Abstract：
:Mechanisms responsible for resistance to Cd-induced testicular necrosis in inbred mice were investigated using strains resistant (A/J) or susceptible (129/J) to Cd-induced testicular damage. Cadmium accumulation was measured in testes of both strains 15 min, 30 min, 1 h, 2 h, 6 h, 12 h and 24 h after intravenous injection of 1 mumol 109CdCl2/kg. The subcellular disposition of Cd was determined at 15 min, 6 h and 24 h by fractionation of testicular cytosol on Sephadex G-75 Superfine. Testicular accumulation of Cd was 5-6 times less in A/J mice than in 129/J mice at all time points examined. Gel filtration revealed 4 Cd-binding peaks; in both strains testicular Cd was bound to a protein with a relative molecular mass (Mr) of 30 000 and to metallothionein (MT). The fraction of the total testicular Cd bound to the 30 000 Mr protein was similar in both strains after 15 min (13-18%) and declined rapidly to 5-7% by 6 h. A/J testes had a significantly greater fraction of the total Cd bound to MT both 15 min; 38% vs. 24% at 6 h). By 24 h both strains had approximately 43% of the total testicular Cd bound to MT. The results indicate 2 possible mechanisms of resistance to Cd-induced testicular necrosis in inbred mice: decreased testicular Cd uptake and sequestration of a greater fraction of the tissue Cd by MT.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Chellman GJ,Shaikh ZA,Baggs RBdoi
10.1016/0300-483x(84)90126-4subject
Has Abstractpub_date
1984-03-01 00:00:00pages
157-69issue
2eissn
0300-483Xissn
1879-3185pii
0300-483X(84)90126-4journal_volume
30pub_type
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