Abstract:
:There is concern about the growing environmental levels of brominated dioxins. Brominated dioxins are known to bind and activate the transcription factor aryl hydrocarbon receptor (AhR), as their chlorinated congeners do. However, data on the potency of brominated dioxins for immunotoxicity in vivo is largely lacking, even though the immune system is a vulnerable target for dioxins. In this study, we investigated the immunotoxic effects on mice of the brominated dioxins, 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) and 1,2,3,7,8-pentabromodibenzo-p-dioxin (PeBDD), in comparison with those of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), the two most toxic chlorinated dioxins, to gain insight into the potency of brominated dioxins for immunotoxicity. C57BL/6 mice were dosed with the dioxins and immunized with ovalbumin (OVA), and several endpoints that sensitively detect immunotoxicity were investigated, including IL-5 production by the splenocytes. The results of the present study demonstrated that TCDD and TBDD show identical effects on a per weight basis at 1.0-10mug/kg for all the endpoints examined. PeCDD also showed effects similar to those of TCDD. On the other hand, PeBDD showed somewhat dose-independent effects and was more potent at a lower dose and less potent at a higher dose than PeCDD. Dose-dependent linearity of PeBDD-induced induction of CYP1A1, an AhR target gene, was also less clear in the spleen than in the liver. These results have provided valuable data for estimating the potency of brominated dioxins for immunotoxicity.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Ao K,Suzuki T,Murai H,Matsumoto M,Nagai H,Miyamoto Y,Tohyama C,Nohara Kdoi
10.1016/j.tox.2008.10.024subject
Has Abstractpub_date
2009-02-04 00:00:00pages
25-31issue
1-2eissn
0300-483Xissn
1879-3185pii
S0300-483X(08)00517-9journal_volume
256pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract:OBJECTIVE:Ozone has become a major air pollutant in recent years, which leading to a variety of lung diseases. This study aimed to explore the mechanisms of pyroptosis and related signaling pathways in ozone-induced lung injury. METHODS:We exposed 120 Wistar rats to ozone, 20 in each group (half male and half female)....
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152668
更新日期:2020-12-28 00:00:00
abstract::The usefulness of cDNA-directed expression of human hepatic P450s in yeast for the in vitro study of drug metabolism is emphasized. The major advantages of yeast expression are: (i) relatively high yields of heterologous P450 (approximately 5-10 nmol/l of culture medium) can be obtained; (ii) the expressed P450s are d...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(93)90058-z
更新日期:1993-10-05 00:00:00
abstract::Rats were injected i.p. with the organophosphate insecticide ABATE and tested over the next 16 days. Animals given 1000 mg/kg showed impaired performance of a previously conditioned avoidance response 6 days after injection but not 2, 8, 10, or 16 days after injection. No behavioral changes were observed in animals gi...
journal_title:Toxicology
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::The effects of D- and L-T3 were compared in male SK & F Wistar rats to define overall effects on the 'pituitary-thyroid-liver axis' at high doses. After in vivo administration of L-T3 (up to 1 mg/kg orally, or up to 0.1 mg/kg subcutaneously) serum TSH and T4 were decreased in a dose-related manner. Similarly, followin...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90108-4
更新日期:1988-03-01 00:00:00
abstract::We have reported that excessive nitric oxide (NO), like other reactive oxygen species (ROS), causes a decrease in cytochrome c oxidase (CCO) activity and ATP levels (mitochondrial damage) resulting in lens opacity. In addition, previous reports have shown that oxidative stress caused by ROS enhances amyloid β (Aβ) pro...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.02.014
更新日期:2017-04-15 00:00:00
abstract::The combined effects of ethyl alcohol (ETOH) intoxication and carbon monoxide (CO) poisoning were studied in the Levine-prepared rat. Infusion or injection of ETOH before and during 90 min of CO exposure to blood levels 2-4 times those considered legally drunk in humans, increased survival at 2400 ppm, and extended th...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(90)90111-s
更新日期:1990-05-31 00:00:00
abstract::The agricultural fungicide, N-(3,5-dichlorophenyl)succinimide (NDPS) induces acute polyuric renal failure which is attenuated by pretreatment with the glutathione depletors, diethyl maleate or buthionine sulfoximine (BSO). In the present study, the temporal aspects of BSO attenuation of NDPS nephrotoxicity were invest...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03581-0
更新日期:1997-02-28 00:00:00
abstract::In an attempt to ameliorate the chemotherapy associated normal cell toxicity, in this study a known antioxidant, grape seed proanthocyanidin extract (GSPE) using Chang liver cells has been used. Chang liver cells were treated in vitro with idarubicin (Ida) (30 nM) and 4-hydroxyperoxycyclophosphamide (4-HC) (1 microg/m...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00280-8
更新日期:2000-11-30 00:00:00
abstract::N-(3,5-Dichlorophenyl)succinimide (NDPS) is an agricultural fungicide which has been shown to induce acute tubular necrosis. The purpose of the present study was to determine if creatinine clearance was altered early in the development of NDPS nephrotoxicity. This study also examined the effect of autacoid modulation ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(91)90007-n
更新日期:1991-01-01 00:00:00
abstract::We performed a reporter gene assay for ERalpha-mediated transcriptional activation and an immature rat uterotrophic assay of 23 chemicals, to study the relationship between these two assays and to examine the usefulness of the reporter gene assay. The chemicals analyzed in the study were as follows: benzophenone, bisp...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(01)00505-4
更新日期:2002-01-15 00:00:00
abstract::Endocrine disruptors (EDs) are exogenous substances or xenoestrogens natural or synthetic, capable of interacting with different systems and altering their normal hormonal regulation, being the reproductive system one of the most affected. EDs produce their effects not only by acting on nuclear steroid receptors, but ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2013.05.014
更新日期:2013-09-06 00:00:00
abstract::Phensuximide (PSX) is an antiepileptic agent which has been shown to induce hemorrhagic cystitis and mild nephrotoxicity following repeated administration in man or rats or when acutely administered to phenobarbital-pretreated rats. The purpose of this study was to explore the role of para-hydroxylation of the phenyl ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90045-g
更新日期:1992-08-01 00:00:00
abstract::The efficiency of the sodium salt of 2,3-dimercaptopropanesulfonic acid (DMPS) and meso-dimercaptosuccinic acid (DMSA) to mobilize mercury from tissues has been assessed in rats pretreated with different doses of HgCl2, phenylmercury acetate or exposed to different concentrations of mercury vapors. These pretreatments...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90067-x
更新日期:1989-03-01 00:00:00
abstract::Evidence from epidemiological studies indicates that acute exposure to airborne pollutants is associated with an increased risk of morbidity and mortality attributed to cardiovascular diseases. The present study investigated the effects of combustion-derived ultrafine particles (diesel exhaust particles) as well as en...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2008.08.018
更新日期:2008-11-20 00:00:00
abstract::Five male and female rats per dose-group received 2,3,7,8-tetrabromodibenzo-p-dioxin (2,3,7,8-TBDD) once on the first day of the study. Doses of 10, 33, 100, or 300 micrograms 2,3,7,8-TBDD/kg body wt. and the vehicle control were administered by gavage. About 20% of 2,3,7,8-TBDD was excreted via feces. Severe body wei...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90170-j
更新日期:1992-01-01 00:00:00
abstract::The effects of triethyl lead chloride (TEL) on the expression of two detoxication enzyme families, glutathione S-transferases (GSTs) and NAD(P)H:quinone oxidoreductase (QR) were determined in rat liver and kidney. Fischer 344 rats were given one intraperitoneal (i.p.) injection of TEL. GST activity, GST isoenzyme leve...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03555-x
更新日期:1997-02-14 00:00:00
abstract::Recent studies have demonstrated that mammalian sperm are capable of generating reactive oxygen species (ROS) and that this activity is significantly accelerated in subfertile subjects. The observed decrease in penetration of zona-intact oocyte might be explained by chemical-induced ROS-related early onset of capacita...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(99)00107-9
更新日期:1999-11-29 00:00:00
abstract::Mitochondria play a central role in the life and death of cells. These organelles serve as the major energy-producing power-house, whereby the generation of ATP is associated with the utilization of molecular oxygen. A significant fraction (2-3%) of molecular oxygen consumed by mitochondria may be reduced in a one-ele...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2004.11.027
更新日期:2005-03-15 00:00:00
abstract::Bromofenofos (BF) was administered by gavage once to non-pregnant and pregnant rats at 50 mg/kg and the plasma concentration-time curves of BF and its metabolite dephosphate bromofenofos (DBF) were determined by high-performance liquid chromatography. DBF reached a peak at 9 h, with 113.4 +/- 5.2 micrograms/ml, follow...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(89)90019-x
更新日期:1989-05-15 00:00:00
abstract::Dimethoate, azinphos-methyl, diazinon and pirimiphos-methyl, widely used organophosphorous insecticides, and benomyl, a benzimidazole fungicide, induce different cytotoxic effects on the human leukemia cell line HL-60. Among the insecticides tested, only azinphos and diazinon induced a dose-related inhibition of prote...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90036-1
更新日期:1994-11-01 00:00:00
abstract::CI-959 is an orally effective inhibitor of cellular activation in both in vitro and animal models. To assess the effects of CI-959 on immune function, male Fischer 344 rats were evaluated for splenic T- and B-lymphocyte populations, antibody-forming cell response to sheep red blood cells (sRBC), concanavalin A and pok...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)02985-4
更新日期:1995-04-12 00:00:00
abstract::Silicosis is a universal occupational disease, which is caused by long-term crystalline silica exposure. Recent studies have shown that noncoding RNAs participate in diverse pathological cellular pathways. However, the precise regulation mechanism remains limited in silicosis. Here, we established a silica-induced mou...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2021.152683
更新日期:2021-01-19 00:00:00
abstract::Consequences of exposure of rats for 2 days or less to O3 at various concentrations between 0.12 and 0.96 ppm were measured using several assays performed on bronchoalveolar lavage fluid. Changes in apparent lung permeability were assessed by measurement of recovery of labelled bovine serum albumin in lung lavage flui...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(86)90074-0
更新日期:1986-08-01 00:00:00
abstract::One of the most sensitive and reproducible immunotoxic endpoints of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure is suppression of the antibody response to sheep red blood cells (SRBCs) in mice. Immunosuppression occurs in concert with hepatomegaly and associated induction of several hepatic cytochrome P450 enz...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2003.11.016
更新日期:2004-04-01 00:00:00
abstract::The possible role of ionotropics glutamate receptors on the HgCl(2)-induced dopamine (DA) release from rat striatum was investigated by using in vivo brain microdialysis technique after administration of selective NMDA and AMPA/Kainate receptors antagonists dizocilpine (MK-801), D (-)-2-amino-5-phoshonopentanoic acid ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2007.05.025
更新日期:2007-09-05 00:00:00
abstract::Valproic acid (VPA) and the unsaturated metabolites, 2-ene VPA and (E)-2,(Z)-3'-diene VPA, demonstrated dose-dependent cytotoxicity in primary cultures of rat hepatocytes, as evaluated by lactate dehydrogenase (LDH) leakage. Cellular glutathione (GSH) was depleted by adding buthionine sulfoximine (BSO) to the culture ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(96)03352-5
更新日期:1996-08-01 00:00:00
abstract::Among exocyclic DNA adducts, etheno (epsilon) bases (epsilond A, epsilond C, N(2),3-epsilond G) are generated by reactions of DNA bases with lipid peroxidation (LPO) products derived from endogenous sources and from the carcinogens vinyl chloride or urethane. The recent development of ultrasensitive methods has made i...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(00)00307-3
更新日期:2000-11-16 00:00:00
abstract::Long-term exposure to isoflurane may induce long-term developmental neurotoxicity and cognitive impairments in the neonatal brains. Trilobatin, a leaf extract from the Chinese traditional sweet tea Lithocarpus polystachyus Rehd, possesses various biological properties including anti-inflammatory and anti-oxidant prope...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152537
更新日期:2020-09-01 00:00:00
abstract::Transferrin, as the major iron-transport protein in serum and other body fluids, has a central role in managing iron the body receives. Liver is a major site of transferrin synthesis, and in this study we present evidence that liver synthesis of human transferrin is suppressed by both the toxic metal lead and bacteria...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(96)03586-x
更新日期:1997-03-14 00:00:00
abstract::We compared the results of the multiple-dose guinea pig maximization test (GPMT) and the non-radioactive murine local lymph-node assay (LLNA) for various biocides. Thirteen out of 17 positive biocides in the GPMT gave positive results in the LLNA. In the GPMT, the minimum first induction doses ranged over four orders ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.02.014
更新日期:2005-07-01 00:00:00