Abstract:
:Nonylphenol (NP) has been identified at low levels in surface waters throughout North America. This industrial chemical is primarily used for the production of certain non-ionic surfactants, and has been reported to have weak estrogen-like activity. As estrogen has immunoregulatory properties and is crucial for normal fetal development, it was hypothesized that adult and developmental exposures to NP had the potential to adversely affect the immune system. Furthermore, developmental exposure to NP might also produce differential immunomodulation in F(1) male and female rats. Thus, a two-generation feeding study was conducted to evaluate the potential for NP to modulate certain immune parameters. Pregnant female Sprague-Dawley rats were exposed to NP (0, 25, 500, and 2000 ppm) in their feed for 65 days, beginning 7 days into gestation. The F(1) generation male and female offspring were exposed in utero at the respective treatment levels, commencing the 7th day of gestation, and continuing through to 64 days of age. Changes in splenic antibody-forming cell response, natural killer cell activity, and leukocyte numbers were used to evaluate NP immunotoxicity. The results from the present study indicate that dietary exposure to NP can increase splenic natural killer (NK) cell activity and splenocyte subpopulation numbers in the F(1) generation rats, without similar changes to the F(0) generation. The immunological changes that were observed in the F(1) generation also appeared to be gender-specific.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Karrow NA,Guo TL,Delclos KB,Newbold RR,Weis C,Germolec DR,White KL Jr,McCay JAdoi
10.1016/j.tox.2003.11.009keywords:
subject
Has Abstractpub_date
2004-03-15 00:00:00pages
237-45issue
3eissn
0300-483Xissn
1879-3185pii
S0300483X03005080journal_volume
196pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::This paper presents an overview of issues related to surface water contamination arising from uranium mining activities in the Alligator Rivers Region (ARR) of northern Australia, and a program of research and monitoring that must assess the potential and actual effects on ecosystem and human health. The program of as...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(02)00470-5
更新日期:2002-12-27 00:00:00
abstract::Antagonistic toxic effects of selenium and lead were studied in growing rats. Chronic lead intoxication was produced by cutaneous application of lead naphthenate solution (80-200 mg Pb/kg body weight) for a period of 8 weeks and chronic selenium intoxication was induced by giving 5 ppm, 10 ppm and 15 ppm selenium in d...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(76)90041-x
更新日期:1976-11-01 00:00:00
abstract::Silver nanoparticles (AgNPs) are widely utilized in various consumer products and medical devices, especially due to their antimicrobial properties. However, several studies have associated these particles with toxic effects, such as inflammation and oxidative stress in vivo and cytotoxic and genotoxic effects in vitr...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2012.09.014
更新日期:2013-11-08 00:00:00
abstract::To elucidate factors responsible for altered proliferation of preneoplastic hepatocytes in rat hepatocarcinogenesis in vivo, EGF-stimulated DNA synthesis of normal and nodular hepatocytes in primary culture was studied. In addition, the influence of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated to clari...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00189-4
更新日期:2000-04-03 00:00:00
abstract::V79 Chinese hamster cells are being genetically engineered for stable expression of cytochromes P450 using a SV40 early promoter containing plasmid as the eukaryotic expression vector. V79 cells lack endogenous cytochrome P450 activity. Therefore, genetically engineered V79 cell lines are defined for the cytochrome P4...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(93)90063-x
更新日期:1993-10-05 00:00:00
abstract::Methoxy-, ethoxy- and n-butoxy acetic acids, known urinary metabolites of the corresponding alkoxyethanol solvents, were administered by gavage to rats as a single oral dose equimolar with 500, 250 or 100 mg 2-methoxyethanol/kg body weight. Testicular weight and morphology were monitored over a 14-day period post-trea...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90071-0
更新日期:1987-01-01 00:00:00
abstract::The rodent Hershberger assay has been used predominantly by the pharmaceutical industry to evaluate androgenic and antiandrogenic chemicals for potential therapeutic use. However, this assay has not yet been formally validated and standardized for use in toxicology testing. There are many variations in the protocol us...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00361-4
更新日期:2001-05-11 00:00:00
abstract::Previous studies have shown that excess dietary Al during development can affect neurobehavioral measures and decrease tissue Mn of 21-day-old weanling mice without a corresponding increase in tissue Al concentrations. Al and Mn have similar tissue concentrations and similar affinities for transferrin, which is the ma...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90154-k
更新日期:1993-07-11 00:00:00
abstract::The intragastric administration to male Wistar rats of T-2 toxin at 1-1.3 mg/kg body weight for 7 days caused a sharp decrease in the liver activity of lysosomal enzymes: beta-galactosidase, beta-N-acetylglucosaminidase, alpha-mannosidase, cathepsins A, B, C and D and in the activity of enzymes of the 1st phase of met...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90094-6
更新日期:1986-12-01 00:00:00
abstract::The effect of administration of a glutamate-containing protein hydrolysate on the arcuate nucleus of 10-day-old mice was studied by two methods. Arcuate nucleus damage resulted when administration was by a single large subcutaneous dose (100 ml/kg). When the same total dose was administered subcutaneously in five smal...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(75)90070-0
更新日期:1975-09-01 00:00:00
abstract::The present study was undertaken to investigate the usefulness of stress proteins as early, sensitive indicators of hepatotoxicity. Induction of stress protein synthesis in precision-cut rat liver slices was examined following in vitro exposure to sodium arsenite or heat shock. Precision-cut rat liver slices were incu...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03119-z
更新日期:1995-12-15 00:00:00
abstract::Envenoming by the pitviper Bothrops jararacussu produces cardiovascular alterations, including coagulopathy, systemic hemorrhage, hypotension, circulatory shock and renal failure. In this work, we examined the activity of this venom in rat isolated right atria. Incubation with venom (0.025, 0.05, 0.1 and 0.2mg/ml) cau...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2014.06.010
更新日期:2014-09-02 00:00:00
abstract::The effect of dose and duration of treatment with chromium on its distribution in certain vital organs and the blood of rats has been investigated. The accumulation of metal was highest in liver and kidneys, followed by testes, brain and blood and was rather more dependent on the dose than on the duration of exposure....
journal_title:Toxicology
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::This review concerns some of the cell culture systems that are most frequently used in toxicology investigations. In particular, it sets out to evaluate the effectiveness of these cell culture systems in assessing the toxic potential of chemicals. Metabolic studies and general and specific toxicology investigations ar...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(81)90046-9
更新日期:1981-01-01 00:00:00
abstract::The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents. Understanding their interactions within the active site of phosphylated AChE is of great significance for the search for mo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2018.05.008
更新日期:2018-08-01 00:00:00
abstract::Dental resin systems have been in use for several decades. (Meth)acrylic monomers are an important part of the matrix system and are either based on BPA while others lack the BPA core. The degree of conversion during restoration is in general between 50-70 % allowing leaching from unreacted monomers to the oral cavity...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.03.007
更新日期:2019-05-15 00:00:00
abstract::To evaluate the developmental toxicity of uranium, 5 groups of 20 pregnant Swiss mice were given by gavage daily doses of 0, 5, 10, 25 and 50 mg/kg of uranyl acetate dihydrate on gestational days 6-15. Cesarean sections were performed on all females on gestation day 18. Fetuses were examined for external, visceral, an...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90181-9
更新日期:1989-04-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) and N-nitrosamines (NNA) are mainly activated by cytochrome P450s, and their associated enzyme activities such as aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH), N-nitrosdimethylamine N-demethylase I (NDMA-dI), NADPH-cytochrome C reductase, and detoxified by glutathione S-t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(02)00048-3
更新日期:2002-05-24 00:00:00
abstract::The subacute toxicity of sodium saccharin and 2 hydrolytic derivatives, o-sulfamoylbenzoic acid (Compound I) and ammonium o-carboxybenzene sulfonate (Compound II) was evaluated by feeding each of the compounds alone at a dietary level of 20 000 ppm to both beagle dogs and albino rats. Additionally, groups of dogs and ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(76)90015-9
更新日期:1976-08-01 00:00:00
abstract::Five male and female rats per dose-group received 2,3,7,8-tetrabromodibenzo-p-dioxin (2,3,7,8-TBDD) once on the first day of the study. Doses of 10, 33, 100, or 300 micrograms 2,3,7,8-TBDD/kg body wt. and the vehicle control were administered by gavage. About 20% of 2,3,7,8-TBDD was excreted via feces. Severe body wei...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90170-j
更新日期:1992-01-01 00:00:00
abstract::Dimethyl sulfoxide (DMSO) has previously been shown to protect against acetaminophen (APAP)-induced hepatotoxicity, but the mechanism of this effect was not clear. Treatment of mice with 1 mg/kg DMSO 4 h before 250 mg/kg APAP resulted in significantly less hepatotoxicity than with APAP alone, as measured by serum glut...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90202-8
更新日期:1988-11-14 00:00:00
abstract::Rats were exposed to 1.5 +/- 0.1 mg ozone/m3 for 4 days and the activities of glucose-6-P dehydrogenase (G6PDH), glutathione reductase (GR) and glutathione peroxidase (GSHPx) were measured in the cytosolic fraction of lungs from exposed and control rats. Enzyme activities were also measured in isolated alveolar macrop...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(85)90083-6
更新日期:1985-12-01 00:00:00
abstract::We have reported that excessive nitric oxide (NO), like other reactive oxygen species (ROS), causes a decrease in cytochrome c oxidase (CCO) activity and ATP levels (mitochondrial damage) resulting in lens opacity. In addition, previous reports have shown that oxidative stress caused by ROS enhances amyloid β (Aβ) pro...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.02.014
更新日期:2017-04-15 00:00:00
abstract::The measurement of levels of organic pollutants and/or their metabolites in body tissues or fluids are specific markers of internal dose and, provided that the pharmacokinetic properties of the compounds in question are known, these levels may also be used as predictors of effects. Although historical data still remai...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(95)03017-a
更新日期:1995-07-26 00:00:00
abstract::Malathion is one of the most widely used organophosphorus insecticides in agriculture. However, malathion may be involved in the etiology of human brain dysfunction. Induction of ROS has been proposed as a mechanism of malathion-induced poisoning cases, but there are few data regarding the effects of malathion on oxid...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.02.004
更新日期:2019-04-01 00:00:00
abstract::Consequences of exposure of rats for 2 days or less to O3 at various concentrations between 0.12 and 0.96 ppm were measured using several assays performed on bronchoalveolar lavage fluid. Changes in apparent lung permeability were assessed by measurement of recovery of labelled bovine serum albumin in lung lavage flui...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90074-0
更新日期:1986-08-01 00:00:00
abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is highly toxic in experimental animals, and is known to induce cytochrome P450 (CYP) gene expression. We investigated the effect of CYP1A1 and CYP1B1 variant genotypes and haplotypes on CYP1A1 and CYP1B1 mRNA expression and ethoxyresorufin-O-deethylase (EROD) activity in lym...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.08.021
更新日期:2005-02-14 00:00:00
abstract::Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), a major constituent of marijuana, has been shown to stimulate the growth of MCF-7 breast cancer cells through cannabinoid receptor-independent signaling [Takeda, S., Yamaori, S., Motoya, E., Matsunaga, T., Kimura, T., Yamamoto, I., Watanabe, K., 2008. Delta(9)-Tetrahydroca...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.01.024
更新日期:2009-05-02 00:00:00
abstract::Genetic polymorphism of drug metabolizing enzymes (DME) can lead to severe toxicity or therapeutic failure of pharmacotherapy. Additionally, genetically determined differences in the activity of the metabolic enzymes can increase an individual's susceptibility to certain types of chemically induced cancers and possibl...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(99)00199-7
更新日期:2000-04-03 00:00:00
abstract::Exposure to cadmium (Cd) can cause a variety of biological effects including alterations of immune responses in animals and humans. Both immunosuppression and immunoenhancement have been reported. The present study was aimed at investigating the consequences of exposure to Cd on the human immunoglobulin (Ig) E synthes...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(03)00044-1
更新日期:2003-06-03 00:00:00