Abstract：
:Silicosis is a universal occupational disease, which is caused by long-term crystalline silica exposure. Recent studies have shown that noncoding RNAs participate in diverse pathological cellular pathways. However, the precise regulation mechanism remains limited in silicosis. Here, we established a silica-induced mouse fibrosis model (all mice received a one-time intratracheal instillation with 50 mg/kg of silica in 0.05 ml sterile saline). MiR-490-3p was significantly downregulated in silica-induced fibrotic mouse lung tissues and TGF-β1 treated fibroblasts. Moreover, overexpressed miR-490-3p could relieve silica-induced lung fibrosis in vivo, and prevent the process of fibroblast-to-myofibroblast transition(FMT)in vitro. Mechanistically, TGFBR1 was one of the major target genes of miR-490-3p, and tightly associated with the process of fibroblasts activation. SNHG20, as opposed to miR-490-3p expression, was elevated in TGF-β1-treated fibroblast cell lines and contributed to decreased levels of miR-490-3p. Taken together, these data indicated that miR-490-3p plays a key role in silica-induced pulmonary fibrosis. Our results suggested that SNHG20/miR-490-3p/TGFBR1 axis may provide a new treatment target of pulmonary fibrosis.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Cheng D,Xu Q,Liu Y,Li G,Sun W,Ma D,Ni Cdoi
10.1016/j.tox.2021.152683subject
Has Abstractpub_date
2021-01-19 00:00:00pages
152683eissn
0300-483Xissn
1879-3185pii
S0300-483X(21)00006-8pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Microcystins are cyclic heptapeptide toxins produced by certain strains of Microcystis aeruginosa and microcystin-LR (MC-LR) is the most toxic among the 70 variants isolated so far. These toxins have been implicated in both human and livestock mortality. In the present study we investigated the microcystin-LR induced ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.12.007
更新日期：2006-03-15 00:00:00
abstract：:Incubation of rat platelets with organotins inhibited their capacity to take up 5-hydroxytryptamine-14C (5-HT-14C) and stimulated the release of preloaded 5-HT-14C as well as endogenous 5-HT. Similar but less pronounced effects also were observed when platelets from rats treated intraperitoneally with organotins were ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(83)90037-9
更新日期：1983-12-01 00:00:00
abstract：:The hypothesis has been put forward that mutagenic polycyclic aromatic hydrocarbons which induce the P-450 I family of cytochromes, the major enzyme system responsible for their activation, are likely to be carcinogenic. In order to test this hypothesis, rats have been pretreated with a number of polycyclic aromatic h...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90171-c
更新日期：1990-01-01 00:00:00
abstract：:The effect of tamoxifen on cytosolic free Ca2+ concentrations ([Ca2+]i) and viability has not been explored in corneal epithelial cells. This study examined whether tamoxifen altered [Ca2+]i and viability in SIRC corneal epithelial cells. Tamoxifen at concentrations > or = 1 microM increased [Ca2+]i in a concentration...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.10.001
更新日期：2009-01-08 00:00:00
abstract：:Atrazine (ATZ) is used throughout North America to control annual broadleaf weeds and grasses in various crops including; corn, sorghum, and sugar cane. Unfortunately, contamination of surface and ground water has occurred as a result of ATZ's chemical and physical properties, and its widespread use throughout the U.S...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.12.002
更新日期：2005-04-01 00:00:00
abstract：:Bisphenol A (BPA), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. Exposure-related reproductive disorders have been found, but recently it has also been suggested that BPA may be involved in obesity, diabetes, myocardial hypertroph...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2016.02.007
更新日期：2016-03-10 00:00:00
abstract：:Glutathione (GSH) plays an important role in the metabolism of arsenite and arsenate by generating arsenic-glutathione complexes. Although dimethylarsinic acid (DMA(V)) is the major metabolite of inorganic arsenicals (iAs) in urine, it is not clear how DMA(V) is produced from iAs. In the present study we report that S...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.07.009
更新日期：2006-10-03 00:00:00
abstract：:The effect of amyl nitrite on the erythrocytes of adult and cord hemoglobin was examined in vitro. This study revealed that amyl nitrite caused oxyhemoglobin to become oxidized to methemoglobin wherein a rectangular hyperbolic curve was generated as the reaction progressed. This curve consisted of a reactionary log ph...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(85)90003-4
更新日期：1985-07-01 00:00:00
abstract：:It is widely believed that the nigrostriatal toxicity of MPTP is due to its oxidation by brain monoamine oxidase first to MPDP+, and eventually to MPP+. Following uptake by the synaptic dopamine reuptake system, it is concentrated in the matrix of striatal mitochondria by an energy-dependent carrier, energized by the ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(88)90169-2
更新日期：1988-04-01 00:00:00
abstract：:The present research examines the effects of 4-nonylphenol (4-NP) on mouse primary calvarial osteoblasts (COBs). Incubation of the cells with 4-NP at 10(-5)M and 10(-6)M striking decreased osteoblasts viability and phosphatidylserine (PS) exposure, measured by Annexin V, was greatly enhanced. In addition, an up-regula...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.10.014
更新日期：2011-12-18 00:00:00
abstract：:The effects of thallous cation (Tl(+)) on: (a) the production of oxidant species and (b) membrane fluidity were evaluated in human leukemia T cells (Jurkat). After 72 h of incubation in the presence of Tl(+) (5-100 microM), no significant changes in cell viability were observed, although the average cell size was decr...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2006.01.028
更新日期：2006-05-01 00:00:00
abstract：:The effect of administration of a glutamate-containing protein hydrolysate on the arcuate nucleus of 10-day-old mice was studied by two methods. Arcuate nucleus damage resulted when administration was by a single large subcutaneous dose (100 ml/kg). When the same total dose was administered subcutaneously in five smal...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(75)90070-0
更新日期：1975-09-01 00:00:00
abstract：:Several studies have reported that hydrogen peroxide (H2O2) is related to the toxicity of amyloid β (Aβ), and that the accumulation of Aβ in the lenses of humans causes lens opacification. In this study, we investigate the accumulation of Aβ1-42 in the lenses of UPL rats, which then leads to lens opacification. In add...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2013.08.003
更新日期：2014-01-06 00:00:00
abstract：:In the present investigation the influence of gossypol on the male sex function and toxicology in the rat have been studied. Gossypol was injected daily for 5 weeks to adult male rats of the Sprague-Dawley strain with 1 or 10 mg/kg body wt. The low dose of gossypol (1 mg/kg body wt.) did not have any effect on the fol...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90084-2
更新日期：1984-09-28 00:00:00
abstract：:The activity of the haem biosynthetic enzymes delta-aminolaevulinic acid synthetase (ALA.S) and delta-aminolaevulinic acid dehydratase (ALA.D) were measured in the peripheral blood of a group of lead workers and control subjects. The haem precursor delta-aminolaevulinic acid (ALA) was measured in blood and urine, whil...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(78)90026-4
更新日期：1978-02-01 00:00:00
abstract：:Our previous study revealed that exposure to 0.4 ppm ozone (O(3)) enhanced nasal allergy-like reactions in guinea pigs. In the present study, we investigated the concentration-dependency of the effects of exposure to O(3) on the aggravation of nasal allergy-like reactions induced by repeated nasal administration of an...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.01.008
更新日期：2004-06-01 00:00:00
abstract：:Troglitazone is a thiazolidinedione antidiabetic agent with insulin-sensitizing activities that was withdrawn from the market in 2000 due to its association with idiosyncratic hepatotoxicity. To address the suspected autoantibody production associated with troglitazone, we investigated autoantibodies in sera from pati...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.07.012
更新日期：2005-12-01 00:00:00
abstract：:Intratracheal injection of zinc oxide dust, a component of many cosmetic preparations caused elevation of alkaline phosphatase and lactate dehydrogenase in serum and lung of guinea pigs. Clearance of zinc oxide dust from lungs through zinc-carrying proteins was evident. ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90120-4
更新日期：1986-02-01 00:00:00
abstract：:The interaction in vivo of four O-alkyl O-2,5-dichlorophenyl phosphoramidates with neural neuropathy target esterase (NTE) and acetylcholinesterase (AChE) and their ability to cause delayed polyneuropathy in hens has been examined. Previous studies in vitro (Vilanova, Johnson & Vicedo, Pestic. Biochem. Physiol., 28 (1...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(89)90081-4
更新日期：1989-01-01 00:00:00
abstract：:We performed a reporter gene assay for ERalpha-mediated transcriptional activation and an immature rat uterotrophic assay of 23 chemicals, to study the relationship between these two assays and to examine the usefulness of the reporter gene assay. The chemicals analyzed in the study were as follows: benzophenone, bisp...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00505-4
更新日期：2002-01-15 00:00:00
abstract：:Defining the impact on health of exposure to a low-dose pesticide mixture via food intake is a topical question since epidemiological studies suggest that this may increase the risk of pathologies and particularly haematopoietic malignancies. Here we investigated on the haematopoietic system of mice, the effect of a m...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.10.024
更新日期：2010-01-12 00:00:00
abstract：:Recently, a large-scale field study in The Netherlands has focused on the effects of estrogenic contaminants on feral fish populations. The freshwater bream (Abramis brama) and the estuarine flounder (Platichthys flesus) were sampled at a large number of locations in the spring and autumn of 1999. Concentrations of th...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(02)00271-8
更新日期：2002-12-27 00:00:00
abstract：:In our experiments on acutely lead exposed rats we observed a marked increase (a 2-fold or 3-fold increase with 30 mg/kg or 60 mg/kg lead acetate, respectively) in [3H]quinuclidinyl benzilate [( 3H]QNB) specific binding to muscarine receptors from striatum and cortex, without any change in receptor affinity. Muscarine...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90005-2
更新日期：1984-05-14 00:00:00
abstract：:Cyclosporine (CsA) is a universally used immunosuppressive drug which induces adverse side effects in several organs, but its impact on the heart is still controversial. Small heat shock proteins (sHSPs), such as HSP25 and alpha B-crystallin, are cytoprotective stress proteins exceptionally represented in the heart. T...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2009.06.007
更新日期：2009-08-21 00:00:00
abstract：:Chronic treatment of BALB and GRS mice with BHT (2,6-di-tert-butyl-4-methylphenol) following a single urethane injection increases lung tumor multiplicity, but this does not occur in CXB4 mice. Previous data suggest that promotion requires the conversion of BHT to a tert-butyl-hydroxylated metabolite (BHTOH) in lung a...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(00)00449-2
更新日期：2001-03-07 00:00:00
abstract：:The role of nitric oxide (NO) in acute renal failure (ARF) is debatable. In the present study, we investigated the effect of acute administration of NO donor, Sodium nitroprusside (SNP), L-Arginine (L-Arg) and NO synthase inhibitor, N(omega)-L-arginine methyl ester (L-NAME) in Fe-NTA induced renal toxicity. Rats were ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2007.01.009
更新日期：2007-04-11 00:00:00
abstract：:The most commonly used assays designed to detect either skin or systemic immune-based hypersensitivity reactions are those using guinea pigs (GP). We obtained data from various FDA records to evaluate the correlation between GP assay results and reported post-marketing systemic hypersensitivity reactions. We examined ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(03)00267-1
更新日期：2003-12-01 00:00:00
abstract：:Flame retardants such as polybrominated diphenyl ethers (PBDE) and tetrabromobisphenol A are used as flame retardants and detected in the environmental, wildlife species and human tissues. Exposure to PBDEs during the neonatal development of the brain has been shown to affect behavior and learning and memory in adult ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2011.07.010
更新日期：2011-10-28 00:00:00
abstract：:The effect of sodium metavanadate (NaVO3) consumption on trace element metabolism, components of the antioxidant defense system and lipid oxidative damage were studied in control (CON) and streptozotocin-induced diabetic (DIAB) rats. Ten days after injection, CON and DIAB rats received either 0 mM NaVO3/80 mM NaCl (0 ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(93)90096-b
更新日期：1993-10-25 00:00:00
abstract：:Metallothionein, a low molecular weight cadmium-binding protein, has been determined for the first time in urine of "itai-itai" disease patients and other Japanese women environmentally exposed to cadmium. On a group basis, the urinary metallothionein levels of "itai-itai" disease patients and suspected patients were ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(81)90036-6
更新日期：1981-01-01 00:00:00
