodchucks (Marmota monax). Two promutagens, 7,12-dimethylbenz[a]anthracence (DMBA) and 2-amino-fluorene (AF) were tested at 5 concentrations with the tester strains TA98 and TA100, against 2 levels o...

journal_title：Toxicology

authors： Rashid KA,Babish JG,Mumma RO

更新日期：1988-01-01 00:00:00

abstract：:Reactions of ethenyloxirane with amino (RNH2) and thiol (R'SH) nucleophiles occur by an SN2 mechanism involving competing ring cleavage at C-2 and C-3. In contrast, 2-ethenyl-2-methyloxirane reacts with amino (RNH2) and thiolate (R'S-) nucleophiles in methanol by regioselective SN2 attack at C-3 ("neo-pentyl" position...

journal_title：Toxicology

authors： Bleasdale C,Small RD,Watson WP,Wilson J,Golding BT

更新日期：1996-10-28 00:00:00

abstract：:Methoxy-, ethoxy- and n-butoxy acetic acids, known urinary metabolites of the corresponding alkoxyethanol solvents, were administered by gavage to rats as a single oral dose equimolar with 500, 250 or 100 mg 2-methoxyethanol/kg body weight. Testicular weight and morphology were monitored over a 14-day period post-trea...

journal_title：Toxicology

authors： Foster PM,Lloyd SC,Blackburn DM

更新日期：1987-01-01 00:00:00

abstract：:The effects of di-(2-ethylhexyl)adipate (DEHA) have been compared in female F344 rats and female B6C3F1 mice fed diets containing 0-4.0% DEHA and 0-2.5% DEHA, respectively, for periods of 1, 4 and 13 weeks. In both the rat and mouse treatment with DEHA at all time points produced a dose-dependent increase in relative ...

journal_title：Toxicology

authors： Lake BG,Price RJ,Cunninghame ME,Walters DG

更新日期：1997-12-05 00:00:00

abstract：:Glutathione S-transferases and glutathione play an important role in the detoxification of most toxic agents. In the present study, the protective effects of some antioxidants (L-ascorbic acid (AA), vitamin E (VE) or garlic) on carbon tetrachloride-induced changes in the activity of alanine amino transferase (ALT), as...

journal_title：Toxicology

authors： Sheweita SA,Abd El-Gabar M,Bastawy M

更新日期：2001-08-28 00:00:00

abstract：:Experiments were designed to evaluate and compare metallothionein (MT), zinc and cadmium levels in human placentas of smoking and non-smoking women. Smoking was assessed by self-reported cigarette consumption and urine cotinine levels before delivery. Smoking pregnant women with urine cotinine levels higher than 130 n...

journal_title：Toxicology

authors： Ronco AM,Arguello G,Suazo M,Llanos MN

更新日期：2005-03-01 00:00:00

abstract：:The presence of inclusion bodies in renal proximal tubules was studied in rats exposed to lead and/or disulfiram (tetraethylthiuram disulfide). Pregnant rats were treated with only lead acetate (0.25% Pb in the drinking water), only disulfiram (0.1 mmol/kg p.o. twice a week) or with both lead acetate and disulfiram fr...

journal_title：Toxicology

authors： Oskarsson A,Johansson A

更新日期：1987-04-01 00:00:00

abstract：:Diesel exhaust particles (DEP) affect health adversely. Our previous studies revealed that DEP extracts up-regulated expression of genes related to drug metabolism, antioxidant enzymes, cell cycle/apoptosis and coagulation, and in addition, n-hexane soluble fraction (n-HSF) of DEP extracts contains aliphatic and polyc...

journal_title：Toxicology

authors： Omura S,Koike E,Kobayashi T

更新日期：2009-07-28 00:00:00

abstract：:The distribution and excretion of radioactivity from [14C]citrinin (3 mg/kg, i.v) was determined in male rats. At 0.5 h after administration maximum values of 14.7% and 5.6% of total radioactivity were observed in the liver and kidneys, respectively, and by 6 h decreased to 7.5% in the liver and 4.7% in the kidney. Pl...

journal_title：Toxicology

authors： Phillips RD,Berndt WO,Hayes AW

更新日期：1979-03-01 00:00:00

abstract：:The toxic oil syndrome (TOS), a multisystemic disease, that occurred in Spain in 1981, was caused by the ingestion of rapeseed oil denatured with 2% aniline. Due to the clinical course of the disease, immunopathological mechanisms have been suspected but a direct connection was never demonstrated. To analyse this poss...

journal_title：Toxicology

authors： Gallardo S,del Pozo V,Cárdaba B,de Andrés B,Martín-Orozco E,Fernandez JC,Tramón P,Posada M,Abaitua I,Palomino P

更新日期：1994-11-11 00:00:00

abstract：:Heavy metals, such as iron and manganese, are involved in neurologic disease. Most often these diseases are associated with abnormal environmental exposures or abnormal accumulations of heavy metals in the body. There is increasing recognition that heavy metals normally present in the body also may play a role in dise...

journal_title：Toxicology

authors： Montgomery EB Jr

更新日期：1995-03-31 00:00:00

abstract：:Pregnant CD-1 mice were administered a commercial 2,4-dichlorophenoxyacetic acid (2,4-D) formulation on days 6-16 days of gestation, in drinking water at concentrations ranging from 0 to 1.0% of the formulated product, equivalent to approximately 0-650 mg/kg per day expressed as the amine derivative. The effect of 2,4...

journal_title：Toxicology

authors： Lee K,Johnson VL,Blakley BR

更新日期：2001-08-13 00:00:00

abstract：:Although manufactured magnetic nanoparticles (NPs) are currently used in many fields, NPs have potential toxicity on cardiovascular system especially atherosclerosis. In our previous study, we prepared novel Fe3O4 nanoparticles surface-coated with aminoguanidine (Fe3O4-AG NPs) which could remove acid dyes from aqueous...

journal_title：Toxicology

authors： Qu G,Wu Q,Zhao B,Miao J,Su L

更新日期：2019-05-01 00:00:00

abstract：:Several different meanings have been attached to the term "chemical sensitivity" by those who use it. Feeling ill from odors is a symptom reported by approximately one-third of the population. The syndrome of chemical sensitivity, frequently called "Multiple Chemical Sensitivity" or "MCS" has been the subject of three...

journal_title：Toxicology

authors： Miller CS

更新日期：1996-07-17 00:00:00

abstract：:Increased antigen-specific IgE expression is a hallmark of the allergic response in mice. IgG1 may also be involved. Co-injection of mice with diesel exhaust particles (DEP) and ovalbumin three times over a 2 week period lead to a rapid and marked elevation of ovalbumin-specific IgE, IgG1 and also IgG2a, compared with...

journal_title：Toxicology

authors： Heo Y,Saxon A,Hankinson O

更新日期：2001-02-28 00:00:00

abstract：:Databases in science and technology dealing with toxicology subjects are of great and increasing interest to the scientific community. International hosts pay their tribute in creating toxicology clusters as a user-aid. Toxicology clusters of DataStar, DIALOG, DIMDI and STN are listed and compared. At the German Natio...

journal_title：Toxicology

authors： Voigt K,Brüggemann R

更新日期：1995-06-26 00:00:00

abstract：:During the past decade, several assessments have estimated the carcinogenic risk of inhaled 1,3-butadiene (BD) to the general population as well as for occupational exposures. Although most of the risk assessments have been based on inhalation bioassays in mice, some of the assessments have included the 2-year inhalat...

journal_title：Toxicology

authors： Cagen SZ,MacDonald RL,Van Gelder G

更新日期：1996-10-28 00:00:00

abstract：:Bisphenol A (BPA) is a commonly used endocrine-disrupting chemical used as a component of polycarbonates plastics that has potential adverse effects on human health. Exposure to BPA during development has been implicated in memory deficits, but the mechanism of action underlying the effect is not fully understood. In ...

journal_title：Toxicology

authors： Wang C,Li Z,Han H,Luo G,Zhou B,Wang S,Wang J

更新日期：2016-02-03 00:00:00

abstract：:Subacute exposure of male rats to various concentrations (70-1000 ppm) of dichloromethane (DCM) produces a selective reduction of dopamine (DA) levels without a change of DA turnover in certain types of forebrain DA nerve terminal systems. In the low concentration (70 ppm) a selective reduction of DA turnover was obse...

journal_title：Toxicology

authors： Fuxe K,Andersson K,Hansson T,Agnati LF,Eneroth P,Gustafsson JA

更新日期：1984-02-01 00:00:00

abstract：:Heavy metal environmental pollutants increase susceptibility of affected individuals to bacterial and viral infections, but the mechanisms responsible for this effect are not known. We established cellular in vitro systems to identify molecular targets for the action of heavy metal ions. We used two model systems to d...

journal_title：Toxicology

authors： Shen X,Lee K,König R

更新日期：2001-12-01 00:00:00

abstract：:Testicular injury is often observed in drug development. Serum hormones are usually used as noninvasive biomarkers for testicular injury; however, their sensitivities are low. Therefore, it is difficult to monitor testicular injury in drug development. In recent years, molecules in body fluid exosomes have attracted a...

journal_title：Toxicology

authors： Kawata R,Kagawa T,Koya Y,Kajiyama H,Oda S,Yokoi T

更新日期：2020-07-01 00:00:00