Abstract:
:Hydroquinone (HQ) is naturally found in the diet, drugs, as an environmental contaminant and endogenously generated after benzene exposure. Considering that HQ alters the immune system and its several source of exposures in the environment, we hypothesized that prolonged exposure of HQ could affect the course of an immune-mediated inflammatory response. For this purpose, male Wistar rats were intraperitoneally exposed to vehicle or HQ once a day, for 22 days with a 2-day interval every 5 days. On day 10 after exposure with vehicle or HQ, animals were ovalbumin (OA)-sensitized and OA-aerosolized challenged on day 23. HQ exposure did not alter the number of circulating leukocytes but impaired allergic inflammation, evidenced by lower number of leukocytes in the bronchoalveolar lavage fluid 24h after OA-challenge. Reduced force contraction of ex vivo tracheal segments upon OA-challenge and impaired mesentery mast cell degranulation after in situ OA-challenge were also detected in tissues from HQ exposed animals. The OA-specificity on the decreased responses was corroborated by normal trachea contraction and mast cell degranulation in response to compound 48/80. In fact, lower levels of circulating OA-anaphylactic antibodies were found in HQ exposed rats, as assessed by passive cutaneous anaphylaxis assay. The reduced level of OA-anaphylactic antibody was not dependent on lower number or proliferation of lymphocytes. Nevertheless, lower expression of the co-stimulatory molecules CD6 and CD45R on OA-activated lymphocytes from HQ exposed rats indicate the interference of HQ exposure with signaling of the humoral response during allergic inflammation. Together, these data indicate specific effects of HQ exposure manifested during an immune host defense.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Macedo SM,Vaz SC,Lourenço EL,de Sousa Mda G,Ligeiro-Oliveira AP,Ferreira JM Jr,Almeida SR,de Lima WT,Farsky SHdoi
10.1016/j.tox.2007.08.085subject
Has Abstractpub_date
2007-11-20 00:00:00pages
47-57issue
1-2eissn
0300-483Xissn
1879-3185pii
S0300-483X(07)00586-0journal_volume
241pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract::Within the framework of an EU project on risk assessment of brominated flame retardants, TBBPA was studied for neurobehavioral effects in rats. To permit benchmark dose analysis, eight dose levels were chosen ranging from 0 to 3000mg/kg body weight. Exposure of parental rats started 10 and 2 weeks before mating in mal...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.01.007
更新日期:2008-04-03 00:00:00
abstract::Renal markers were investigated over 96 h in male Sprague-Dawley rats after i.v. administration of 10.7 mg kg(-1) of digoxin-specific Fab fragments (DSFab). The dose was calculated by an allometric equation as equivalent to a high clinical dose. DSFab both alone and pre-incubated with digoxin were tested. None of the ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00022-5
更新日期:1998-04-03 00:00:00
abstract::In this report the neurotoxicity of aspartame and its constituent amino acids aspartic acid and phenylalanine is reviewed. The adverse reactions ascribed to the consumption of aspartame-containing products, as reported in the U.S.A., are discussed and placed in perspective with the results of recent behavioural studie...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(88)90117-5
更新日期:1988-06-01 00:00:00
abstract::Heavy metals, such as iron and manganese, are involved in neurologic disease. Most often these diseases are associated with abnormal environmental exposures or abnormal accumulations of heavy metals in the body. There is increasing recognition that heavy metals normally present in the body also may play a role in dise...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(94)02962-t
更新日期:1995-03-31 00:00:00
abstract::Fusarenon-X (FX), a trichothecene mycotoxin, is well known to be cytotoxic to mammalian cells. Our previous study revealed that FX induced apoptosis in mouse thymocytes both in vivo and in vitro. We investigated the mode of apoptosis induced by FX using HL-60 cell culture. When FX at a final concentration of 0.5 micro...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00586-8
更新日期:2002-03-20 00:00:00
abstract::A fixed combination of the three components, fructose, cyclosporin A and trifluoperazine (FCAT), was found to protect in the late stage of paracetamol-induced liver cell injury both in vivo and in an in vivo/in vitro system. Rats pre-induced with phenobarbitone were given a paracetamol dose of 1 g/kg i.p. The combinat...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)03262-e
更新日期:1996-03-18 00:00:00
abstract::There is concern about the growing environmental levels of brominated dioxins. Brominated dioxins are known to bind and activate the transcription factor aryl hydrocarbon receptor (AhR), as their chlorinated congeners do. However, data on the potency of brominated dioxins for immunotoxicity in vivo is largely lacking,...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.10.024
更新日期:2009-02-04 00:00:00
abstract::Fire creates a complex toxic environment involving flame, heat, oxygen depletion, smoke, and toxic gases. The nature of that environment is dependent upon not only the materials present but on the fire event, that is, the fire scenario. Materials have different toxic gas profiles under different conditions; therefore,...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90167-3
更新日期:1987-12-01 00:00:00
abstract::Quantum dots (QDs) are potentially beneficial semi-conductor nanocrystals for use in diagnostics and therapeutics. The chemical composition of QDs however, has raised concerns as to their potential toxicity. Although a thorough examination using specific biochemical endpoints is necessary to assess QD toxicity, an und...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.05.006
更新日期:2011-08-15 00:00:00
abstract::Adult female F-344 rats were trained (avoidance rate > 70%) over four days with a coupled tone- (n = 10 rats/dose) or 2 ppm acetaldehyde-cued (n = 6 rats/dose) foot shock paradigm. Rats were gavaged with chloroform dissolved in corn oil for 5 days/week for 3 week at 0 or 400 (tone-cued) or 0, 34, 100, or 400 (odor-cue...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(97)00076-0
更新日期:1997-09-26 00:00:00
abstract::The question as to whether or not the hypotension observed as part of the effect of tricholorofluoromethane (FC11), dichlorofluoromethane (FC 12), dichlorotetrafluoroethane (FC 114) and methyl chloroform was due to a vasodepressor component of action, in addition to the previously documented depression in myocardial c...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(76)90048-2
更新日期:1976-03-01 00:00:00
abstract::Nowadays, very little information concerning the effects on behavior in mammals of perfluorooctane sulfonate (PFOS), a widely distributed persistent environmental pollutant, is available. In the present study, we assessed the behavioral effects of PFOS on 3 months old mice after 1 month of exposure to this pollutant. ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.09.012
更新日期:2007-12-05 00:00:00
abstract::Antidepressants are generally used for treatment of various mood and anxiety disorders. Several studies have shown the anti-tumor and cytotoxic activities of some antidepressants, but the underlying mechanisms were unclear. Maprotiline is a tetracyclic antidepressant and possesses a highly selective norepinephrine reu...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2012.11.013
更新日期:2013-02-08 00:00:00
abstract::The cytochrome P-450 enzymes are responsible for the oxidation of xenobiotic chemicals including drugs, pesticides, and carcinogens. These enzymes include cytochrome P450, cytochrome b(5), arylhydrocarbon (benzo[a]pyrene) hydroxylase (AHH), NADPH-cytochrome C reductase and dimethylnitrosamine N-demethylase I (DMN-dI)....
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00473-5
更新日期:2001-12-14 00:00:00
abstract::As a new method, support vector machine (SVM) were applied for prediction of toxicity of different data sets compared with other two common methods, multiple linear regression (MLR) and RBFNN. Quantitative structure-activity relationships (QSAR) models based on calculated molecular descriptors have been clearly establ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.08.019
更新日期:2006-01-16 00:00:00
abstract::In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid co...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00570-4
更新日期:2002-02-28 00:00:00
abstract::Experiments were done in vivo to determine the effect of oxygen at high pressure (OHP) on NAD+ and NADH in mouse brain cortex. A 7% decrease (N.S.) in NADH was found in brain cortex from mice exposed to 6 atm of 100% oxygen for 8 min, while a 20% decrease (P less than 0.01) in cortical NADH, when compared to controls,...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(82)90014-2
更新日期:1982-01-01 00:00:00
abstract::The effect of thimerosal, an organomercurial preservative in vaccines, on cerebellar neurons dissociated from 2-week-old rats was compared with those of methylmercury using a flow cytometer with appropriate fluorescent dyes. Thimerosal and methylmercury at concentrations ranging from 0.3 to 10 microM increased the int...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2003.09.002
更新日期:2004-01-15 00:00:00
abstract:OBJECTIVE:We investigated the potential dose related apoptotic effect of subchronic administration of the alkylating chemotherapeutic agent ifosfamide in different sites of the small and large rabbit intestine. MATERIALS AND METHODS:Twenty New Zealand White rabbits received intravenously every week, for 10 weeks, 0 (g...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.03.020
更新日期:2004-08-05 00:00:00
abstract::N-Heterocyclic aromatics are by-products of incomplete combustion of organic material. The overall objective of this study was to determine the relative carcinogenic potencies of 7H-dibenzo[c,g]carbazole (DBC) and dibenz[a,j]acridine (DBA) in a bioassay of complete carcinogenicity on mouse skin in a sensitive strain (...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90074-4
更新日期:1994-11-11 00:00:00
abstract::Molybdenum trioxide (MoO3) nanoparticles (NPs) embedded in polymer films have been proposed as a cheap way of producing antibacterial coatings on external surfaces. Recently, we synthesized MoO3 nanowires in a unique shape and degree of anisotropy, which enables their fast water dissolution and quick antimicrobial rea...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152564
更新日期:2020-11-01 00:00:00
abstract::The interaction in vivo of four O-alkyl O-2,5-dichlorophenyl phosphoramidates with neural neuropathy target esterase (NTE) and acetylcholinesterase (AChE) and their ability to cause delayed polyneuropathy in hens has been examined. Previous studies in vitro (Vilanova, Johnson & Vicedo, Pestic. Biochem. Physiol., 28 (1...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90081-4
更新日期:1989-01-01 00:00:00
abstract::Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2017.07.019
更新日期:2017-11-01 00:00:00
abstract::The intravenous LD50 of cefuroxime sodium for mice was 10.4 g/kg. The maximum dosage administered in other acute toxicity tests was well tolerated by mice (10 g/kg, subcutaneous), by rats (4 g/kg, intravenous, 5 g/kg, subcutaneous) and by cats, dogs and monkeys (2 g/kg, intramuscularly). Cefuroxime sodium was administ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(79)80003-7
更新日期:1979-05-01 00:00:00
abstract::This study was designed to evaluate the cardioprotective potential of naringin on lipid peroxides, enzymatic and nonenzymatic antioxidants and histopathological findings in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (85 mg/kg) to male Wistar rats showed a significant ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.09.005
更新日期:2006-12-07 00:00:00
abstract::Leflunomide, used for the treatment of rheumatoid arthritis, has been reported to cause severe liver problems and liver failure; however, the underlying mechanisms are not clear. In this study, we used multiple approaches including genomic analysis to investigate and characterize the possible molecular mechanisms of t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.10.002
更新日期:2017-12-01 00:00:00
abstract::After i.v. injection of 0.33 mg nicotine/kg the elimination of unchanged nicotine as well as nicotine-N-oxide, cotinine, nornicotine and norcotinine was determined in the urine of pigs dependent on time. In female pigs 16.3% and in male pigs 25.9% of the applied nicotine were recovered in form of the mentioned compoun...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(76)90013-5
更新日期:1976-06-01 00:00:00
abstract::Exposure of cultured rat mesangial cells to CdCl2 caused a dose- and time-dependent increase in intracellular glutathione that was significant at 0.5 microM and maximal at 1 microM Cd2+. The effect depended on glutathione synthesis and was masked by inhibiting synthesis with buthionine sulfoximine. The cells responded...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90145-i
更新日期:1993-01-29 00:00:00
abstract::Neonatal rat hearts were separated into separate cultures of beating myocytes (M cells), endothelial cells (E cells) and fibroblasts (F cells). Their susceptibilities to the toxic effects of emetine, chloroquine and metronidazole were then compared using a quantitative metabolic inhibition test (QMIT) and morphologic ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90066-0
更新日期:1984-11-01 00:00:00
abstract::Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(78)90029-x
更新日期:1978-02-01 00:00:00